Update: October 12, 2024
When Shiseido’s hair loss treatment came out in June 2024 and I wrote this post, I was certain that this is the best news of the year. I was also optimistic that this dermal sheath cup (DSC) cell hair multiplication procedure would be superior to existing FDA approved hair loss treatments such as Minoxidil and Finasteride.
However, since Shiseido is only offering this S-DSC procedure to Japanese citizens at the moment, it will be a while before we get more details about success rates. So I am updating this post due to a possible new report on Shiseido’s efficacy (h/t “Theo” for the below link and translation), though it is a bit speculative and anecdotal.
In a new hair multiplication related article in Japanese newspaper Nikkei, they mention the “Big 3” of OrganTech (Japan — led by Dr. Takashi Tsuji), Stemson Therapeutics (US) and TrichoSeeds (Japan — led by Dr. Junji Fukuda). According to Nikkei, Stemson and OrganTech will start clinical trials in 2026 for their “Gen 2“ hair regeneration treatment. Junji Fukuda states that they have created a similar technology as OrganTech, but plan to start clinical trials in 5 years from now (i.e., in 2029).
The title of the article is:
“Planting hair seeds to treat alopecia. Clinical trials underway in Japan and overseas”.
However, the most significant news is via implication. In the article, it says that “Gen 1“ treatment is already in practical use in Japan with a success rate from 30-60% (which is ambiguous). This is quite likely to be Shiseido’s treatment, now available at both Toho University and Akihabara Skin Clinic, both in Tokyo.
In the article, it says that for “Gen 3“ they are planning to use animal stem cells. “Theo” was not sure what this meant, and neither am I. If anyone subscribes to Nikkei, please read the entire article and give us your thoughts.
In general, I do not think that cosmetics behemoth Shiseido would ever take over a decade to bring something to market with only modest benefits. Lets keep our fingers crossed.
June 28, 2024
Shiseido’s Dermal Sheath Cup Cell Hair Multiplication Treatment Has Arrived
Today might be among the five most important days in the hair loss world since I first started writing this blog in 2013. Shiseido’s decade-plus-long much awaited dermal sheath cup (DSC) cell hair multiplication (cell culturing and implantation) procedure is finally here for patients starting July 1, 2024. Albeit only in Japan, where they have favorable regulations for faster in-clinic use when it comes to regenerative medicine and stem cell based technologies.
Shiseido (Japan) completed small-scale Phase 3 equivalent trials for this hair multiplication technology in 2023. The results were positive but modest, with no major side effects. I hope the results will improve as they use this autologous DSC cell transplantation process in more patients and gain experience.
For now, you should only expect existing scalp hair thickening and perhaps minimal hair regrowth if you are lucky. Thicker hair in and of itself could lead to a slowdown in further damage from the ravages of dihydrotestosterone (DHT).
You can read today’s full announcement here (h/t “Theo” for the super find). The technology is described as having been developed by Tokyo Medical University Hospital, Kyorin University Hospital, and Shiseido. Interestingly, they leave out any mention of Replicel (Canada), with which Shiseido has had past legal issues after a technology sharing agreement went wrong.
S-DSC® Hair Regenerative Medicine
Shiseido has also created a new website related to S-DSC hair regenerative medicine, where the “S” stands for Shiseido. The about S-DSC page is very interesting. S-DSC® treatment promotes hair growth by supplementing the thinning areas of your scalp with your own cultured DSC cells.
They only make claims that existing hair will get thicker and more voluminous, while scalp inflammation will be reduced. Perhaps they also want to temper expectations, even if some people may get good regrowth? Interestingly, women might get better results then men.
The key person who led the development of this technology is Professor Emeritus (Department of Dermatology, Tokyo Medical University) Dr. Ryoji Tsuboi. I feel like a genius for using his image as my main one on my global hair loss research page from the get go. I originally picked Dr. Tsuboi over Dr. Takashi Tsuji just due to a more interesting image of the former at a white board.
Hair Regenerative Outpatient Treatment Begins in Japan on July 1, 2024
Associate Professor Shiro Niyama of the Department of Dermatology at Toho University Ohashi Hospital will start offering this “hair regenerative treatment for thinning hair” using cultured autologous hair bulb root sheath cell products (S-DSC®) from July 1st 2024. Patients will be required to get a referral, and also be responsible for their own costs due to the elective nature of the procedure. Note that this treatment is available for both men and women.
In the procedure itself:
- First, healthy scalp tissue of about 5 mm diameter is taken from a non-balding area such as the back of the head.
- From this, DSC cells are isolated.
- S-DSC is produced after about 6 weeks of culture and quality inspection (a total of 7 vials of S-DSC can be produced).
- Once production is completed, patients will return to the hospital and the cultured DSC cells will be injected with a special syringe.
Also check out the November 2023 study from the same team that is titled: “High migratory activity of dermal sheath cup cells associated with the clinical efficacy of autologous cell-based therapy for pattern hair loss.” The conclusion was that ITGA6-positive DSC cells, with superior migratory activity, may promote cell migration into nearby hair follicles.
I remember reading about this treatment on your page years ago, when it was considered a proper cure. Such a disappointment unfortunately, though I’m surprised they released a product at all not hearing about them for a long time.
Sorry Admin, this does not seem any better than Fin. There is no info on how low it will last. Whether continual treatments will be needed. No info on the cost and sounds just like CosmeRNA.
Surely this might be better than nothing. How much better?
Agreed… it will be like cosmerna and will go quiet after initial buzz. It’s surprising that no “hair loss experts” are even talking about it…
They only claim hair thickening. All forums and blogs have been talking about Shiseido and Replicel for over 10 years. The new links in this post are due to “Theo” e-mailing me. They are Japanese sites…I would have never found the Toho University site by myself.
Even they do not claim it to be better than Fin Abbot. Did you read the entire post?
It is a miracle that we can now get our own hair cells cultured and multiplied and then implanted back into our scalps.
Is there any possibility that this can be repeatedly performed to eventually culture the entire scalp?
I’ve been a reader of your blog for years. And years back I couldn’t afford any of these. I pray that this is the final nail in the coffin.
The part that worries me is that a 5 mm diameter hole will be taken from healthy scalp. Won’t that leave a visible circular scar every time that can only be covered with longer surrounding hair? That would add up with repeated procedures
Hair thickening? As in increasing hair shaft diameter? Any word on pricing? This is great news and hopefully leads to a way to increase new hair growth, the panacea we are all looking for.
Rick C. check out my past post on Shiseido where I discuss their Phase 3 results (link is in the post).
As far as cost, it says the following on their new site:
“This treatment is offered as an elective medical service, so please contact each medical institution for details on costs.”
They plan to offer this at more centers in Japan, but initially, only Toho University Ohashi Hospital.
From over 10 years ago:
https://www.hairlosscure2020.com/shiseido-opens-new-research-facility-dedicates-hair-regeneration/
Shiseido opened it’s Cell Processing and Expansion Center (SPEC) on May 1, 2014.
I don’t understand the excitement with this product. It only thickens existing hairs? Does it even prolong the anagen phase of hair cycles?
Incredible news, even if it ends up being just hair thickening (as long as guaranteed, unlike PRP). Congratulations on your 10+ years of patience covering Shiseido and Replicel Admin!
Today is a great day for the hair loss world!!! I was sure that sooner rather than later this treatment was going to be effective because it was not a complex process and this day has arrived and I am glad that it came like this, by surprise, instead of following schedules that are always delayed or never arrive. until the end!!! I am very happy for everyone and especially for you, administrator, for all the informative work that you have done for many years, and that, like the other readers, you have felt the desperation of following the work of so many companies that have never materialized and that at the same time The final solution for us for so many years has been hair grafts, finasteride and minoxidil as truly effective methods. Well, the time to continue taking these medications daily has changed and we will be able to preserve our hair with a transfer of resistant DP cells from the donor area to replace the weakened and lost ones affected by DHT. Great news, congratulations on your work and your perseverance administrator.
Thanks Alvaro!!
And everyone, please let me know if your comments do not get approved in 2 days. I had to remove the old spam comment detection plugin and try something else unfortunately. It is time consuming.
Admin, you are a genius! Hopefully the first of many new treatments to come over the next few years.
Geniuses do not use “2020” in their domain names :-)
Ok, how about a comedic genius! ;-)
Admin, I told you that you just need to add an “s” at the end of the website title to buy yourself 9 more years with this domain. So, “Hair Loss Cure 2020s” … Done :-)
True :-) But I hate the idea of redirecting web pages.
While I am a very positive person I think this is getting a little too optimistic… it may serve as a very short term therapy but I don’t think it’s going to be anything better than the current medical treatments we have today. Will be expensive and very little effectiveness… it sounds like another Cosmerna or PRP like treatment. It may catch buzz for a couple weeks or months and then will fizzle. We need gene editing or full blown hair cloning for a cure.
I am just excited that a country is allowing cell culturing and implantation to anyone who gets referred.
A first. Japan and South Korea will lead the way it seems. Shiseido’s Phase 3 trials were small and inadequate my US standards. Yet they are allowed to proceed.
And we have had no FDA approved hair loss treatments since Finasteride and Minoxidil.
Albeit good news, isn’t this just hair transplant, now with more hairs to plug? Please correct me if I’m missing something.
No friend, this technique consists of extracting a small amount of hair from the donor area (which is not affected by alopecia), and from those hairs extracting the cells of the dermal papilla, or hair bulb, that is, where a hair is born and multiply them. These cells are what determine the length, thickness and color of the hair and in people with baldness, these cells are destroyed in the area of alopecia by the action of dihydrosterone (DHT), which is why we talk about hair miniaturization. hair, because as these cells are lost, the hair becomes increasingly finer until the hair bulb has completely disappeared and there is no longer any possibility of saving that hair because it has been left without a root. But with this technique you can replace the affected cells with immune cells, which is why the miniaturized hair will become progressively thicker, because the greater the number of DP cells, the greater the thickness. And in this case, by replacing DP cells genetically programmed to be sensitive to DHT with DP cells immune to alopecia, this is a potential cure for many people who experience alopecia in early stages. I hope you have understood me!!
Thanks Alvaro! And Yoda :-)
Thank you very much administrator! For those of us who have been worried about hair loss for so long, and visiting this page, we can only thank you from the bottom of our hearts for all the information work that you do selflessly. I started visiting this page when I was 18 when I started losing my hair and now I’m 28 and from the beginning I was clear that the cure was hair cloning, because in the end a hair graft is moving the hair from one place to another and the Medications only serve to maintain what you have and depend on them… That is why I am so happy about this news, which in the end is science, and I am sure that everything will change from now on!!
Cells or hair follicles from donor area that are resistant to DHT, would turn into DHT sensitive when they grafted into the recipient (DHT sensitive) area. That’s similar to what happens after hair transplant . We will still have to use DHT blocker and/or minoxidil to protect them from the DHT effect.
Sensitivity to DHT is not determined by the area of the head where baldness mainly occurs, but by the androgen receptors located in the follicles of this area. That is why generally hair grafts, in which the hair is moved from the donor area to the bald area, this transplanted hair is permanent and will no longer fall, because the hair from the donor area does not have as many androgen receptors and is resistant to DHT. The same thing happens with this treatment, but instead of moving entire follicles, only the cells of the dermal papilla or root are moved, to replace the cells that are lost due to alopecia in the bald area. Of course, it is not a cure for people who have already lost a large part of their hair and it is true that it will be necessary to repeat this treatment from time to time because the alopecia will continue its course.
That’s not true, Alvaro. Look at anyone who had hair transplant, you will find out that if they don’t use propecia, the transplanted hair will mostly fall out over time (not only the native hair as they claim
). Plus there are signaling mechanisms in the recipient area that transforms the grafted hair into sensitive ones to DHT over time. The baldness area has many signaling mechanisms (not only DHT or receptors) that reprogram the newly implanted follicles, at least partially. I’m an old scientist with PHD in gene therapy, btw, and have extensively researched, read and watched experts opinions on that issue. Plus I had one transplant surgery, myself, and it was negatively impacted by not using DHT blocker after surgery. I hope that this new cell therapy works though. Fingers crossed.
I have seen guys whose transplant still looks amazing 20 years later. I think the permanent donor hair remains permanent in at least half of people.
In many people, the problem is that the permanent donor zone hair is not permanent. My grandfather lost all his hair in the permanent zone by age 60.
On a kind of related note, check out the Jeff Bezos’s grandfather story on this blog. His grandfather’s ass hair lasted on his hand (once grafted) for a lifetime lol
I don’t need to look at someone who has undergone hair transplant surgery because I underwent one myself. If you have not taken medication after your operation, the alopecia will continue its course and the native hairs that you retained will have disappeared. What the administrator says is also totally true, that many doctors, as happened in my case, took hair for the transplant that are still sensitive to DHT because in my case they took hair from the crown area, and many people with their Fully developed alopecia experiences a fall in its donor area. That is why I have always said that to perform this technique, there must previously be a test or diagnosis to determine that the multiplied cells come exclusively from hairs that are 100% resistant to the effect of DHT.
Definitely not true… for many men donor hair will thin as well over time if dht blockers aren’t taken. Even with medication donor still can thin…. I have also watched numerous world renown hair transplant surgeons talk about this… and all of them agree transplants thin over time because donor hair miniaturizes.
Is this so? It doesn’t seem to mention DHT resistance, although that be awesome.
But it won’t work in DP cells that do no produce hair anymore ?
So it is still not satisfying, only interesting for people who started to bald recently no ?
Would that not be a cure though? Unlimited donor supply? If I had 10k-50k grafts or whatever I would be getting mega sessions every time I lost density lol
Wow never thought Shiseido would come through. Thought they were just another Follica or Histogen lol. Now I am almost 50, but maybe a first Japan trip is needed.
From what I read, one would need to go to Japan for ~2 months to have this treatment as they need to culture the cells before treatment, or is there some suggestion that they will expand the harvesting globally and allow shipping of cells so international patients can then fly out once the treatment is ready?
Yes, but 6 weeks not 2 months. This is truly fantastic news as we head into a new era away from the classic route of finasteride and minoxidil. We know that DHT is what caused hair loss as it kills off DP cells at the base of follicles. If we replace those DP cells with fresh DP cells then we see new hair growth. Shiseido is the world’s 4th largest cosmetic company and have been around for more than 100 years so they are not just any company. This is going to expand to other cities around Japan such as Tokyo and Hiroshima.
But the point is, who has 6-8 weeks to visit and stay in Japan to go through this procedure if that’s the requirement? Don’t get me wrong, it’s encouraging news in this lacklustre area of medicine, but it may be a while before it’s useful to anyone on this board.
It depends on how long each treatment lasts for, though at this point I need regrowth as well as thickness. 6 weeks is nothing if something lasts for 10 years, but I doubt that is the case with DSC cell injections.
Fair point, but also not everyone has such long holidays from work nor can take them all at once like that, I’d be surprised if even a significant minority of posters here could take 6 weeks off work to stay in Japan for this procedure, even if it realistically lasts a few years.
I forgot to add that the 6 weeks time frame makes it more legitimate to me. They could easily have said 2 weeks and drastically increased their client base.
Presumably at the cost of massively disappointing their customer base at some point in the future, this is a high tech expensive treatment for discerning gentleman managed by one of the biggest cosmetics companies in the world. I don’t think they’re worried about pitching this to the hoi polloi.
While this is great news it does seem disappointing to read that results are merely modest. I’m not sure how to quantify that exactly, but it sounds a bit underwhelming and certainly far from a cure. I do wonder however if repeated treatments lead to greater results. I think it’s best to hold off for now and let them gain experience and see what works best and to which extent. Nonetheless I am modestly excited to see this come to fruition.
What are the other 4 most important days out of interest?
Has anyone come across before/after photos for this procedure?
Reading shiseido text in japanese.
Seems like no serious sides but treatment seems like not last forever and 60％ of male patient felt hair loss progresses after treatment which will cost 10k to 23k.
I dont see anything positive ….
where did you find the cost?
https://www.lab.toho-u.ac.jp/med/ohashi/dermatology/information/2024/r3fc8g0000000047-att/saisei_iryou_info.pdf
toho university is the only one medical institution providing this treatment so far and treatment starts from tomorrow
The photo posted are not that bad in terms of thickness. But they need spread this treatment in the world, do you think it is going to happen soon?
Does that mean there is still a chance for Replicel?
Is the cost 10k – 23k USD accurate admin? How does someone international go about getting a referral for this treatment in Japan.
I can’t seem to find any before and after photos in the references you linked, are you aware of any you could point me to please?
They say prices will vary by clinic once more in Japan start offering. $10k seems about as high as I would expect if you need this procedure every few years. Hopefully the person who posted these numbers converted from Yen to $ correctly.
What does this mean for Replicel moving forward ? With Replicel still holding patents and marketing rights to this procedure outside of Asia it will be interesting to see if Shiseido or some other large Pharma will swoop in and try to buy Replicel. This is very good news for the long suffering Replicel shareholders !
It‘s the very first cell-therapy to be commercially released, which is an absolute watershed in the history of hairloss-treatments.
I hope this is a good signal to all the other developers around the world.
I think we have to wait for more results, I remain skeptical that it‘s a) effective enough and b) lasting. I hope to be wrong though.
The Aderans-method seems much better to me. According to the trials it is a one-off treatment which is long-lasting and gives you thickening of existing hair plus minor regrowth. Fingers crossed that they start phase 3 soon!
I feel compelled to have to rectify my previous comments. When I read the news and the article, something didn’t add up to me with the acronym DSC. I had always read the dermal papilla cells as DP and searching for information about this, I understood that the hair bulb contains the dermal papilla inside (which determines the thickness, length and color of the hair), although I always I had considered that both terms were equal. The difference in this is that the other companies (Stemson-Aderans, Tsuji, Fukuda, Epibiotech, HairClone…) that were working on this method of multiplication and injection of autologous cells work with DP unlike this company Shiseido that works with DSC, that is, the cells of the hair bulb, which is the envelope of the dermal papilla, and from what I have briefly read these cells have the potential to induce the growth of new dermal papilla (DP) cells or even induce the growth of new hairs!!! If this is so, this technique is better than what other companies are developing, but we need more information.
When I talk about how these cells (DSC) may even have the potential to create new hairs, it is because they are mesenchymal cells, those with which Fukuda worked, for the creation of hair follicle germs, and which have the potential to transform into cells. of the dermal papilla (DP) but perhaps also in other hair bulbs and consequently in new hair. This may be a bit bold to say, but reading between the lines, I imagine this is what they mean. I understand you, administrator, when you say that the comments that this technique will only improve thickness and reduce inflammation are very cautious, but in any case we need time to see how this technique evolves and an analysis of the results, but in my opinion this treatment has a lot of benefits. potential, almost as much as a real cure!!
And furthermore, these DSC cells are those at the base of the hair bulb, which are the ones that have the potential to induce the creation of the other cells, since the cells of the hair bulb themselves are called DS. I am happy to learn more every day and above all to know that the first technique in the world of this type in terms of hair loss has preferred to multiply these mesenchymal stem cells rather than DP cells, which other companies are developing, and that it will be just as effective because the lost DP cells can be replaced, but much better to multiply these DSC cells and induce the creation of new DP cells. Very excited again!!(:
We still don’t know much about the details of the procedure, and I haven’t read anything on mainstream channels yet, something doesn’t add up…
Fingers crossed we get a post like this for OrganTech and Stemson !!!
Don’t forget Fukuda too lol
In the immortal words of the poet Alexander Pope, hope springs eternal!
Now if we can just switch “hope” with “hair”…
Thanks for the hope in the meantime, admin.
Eirion therapeutics have started phase 1 for et-02 topical for androgenetic alopecia.. They go on to say that they believe et-02 can also prevent and treat hair greying and they plan to persue that in the future but if it’s the same then will the trials for androgenetic alopecia not also show that it is reactivatiing melanocyte stem cells and be a double celebration? I’m confused as to why they are doing them separately can someone explain as to why that may be, thanks
https://www.prnewswire.com/news-releases/eirion-therapeutics-announces-initiation-of-first-in-human-clinical-trial-evaluating-topical-et-02-for-the-treatment-of-androgenic-alopecia-302186429.html
Wow Andy that’s fantastic news. I was always intrigued by them, but lost my interest as there was no new information from them. They are well financed and have product candidates for other indications already in human trials.
Better late than never, they originally planned trials for 2022. Happy to have another contender officially in trials – it’s a small circle if we are honest. This is the only true measurement of seriousness, is a company in a trial or not. Everything else is a pipe dreams, a scam or a decade away.
Hi Andy, they still need to demonstrate efficacy separately for hair greying indications.
My guess is that once Phase 1 finishes they will have two separate phase 2 studies.
Good find Andy. Eirion AGA ET-02 topical is a really promising thing that if it works could potentially reactivate dormant hair follicles.
The study is 24 subjects over 28 days. I hope they are fast enough to finish it by years end.
To me ET-02 is up there next to SCUBE3. I do hope it will at least have better efficacy than GT20029.
It’s exciting but….10-23k every few years for thickening only? That’s not all that great, esp when you consider whatever the price ends up being in Japan (let’s say 15k) the US market will jack it up (double at least). Just wait. I see clinics/docs here already coming up with plans for their new mansion.
Out of range for most people. It’s the price of a HT but a HT lasts way longer (with better results).
I do not think this will be approved in the US anytime soon. Japan and South Korea seem to be where the action will take place in the near future.
“I see clinics/docs here already coming up with plans for their new mansion.” Where and can you proof that? I am really interested in this treatment and I will prove that as soon as possible.
This should probably be it’s own topic…
…and I don’t see that this company has been covered here before. I found a link from 2021 when they got some funding.
https://www.gorerangecapital.com/post/eirion-therapeutics-inc-closes-40-million-series-a-investment-and-licensing-deal-with-shanghai-ha
This company has been going for some time with this. And for all I know claims are made to substantiate raising finances -that this topical (oral variant also in the works) should work superior to minoxidil (considering 60% do not get serious results from topical minox). The mechanism does not deal with androgen receptors but keeping the follicle chugging along.
Their pipeline: https://moonink6.wixsite.com/eirion/pipeline
Search for their name via top right magnifying glass icon. I covered Eirion in a grey hair cure post. Will do a separate post this year.
Where is SummyKim these days?
I’m still here! Just been extremely busy. Still squirting Fin on my head and popping Min. (I’m not going down without a fight.) A mate of mine is completely bald though. Reckons his brain is so big, it pushed all his hair out! Don’t tell me it’s been boring without me admin?!
Glad you are still kicking SK. Only the spam comments that I have to weed out are ever as creative as yours!
The Legend that is SummyKim!
Thanks lads.
Good news ,finally the cure i wondering how much will cost .
Sorry for the pessimism… but no newspaper has given relevance to this new therapy, once again we are faced with nothing.
Plus people keep saying it’s a cure. Are all these same people going to spend 10-20k every few years? Doubtful (esp in this economy). If people can’t afford a HT they can’t afford this. It strengthens existing hair…to some extent. But will it 100% stop all hair from falling out? I’m not convinced. And nobody should be convinced this early.
Imo, this shows great progress (and promise) but I’m not going to call it a cure. It’s a (potentially) huge step.
Almost noone is saying it’s a cure. Especially Shiseido lol.
Some comments above mention the word cure. I guess I should have said “some people” vs just people.
Admin,
I’ve been following this site for a decade now, and funny enough this was one of the first treatments I had hope for. I have both the work flexibility and the means to go to japan to try this out, but do you have an email to get in contact with the right person at Toho Univ Derm Clinic? I checked out their website and not one email offered…
Wow that is great “able42”, I hope you can get permission.
On the list of facilities page:
https://www.s-dsc.com/facilities/facility1
They mention the dermatology department at Toho.
They have a phone number on the dermatology department’s page which you might be able to try?
https://www.lab.toho-u.ac.jp/med/ohashi/dermatology/index.html
TEL: 03-3468-1251 (main office)
I called that number but they only speak Japanese on the other end. They must have an email. Do you have any contacts at shiseido you can ask?
Perhaps from years ago, though unlikely. Will check my past emails when home.
Any luck on this admin?
I emailed one person that might be able to help. No response as yet, but now I found another person today and have also e-mailed him. Would be great if they accept you as a patient.
Hi Able42,
I got a response from someone who contacted the doctor in charge at this particular clinic at Toho University. They did not give me his e-mail address and I think they prefer the privacy.
In any case, the doctor said that for now, they are only accepting Japanese patients :-(
I hope they change this requirement in the future.
I called them but they only speak Japanese, is there another way to contact them?
New press release:
https://www.nikkei.com/nkd/disclosure/tdnr/20240808566465/
Translation:
August 8, 2024
Started contract manufacturing of new specific cell processed product (“S-DSC®”) for hair regeneration.
In recent years, research into hair regeneration as a treatment for alopecia has progressed, and results have shown that hair growth may be promoted by culturing DSC cells located beneath the dermal papilla cells, which are thought to be essential for hair growth, and administering them to the scalp as “S-DSC®.” This treatment involves extracting hair bulb sheath (DSC) cells from the scalp at the back of the head where hair loss has not occurred, and then multiplying the cells in vitro.
We have concluded contracts with medical institutions for the outsourcing of the manufacture of the specific cell processed product “S-DSC®” and have been working on
establishing a contracting system. Now that the medical institutions have established a system for providing this treatment and we are ready to accept contract manufacturing from medical institutions, we will begin accepting contract manufacturing of “S-DSC®”.
“S-DSC®” is manufactured at our company’s manufacturing facilities under the technical support of Shiseido Co., Ltd., and process supervision by the company. We are pleased to announce that we have begun accepting contract manufacturing of specific cell processed products used in the following:
A specific cell process (called “S-DSC®” in this treatment) is administered to the area of hair loss.
We have recently announced the launch of a new treatment for male and female pattern hair loss using cultured autologous hair bulb sheath cells (hereinafter referred to as the “Treatment”).
Everyone We will manufacture appropriately. We will disclose it promptly. The impact of this matter on the financial results for the fiscal year ending September 2024 will be minor. However, if a timely disclosure becomes necessary in the future, that’s all.
For more information on this treatment, please visit the following website:
S-DSC Hair Regenerative Medicine: https://www.s-dsc.com/
What are your thoughts on this admin, is Shiseido gonna solve everything or what? I only got on this wild ride in 2018, so still feel new to the game.
Skin related, but quite interesting:
https://corp.shiseido.com/en/company/talk/20240821.html
30-60% is far from 100%.
Because why would anything actually help everyone?
Can’t wait for 2026 when Tsuji moves his clinical trials to 2028
Lol so painfully true bro
Hi I’m Angel from Spain
Nice to meet you all!
I have a doubts
The question is the following:
Will there be some type of hair cloning in which the procedure is injectable and not grafted and in which a hair follicle is generated from scratch as if it were grafted?
As I understand it, hair companies are working on three techniques or three procedures but the doubt I have is if in the cell multiplication procedure a cell could be injected and new hair would grow from scratch even for scars.
Not great news, but hopefully a positive trend: a second clinic in Japan has now also started this treatment (albeit only for women). Let’s hope that patients outside Japan will soon also have access to this treatment.
https://www.akihabara-skin.com/s-dsc/
Thanks! It is also mentioned on their main site that I linked to in the October 12 update (bottom part).
Edit: Now I have broken out both clinics separately too.
Admin please reply to my query.
Please post it here Angel as I do not reply on Instagram messaging. Thanks!
Hi admin
I’m new here and I don’t know what the procedure is like regarding the functions of the website.
I asked my question above and on Instagram too, but I’m asking my questions again to see if you can help me.
Hi I’m Angel from Spain Nice to meet you all!
I have a doubts The question is the following: Will there be some type of hair cloning in which the procedure is injectable and not grafted and in which a hair follicle is generated from scratch as if it were grafted?
As I understand it, hair companies are working on three techniques or three procedures but the doubt I have is if in the cell multiplication procedure a cell could be injected and new hair would grow from scratch even for scars.
I expect your response
Thanks again
Kind regards
Angel
Okay, let me jump in…
The technology you ask for is a DP-cell-type one (Dermal Papillae). It’s supposed to be effective for reviving follicles that are miniaturizing and should strengthen healthy follicles too (the amount of DP-cells in a follicle determines the thickness of the hair). It’s likely not effective for hair that is long gone.
There’s 2 companies which are officially working on that: Epibiotech and Hairclone. Both have failed to deliver so far and I doubt any of them will be successful – solely based on their disappointing history. Trichoseeds/Fukuda have something similar in the works, but there’s only little information available so that’s more speculative.
Then there is a DSC-cell-therapy („Dermal Sheath Cup Cells“) from Shiseido which is already available in Japan, but I suspect it to be not satisfyingly effective.
The most promising injectable type of therapy is the Stemson/Aderans-method which is afaik dermal fibroblasts and epithelial cells. It has shown good effects in trials and is imho the only cell therapy which is worthwile to follow and highly likely the first one available of all of the ones above. Yet all of them are not a cure.
The only real cure is the implantation of a early stage follicle where the growth of hair is imminent. But this is not a single cell injection, it’s basically an organ transplant. There’s 3 serious contenders for that technology: OrganTech, TrichoSeeds and Stemson. My personal opinion is that Stemson is the only real hope in that endeavor, for different reasons.
Regarding scars, I don’t know. Scar tissue is a different area and cell injections might not work there as the membrane of the skin is not able to let a follicle grow in and out of the skin.
You‘ll find every useful information to these ventures on this very blog, thanks to admin.
I am no expert so take my infos with a grain of salt and make your own picture of the field.
I‘d like to add again that admin has no obligation to answer any questions – this is not a customer service center and he probably earns not even remotely enough money which would justify his endless hours writing articles.
Ok Ben , thanks for explain me all.
Kind regards
Thanks for the detailed response Ben!
Angel, please check out all the links in the below page, especially for companies in the US, Japan and South Korea. In case Ben missed anything. e.g., Han Bio and Kangstem.
https://www.hairlosscure2020.com/hair-loss-research-around-the-world/
Some of the South Korean companies are trying so many different things at the same time, that is is hard to take them seriously for now.
For example, in one article, Epibiotech is described as having expertise in four key areas:
— Hair papilla cell isolation and cultivation technology.
— Induced pluripotent stem cell manufacturing technology.
— Organoid-based hair follicle cell differentiation technology.
— Gene editing technology.
Their pipeline is also very wide ranging, but their website does not seem to load for me when I tried today.
https://epibiotech.com/en/
Thanks for share me the information and the links admin.
Also Ben, don’t forget the hair growth vaccine from Amplifica Scube3, this together with Stemson and Organ Tech, I think they will be the anti-baldness triad.
I don’t forgot anything – you specifically asked for cell/cloning-type treatments.
Every other treatment is somehow influencing signalling-pathways, except Keratin and Minox maybe.
Scube3 is not being trialed atm. OrganTech disappointed over and over again. Stemson is serious though. South Korean ventures are traditionally bad except Olix.
Be careful with your expectations regarding full cures, it’s a long way. Our best shot seems to be Pelage at the moment, but don’t be too optimistic.
Perfect Ben:)
We will remain strong until we find a definitive hair cure.
I think admin is not obliged to reply to any comment at all, he’s not your or our servant.
I find that rude tbh.
Thanks Ben, though in this case he did say please. I just prefer people asking here rather than via Instagram or Twitter messaging.
Ben, don’t be so stubborn about that.
I already said that this is the first time I’ve entered the forum and I don’t know the functions of the site.
I also asked him politely.
If that’s not education for you, then I think you really have a big problem with understanding or logic that escapes my logic.
No hard feelings.
Greetings
Hello everyone! Lately I haven’t visited the forum much for work reasons, but now I have a little more freedom. I have read the last comments on this post and you are right Ben! The administrator is not Google to answer each of the users but you also have to think that each person who comes to read the page has the same problem that affects the rest of us and has the right to be informed (always with respect). That said, I understand that we have all been tired for so many years and I have no problem with any reader. Yoyo, for example, has the interest and ability to investigate new developments and news, doing a great favor to this website, just like you, Ben. . Regarding my point of view, although this DSC solution from Shiseido has not yet demonstrated its levels of effectiveness in real patients, I can assure you 100% of the readers that it is an effective solution to preserve the hair that you still have until it exists. hair cloning without the need to use medication, which is also not proven to be 100% effective. The only step left is for them to offer this technique outside of Japan and we can use it. If it’s any consolation, I have recently suffered a very strong telogen effluvium and I have lost a very large amount of hair, but it is best not to get nervous and know that it is due to seasonal change and stress and that it will recover because the body is wise. Greetings to all
Didn’t expect a compliment, thank you Alvaro lol
and why can you assure that?
Excuse me, but my critical ability on medical issues is not good, and I tend to be guided by the comments of people who know more than me. I’m just a person who suffers a lot from alopecia and turns to these media in search of “hope.” Can anyone tell me why the optimism about the treatment of this article has faded? I have read all the comments and at first you took it as great news and suddenly as almost another failure. Am I wrong?
It is only available in Japan at the moment. And it is not a cure. Just hopefully a very good new treatment.
Admin,
Great work, any idea when we as US folks can go to Japan assuming we have the means? Also what is our biggest hope now? Sanford Burnham, Riken, Tsuji?
In the short term, I want to see results from Shiseido in Japan. They are only treating local patients for now :-(
Actually I think Stemson is our biggest hope right now…
You are wrong friend! Stemson will offer this solution if it offers it….! I would only trust Stemson for the definitive cure for baldness, which is hair cloning but very very very long term (: . Shisheido has experience and you can read it on his website. Those of us who have been informing ourselves for a long time know that for some years ago there was a therapy with Replicel Rch-001 I think??? It was the same procedure as Hairclone… Now the results say that it is 60% effective in women and 40% in men, I think, isn’t it a lie? They know what they are doing and I assure you that when they offer this technique outside of Japan it will be a 100% safe alternative to dutasteride and Minoxidil!!! I just hope they offer it as soon as possible because I will be the first patient. Regarding other comments from Organtech, I totally agree, they are companies that seek marketing and credibility 0!!! Don’t worry about the results of the Japanese in Shisheido, when they offer it to the rest of us they will change the results. rules of the game…. for everyone (:
I only really hope that they offer the treatment outside of Japan as soon as possible… We have been researching for many years and I know that there are many people like me… and it is always one disappointment after another… please, my God, please tell you. I ask, but that we can use this and pay whatever but that we can do it….
I hope you are right my friend. They have been offering this treatment in Japan for 6 months now. Probably hundreds of Japanese patients received this treatment by now. Don’t you think if it was very effective, we would know by now? I mean i hope it’s effective….
Why wouldn’t there be communication between Japanese people who have used it and us? can’t we know if it works?
Dear,
Nice to meet you, this is Andrea.
I congratulate you very much for your website which is always constantly updated and with remarkable news.
I suffer from androgenetic alopecia and therefore I have very thin hair. A question, do you have any news on the results of the hair multiplication technology just launched by Shiseido?
If you can answer me I would be grateful.
A warm greeting.
Hi Andrea, unfortunately it is only available for Japanese citizens at present. We also don’t yet know how good the results have been so far.
Many years ago, a clinic in Spain carried out a clinical trial transplanting only the cells of the hair follicles from the donor area with a much finer extractor than the one used in traditional hair transplants to the bald recipient area, promising regeneration of the donor area. of 100%. In the end, this technique was abandoned because the results were much less effective than those of a conventional hair transplant (the donor area was not regenerated 100% because the cells were basically extracted from the entire donor area, without multiplying them, and by injecting them into areas where hair had been completely lost they were not able to create new follicles). More than 10 years have passed since this and no one has ever conducted a clinical trial again… This trial had all the logic in the world and that is why I have followed Hairclone closely for years and recently they are developing it Tsuji, Fukuda and now Shisheido is offering it. If you multiply the dermal papilla cells with resistance to DHT and inject them into affected hair, those hairs could be regenerated and survive infinitely because androgenetic alopecia is determined in more than 80% by genetics. It’s a simple technique, I don’t understand why they haven’t offered it in so many years, I hope we can use it once and for all…
Hey admin, I subscribed to Nikkei just to be able to read this article. There nothing super interesting, but I can send it to you as screenshots if you wish.
Thanks Eko. If nothing new of major interest, no need!
Sure! Its basically what you have summarized up in the post!
But what about this? Don’t they offer it to those of us from outside Japan? Why so much secrecy? This is disgusting.
I exchanged e-mail with both Oashi hospital and Akihabara clinic (only 2 places this treatment is available).
Oashi said until now they treated around 9 people with this procedure. I asked if I can come to Japan to take it. They said since the effectiveness was only tested in Japanese people, they are currently only offering it to Japanese citizens.
Akihabara clinic said they are only treating women with this treatment. Men are not able to get this treatment in Akihabara.
Thanks Eko.