Note that Kintor is already selling KX-826 (Pyrilutamide — androgen receptor antagonist) as a cosmetic on Amazon.
Update March 21, 2025
Phase III Clinical Trial Of KX-826 Reaches Primary Endpoint
Kintor Pharmaceutical just announced that the long-term safety Phase III clinical trial of its first-in-class KX-826 (pyrilutamide) tincture for the treatment of androgenetic alopecia has reached its primary endpoint. The results are very good, the safety profile is excellent and therefore the company’s stock price went up a stunning 51% so far today. The first person in this 52-week trial was enrolled on 19 July 2023. The results demonstrated excellent safety and efficacy. Key highlights:
- 46% of patients saw a ≥10 hairs/cm2 change in total area hair count (TAHC) from baseline.
- 20% of patients saw a ≥20 hairs/cm2 change in TAHC.
Note that this clinical trial involves a total of 16 clinical research centers in China. It seems like earlier “pre” primary endpoint positive results were also released last year (see my update from October 17, 2024).
Even better news is that this trial used KX-826 tincture 0.5% BID (twice per day) as the dosage. Kintor also began a Phase III trial for the higher-dose 1.0% at the beginning of 2025. That dose might give even better results.
Update January 28, 2025
A lengthy and thorough interview with scientists from Kintor Pharma.
Update January 1, 2025
KX-826 (Pyrilutamide) 1.0% Phase III Trials
Kintor has enrolled its first subject in the Phase III pivotal clinical trial of its KX-826 tincture 1.0% in China for the treatment of male androgenetic alopecia. Note that the Phase III results for the 0.5% dosage were released in 2024 (see further below) and total area hair counts increase by around 10%, with results lasting even at 52 weeks.
The 1.0% dosage will likely lead to even better results based on prior preclinical findings. Kintor plans to recruit 666 patients and complete the trials by the end of 2025.
Update November 29, 2024
Earlier this week, scientists from Kintor Pharmaceutical (and Koshine Medical) did a Reddit AMA. Some of the highlights:
- They are currently developing a 2% foam version of KX-826, though the timeline for its release is yet to be determined.
- Phase 3 trials for GT20029 are planned in China in 3Q 2025. US will be 6 months later. This is for the actual medication, and not for a cosmetic (for which such trials are not required).
- GT20029 has the potential “to be revolutionary” for AGA treatment. They have found that once-a-week dosing with GT20029 demonstrated similar efficacy to daily dosing. this is a significant advantage compared to the twice-a-day dosing required for treatments such as Minoxidil, CB-03-01 (Breezula), and KX-826 (Pyrilutamide).
Update October 17, 2024
Kintor Releases Phase 3 Results for KX-826 at a 0.5% Dosage. Now they will Test 1.0%.
A new update on KX-826 (Pyrilutamide) Phase 3 Trials from Kintor that is not yet on their website.
- They have completed the first subject enrollment in the pivotal Phase II/III clinical trial of KX-826 tincture 1.0% for the treatment of male adult androgenetic alopecia in China. The company’s preclinical studies have shown that the KX-826 tincture 1.0% has a significantly higher retention rate in human scalp cells compared to the KX-826 tincture 0.5%. and good chance at showing greater efficacy. The latter lower dose was used in the previous Phase III clinical trial (see next point).
- They also give results of the Chinese Phase III clinical trials for the 0.5% dosage. This trial entailed the use of KX-826 tincture 0.5% BID (twice per day) on 95 male patients for 52 weeks. There were no serious adverse events reported. In terms of efficacy, after 12, 24, 36 and 52 weeks of treatment, both total area hair count (TAHC) and target area non-vellus hair width (TAHW) showed an increase from baseline. The TAHC increased by 9.5%, 13.0%, 11.4% and 9.7% respectively, while the TAHW increased by 12.1%, 18.6%, 15.7% and 10.0% respectively. So the best results are at 24 weeks, though there is still significant positive growth at 52 weeks.
Also check out my July 2024 post on KX-826 Hair Growth Spray Launched.
Kintor Pharmaceutical: KX-826 and GT20029 for Androgenetic Alopecia
My original post on Kintor Pharmaceutical (China) has become way too lengthy after so many updates. Therefore I will add all new developments in this post (below this product introduction section).
This rapidly moving well funded company is in Phase 2 and Phase 3 trials in the US and China for both its male androgenetic alopecia (AGA) products. Kintor (pipeline here) is conducting hair loss trials for:
- Two separate androgen receptor (AR) targeting products: a degrader (GT20029) and an antagonist (KX-826 aka Pyrilutamide).
- Each of these trials is being conducted in both China and the US.
- Each of these products is being tested for both males and females with androgenetic alopecia (aka pattern hair loss).
i.e., a total of 8 types of clinical trials times 3 phases in each = 24 developments we have to track. A bit too much if all of these do end up taking place, but a most welcome development. Over one-half of these 24 potential trials are already finished.
- The GT20029 product is an androgen receptor degrader (AR Degrader). It is developed using Kintor’s proprietary Proteolysis Targeting Chimera (PROTAC) platform. This is the world’s first topical androgen receptor (AR) compound (AR-PROTAC) to enter clinical trials. GT20029 degrades the AR protein via the E3 ubiquitin ligase pathway. During preclinical studies, GT20029 did not cause any notable side effects or systemic drug accumulation.
- Kintor’s main product for treating male pattern hair loss is KX-826 (Pyrilutamide) and is an androgen receptor antagonist (AR Antagonist). KX-826 is currently in Phase 3 clinical trials in both China and the US per the pipeline chart. In China, these trials are now completed.
Note that Cassiopea’s Breezula (Clascoterone) is an AR antagonist that is also currently in Phase 3 trials in the US. Kintor’s website has an interesting article discussing both these competing AR antagonist products and hair loss.
Make sure to also read my related past post on destroying the androgen receptor to reverse hair loss.
Update: July 11, 2024
Kintor Launches Cosmetics with KX-826 as the Main Ingredient
Kintor Pharmaceutical has officially launched a line of cosmetics with KX-826 as the main ingredient. This is the second widely discussed hair loss product that has been launched in the past two years as a cosmeceutical (with the first being CosmeRNA).
Update: June 5, 2024
KX-826 Receives The INCI Cosmetic Designation
Kintor Pharmaceutical’s KX-826 (Pyrilutamide) has received the International Nomenclature Cosmetic Ingredient (INCI) approval from the International Cosmetic Ingredient Nomenclature Committee. The assigned INCI name is Methylpyridinyl Fluoromethoxybenzonitrile Dimethyloxothiooxoimidazolidine. INCI names are recognized worldwide when identifying cosmetic ingredients. This development will facilitate the potential future global launch of Kintor’s line of cosmetics that have KX-826 as the main ingredient.
Update: May 24, 2024
More Effective KX-826 Tincture 1.0% versus 0.5%
Kintor’s clinical trial of KX-826 tincture 1.0% for treating male androgenetic alopecia in China just received clearance. The company’s pre-clinical studies showed that KX-826 tincture 1.0% had a significantly higher retention concentration level on human scalp cells compared to KX-826 tincture 0.5%. The latter was used in the Kintor’s previous phase III clinical trial.
Update: April 22, 2024
Positive Update on GT20029 Phase 2 Clinical Trial
Kintor Pharmaceutical just announced that its China Phase II clinical trial of its first-in-class androgen receptor (AR) proteolysis targeting chimera (PROTAC) compound GT20029 for treating androgenetic alopecia has reached the primary endpoint. The results are statistically significant and clinically meaningful, while safety and tolerability is good.
GT20029 demonstrated statistically significant efficacy compared to placebo in both the QD (once a day) and BIW (twice a week) dosing cohorts.
- After 12 weeks of treatment, the 0.5% QD GT20029 group showed an increase of 16.80 hairs/cm² from baseline. This was 6.69 hairs/cm² more than the placebo group.
- The total area hair count (TAHC) of GT20029 1.0% BIW group showed an increase of 11.94 hairs/cm² from baseline. This was 7.36 hairs/cm² more than the placebo.
- The 1% BIW dosage of GT20029 was identified as the optimal dosing level and has been recommended for the phase III clinical trial in China.
Key Quote:
“Based on the results of the Phase II clinical trial, the company will actively deploy subsequent clinical strategies for GT20029, such as initiating a phase III clinical trial in China and a phase II clinical trial in the US for male AGA.”
Update: February 1, 2024
Clinical Trial of KX-826 and Minoxidil
Kintor Pharma is undertaking clinical trials for two different androgen receptor targeting hair loss products (KX-826 and GT20029); in two countries (US and China); and for both males and females.
Now comes news that Kintor will also undertake Phase 1b/III clinical trials of KX-826 in combination with minoxidil for the treatment of androgenetic alopecia (AGA). The trial was just cleared by the National Medical Products Administration in China.
Update: November 27, 2023
Maybe Bad News for KX-826 Phase 3 Trial Results
According to this Reddit source, the results of the Chinese Phase 3 trials for KX-826 (aka Pyrilutamide) were ok, but not good enough. There were no serious adverse events or side effects. And positive hair growth was observed when compared to baseline (at all visit points) after 24 weeks. However, compared with the placebo group, the total area hair count (TAHC) improvement in the KX-826 treated group had no statistical significance. Albeit there was a “trend in efficacy observed”.
On a positive note, Kintor plans to continue with its multiple KX-826 related trials (in the US and China) for the topical treatment of androgenetic alopecia. I appreciate the speed with which the company released these findings. I expect there will be an official press release in the next few days. Edit: Seems like this never happened?
November 18, 2023
Phase 3 Trials for KX-826 (Pyrilutamide)
KX-826 (Pyrilutamide) is currently in the most advanced stage and has a good chance of coming to market in China by the end of 2024. In Kintor’s pipeline page, it is shown to be in the final stage of Phase 3 trials for men in China; and early stage of Phase 3 trials for men in the US. Moreover, it is also in the early stage of Phase 3 trials for women in China.
Kintor is also undertaking a second Phase 3 trial in China for long-term safety of KX-826, which I discussed in detail in my original post. Even more exciting, one my Chinese readers sent me the below partial translation of a new October 2023 presentation by Kintor. He said that his English is not good, but I only changed a few words that were confusing or out of place.
“KX-826 is a topical androgen receptor (AR) antagonist independently developed by Pioneer Pharmaceutical. It is the first AR antagonist in the world to enter phase III clinical trials for the treatment of hair loss. KX-826 binds the AR by competing with dihydrotestosterone (DHT) to locally block androgen-mediated signaling to limit hair follicle miniaturization and promote peripheral hair growth. After reaching the circulatory system, KX-826 is rapidly metabolized into inactivated metabolites, which has little influence on the whole body AR signaling pathway and has good safety.
The Phase II clinical trial in China included 120 men with hair loss. Of these, 90 subjects were randomly assigned to KX-826 0.25% twice daily, KX-826 0.5% once daily, and KX-826 0.5%, and the remaining 30 subjects were randomly assigned to placebo. After 24 weeks of treatment, the 0.5% concentration group of KX-826 showed a significant improvement in the amount of non-vellus hair in the target area. An increase of 22.73 roots per square centimeter compared to baseline.
Finally, news about Phase III: KX-826 is currently in or planned for five Phase III clinical trials (two in China and three in the United States). Among them, the Chinese Phase III clinical trial of KX-826 for male alopecia has completed the last subject visit, and the company is making full efforts to promote the data collation, library un-blinding and data statistical analysis of this clinical trial.”
Phase 2 Trials for GT2009
In Kintor’s August 22, 2023 update, they announced the completion of patient enrollment in Phase II clinical trials of GT20029 for male pattern hair loss in China. The current pipeline shows that these trials are almost over in China, and close to beginning in the US.
In the middle the post, I have linked to the October 2023 Chinese presentation image that someone from China sent me. This Chinese correspondent attempted to translate it, but feel free to check for any errors if you know Chinese.
Great work, admin. I’m sure this took quite a bit of time. I appreciate it. I guess we’ll see how it goes from here.
Nothing will happen.
You’re probably didn’t and honestly, from what I’ve seen leaked (if true and could be way off) much of this is as good as minox. I’m getting a little tired of stuff that claims it’s as good as minox. We need better. Way better.
I ordered Pyrilutamide on the grey market, and got some pretty shite sides. I’m hoping the real deal won’t feel like that, as I can’t handle fin.
So mind your own business then.
Note that beezula is a mild fail since it didnt work longterm in the 12months study. The efficacy decreased significantly indiecating that this trend will continue over a year and patients end up under baseline nevertheless.
So breezula is trash and kx need to shownit works long term.
breezula loos 50% of its power after 6 months of usage…but that doesn’t mean that it does not work at all..i use it since 3 years..
kx is trash, used it for 8 month, no result at all…
Admin – are you expecting KX-826 to be available in the US market by end of 2024? Or just Chinese?
Great question.
Just Chinese approval (best case scenario, assuming Phase 3 results are good). But it is so easy to get drugs from China these days.
Btw Dutasteride is still only approved in South Korea and Japan for hair loss.
Why would someone use this vs fin/dut? As a stack? What’s the difference between an androgen blocker, degrader, and antagonist?
Like others have said, if it’s as good a minoxidil and finasteride, then I see no reason why would you change drugs. Let alone add more to the inconvenience of topical application rather than oral.
Given how strong androgenetic alopecia is we need all of them. Stopping the convertion T/DHT (Dutasteride/Fin) is the most critical step but blocking (KX-826) and degrading the AR (GT20029) will be crucial for achieving long term success (20+ years).
That approach will be a true game changer for the young starting early enough.
Probably just for people who can’t handle Fin or Dut.
I’m more interested in the AR degrader product. If it works as it’s theoretically claimed, the results could be very significant. Rigorous safety studies are essential though !
https://www.wionews.com/science/scientists-achieve-major-leap-forward-to-potential-hair-loss-cure-660474
Wow, now that is huge. Long term, of course (maybe not in my lifetime) , but amazing nonetheless.
100% I agree with you, minimum 40 years (if we’re being generous).
What’s the point then. Why care if there isn’t a cure coming soon?
You must be new in the forum ;-)
I was being cynical Alex.
Does anyone have any information from stemson therapeutics? What are they doing? It’s been awhile.
Hope you have a good thanksgiving admin and everyone. (if you live in the U.S) and Yoda :). Take care.
Thanks and you too!
kintor released new news today, kx826 is hopeless, and its stock price has plummeted. I couldn’t cry or laugh when I heard the news. I was numb.
Thanks. There is some discussion about this on Reddit, but nothing on their site.
Sounds bad, though at least they released the results super fast.
https://www.reddit.com/r/tressless/comments/184pdh7/kintor_has_released_an_investor_relations_memo/
The last hope for a short term new product is breezula… After that, no new meaningful treatment until… 2030.
Kintor released the press release overnight (US time).
https://www.marketscreener.com/quote/stock/KINTOR-PHARMACEUTICAL-LIM-111325374/news/Kintor-Pharmaceutical-Limited-Announces-Results-of-Phase-III-Clinical-Trial-of-KX-826-Topline-Treatm-45442274/
I initially had high hopes for them until the Phase II results disappointed. I wish they would just drop KX826 and focus all their hairloss energies and resources on GT20029.
Thanks. They have enough resources, so hopefully no cannibalization of time and staff across so many trials.
Tough day.
Well I still can’t see official news on their website, but one has to assume the information is legit. I was wrong and initially thought the posts are doomerism and pessimism yet again…well alright.
Here we are, the one possible future product with the least efficacy (see phase 2) is gone down the drain. I personally wouldn’t have bought it anyhow, application twice daily for a dozen of hair is not worth it for me.
It makes no difference guys. We need treatments which are better than anything on the market now. Looking forward to Q1 when they release GT-results. I also think the company needs a homerun, there’s too many failed products already (see Covid-medicine) – otherwise they’re gone.
Make sense Ben. I deleted your short comment (as you probably guessed), but I would have thought the same in your place.
I had the advantage of being able to see that reader’s email address (a Chinese one) and his past one other comment on this site, so decided to check Reddit before concluding anything.
Totally fine with the deletion as I was in the wrong.
There’s been these absolute pessimistic and annoying comments lately from the known trolls which I want to counter (sometimes), and I shot from the hip in this case.
Let’s try to keep an optimistic view, as hard as it is sometimes.
This completely explains why they started the long term 52 week phase 3 trial this past summer. They saw that the efficacy wasn’t great but trending in the right direction, and they’re hoping a longer trial period will show a clear divergence in results vs placebo.
This also explains how breezula has designed their phase 3 trials, as they’ve had similar issues with their results.
The overall consensus on topical androgen antagonists is that they work, but not as good as 5a inhibitors. Therefore, they’ll need more time to show results which I think is worth it. This could still replace 5a inhibitors or stacked with it for more total efficacy.
I hope they commercialize this asap, and not wait for their long term phase 3 study.
Great point Johnny, and hope that is the reason!
Good post. Hope youre right as we need more weapons to the arsenal. AGA is a pretty strong beast.
No, breezula actually lost efficacy after 6 months with a decline to 9 months and was barley above basline at 12 months. When this trend continues breezula is trash.
For kx i dont know how 3 trials male and females has showed efficacy and now all of a sudden the point changed. Its interesting neverless if the product is trash or the trial design or maybe even the data analisis.
Phase 2 gt20029 is a pivotal moment for the company otherwise it may say good bye.
Yes, we’re aware of breezula’s declining results for months 9 and 12. If you look at their phase 3 design, they’re taking only those that were on the actual drug after 6 months and testing them vs placebo for an additional 6 months. It seems that their goal is to show that even though the results don’t hold long term, it’s still gives you more hair than you would have without the drug.
Not every new hair loss drug is going to be as efficacious as finasteride. It’s a different MOA that will show clear benefits and will appeal to way more people because of its 0 side effect profile.
I had a feeling that Pyrilutamide wouldn’t be as amazing as advertised. Especially at this point since 1993, big interventions are needed for drastic improvement of hair, dermal papilla multiplication, hair cloning, Amplifica, GT20029 etc
Im really lost as to how the results can suddenly drop off a cliff…anyone?
Are we saying it’s a total dud?
That’s the thing. Phase 2 data showed this was comparable to finasteride. We haven’t seen the data yet for phase 3, but now they’re saying that it worked but it wasn’t much better than placebo.
Hard to draw any conclusions until they share the actual data and we can compare them to phase 2 results.
Is it fair to say that it’s also unlikely to be effective for maintenance?
I don’t think that’s fair to say at all. Without seeing the actual data, we’re just guessing. But if that memo is legit, it sounds like the company still believes in the efficacy of this drug, and that they’ll be able to show it with longer 52 week study, which they’ve already started.
But even based on this memo, it said they’ve observed positive hair counts versus baseline over 6 months. Most people who are balding and not taking any treatments for hair loss will gradually continue to lose hair or stay the same after 6 months. Rarely do they see increases in hair counts, so this drug seems to not only maintain hair but also regrow some.
It’s the under performing delta versus placebo that’s confusing.
I am not surprised at all. We need something that shows legit hair growth. Not anti androgen topicals etc. On to the next drug. Hopefully that Bayer drug with the monkeys will work….2040 will have cloning…in the meantime it’s the big 3 snd fue.
I get legit hair growth from Pyrilutamide. I have been on it for over a year and basically regrew my bald temples.
I saw that three netizens in the stock market called kintor, and they were the following responses: 1. “The other party said that there was a mistake in the operation calculation, and they will continue to find the cause and strive for listing next year” 2. “I just called and asked, and I was analyzing the data, but they all think that the result is unlikely to reverse, and there will be no further announcements.” 3. “Just hit, the possibility of re-listing is not big, basically declared failure”
alas！
what is a netizens?
I’m open to anything but when they say “in combination with min” they lose me. That means by itself it stinks. And we already know minox isn’t a cure (I’ve been on it for months – stopped shedding but it’s not a real game changer, though yes it’s helpful). I feel like this is another bust, unfortunately.
The combo w/Minox seems like throwing spaghetti at the wall, Hail Mary to get some assemblense of results. I’ll take it if it’s an improvement of effectiveness over what we have now. If not, what’s the point?
Thanks for this update, we’ve all been waiting with bated breath to hear about GT20029. But given that Pyrilutamide also seemed promising after phase 2 trials, how skeptical should we be here?
During the last 15 years, how many phase 2 trials results are statistically significant and clinically meaningful, yet failed to reach phase 3 or market ? I lost the count.
Agree… I’m still waiting on word from the Maksim Plikus trials. He sure had a ton of confidence but no news so far!
About half-a-dozen. The greatest disappointment was Follica, because that protocol works and many people are getting great results with a crude, home-brewed version of Follica’s optimized technology. The admin should change the name of this site to HLC2050, because that’s probably an accurate prediction.
I was certain that Follica would be commercially available by 2023 (my “worst case” scenario was by Q2 ’24); at this point, all men should be subscribed Finasteride prophylactically on their 22nd birthday – it’s really the only solution to this problem.
Finasteride looses it’s effectiveness over time, all treatments do to one degree or another. Or maybe our baldness genes become more potent. I know, started (topical) minox approximately 40 years ago, (oral) fin (now dut) 30 years years ago. Need to keep tinkering with oral, compounded topical versions in the attempt to tread water. I’m grateful to have at least had these tools in the toolbox, however I sure as hell hope some guy isn’t writing something similar 30-40 years from now! :-(
I agree, though the Japanese seem different:
https://www.hairlosscure2020.com/does-finasteride-work-after-20-years/
Right, my experience doesn’t mean everyone will be the same. Depends on your genes, a guy who has a lower degree of hair loss might fair better, e.g. Aston Kutcher. However for the majority that read this thread my guess is that the grim reaper of hair loss will always be after you. I’ve saved a lot of hair, however it’s not the same as 30 years ago, for sure.
Maybe it’s me but ‘statistically significant’ sounds impressive after just 12 weeks/3 months.
Normally with hairloss cures we tell our self’s to wait 6-8 months before judging.
Reddit discussion on the GT20029 China phase II trial primary endpoint results:
https://www.reddit.com/r/tressless/comments/1c9qdi6/gt20029_china_phase_ii_trial_for_aga_reached/
So Kintor’s GT20029 Phase II trial results were released yesterday, below are the current results of total Target Area Hair Count (TAHC) increase:
Finasteride:
Finasteride 1 mg/day significantly increase total hair count compared to placebo 12.4 hairs/cm2 after 24 weeks.
5% Minoxidil:
The mean change in nonvellus TAHC between baseline and week 16 was +22.0 hairs/cm2 (95% CI: 18.1; 25.9) in the DC0120 group and +20.5 hairs/cm2 (95% CI: 16.6; 24.4) in the comparator group.
Bioneer CosmeRNA:
The mean change and rate of total hair count increased by 7.545 ± 7.896 and 4.264% (p < 0.001) at 16 weeks and 7.727 ± 8.659 and 4.421% (p < 0.001) at 24 weeks in the AR68 5 mg/ml treatment group.
Technoderma (TDM-105795), Phase 2a trial:
The results indicated that TDM-105795 led to a mean increase in non-vellus Target Area Hair Count (TAHC) of 24.3 hairs/cm² with the high label strength (0.02%)
Kintor (GT20029), Phase II trial:
The TAHC of GT20029 1.0% BIW group showed an increase of 11.94 hairs/cm² from baseline, which was 7.36 hairs/cm² more than the placebo, also yielding statistically significant results (P<0.05) after 12 weeks.
Hope (HMI-115), Phase Ib trial:
14 hairs/cm² mean increase in non-vellus target area hair count (TAHC).
Breezula (CB-03-01), Phase II trial:
14.3 hairs/cm² increase after 12 months of 7.5% BID clascoterone solution dosage.
Follicum (FOL-005), Phase 2A trial:
The topical compound resulted in a 6.6 hair/cm² increase in hair growth.
Amplifica AMP-303 trial:
no results published yet, they announced that results should be out 2024Q1 but nothing so far.
Amplifica didn’t say that results should be out 2024 Q1. They said the trial would be completed by Q1, meaning that they require a few months minimum to gather the data, present it to FDA etc. The results won’t come out most probably before June.
Helpful post, is it just me or do most of these look like total sh*t for regrowth except technoderma? I hadn’t realised the pipeline was quite this lackluster.
It really is all about where you are in your hair loss stage. For those at NW 1-2, anything that even maintains for 10 years is amazing. For those at Norwood 3 but whose hair loss started less than a few years ago, a whole bunch of these treatments could bring back recently lost hair.
Then we also have the Fukuda dermal papilla transplant and Aderans cell therapy treatments that could come to market within several years.
What are your expectations of Pelage and Amplifica (in terms of timeline and effectiveness)?
Pelage is supposed to start Phase 2 trials in mid-2024 and has raised the requisite funds.
Amplifica was supposed to have finished Phase 1 trials in the first quarter of 2024.
So both are still a few years away from market, assuming all goes well in future trials.
For sure, I hold high hopes for both these, but I’m more so keen for Fukuda (timeline and efficacy).
Are you sure the amplifica AMP-303 trial was Ph1? I thought the drug was already proven safe in man.
Am away from computer, but maybe you can check my Amplifica post in case there are more details?
What about hairClone in UK they will start there trials in UK any news from them?
What does that INCI mean? Will it launch as Cosmeceutical as well or is it still a prescription drug only?
Acronym is spelled out in the update:-)
Not sure, but my guess is that they will try cosmetic first, then maybe (high-dose?) prescription too.
Thanks Admin, I should have asked more precise. My question was will it come as Cosmeceutical OTC and what would be the timeline to expect? But good to hear they move forward with both products for AGA in the pipeline.
More discussions on the cosmetic route here:
https://www.reddit.com/r/tressless/comments/1d907lf/kintor_to_launch_pyrilutamide_as_a_cosmetic/
But they’re still going through full clinical trials even though it’s a cosmetic, right?
They have gone through Phase 2 and/or Phase 3 trials for both key products. They will likely be able to use them in cosmetics without the need for another 5 years of trials.
But Pyrilutamide failed Phase 3. How can anybody trust their products if they don’t demonstrate that the higher dose is effective?
It is not clear if it is a certain failure, since there was some hair growth.
They are continuing with Phase 3 trials for Pyrilutamide, and also check out the May 24 update on 1% versus 0.5% trials. But my gut feeling is that this will not be much better than Finasteride. Albeit with hopefully no side effects.
If it doesn’t work they can bring out as a cosmetic. It will perform as well as all cosmetic treatments for hair loss have to date (sarcasm)!
All my posts are not going through, admin. FYI.
Hey Ben, thanks for letting me know here and via email! For some reason, a lot of comments are going into the “Trash” folder (which I almost never check) rather than the “Spam” folder. I managed to get most of them moved over in time thankfully.
The spam control plugin that I use is also giving me some strange messages lately. Will try to resolve.
Do we know when the results for the phase 3 results for the 1% Pyrilutamide trials are expected?
Thanks for all of your hard work and for keeping us in formed.
Hi @Admin,
did you see: https://www.topadur.com/pipeline
Medical cosmetics|TOP-M119
Alopecia, Skin aging
Solution -> TOP-M119
Yeah it is still in pre-clinical. Someone asked me last year to write about them, but I will wait till they start Phase 1.
Stemson has laid off over 10 employees.
The twice weekly protocol for GT20029 is stupid! If the concentration of 0.5% is used daily, then it is reasonable to use the concentration of 1% every other day.
A question about pyrilutamide:
If 1% concentration is more effective (and safe), why didn’t they use this concentration from the beginning? What guarantee is there that the concentration determined for GT20029 is correct? This company is not careful in determining the maximum safe dose.
GT20029 group buy.
Admin: I removed the Discord link as I am not sure about these suppliers. You can find these links on Reddit or on the various hair loss Discords, if you want to risk it!
You can post such links on this site’s Discord chat FYI. I do not log in to that Discord daily, but email me for an invite if you want to join.
Hi Admin,
We want to risk it from here. Please share the details and leave the rest for us to decide. We will do out own research.
Launched!
Where do you buy this?
Why would they launch it as a cosmetic since they’re doing clinical trials including phase 3 ? Will they sell it as two separate products in the future ? One cosmetic and one as medical treatment ?
The cosmetic is launched.
Admin: Thanks, just published a new post on that, but removed your link above and added my replacement text.
Interesting read …
https://www1.hkexnews.hk/listedco/listconews/sehk/2024/0826/2024082601130.pdf
Kintor is getting ridiculous … new Trial till 2028 !!!
https://clinicaltrials.gov/study/NCT06622824?cond=Androgenetic%20Alopecia&rank=1
Use the 1% concentration twice a day yourself and see what results you get. Don’t wait for kintor!
Ah yes, the famously successful “don’t wait for evidence” approach to hair loss treatments.
Kintor released 1% cosmetics
It’s on amazon
Yes, I have already mentioned it in this post, as well as in the past KX-826 cosmetic launched post! Thanks.
I don’t understand – didn’t they already release .5% results and they weren’t statistically significant?
So there is a huge decline of efficacy with time ?
“The TAHC increased by 9.5%, 13.0%, 11.4% and 9.7%.”
Would not call that “huge decline” by any means. You are still up 9.7% at 12 months.
I don’t understand that at all
if they released cosmetics kx 826 of 1%
and in the meantime they are testing the drug kx 826 of 1%
You might want to read this well written article on the development of Pyrilutamide, launch of the cosmetic version and now the testing of the 1% version: https://perfecthairhealth.com/pyrilutamide-kx-826-a-promising-future-treatment-for-hair-loss/
Thanks for sharing this article, Pinotq, it’s the most comprehensive thing I’ve read about KX 826. It’s frustrating to read about the strong placebo response in several of the trials. Much has been written about “the placebo effect ” because it poses profound philosophical questions. Can we influence reality with our thoughts alone? Are people growing hair simply because they think they might? Seems absurd but it’s a persistent finding in hair loss drug studies. Makes me want to save my money and just get hypnotized.
Just a heads up for anyone thinking about using this product, you might want to read the reviews as at least 4 people reported getting headaches. I tried Pyri previously from a group buy and got headaches so I discontinued immediately…………..thinking it was not pure pyri. But after seeing the reviews, it sounds more like it is a side effect of pyri that might not be getting reported.
Trying the 0.5% bottle bought from Koshine mall.
I did notice a thickness in my hair by using the product. Never got a headache or any issues with ED but I did get brain fog, I also felt more anxiety but not sure if this was from the product hosnestly. Very interested in seeing long terms results using kx-826.
3 weeks of use and zero side effects.
I am using kx826 koshine826 1% since now more than 2 months and no results so far.
How do you know it’s 1%? I’m confused about what’s actually being sold on Amazon and elsewhere.
John, The more expensive of the 2 products says “Enhanced Formula”, but it does not give you the percentage of solution. When I made a support request to Koshine, they replied saying that the “Pro version is an upgrade of the basic version formula, including a doubling of the formula” but they did not dislose a percentage.
Thank you PinotQ. I think I’ll go with the least expensive until this gets sorted out. Hopefully.
A couple of the small amount of reviews claim that it gave them ED. That pretty concerning especially since it’s something that kintor is claiming no side effects
Most likely nocebo, there are people that stress themselves already with using hairloss. Some people even mention they got ED from using minoxidil. While concerning I highly doubt its actually because of KX.
I think it’s pretty clear blocking DHT is not healthy.
Why do we never address how we can balance hormones through diet?
Because balancing hormones through diet is difficult and doesn’t make any sense?
And blocking DHT *so far* hasn’t seen to have any negative or adverse side effects on male health other then the enlargement our prostate and hairloss, with the former being actually potentially dangerous health hazard.
Try cutting out sugar for a while. Try nutrition. Too difficult. Then get ED. Doesn’t make sense? That’s just you.
Tried for a couple of weeks. Observed consistent worsening of morning wood and got better after I stopped.
This guy could have been part of the placebo group or gotten the treatment, so not very useful.
Nevertheless, yet one more Reddit clinical trial participant report.
https://www.reddit.com/r/tressless/comments/1gqioiw/completed_my_clascoterone_study_updating_as/
His original post:
https://www.reddit.com/r/tressless/comments/1cd9cxc/clascoterone_study_going_on_right_now/
Is it possible that the efficiency is falling because of androgen receptor upregulation? That would mean efficiency of this product would be 0% after 2 years and if you refuse to take kx your balding would accelerate. Is there anyone who could prove me wrong?
3 months Pyrilutamide (1.5 months 1% ) + Alfatradiol 0.1% + Minoxidil:
https://www.reddit.com/r/tressless/comments/1grzaab/3_months_pyrilutamide15_months_1_alfatradiol_01/
Kintor is making an AMA about KX-826 on reddit here :
https://www.reddit.com/r/Koshine826/comments/1gzktsq/ama_with_kintorkoshine_medical_scientists_the/?sort=new
Thanks Arthur!
So GT won’t be getting a phase 3 until the second half of 2025, and it’ll only be 24 weeks. What a joke of a company.
And that 2H of 2025 is just for China’s Phase III study. They said the USA Phase III start is expected to lag the China Phase III start by about 6 months.
In the Reddit AMA, they also posted two before and after photos from the latest Phase III, 52-week study for KX-826:
https://www.reddit.com/media?url=https%3A%2F%2Fpreview.redd.it%2Fama-with-kintor-koshine-medical-scientists-the-science-v0-p1c1ccd3jb3e1.png%3Fwidth%3D1620%26format%3Dpng%26auto%3Dwebp%26s%3Dbe071f3754f17a0d48c55261724bc4d9d76be3ca
https://www.reddit.com/media?url=https%3A%2F%2Fpreview.redd.it%2Fama-with-kintor-koshine-medical-scientists-the-science-v0-tcecg5nzib3e1.png%3Fwidth%3D1620%26format%3Dpng%26auto%3Dwebp%26s%3D1be622c9af91ff12d66f0595f94c23137ded9ead
Interesting, they have two heavyweights in the scientific board: Dr. Shapiro and Dr. Tosti. However, it looks like they are not delivering since 2022…
I was really skeptical of Pyrilutamide after their last trial. Given the newest results, do you think it’s reasonable to conclude that it works fairly well?
I guess this answers my previous question. We can’t even trust that their photos are real.
https://www.reddit.com/r/tressless/comments/1ebwpjy/kintor_stealing_pictures_from_a_hair_transplant/
That… is just scandalous. Wow.
I’m using KX-826 from October and I see new small black hair where before was thin small hairs. I also used dutasteride for last 3 years, but new hair I think a little more stronger then before. But I also have a very big shedding still i started to use KX-826, it was an even scary for me that i bought cheap microscope to track growing of my hair :) And i see new hair on microscope, hope in two months it will look much better on head.
Hey Dima, that sounds great! Could you give more insights on your case? Age, NW grade, etc? Did you have any side effects?
I am wondering why the internet is not swamped with before/after pictures of people using Pyralutamide. It’d be great if you could share something more about your experience taking it.
Hi, Pellata. My case is that im balding from about 2011 and in 2016 i started to use minox twice a day. At first my results was great but then after every year of sheddig period my hair became more thinner and in 2020-2021 i started to use duta 0.5 mg and it stabilizated my hair and make them some better. Before i also used a lot different treatment like Minoxboost for minoxidil, ketazanole shampoo, botox in head, duta on head, zink on head, mesoroller and i think something else :). Im 36 six old and i think i have NW 4-6 from different period of shedding. Side effect from KX826 just sometimes i have small dizzinnes for several minutes. When i started to use KX i have a great shedding and it still going on. Im not sure that new hair is not because of duta using but for me they look a bit stronger then before after shedding of dut
Thank you so much for your quick reply, Dima!
Genuine feedback on KX826 is what many of us (including myself) are waiting for to decide to give it a try. In your case, that of a long time duta (+other molecules) user, it will be key to assess whether KX826 allows better results than whatever you tried in the past. When is related to the initiation of a new treatment, shedding is in general a good thing. I do not want to bother too much, otherwise I would have asked more (perhaps also microscope pictures). Please feel free to keep us posted on how the situation evolves and good luck!
As the year is wrapping up I’d like to thank you Admin and to everyone else for the constant hard work you guys put into this blog. Here’s to a better 2025 and hopefully great news that will cause misery to the pessimists.
I second you, YoYo. Thank you Admin and all! Really!
Aren’t pessimists already miserable? Thanks Admin?
Admin, what about talking to HairDAO and hear what they are doing? They now have their own lab, and are able to do a lot of testing, which is really promising!
Please post all comments about HairDAO in the below post:
https://www.hairlosscure2020.com/hairdao-blockchain-driven-hair-loss-cure/
News … Kintor started its Phase 3 already. Quite interesting they call it 2 in 1 design with combined Phase 2 and Phase 3. What I really dont get is they say Phase 3 will be finished end of 2025. How can this be? In the official clinical trials they show end in 2028.
https://en.kintor.com.cn/news_details/6.html
Look what I found guys:
https://youtu.be/OoBUNxQsm5I?si=HVsgJjy6eQZM8Zjv
This guy is having amazing regrowth from kx!
I will note that he was on minoxidil for 10 months prior to this.
The cost seems ridiculous. What was the last product that went the cosmetic route a few years back? Was it cosmerna? Yeah that was a joke. Total bust.
Time will tell I guess. But I’ll let others pay for it while I wait.
My god, what a crock. Just stick to the biggies until something REAL comes along. They can ‘Phase’ all they like, but where is the cold hard evidence? Yeah, let’s all wait till ‘28! Instead, save your coins for the clone wars kiddies. You’ll have a mop like Rob Lowe with hair extensions. Although, your wallets will be as empty as a Chinese Buffett on fish sticks Tuesday. However, if that glorious day ever comes to fruition, it’ll wipe these (vague) money-grubbing butt stains off the market forever. *if any CCP members are offended, I’m sure there’s a 1800 number you can call. Happy New Year.
It’s not really accurate to say Kintor is selling their product “as a cosmetic.” Somehow they’re getting away with making medical claims on their advertising and packaging that hair regrowth is achieved. Cosmetics are allowed to claim “makes hair look fuller” not “new hair growth is seen in 4-6 weeks.” The FDA is asleep at the wheel. But I’m sure Elmo will wake em up.
I suspect that during the Trump administration, the FDA will become more lax. The right wing and libertarians seem to hate government slowing down things. Or even being there in any capacity per the most hardcore.
Good point, unlikely they’ll work very hard.
Be careful, TDS raises coritisol.
Kintor Pharmaceutical Limited Announces Long-Term Safety Phase III Clinical Trial of KX-826 for the Treatment of Aga Reaches Top-Line Results
https://www.marketscreener.com/quote/stock/KINTOR-PHARMACEUTICAL-LIM-111325374/news/Kintor-Pharmaceutical-Limited-Announces-Long-Term-Safety-Phase-III-Clinical-Trial-of-KX-826-for-the-49386190/
I used it for about three months in Autumn and KX-826 just ruined my hair. I had so much shedding. Then I hoped that better hair will grow, but nothing happened. At the end, I just stopped using it even though I still have two new bottles of KX-826.
Hi @Admin, you have seen it all and iirc you are on Dut and OM. Would you consider KX? I am also on Dut and OM (for 20 years) and am slowing losing ground. KX seems like the perfect solution (I have always suspected testosterone to be an issue which is blocked by KX). Also Dut only blocks 50% of scalp DHT. I am going to buy KX from Koshine now. Nothing to lose (I hope).
I would strongly consider it.
Thumbs up emoji. Would you try from Koshine or wait until officially released as a drug?
I am tempted to try the Koshine 1.0% one first, though I do not want to spend this much on a regular basis.
Same here, going to swallow the cost and hope for the best. I can’t see it coming down in price when officially released. Maybe economies of scale will help us. Koshines pricing won’t have factored in that the vast majority of users are using other treatments too.
Can you also clarify why admin?
What’s your reasoning? I only see minimal effects and maximal costs.
My scalp hair condition is such that a minimal benefit is still worth the hassle, albeit not beyond a certain price point that I can’s afford. I also never tried any of the numerous anti-androgens out there, so these newer topical androgen receptor targeting products are a tempting alternative.
Breezula and Pyrilutamide seem to have the most research and trials behind them.
Can you modify the comments section so that we can do a simple sorting?
Unfortunately, not possible with the theme and plugin system that I am using.
I use 1% koshine since now more than 8 months and no regrowth at all.
Thanks for sharing this Eric. Are you applying twice daily?
No only once a day.
Why can’t they make something that grows hair without the shedding ? Geez.
Realistically, this will be marketed in the West after Breezula right?
Is this Reddit comment accurate? If so, it gives us a lot of reasons to doubt these results.
https://www.reddit.com/r/tressless/comments/1jgzp2s/comment/mj3yc2p/?utm_source=share&utm_medium=web3x&utm_name=web3xcss&utm_term=1&utm_content=share_button
Mmm, it’s an open-label study and they’re relying on self-reported indicators from patients and then indicators from the researchers. So we have four problems – lack of blinding, self-reported measures/expectation bias, observer bias, and possibly an inflated effect size.
There’s a lot of bias stacking there – patients know that they’re taking the medication (not a placebo or an unlabelled alternative like Minoxidil), the researchers are also aware and motivated to find a result, and the patients are also motivated to find a result as they know they’re taking something. Also… There’s the question of statistical significance vs clinical significance. They’ve reported a highly significant P value but that doesn’t actually mean the effect size is good. As there’s no control we can’t know if that’s due to the drug or just normal regrowth.
That to me warrants scepticism about the results. That’s not to say the drug doesn’t work, just that everyone involved is being incentivised to find that the drug does. I’d need to see something blinded with an unlabelled alternative and/or placebo to believe their results are accurate.
What would be more likely to me is that the results found here are the best numbers they’ll have, and then if they did something closed the efficacy will decrease as biases are removed.
I recommend you read the thread on their AMA on Reddit. It highlights that their trials were hampered by Covid. Which seems like a somewhat reasonable reason. Although I appreciate I feel I am on full on confirmation bias with KX.
After COVID, I just don’t trust anything coming out of China. Best of luck to those willing to risk it.
This is not an unreasonable take. I’m skeptical that the koshine products have anything bioactive in them.
@No Thanks: After COVID I don’t trust anything coming out of the world.
So with this and Breezula both phase 3 which will be better? Breezula phase 3 results should be released soon as they plan on getting it out to market 2026 but they have had that many delays since covid who knows….
What about GT 20029?
It was pronounced to be safer with better efficiency?
Are there hair scientists or enthusiasts that use AI like AlphaFold to create new treatments and to possibly update current ones?
Year financial report with updated pipeline … the report mentions AGA 75 times :-)
https://www.hkexnews.hk/listedco/listconews/sehk/2025/0326/2025032601884.pdf
Weird that no one has seen results on this drug on Reddit. I tried it and had to stop because of brain fog.
Maybe they are selling a modified version of what they are testing. A cosmetic and a drug are 2 different things.
Cosmetics and pharmaceuticals differ mainly in legal status. A cosmetic can claim “makes hair look fuller”, a pharmaceutical can claim “regrows hair.” How Khoshine can sell this Kintor stuff (if in fact there are any active ingredients included) with no FDA approval and make claims for hair growth is a mystery.
Too bad it doesn’t seem like anyone is expediting testing the sugar gel. So many articles out there about it, but nothing about testing.
Please post your comment in the 2DDR post Tom.
There are loads of people on Reddit with good results. Join the chat group.
You mean sugar gel or KX-826?
I’ve seen multiple ppl on reddit talk about great results with the sugar gel.
Kx.
Kintor has updated Pipeline on the website and now shows status of KX-826 as NDA … is Kintor applying for Drug Approval already ?
https://en.kintor.com.cn/about/1.html
In China maybe, give it a few years before it’s approved in the West.