Androgen Receptors, AR Antagonist, Kintor Pharmaceutical, KX-826, Pyrilutamide

KX-826 (Pyrilutamide) Cosmetic Launched

77 Comments

In my regularly updated post on Kintor Pharmaceutical (China)’s clinical trials, the latest development was that Kintor was launching a KX-826 (Pyrilutamide) based cosmetic product. They received International Nomenclature Cosmetic Ingredient (INCI) approval in June 2024.

July 26, 2024

KX-826 Hair Growth Spray Launched

Now the product is for sale on Amazon at a price of $69 for a 1-month supply (plus a 5% off coupon) with 0.5% pyrilutamide. Update: The 1% version is also on Amazon now. It is made by Koshine Biomedica (China). It comes as a topical spray. There are no reviews or product ratings at the time of writing this post. The product description mentions that it is a dihydrotestosterone (DHT) blocker, and reduces sebum excretion and scalp oiliness.

Note that the actual androgen receptor antagonist KX-826 is still in Phase 3 clinical trials in the US and China. The cosmetic product (image below) is a way for the company to release a topical product faster.

Kintor KX-826 Cosmetic
Kintor Pharmaceutical (China)’s KX-826 Cosmetic Androgen Receptor Antagonist. Made by Koshine Biomedica (China).

Also of interest, one of the images on Amazon implies more rapid hair growth from this spray product in comparison to FDA approved Minoxidil:

KX-826 versus Minoxidil
KX-826 versus Minoxidil hair growth comparison.

Usage Instructions

The instructions on using this KX-826 spray are as follows:

  1. Open the outer packaging and insert the spray head onto the bottle.
  2. Find your area of hair loss, use your fingers to expose the scalp, and then apply the anti-hair loss liquid spray.
  3. Use once in the morning and once in the evening. For a total of 6-8 sprays each time, which equates to about 1ml.
  4. Massage the scalp for about 3 minutes after the spray has been applied.

Note: Only meant to be used when your scalp and hair are both dry.

77 thoughts on “KX-826 (Pyrilutamide) Cosmetic Launched”

      2. Any side effects so far? When did you begin kintors product? Notice anything different? Less oiliness etc?

        Reply

        1. Dear Tom, I have not used it yet, but I will buy this product at the first opportunity when it is available in my country.

          Reply

    1. Thanks Daniel, I got 4 e-mails about it (and also posted a comment about it earlier under an older “natural cures” post)!

      Lets see if it ever works in humans.

      Reply

    2. The story is clickbait.

      “The deoxyribose gel was so effective, researchers found it worked just as well as minoxidil, a topical treatment for hair loss commonly known by the brand name Rogaine.”

      ***as well as minoxidil***

      Reply

  4. Is the cosmetic identical to what is being tested in Phase III, but they just can’t make the claims yet?

    Reply

  6. @admin

    Can you elaborate on this

    “The cosmetic product (image below) is a way for the company to release a topical product faster.”

    What exactly allowed then to release it faster? Just labelling it cosmetic product? Or something else?

    Thanks

    Reply

    1. Mg89 puts it perfectly. What is this stuff? Same strength? If it’s different, how so? This drug doesn’t appear to be very effective in any case and if this cosmetic product is watered down it’s almost certainly a colossal waste of your money.

      Reply

  8. Hi Admin. when i click on the link in your write up for the product for sale on amazon. It send me to a blue hair dye. i cannot seem to find this product on there. any help is appreciated.
    Thanks
    D

    Reply

  9. I ordered 3 months worth. Seems like a complimentary approach to the main stack. I’ll let you guys know if I see anything decent.

    Reply

  13. Crazy they can’t come up with one product that works… instead we have to have a 7 layer stacked burger of products that will probably (eventually) do something negative to us when combined and used long term.

    Reply

    2. hello, please any website to purchase this topical i want to try it out “pterostilbene and nicotinamide” greyhair reverse . BR

      Reply

  16. Unfortunately, based off product images listing the ingredients list, this version sold on Amazon has propylene glycol. PG causes skin irritation for a lot of people, as PG allergy is common. In kintor’s panel literature for KX-826, they talked about the downfalls of competing hair loss treatments including the use of PG and the ensuing irritation it causes. Yet they’ve licensed a distributor that chose to use PG in the solution, making this product unusable for many.

    Hopefully, they’ll make a PG free version soon.

    Reply

  19. Does anyone know if this goes systemic? Admin any comment? I cannot find the study and if this had an affect on hormone (testosterone) levels or if it was found on the serum of the participants. I guess a doc must advice since its a new drug. I really hope it is sides free.

    Reply

    1. I was ordering grey market from a popular supplier in Europe. It gave me crazy insomnia and racing heart.

      I’m not sure if anyone else experienced that

      Reply

  20. Unfortunately, Kintor carelessly destroyed the pyrilotamide. I request you, the readers, to visit the pubchem website and view the chemical structure of enzalutamide and pyrilutamide. The two drugs are surprisingly similar, and it is quite clear that pirlotamide is made from enzalutamide. Question? So why didn’t pirlotamide work? Answer: The dosage is ridiculously low. I’ve tried up to 3% (30mg) with great results so far (no side effects) and I’m also planning to try higher concentrations to see how my body reacts to it. Unfortunately, Kintor does not achieve the desired result even with a concentration of 1%, and higher concentrations should be tried. If enzalutamide works as an antiandrogen, pyrillutamide should work as well. I hope more people like me try higher doses based on individual tolerance. Unfortunately I predict we will have the same problem later with GT20029.

    Reply

    1. it could be that they tried lower doses because they were worried about possible side effects causing adverse events and causing the trial to fail.

      Reply

      1. Kintor tested doses of 3 mg, 12 mg, and 48 mg in a phase 1 clinical trial. Even at the dose of 48 mg (4.8%), there were few side effects. I laugh when I compare the dose of pyri (5mg) with the dose of ru58841 (50mg). It is true that pyri is stronger than ru58841 but not 10 times!! In my experience with pyri, the minimum dose is 25 mg (2.5%).

        Reply

        1. Which means that the current 0,5% (KX826) will not be absorbed systemic? I am sorry for asking but I cannot find the studies etc and I am concerned about any systemic exposure

          Reply

          1. According to the phase 1 clinical trial, the systemic absorption of 3 mg (0.3%) was zero, but the systemic absorption of 12 mg (1.2%) was 0.3 ng/ml, which is practically safe. It can be assumed that a dose of 5 mg (0.5%) has a systemic absorption close to zero.

            Reply

    2. This is an intriguing post, Bill. How can we follow your progress? Do you have pictures showing your very positive results? Good luck!!

      Reply

      1. John, it’s been about 2 and a half months since I started using it. I will share my before and after pictures when I reach 6 months.

        Reply

      1. dark prince, I order pyri powder from China. I sent the powder to the lab before using it to make sure they didn’t sell me another substance instead of pyri!

        Reply

    1. Thanks for the post Lorence, but Mr. Admin, could we make this its own thread? It’s clearly been a new story that is noticed, but it would be easier to follow as its own post??

      Reply

  25. @Admin
    Kintor might release the 1% dosage before finishing the trials as well. I have found the item on the website already.

    Reply

      1. You will find postings on Reddit already. We have contacted Koshinemall. They were saying release of 1% solution within the next 3 Month.

        Reply

  26. I don’t know what you think about GT20029, but I am very skeptical about the results of the phase 2 clinical trial of GT20029. In the 0.5% group, after 12 weeks (less than 3 months), the placebo group had an increase of 10.11 hairs per square centimeter! Can someone explain to me what is this placebo that causes an increase of 10 hairs per square centimeter in less than 3 months?!!!! I can’t believe it with any logic. I believe that the placebo group participants cheated and used fin or min. In the 1% group, the result of the placebo seems reasonable, but the result of the GT20029 group with a concentration of 1% twice a week does not seem reasonable to me, which caused the growth of 11.94 hairs per square centimeter by using only twice a week and less than 3 months. Yes, and I am sure that the participants of this group also cheated and used fin or min.

    Reply

    1. I agree with you bill. What do you think about the twice weekly protocol for GT20029? I think that twice a week reduces the effectiveness of the drug and you should use a concentration of 1% daily.

      Reply

      1. In the phase 1 clinical trial, the maximum concentration they tested was 2%, and interestingly, the average maximum serum concentration of the drug was 0.015 ng/ml. That is, the systemic absorption of the drug was severely limited. I also believe that the twice-a-week protocol is a poor protocol and the drug should be used daily. Also, due to the limited systemic absorption of the drug, they should have tested higher concentrations. Unfortunately, kintor didn’t learn from the mistake he made with kx826 and made the same mistake again with GT20029. Instead of using the maximum safe dose, they use the minimum safe dose, and this increases the probability of clinical trial failure.

        Reply

  27. Coegin Pharma is a Swedish biotechnology company with innovations in dermatological cosmetics for hair growth and skin pigmentation, as well as leading drug candidates for the treatment of heart attacks and leukemia. Coegin plans to launch its first line of hair growth products in 2025, followed by a skin pigmentation product in 2026.
    The company received the INCI name, which is crucial to be able to sell beauty products globally, and a memorandum of understanding was signed with the Chinese company Zhejiang Sukean Pharmaceutical. shares

    Reply

    1. It is not helpful to place unrelated news/stories – please send link to admin to create a new h th read if it’s substantial.

      Reply

  28. Another BS diluted cosmaceutical to add to your heavy hairloss “med stack” that will do nothing more than hold onto thinning, wispy hair. Marketing to desperation.

    Reply

  30. I think Kintor’s financial situation is terrible that they had to sell 1% concentration before clinical trial. Although 1% concentration is still not enough and more than 2% should be used to be effective.

    Reply

  31. An update to one of the Amazon reviews is interesting:

    “After 3 weeks of use I can report it stopped my shedding, but I also got very bad side effects: head ache, dizziness and ED. I am fully aware that all medications can have a side effect and thus definitely went systemic.”

    3 reviews in there so far:

    https://amzn.to/3ZiqFNV

    Reply

    1. The review seems strange since the active substance stops DHT binding to the follicle and does not stop testtosrone being convrted to DHT. Since there is no change in DHT how can one get sides worse than fin?

      Reply

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