Epibiotech Hair Loss Cell Therapy

On May 10, reader Ben let us know that Stemore (South Korea) was renamed as Epibiotech. Since then, the new company has been in the news every week.

Epibiotech Hair Cell Multiplication
Epibiotech hair multiplication via dermal papilla cells. Source: Company website.

Epibiotech New Hair Loss Facility

  • On June 3rd 2021, Epibiotech and T&R Biotech announced a partnership to develop a hair loss treatment involving pluripotent stem cells. According to T&R Biotech’s CEO:

“Epibiotech’s dermal papilla cell differentiation technology and our pluripotent stem cell line will create a combination with high synergetic effect.”

  • On May 31, 2021, Epibiotech and its CEO Jong-Hyuk Sung announced the construction of a new production facility at its Songdo headquarters. This GMP facility will be used to produce “2,000 self-made dermal papilla cell therapy products annually”.

Epibiotech’s platform technology page is all over the place and a bit confusing. Note that CEO Jong Hyuk Sung is a professor at Yonsei University. This company was originally founded in 2015.

  • On April 30, 2021, Epibiotech signed an agreement with Professor Hyung-beom Kim of Yonsei University to develop a hair loss treatment using gene editing technology.

All of this seems a bit too fast and crazy.

However, as I outlined in my recent post on Han Bio, South Korea is becoming a world center for hair loss cure research. On par with the US and Japan if media articles are to be believed.

Renaming from Stemore

I e-mailed Epibiotech to inquire about their technology and their  May 1, 2021 renaming from Stemore. Below is part of the reply (with minor corrections) from Dr. Nahyun Choi, the company’s director of research:

“The name STEMORE, used previously, was based on a focus on research on hair loss using stem cells when the company was founded. However, our company is now researching and developing not only stem cells, but also various hair cells. This includes dermal papilla cells, and an expanded pipeline to low molecular substances and whitening agents. Therefore, the scope of the research and development was extended to hair and skin. So the company name was changed to Epibiotech after the foreword of epidermal cells.”

Epibiotech Pipeline

According to the company’s pipeline page, they are working on three hair loss products.

  1. The main focus is on EPI-001, the autologous dermal papilla hair cell therapy treatment. It is scheduled to enter Phase 3 clinical trials in 2024.
  2. The EPI-002 Ripk1 inhibiter (gel or ointment) will also enter Phase 3 trials in 2024.
  3. Finally, the EPI-003 oral PGD2 inhibitor product will finish Phase 2 clinical trials in early 2025.

Company Hair Loss Treatment Video

39 thoughts on “Epibiotech Hair Loss Cell Therapy”

  1. Yeah so are they working on hair cloning? Or just topical? If its just a topical I honestly don’t think it will help much.

      1. @yoyo thank you for the explanation, so they are working on hair cloning and not just a injectable? Or both? Thanks again.

        1. They are working on three separate solutions for hair loss. The information on their website is very confusing and all over the place, but from what I understand, the 1st is hair multiplication by extracting a few hairs from the back of the patients head and culturing those hair follicles to mass produce and transplant them on the patient, like a regular hair transplant. However, they also mention stem cell research from iPSC (very similar to Stemson if you are aware of what they are currently doing). The 2nd is some ointment/gel that inhibits Ripk1, not too sure what that is. The 3rd being a Prostaglandin inhibitor which you take orally, there was research a few years ago that showed that prostaglandin can also contribute to hair loss so this medication is supposed to inhibit it. Being a med student I know that there can be some rare serious side effects inhibiting prostaglandin though, so I’m not sure on the safety of such a medication. If you want my honest opinion you should wait on Stemson, they are funded by Allergan which is a famous pharmaceutical company and the science and technology behind Stemson seems solid. They are currently testing their product on pigs (similar skin to humans, mice aren’t as reliable). Wait around the end of this year to see what their preclinical results will show, plus it’ll be way more affordable than Tsuji. Hope this helps.

          1. @yoyo dude thank you very much for the explanation I was confused about it. OK so wait for stemsons therapeutic which might be available in 2030 just kidding but remember that link Jan sent us on here where fortunis there investment partner said the pig trials where a success and that they were hoping to start human trials later this year oh by the way they took that video off of vimeo I can’t find it anywhere anymore. But anyways we now have 5 companies working on hair cloning and I really only trust stemsons therapeutics. I honestly feel that Dr tsuji is done and over with and tissuse is a joke.

            1. No worries dude. https://www.linkedin.com/jobs/stemson-therapeutics-jobs-worldwide/?f_C=20275102&trk=top-card_top-card-primary-button-top-card-primary-cta This website shows the job listings that Stemson are currently looking for, by the end of this year hopefully there should be an update on what progress has been made (and human trials next year hopefully). Alexey did say he expects this to come to the market around 2023/2024, but did say it would probably take a little longer than that. Yes Tissuse is nonsense, Tsuji is a big question mark for me, the price is ridiculous. Yokohoma, Epibiotech, Han Bio are all to look out for. There’s also GT20029 from Kintor which is an androgen degrader which I’m excited for but that might be a while.

      2. More like they’re working on money multiplication via fleecing investors, like every other hair loss company for the last 50 years

  2. I always find it flattering to be credited, thanks Admin.

    Great article. The race is on, Yokohama vs Stemson vs Epibiotech in the cell-approach. Tsuji being a questionmark. Hairclone is out imho.

    1. Hairclone was always out lol in my opinion. They should just be a company that only preserves your follicles thats a good business model. It’s insurance for your hair.

    2. Why would Tsuji be a question mark? Seems their issues now are more administrative and financial than technical. I think it’s just a matter of time for them.

      Few years I guess. I think Tsuji will probably be the first to have a working cure on the market.

      1. tk are you joking? In the past years before covid the guy raised hopes on his trials being accomplished several times by 2020/21. When the time finally came, no announcement at all on the current state of trials was made, we didn’t even know at that time of they occurred at all. First and last thing announced was one of their main companies driving the technology went bankrupt, that’s all. Tsuji and related firms failed totally. Even replicel has higher rank since they had trials and announced their (unsuccessful) results.

  3. Seems like the race is really on. For the first time ever I feel kinda hopeful. Let the last of the real ones battle it out. They all have promise (those four or five). Let’s goooo!

  4. Does anyone remember if the marketing of propecia was pre-announced in some medical magazine or other media? Or was it a sudden news?

  5. Admin which brand on vitamin d do you take? I’m trying to get a liquid vitamin d the regular vitamins arent raising my levels.

    1. NOW Foods- Liquid Vitamin D-3 Extra Strength – I’ve been taking 10 000 UI/day for 8 years more or less (Bechet disease) For me the best value hands down, I tried every major brand. Fun fact, this hormone (yes it is) will help “regulate” your mood ps: Anything below 8 000UI didn’t help much.

  6. And I wonder what the people that say hair cloning is years away or never coming are on these sites now, said about Finasteride back in the 80s or 90s when it wasn’t available until 1997 I wonder if they were always this negative?

    1. I feel like people who were experiencing hair loss in the early 2000’s/90’s were expecting hair cloning or a cure back then. However, the science and technology weren’t even close to what it is now and over the years they developed immense negativity because they were promised hair cloning and etc back then so they create doubt in future generations who are currently experiencing hair loss. So people talk about Intercytex for example, back in 2006 where they tried hair cloning and failed because of poor financial support and underdeveloped science and technology. The past 5 years alone have taught so much about hair loss that we never knew before. So of course they hold onto this negativity and pass it to future generations to not get your hopes up. However, there is so much to look forward to now, for example, OliX, Aneira, Cassiopea, Kintor, Stemson, Epibiotech, Tsuji(?), Yokohama, Han Bio etc. Hair loss suffers have so much to look forward to. Let’s just stay hopeful and patient that a cure will be viable in the near future. Sorry for the long response lol.

      1. If you are 20 and losing your hair, consider yourself more than lucky if a cure comes out in 10 years. If a cure would have come up when I was 30 by now I would have already lived almost 20 years of my life with a full head of hair, unfortunately it did not happen …

  7. Anyone know the reason why vitamin d levels can be extremely challenging to raise when one is on fin (for some people)? When I was on fin best I could do after heavy supplementation was to get my levels to the low normal range. Now that I’ve been off fin for years I take a vitamin every now and then and my levels are in good range.

  8. I’ve been following different forums and followed different kinds of stuff trough the years. From about 16 years of age until now. 36. To be honest. All I’ve seen is just plain bs. Did minox and fina for a long time. But now i give up. This s ain’t gonna be fixed when I’m still young so this stuff… Correct me if I’m wrong. But for me it just seems like old news changed name. It’s ok now. I can be Kojak.

  9. Started following things here on HLC several years ago and occasionally over on FT. Both very informative sites. I don’t even bother with The Bald Transplant or YouTube anymore. I like YoYo’s comments but I remain cautiously sceptical, still hopeful in some ways, but not holding my breath either.

  10. They will never find a cure…All the big shampoo companies buy up all the patents…so they can make billions selling you things that don’t work.

      1. He has not, this is not how market works, otherwise there will never be new cars because they steal business to those who are already around. No new phone either.
        Same with literally every technology developed by the human race that has sometimes killed a business (but sometimes created another one!). Market is based on competition.

        Plus, an effective cure would attract much more customers than the lousy solutions we have today. May I remind you that the vast majority of bald people have probably never even seen a pill of finasteride and if they did they said no in fear of its side effects?
        C’mon, stop with this childish conspiracy theories!

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