Category Archives: Dermal Papilla Cells

HairClone Begins Carrying out Dermal Papilla Cell Hair Multiplication in Humans

HairClone Cell Culturing Lab
HairClone’s new dermal papilla cell culturing and expansion lab.

New updates are at the bottom of this post.

February 24, 2026

I have covered HairClone (UK) in four different posts over the past decade. The company began the world’s first ever officially licensed hair follicle banking program in 2019. Thereafter, they planned to begin actual autologous dermal papilla (DP) cell multiplication (1,000 fold) and implantation work in a clinical setting in humans in the UK. However, initial delays due to Covid were followed by further delays due to financial reasons. But in February 2026, they finally made this jump. Read till the end of this post.

Note that Shiseido (Japan) started offering its dermal papilla sheath cup (DSC) cell hair multiplication procedure in Japan in 2024. This was after more than a decade of work in completing all three Phases of clinical trials, which were delayed by legal issues. Unfortunately, Shiseido’s hair multiplication procedure is still very difficult to get if you are not a Japanese citizen.

Per a study I covered last year on effective cell therapy for hair regeneration, both DP cells and DSC cells can induce new follicle growth. I also vaguely remember reading about a South Korean company that might offer both procedures together in the future.

HairClone’s current CEO Dr. Paul Kemp is also its founder. Moreover, Mr. Kemp also founded and led Intercytex (UK) several decades ago. Just like HairClone, Intercytex was working on dermal papilla cell culturing, but had to abandon this work in 2010 due to financial difficulties. This was a big surprise, since they even completed successful small-scale Phase 1 and Phase 2 clinical trials in the UK. HairClone’s clinical target is an improvement over Intercytex’s past work due to advances in technology per Dr. Kemp. See his latest e-mail to me at the bottom of this post.

Note that on HairClone’s site, they primarily only claim that more dermal papilla cells means thicker hair. And they say that when DP cells are injected into thinning regions of one’s scalp, they can reprogram miniaturizing follicles into non-miniaturising ones. By getting this treatment every few years, you can maintain hair density throughout your life.

HairClone Begins to Carry out its Dermal Papilla Cell Multiplication Procedure in Humans in Guatemala

In a major new development, HairClone is now offering its dermal papilla cell multiplication and implantation (via injection) procedure in Guatemala. As of February 2026, it is mainly being carried out on Guatemalan residents so that HairClone can better follow up on these initial patients.

HairClone Dermal Papilla Multiplication Equipment
HairClone’s new equipment at its dermal papilla multiplication lab in Guatemala.

HairClone is developing this groundbreaking hair loss treatment in partnership with Dr. Marie Schambach of the Schambach Hair Clinic in Guatemala City, Guatemala. On the latter’s “Cloning Services” page, it states the following:

“The future is here! Technology allows us to store hormone-insensitive (DHT) follicular units in an international biobank and reproduce specific hair bulb cells for re-implantation in the affected area. This will allow the cells to migrate to the deficient bulb and not only regenerate it but also inactivate the hormonal function of each hair, enabling it to continue its normal growth. This technique is ideal for those experiencing early hair loss who want to maximize their chances of maintaining adequate hair density. The procedure should be performed approximately three times, with two to three years between each treatment.”

Schambach Hair Clinic Lab
Schambach Hair Clinic lab in Guatemala.

Lot of western companies in the stem cell and regenerative medicine world have undertaken this kind of move to countries in Central and South America. Largely due to more favorable government regulations where autologous cell therapy is seen more like a transplant than a medicinal product.

Dr. Paul Kemp’s Email

I only got this news last week after I decided to contact Dr. Paul Kemp after several years. I wanted to know if HairClone would ever start offering this procedure in the UK. Instead, I received a most unusual surprise. Below is Dr. Kemp’s email to me:

“Great to hear from you. Yes lots is happening here and we have a lot of exciting news. As you know, Dr. Marie Schambach is one of our clinical partners based in Guatemala City. I visited her last year and was really impressed with both her clinic and the private hospital where she is based, which is a facility shared by a number of other clinical specialties.

When given a tour of the state of the art molecular sequencing lab there, they mentioned that there was space next door. To cut a long story short, we obtained equity financing and built out, equipped and staffed a small GMP follicle banking and manufacturing facility there. It has been operational now for a few months and we have now tech transferred and validated our processes developed in the UK to the facility there.

Their regulatory system treats autologous follicle cells the same as a hair transplant, which gives us the ability to culture cells in our facility and have them implanted in Dr Schambach’s clinic. Through scientific collaborations that we have, we also have the ability to identify and analyse individual hair follicles even down to single cells in order to examine their response to treatment. This will be important and allow us to rapidly monitor and optimize the efficacy of the cell treatment.

Through the pioneering work of Intercytex, Aderans Research Institute, Replicel and others, it has been shown that autologous follicle cell therapy is safe and all have seen indications of efficacy. However, because of US and EU regulatory and scientific constraints, none were able to optimize this. This is not the case with us because of our links to the Schambach Hair Clinic, our clinical partner network, new manufacturing facility, UK research labs and scientific advisors.

I have been involved in trying to use cell therapy to treat androgenic alopecia since the founding of Intercytex in 1999. Back then all we could do was multiply cells and look at total hair count and hair shaft diameters over the treated area. Whilst this is obviously important, we had no way to scientifically understand the mechanisms involved and how we could improve the efficacy that we were beginning to see.

Our new set up is designed to overcome this and we are already culturing the cells from our first cohort of volunteer patients and are going to be starting treatments in the next month. Our plan is to concentrate on local patients so that we can more closely follow their progress and gain information on their response.

Once we are confident of the results, we can then offer the treatment more broadly and at a discount for patients who have banked follicles with us through our clinical partner network, although the actual cell treatment will need to occur at the Schambach Hair Clinic. Patients can have follicles extracted at any of our clinical partner clinics and sent to us. They only need to travel for the cell injection. Follow-ups take place back at the original partner clinics.

In the longer term we plan to scale up the facility and then obtain the local regulatory clearances in the US and elsewhere in order be able to start to treat people at our clinical partner clinics.”

Update: August 23, 2026

Dr. Sara Wasserbauer (US) visits Dr. Dr. Marie Schambach (Guatemala)

I previously mentioned US-based hair transplant surgeon Dr. Sara Wasserbauer in my post on hair rejuvenation versus hair cloning. She has been affiliated with HairClone since 2020. US residents can bank their hair follicles at her clinic in California.

Last week, Dr. Wasserbauer visited Dr. Marie Schambach of the Schambach Hair Clinic in Guatemala. Video can be seen below. Moreover, Dr. Wasserbauer has an updated page on her site regarding HairClone’s dermal papilla cell therapy.

Even more encouraging, she recently sent a newsletter out with the following information:

“Regenerative medicine and cell multiplication are the buzzwords in hair restoration. No research is more exciting than the tissue banking and hair follicle cell multiplication treatments going on in the HairClone facilities in the UK and Guatemala! Patient studies conforming to all international standards were initiated starting in March of this year, and so far, the first 3 patients have returned for their follow-ups – ALL with positive regrowth results!

Results from more patients will be available in the next few months, and the data is so promising that the research has been accepted for presentation at the ISHRS World Congress of Hair Research taking place in Rio, Brazil, this October.”

A Visit to Fukuda Lab at Yokohama National

This post was originally written in 2024. I have added new updates from 2025 and 2026 at the bottom.

I have extensively covered the work of the esteemed Japanese hair loss researcher Dr. Junji Fukuda for over ten years. Among the posts that I have written in relation to his team’s work at Fukuda Lab include the following:

February 21, 2024

A Visit to Fukuda Lab at Yokohama National

Reader “Theo” just sent me a link to a very interesting diary of a hair transplant surgeon from Japan who just visited the Fukuda Lab.

Note that while Dr. Fukuda is based at Yokohama National University, the research seems to be taking place at Kanagawa Life Innovation Center (per the above link). One of the images also mentions the Kanagawa Center for Clinical Research & Strategy (KCCR). Yokohama is the second largest city in Japan and is the capital of Kanagawa Prefecture. Check out this PDF of the regenerative medicine sector at Kanagawa Prefecture.

From this visit and summary, I learn some very interesting things. There are three distinct methods in which Dr. Fukuda is pursuing hair regeneration. I mentioned them in my past lengthy post too, but now we have more clarity.

1) Dermal Papilla Cell Transplantation

“Dermal papilla cell transplantation is about to begin in Japan.

Transplantation of dermal papilla cells (via stratified culture). I assume that the “stratified cuture” in the translation means 3D culturing. Dr. Fukuda mentions that Shiseido already conducted a clinical trial using 2D culturing. In this method, cells are are lined up on a flat surface when culturing, but it only resulted in a 5% increase in hair volume. The 3D method will likely be superior and the clinical trials are about to finally begin! It is hoped to be “put into practical use within five years”.

2) Transplantation of Hair Follicle Primordium

“I think this will take some time.”

The creation of hair follicle primordia means generating hair from scratch. i.e., hair multiplication. I previously discussed the Yokohama team’s process of achieving this via increasing and mixing epithelial cells and mesenchymal cells. These then form “hair follicle primordia“ that are transplanted to the same donor’s scalp in order to regenerate hair in thinning regions of the scalp.

Per the latest feedback from Dr. Fukuda, while this process has already been proven by them in mice, human hair is a different animal. Once the primordium tissue is transplanted to human heads, the direction and length grow haphazardly. He thinks that this will take some time.

3) Transplantation of Regenerated Hair Follicles in Vitro (Organoids)

“It will likely take more than 10 years before it can be used in humans.”

The final method is in vitro regenerated hair follicle transplantation (also called organoid). In this process, hair follicles are regenerated outside the body, lengthened by almost 100%, and then transplanted into the scalp. Per Dr. Fukuda, it will likely take more than 10 years before it can be used in humans.

Other Notes

In March 2023, Dr. Fukuda and his Yokohama team published an important hair regeneration related study. They made an improvement in the expansion of hair follicle stem cells (HFSCs) and dermal papilla cells via the use of a newly designed microwell array device.

Fukuda Lab Hair Research
Fukuda Lab’s hair research summary poster. Source:
Naohiro Uchida, Director of Almo Plastic Clinic Hair Transplantation.

Update: April 18, 2024

New Junji Fukuda interview given to Tokyo Television. Someone please translate it into English if you know Japanese. Not yet on YouTube.

Junji Fukuda TV Interview
Junji Fukuda TV Interview.

Update: June 15, 2025

Yet Another Visit to Fukuda Lab

Yet again, Tokyo TV visited world renowned hair loss researcher Dr. Junji Fukuda at Yokahama National University. A Japanese reader posted a link to the full video in the comments, but it did not load for me. However, I managed to find two of the segments on YouTube. You can turn on English captions in the videos. The Japanese viewer comments underneath the first video are funny.

Update: June 12, 2026

A number of new updates in recent months.

In December 2025, Dr. Fukuda gave an interesting interview. He said that his team’s initial goal is to popularize hair regeneration therapy, thereby establishing the necessary infrastructure (such as cell processing facilities). In the future, they aim to expand this technology to regenerative medicine for various organs, in particular, the liver. Quote:

“Hair is naturally formed by two types of cells (epithelial cells and mesenchymal cells) exchanging information with each other. We are challenging ourselves to unravel the mechanism of this “interaction” and completely reproduce it in a culture dish. In fact, most of the organs in our bodies are formed by the interaction of these two types of cells.”

Of note, Dr. Fukuda is described as the President and CEO of TrichoSeeds, a company he co-founded several years ago. He also continues to work at Yokohama National University via Fukuda Lab as a professor and researcher.

In March 2026, Dr. Fukuda co-authored a paper on the potential of employing hiPSC-derived ectodermal precursor cells in hair follicle organoid cultures in hair regenerative medicine.

In April 2026, it seems like the Fukuda Lab got some funding from Beyondge Capital (Japan). Also in April 2026, Dr. Fukuda gave a presentation titled: “Treatment of male pattern baldness using microRNA produced by human papilla cells in stratified culture.”

In April, Dr. Fukuda and his team authored yet another paper. They discuss their findings about the correlation between reduced CD200 expression and increased hair regenerative capability of cultured hair follicle bulge cells. Quote:

“Our study refines the functional interpretation of CD200-defined bulge heterogeneity and provides insights for optimizing human bulge cell-based approaches to hair follicle regeneration.