Category Archives: Dermal Sheath Cup Cells

Mesenchymal Stem Cell Injections and Hair Growth

In 2015, I discussed new hair multiplication related collaborative work between the University of Manitoba (Canada — led by Dr. Malcolm Xing) and Nanfang Hospital Southern Medical University (China). Researchers from the latter recently published two new hair related studies, one of which analyzes the results of Chinese clinical trials involving mesenchymal stem cell injections for hair growth.

Note that hair follicle derived mesenchymal stem cells (HF-MSCs) include both dermal papilla (DP) cells and dermal sheath (DS) cup cells. Mesenchymal stem cells can also be derived from: adult tissues (bone marrow, peripheral blood, adipose/fat and teeth); and neonatal-birth associated tissues (Wharton’s jelly, placenta, cord blood, umbilical cord and amniotic fluid).

In recent years, mesenchymal stem cells have been in the news a lot due to the rising popularity of mesenchymal stem cell (MSC)-derived exosomes in regenerative medicine applications.

Treating Androgenetic Alopecia with Mesenchymal Stem Cell Injections

Recently, reader “Theo” sent me a link to a new November 2024 study from the Department of Plastic and Aesthetic Surgery, Nanfang Hospital, Southern Medical University. It entails a superior method of isolating human hair follicle dermal papilla cells (DPCs).

More importantly, several of the co-authors of this study also co-authored a September 2024 study titled: “A Clinical Trial of Treating Androgenic Alopecia with Mesenchymal Stem Cell Suspension Derived from Autologous Hair Follicle.” This trial occurred at the Department of Plastic and Aesthetic Surgery, Nanfang Hospital, Southern Medical University (China). The link to the actual 50-person trial that ended in 2022 can be seen here.

Treating Androgenetic Alopecia with Stem Cell Injections
Treating Androgenetic Alopecia with Stem Cell Injections. Source: Plastic and Reconstructive Surgery, September 2024.

The results were encouraging, although the increasing hair count and hair thickening effects lasted for just 3 months. Note that at around 7 months, the treated group still had slightly higher terminal hair counts and mean hair diameters compared to when they started out. If this method is improved, a once-a-year injection session is totally fine by me.

“An increased proportion of terminal hair and hair shaft diameter was observed in the experimental group at 1 month. The effect lasted for 3 months. The hair-thickening effect of advanced miniaturized hair follicles with hair shaft diameter less than 60 µm was more notable than that for above 60 µm. No patient experienced any obvious side effects.”

Mesenchymal Stem Cell Injection Hair Growth
Mesenchymal Stem Cell Injection Hair Growth Increase. Source: Plastic and Reconstructive Surgery, September 2024.
Mesenchymal Stem Cell Injection Hair Diameter Increase
Mesenchymal Stem Cell Injection Hair Diameter Increase. Source: Plastic and Reconstructive Surgery, September 2024.

They also include two images showing before and after (3 months) hair growth results. The left side in the below image is the before photos.

Before and After Stem Cell Hair Growth
Before and After Stem Cell Hair Growth. Source: Plastic and Reconstructive Surgery, September 2024.

Stem Cells and Hair Multiplication

This makes me even more positive about Shiseido’s dermal sheath cup cell hair multiplication procedure that was released in 2024. And perhaps HairClone will finally test its dermal papilla cell injection treatment on humans in the UK in 2025. Also of note, in 2024, Dr. Junji Fukuda of Fukuda Lab announced that “Dermal papilla cell transplantation is about to begin in Japan.“

And several South Korean hair loss companies could test this in humans in 2025 too. I would also never discount the cursed Aderans coming back from the dead a second time. And dying again.

Note that similar attempts have been done in animals and humans in the past. Further reading:

In my 2015 interview with Dr. Xing, he said that he had just returned from a trip to Nanfang Hospital and that:

“A team of more than 10 clinical doctors is working on hair loss in the Department of Plastic Surgery, Nanfang Hospital.”

It is always great to see more hair related research and clinical trials taking place in China. Within East Asia, the country has lagged Japan and South Korea in importance when it comes to hair research.

Shiseido DSC Cell Hair Multiplication Procedure Is Finally Here

Shiseido Dermal Sheath Cell Hair Multiplication.
Shiseido (Japan)’s Dermal Sheath Cup Cell Hair Multiplication Process. Image from Toho University.

Update: October 12, 2024

When Shiseido’s hair loss treatment came out in June 2024 and I wrote this post, I was certain that this is the best news of the year. I was also optimistic that this dermal sheath cup (DSC) cell hair multiplication procedure would be superior to  existing FDA approved hair loss treatments such as Minoxidil and Finasteride.

However, since Shiseido is only offering this S-DSC procedure to Japanese citizens at the moment, it will be a while before we get more details about success rates. So I am updating this post due to a possible new report on Shiseido’s efficacy (h/t “Theo” for the below link and translation), though it is a bit speculative and anecdotal.

In a new hair multiplication related article in Japanese newspaper Nikkei, they mention the “Big 3” of OrganTech (Japan — led by Dr. Takashi Tsuji), Stemson Therapeutics (US) and TrichoSeeds (Japan — led by Dr. Junji Fukuda). According to Nikkei, Stemson and OrganTech will start clinical trials in 2026 for their “Gen 2“ hair regeneration treatment. Junji Fukuda states that they have created a similar technology as OrganTech, but plan to start clinical trials in 5 years from now (i.e., in 2029).

The title of the article is:

“Planting hair seeds to treat alopecia. Clinical trials underway in Japan and overseas”.

However, the most significant news is via implication. In the article, it says that  “Gen 1“ treatment is already in practical use in Japan with a success rate from 30-60% (which is ambiguous). This is quite likely to be Shiseido’s treatment, now available at both Toho University and Akihabara Skin Clinic, both in Tokyo.

  1. Toho University announcement.
  2. Akihabara Skin Clinic S-DSC.

In the article, it says that for “Gen 3“ they are planning to use animal stem cells. “Theo” was not sure what this meant, and neither am I. If anyone subscribes to Nikkei, please read the entire article and give us your thoughts.

In general, I do not think that cosmetics behemoth Shiseido would ever take over a decade to bring something to market with only modest benefits. Lets keep our fingers crossed.

June 28, 2024

Shiseido’s Dermal Sheath Cup Cell Hair Multiplication Treatment Has Arrived

Today might be among the five most important days in the hair loss world since I first started writing this blog in 2013. Shiseido’s decade-plus-long much awaited dermal sheath cup (DSC) cell hair multiplication (cell culturing and implantation) procedure is finally here for patients starting July 1, 2024. Albeit only in Japan, where they have favorable regulations for faster in-clinic use when it comes to regenerative medicine and stem cell based technologies.

Shiseido (Japan) completed small-scale Phase 3 equivalent trials for this hair multiplication technology in 2023. The results were positive but modest, with no major side effects. I hope the results will improve as they use this autologous DSC cell transplantation process in more patients and gain experience.

For now, you should only expect existing scalp hair thickening and perhaps minimal hair regrowth if you are lucky. Thicker hair in and of itself could lead to a slowdown in further damage from the ravages of dihydrotestosterone (DHT).

You can read today’s full announcement here (h/t “Theo” for the super find). The technology is described as having been developed by Tokyo Medical University Hospital, Kyorin University Hospital, and Shiseido. Interestingly, they leave out any mention of Replicel (Canada), with which Shiseido has had past legal issues after a technology sharing agreement went wrong.

S-DSC® Hair Regenerative Medicine

Shiseido has also created a new website related to S-DSC hair regenerative medicine, where the “S” stands for Shiseido. The about S-DSC page is very interesting. S-DSC® treatment promotes hair growth by supplementing the thinning areas of your scalp with your own cultured DSC cells.

They only make claims that existing hair will get thicker and more voluminous, while scalp inflammation will be reduced. Perhaps they also want to temper expectations, even if some people may get good regrowth? Interestingly, women might get better results then men.

S-DSC Hair Regenerative Medicine
S-DSC Hair Regenerative Medicine Treatment.

The key person who led the development of this technology is Professor Emeritus (Department of Dermatology, Tokyo Medical University) Dr. Ryoji Tsuboi. I feel like a genius for using his image as my main one on my global hair loss research page from the get go. I originally picked Dr. Tsuboi over Dr. Takashi Tsuji just due to a more interesting image of the former at a white board.

Hair Regenerative Outpatient Treatment Begins in Japan on July 1, 2024

Associate Professor Shiro Niyama of the Department of Dermatology at Toho University Ohashi Hospital will start offering this “hair regenerative treatment for thinning hair” using cultured autologous hair bulb root sheath cell products (S-DSC®) from July 1st 2024. Patients will be required to get a referral, and also be responsible for their own costs due to the elective nature of the procedure. Note that this treatment is available for both men and women.

In the procedure itself:

  1. First, healthy scalp tissue of about 5 mm diameter is taken from a non-balding area such as the back of the head.
  2. From this, DSC cells are isolated.
  3. S-DSC is produced after about 6 weeks of culture and quality inspection (a total of 7 vials of S-DSC can be produced).
  4. Once production is completed, patients will return to the hospital and the cultured DSC cells will be injected with a special syringe.

Also check out the November 2023 study from the same team that is titled: “High migratory activity of dermal sheath cup cells associated with the clinical efficacy of autologous cell-based therapy for pattern hair loss.” The conclusion was that ITGA6-positive DSC cells, with superior migratory activity, may promote cell migration into nearby hair follicles.