Category Archives: Hair Regeneration

Adipose-Derived Stem Cells (ADSC), Cell Therapy, Dermal Papilla Cells, Dermal Sheath Cup Cells, Hair Regeneration

Effective Cell Therapy for Hair Regeneration

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Update: Epibiotech CEO Sung (who is the author of the new paper covered in this post) is answering our questions in the comments this week. Please note that English is not his first language.

Earlier this month, Epibiotech CEO Jong-Hyuk Sung published a detailed new paper titled “Effective and economical cell therapy for hair regeneration.” It was widely covered in South Korean media (h/t “Theo”, who also sent me this update on Mr. Sung’s presentation covering the paper). They call him Seong Jong-Hyeok in that article.

My interest piqued when I read such a thorough scientific paper from a CEO (almost unheard of in this industry). I showed it to a well known hair transplant doctor, and he found it to be a great summary. I also e-mailed one of Epibiotech’s media representatives with some questions, but no response so far.

Adipose, Dermal Papilla and Dermal Sheath Cells

Note that Dr. Sung has publiched numerous papers on adipose-derived stem cells (ADSC) and hair regeneration (and wound healing) for 15 years. This CEO seems to be a scientist first and foremost, rather than a business person.

This latest paper covers the three main types of cell based hair regeneration treatment strategies that are currently being developed:

  1. Adipose-derived stem cells (ADSC or ASC).
  2. Dermal papilla cells (DPC).
  3. Dermal papilla epithelial cup cells, better kown as dermal sheath cup cells (DPSC or DSC).

The paper also mentions the manufacturing of hair organoids using induced pluripotent stem cells. Including a shout out to Dr. Takashi Tsuji.

  • Note that Shiseido (including its use of Replicel’s technology) is working on a hair regeneration treatment involving culturing of dermal sheath cup cells. More details here.
  • Also note that in the past, Aderans and Intercytex both saw some succes in hair growth via dermal papilla cell culturing and injection into balding scalps. HairClone is currently trying something similar.

Dr. Sung’s company Epibiotech is ultimately driven by “Off-the-shelf” allogeneic DPC therapy. It aims to begin Phase 1 clinical trials for its EPI-001 dermal papilla cell hair multiplication treatment in 2023. We are all hopeful that things will move faster in Asia in comparison to the US or Western Europe. The company can already mass-produce dermal papilla cells with hair growth ability using spheroid culture, hypoxic conditions, and growth factors.

Cell Therapy Hair Growth
Cell therapy for hair growth. Adipose, dermal papilla and dermal sheath cup cells. Source: Biomedicine & Pharmacotherapy, January 2023.

Adipose Derived Stem Cells

Given the author’s background, the paper is especially detailed when it comes to ADSC (ASC). Dr. Sung highlights the pros and cons.

    • Adipose-derived stem cells are easy to access and isolate in large quantities. This is not true when it comes to dermal papilla cells and dermal sheath cup cells.
    • While ASCs promote hair growth through the paracrine effect, they have a poor potential in hair neogenesis. Dr. Sung suggests further development in methods to enhance the trichogenecity of ASCs.

Other New Studies on Hair Regeneration

As if this was not enough, two new papers on hair regenearation came out in the past month.

  • A lierature review from Japan coveres numerous cell therapies for hair regrowth. This includes mesenchymal stem cell (MSC) implantation. Adult sources of MSC include: adipose tissue (including SVF); bone marrow; DPC; DSC; placenta and umbilical cord. The paper also analyzes non-cell therapies, including exosomes, extracellular matrix, platelet-rich plasma, and the MSC secretome. The last mentioned “comprises bioactive materials, such as growth factors, cytokines and nucleic acids that play an important role in regulating the hair follicle cycle and regeneration”.
  • A new study from China on microenvironmental reprogramming of human dermal papilla cells for hair follicle tissue engineering.
  • And finally, a recent video on regenerative medicine for hair loss starring Dr. Jerry Cooley (interviewed by Dr. Robert Haber).
Hair Regeneration, Wound Healing

Scarless Wound Healing and Hair Regeneration

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Scarless Wound Healing and Hair Regeneration

— From a team led by the most famous hair loss researcher in the world Dr. George Cotsarelis (who has been at it for at least 20 years), comes a new study on how to heal wounds without leaving any residual scars. Key quote from Dr. Cotsarelis:

“Essentially, we can manipulate wound healing so that it leads to skin regeneration rather than scarring. The secret is to regenerate hair follicles first. After that, the fat will regenerate in response to the signals from those follicles”.

I have discussed the link between fat cells (adipocytes) and hair cells many times on this blog, including in the last post on the arrector pili muscle. These latest findings were widely covered by the global media, with headlines such as “The End of Scars“. The Reddit thread on scarless wound healing blew up. However, as with all things Cotsarelis and his headline grabbing findings, one gets the feeling that practical use is at least a decade away.

— Researchers identify how skin cells become hairy or sweaty during the embryonic stage of development. Actual study.

— Replicel’s CEO provided a detailed 2017 forecast, and this was followed up by the release of an important PowerPoint presentation in which the company summarized 6-month results of their RCH-01 product. Key current finding: “mean change in total hair density at 6-months = 6.1% vs 5.0% target”. 70% of responders saw a 14.3% average increase in density at 6-months. While they did not mention 12-month RCH-01 results, they do point out 12-month results from Finasteride (7-14% increase in hair density) and Minoxidil (8-16% increase in hair density) for comparison. Also of note, Replicel partner Shiseido’s Japanese clinical research findings are expected in 2018.

— Aclaris Therapeutics made yet another presentation (pdf downloadable from their press releases page), this time at the 35th Annual JP Morgan Healthcare Conference. At the end of the report they mention that pre-clincial development is now underway for their topical ATI-50003 selective covalently binding JAK 3 inhibitor to treat androgenetic alopecia. However, nothing in the report mentions when they aim to start phase 1 clinical trials. I hope it will be before the end of 2017.

— Follicum announced patent approvals in Russia and in Japan. The company had earlier also announced that they were scheduled to complete the multiple dose part of their clinical phase I/IIa study in January 2017 at the prestigious Charité University Hospital in Berlin.

— Judging from the latest update from Fidia Farmaceutici (Italy), The Dr. Brotzu lotion will not come out as early as some people expected. A lot of people on the hair loss message boards got mad, but a few took it as a positive sign that Fidia is finally releasing dates even if ambiguous i.e., “development of the potential product candidate being completed by 2018”). Ever since I first wrote about Dr. Brotzu, I have not paid much attention to this product. If you are inclined, go through the last 50 pages of this record breaking HLT thread and check out the Italian hair loss forums for more.

— Also from Italy, some kind of PRP plus insulin type of treatment (hard to tell for sure after translation).

— YouTube celebrity Fouseytube got a toupee to cover his bald head and this led to quite a lot of online discussion, including on reddit. In the past, it has also been rumored that Fouseytube has received a scalp micropigmentation treatment.

And now on to medical items of interest:

— Babies born without mothers (via embryos made from male skin cells) will come sooner than expected warn scientists. Surreal.

— Designer babies: an ethical horror waiting to happen? I am all for it even if it turns out horrific.

— Alzheimer’s drug “tideglusib” helps rotten teeth regenerate, reducing the need for fillings.

— Chinese company implants 3D prints blood vessels into monkeys.