Han Bio Hair Multiplication via Dermal Papilla Cells

At the end of March 2021, I read about a new South Korean company named Han Bio. Apparently, this company has managed to successfully develop a dermal papilla cell culturing technology.

Update: March 18, 2022 — Hanmo Bio gets approval for manufacturing advanced biopharmaceuticals. (h/t “Ben”). Per CEO David Kang:

“We got approval of the cell treatment facility last year, the entry into preclinical trials, and the recent approval for the manufacturing of advanced biopharmaceuticals. We are now standing at a very important start line for the fundamental and complete solution of the hair loss problem that Hanmo Bio is planning.

Update: January 2022  — South Korea is the first country in the world to suggest that the government should pay for hair loss treatments. Thank you President Lee Jae-myung. It seems like I am not as libertarian as I thought. Please see the middle of this post for much more on South Korea’s leadership in hair loss research.

Lee Jae-myung said on Wednesday that hair loss coverage is necessary from the aspect of “body completeness.”

Update: October 2021 — Clinical trials will start in the first half of 2022. Han Bio will partner with Dt&CRO. The latter is South Korea’s first and only full-service contract research organization (CRO). Non-clinical trials will commence in November 2021.

Another article from March 2021, with CEO David Kang making a bold prediction:

“By collecting 50 to 100 healthy hair follicle tissues from the back of a patient suffering from hair loss, extracting the dermal papilla cells, cultivating them, and transplanting them back to the head, we can fundamentally cure hair loss.”

Of course at first I was incredulous. However, after further research, I decided that I should at least take the company semi-seriously. Han Bio’s blog is especially extensive. Some hair related articles on there go into many pages, so be sure to navigate thoroughly (after translation). Another version here seems to have additional news.

Note that when I contacted the company, they directed me to the above blog.

South Korea: Groundbreaking Hair Loss Treatments

South Korea is a world leader when it comes to plastic surgery and cosmetic procedures. When it comes to treating hair loss, South Korea is especially impressive in developing and/or using new technologies. For example:

Han Bio’s Dermal Papilla Cell Storage and Culturing

Note that Han Bio is also called Hanmo Bio and Hanbio Group in news articles and on the company’s site. The externally located blog has some lengthy posts regarding this new technology. Some include images and video (screenshots further below).

In December 2020, Han Bio introduced its dermal papilla cell storage service called HDPC-480. The list price is 4.8 million South Korean Won ($4280 at current exchange rates). They offer a steep discount for the first 500 patients.

Note that in the western world, we have a similar option available via HairClone (UK). Moreover, HairClone has already been active for several years.

Han Bio Dermal Papilla Cell Storage
Dermal Papilla Cell Storage. HDPC-480 procedure from Han Bio.

According to the balding CEO Kang Da-Witt (also called Kang David):

“Han Bio has secured technologies to separate and regroup the dermal papilla cells in hair follicles. It would take just a single strand of a patient’s hair to cultivate enough cells to reproduce around 30,000 hair strands.”

The company’s method is described as “chopping separation technology” after translation from Korean into English.

Han Bio has finished construction of its first plant, where the company stores and cultivates patient dermal papilla cells. These can then be cultured, multiplied and then implanted into the same patient via a hair transplant. This new plant will open by the end of May 2021.

Han Bio Clinical Trials and Patents

Han Bio Presentation
Han Bio video presentation screenshot.

Han Bio will start clinical trials in the second half of 2021. According to CEO Kang Da-Witt, he expects that the time required for clinical trials will be shortened. This is due to a favorable new South Korean law which became effective on August 28, 2020. It is designed to help fast-track the market entry of regenerative medicine and biologics related products. Similar to Japan’s fast-track laws.

Han Bio is now preparing to apply for patents in the US, Japan and China. The are also open to out-licensing the technology.

Transplanting Someone Else’s Dermal Papilla Cells

From Han Bio’s extensive blog, one FAQ section caught my eye. It seems like the parent company of “Hanmo Bio” has successfully transplanted hair stem cells from one person to another. Without any immune reactions.

Dermal Papilla Transplant
Dermal Papilla Cell Transplant from Another Person.

Obviously, this all sounds way too good to be true. But I have to prognosticate.

Asian countries dominate the world in the manufacturing of nano-scale semiconductors, microchips and integrated circuits. Perhaps our invisible-to-the-eye dermal papilla cells are next?

61 thoughts on “Han Bio Hair Multiplication via Dermal Papilla Cells”

    1. I did, but they just referred me to their blog. They did answer my timeline question and said good chance trials can be completed before 2025 due to the new favorable regulations.

  1. Hi Admin,

    Any update from Hairclone? Are they still in position to offer cell injection this year to clinics?

  2. Great thanks for the find, but are they working on hair cloning?and im not fond of ukhairclone they have nothing going on other than freezing your follicles !

  3. “By collecting 50 to 100 healthy hair follicle tissues from the back of a patient suffering from hair loss, extracting the dermal papilla cells, cultivating them, and transplanting them back to the head, we can fundamentally cure hair loss.” Wait I’m confused so they take the dermal papilla cells from the follicles they then create hair follicles from that and then transplant to the person’s scalp? Or is this another replicel?

  4. I have more hope for this company than Hairclone lol. Hairclone with their freezing hair follicles business lol. I dont want to say anything more.

  5. Hello Admin,

    I wanted to get your perspective on this: Do you believe the pandemic will drastically delay the availability of any possibly future cure for hair loss? I appreciate your opinion. Thanks!

  6. @ADMIN @HLC2020 @hairlosscure2020

    what is the movement at HopeMedicine?
    When will they publish their website?
    When will they Start trials For HMI-115?

  7. Don’t see the hype, they’re doing the same thing hairclone are doing now and Aderans have done in the past, DP cell multiplication. We’ve already seen the results and they don’t grow new hair, just thicken existing.

    Changing the way you administer it isn’t going to make any significant changes in outcome IMO.

    1. Hey Sahak…Check out this patent…WO1994005250A1..it’s an old 1994 which means it can be used by any one now…and it showed 100 % success rate…
      I am in the process of buying the compounds and mixing it my self…
      All the compounds are organic and they are sulfur based .

        1. I will report here…and hopefully will provide before after photos …
          I think this patent is legit…and would be nice if other people give it. A try …
          Have you read the claim and patent details ?

  8. They talk as if they were already successful don’t they?
    I don’t understand if this is another pretentious claim or they actually got something.
    Anyway the idea that a company we’ve never heard before could come out of the blue and cure hair loss is fun

  9. If half of what they say is true, they would have been acquired by now. they would have been billions eur worth. come on guys, almost a year ago a “start-up” biontech was discovered by pfizer and now they are playing for cancer treatments.
    i would only believe if loreal or big pharma acquires them or make partnership with them

  10. Reminds me of “Stemore” – appeared out of nowhere with groundbreaking treatments.

    Then quiet for a long time and now with a much more conservative timeline and no public statements at all.

    Han Bio‘s CEO looks like a character from “The Office”. Which makes him almost more credible than one of these over-the-top-styled model-like CEOs.

    Great find, Admin. The more players the better!

  11. Nice birthday present for me today.
    Well if the CEO is balding we can focus on his head as proof of concept.

  12. Why would they need to transplant hair from one person to another if all you need is 50-100 hair follicles? I mean even Norwood 7 people can manage to find 50-100 hairs don’t you think?

    1. Some with male pattern baldness preserve thick and healthy hair in the remaining horseshoe into old age. Many others, I’m one of them, have thin hair in the horseshoe which diminishes over time. The concern is that the hair follicles that are used from this area are not sufficiently long lasting. Would be good if someone could work out a method to determine whether a follicle is permanently immune to MPB. Indeed, that’s needed for person to person transplants as the donor follicles might also be susceptible.

  13. Well, this may be similar to hairclone. But do you know the difference? In the western world something that will take 15 to 20 years to complete and get approved can be fast tracked in South Korea. And it’s proven South Korea has massive success, not necessarily with hair loss cures, but with things in a similar arena. This is definitely worth watching. Heck, I’m in the US and I’d fly to SK to get this done if I had to, though I don’t think I’d have to.

    I think other cures (pharm) will “help” with hair loss but the only true cure is hair cloning. If they can clone them you can literally keep getting hair transplants until you’re happy with your thickness – if you’ve got the money, that is (meaning if you’re quite bald it’s going to be costly to clone and get then MANY transplants as it’s usually just 3-4K per procedures, typically).

  14. I have a deja vu. Maybe they should consult replicel to learn where this will end. Even though I’d welcome a cure through cell injection over one with the manual transplant of cloned follicles, like tsuji wanted.

  15. Admin, anyword on how the funding for 4.8 million for Dr tsuji to be able to start human trials is going? Either way i think most people who have researched this topic can relise that its not going to happen until the next decade mark my words.its just not feasable !

  16. If true, this would be a dream come true. I’m not getting my hopes up though. I blindly put all of my faith into Replicel and followed them closely for YEARS, only to be punched in the stomach.

  17. Well, it’s good news so I’ll take it. Better there than some other places – I think they’d get a product out to market sooner than many other countries. If the trials are all successful, of course. The tech is there…someone (hopefully them) just needs to commit and see it through.

    1. Not in South Korea. Maybe in the US. They have a better records with approving and marketing times. I mean, yeah, it’ll take a while still but not 2032 (if it works I mean).

  18. Johnathan, if they release a cure (i.e. not just a treatment) by 2032 that would be a fantastic. We’ve been let down countless times over the past decade(s). So having a cure by then would be a miracle. I know that sounds bad to some of you, but that’s that reality we’re faced with

    1. In 10 years I’m 60, but you are right and I hope that many young guys don’t have to ho what I and many others went through… I starting losing my hair when I was 20, nobody should lose hair so early.

  19. Han bio is just like replicel, it will not restore anyone’s hairline. We need hair cloning! I don’t understand why stemsons therapeutic is taking so long to do human trials (which will fail) my dermatologist already looked into them, but the point is they’ve already cloned human hair on mice and pigs and they were successful,why take 10 more years to start human trials? Which will fail.

  20. South Korean presidential candidate promises baldness cure to get votes. For this reason, I think that one of the first countries that will take the lead in treating baldness is South Korea.

  21. Guys anyone tried Clascoterone, Winlevi? It’s out now in the US?

    This is the same as the companies hairloss treatment but at 1% concentration (instead of 7.5%) and supposed to be used for acne.

  22. First pig heart in human transplanted. Great step for xenotransplantation. Its so sad that they try cloning instead of xenotransplant for hair..

    1. I was 50/50 about writing a post on that development! Crazy.

      I am more interested in person-to-person hair transplants (that do not require taking anti-rejection drugs). The research is based in South Korea, so it is hard to get new info.

  23. Dear admin, When will han bio start human trials for hair cloning? And are they doing stem cell injections or actual hair cloning or both? If someone can please explain this to me I would be appreciative.

  24. Seems that Hanbio has gone into partnership with Soonchunhyang University Seoul Hospital in regards to cell research, additionally they have started pre-clinical trials expected to be done by June, and they also expect to start clinical trials second half of 2022 through both 1 and 2a. studies.

  25. I’m surprised that Hanbio was able to finance $40 million US to fund its preclinical and clinical trials when Tsuji could not even get a free salad at an all you can eat Salad Bar.

  26. Injecting cells into human head will not grown hair. Or it will grow, but not significantly, and hairs will died after year or two.

    My opinion is that Han Bio give very false hope to the people with using words like ’cure’ and ’hair loss it will be thing of the past’.

    Sorry, but growing hairs on mice and human heads are totally different things.

    CEO of Han Bio has a chance to test his technology on himself, because he is having hair loss, as well, so we will have a valid proof that technology is working.

    1. If it is dht/testorone resistant cell from the back of the head it could work…and it could help women Who are on HRT because of menaupose or are treated for PCOS and for who the treatment stopped the hairloss but did not regrow haire (like me and plenty of others)…why do you say it won’t work?

  27. Every bald man’s dream is a shampoo that can regrow all lost hair within 3 months, maybe one day, who knows.

  28. I’d say it’s suspicious, at least, that they suddenly stopped updating blogs since March. Compared with the previous frequency there must have been a big problem somewhere. Clinicals still in the second half?

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