Medeze Group: Hair Follicle Banking and Cultivation

Medeze Hair Renaissance

Hair Follicle Banking and Cryopreservation of Dermal Papilla and Dermal Sheath Cells

In 2019, UK-based HairClone launched the world’s first hair follicle banking service via cryopreservation. The idea is to store your existing young and healthy hair follicles for future use when hair multiplication technology comes to fruition.

In fact, HairClone itself was planning to offer cell expansion services via dermal papilla cell multiplication and implantation in the UK by 2022. But this potentially groundbreaking development has kept getting delayed. This is especially surprising, since the company’s CEO Dr. Paul Kemp previously led Intercytex (UK), which managed to successfully undertake this exact type of treatment in 2009. But they had to fold in 2010 due to lack of funding, despite successful Phase 1 clinical trials.

In 2020, Han Bio (South Korea) started offering a dermal papilla cell storage service. They were planning to cultivate, multiply and implant these cells into patient scalps. But it is not clear as to how far they have since progressed.

In 2021, Epibotech (South Korea) launched a hair follicle dermal papilla cell banking service. Like Han Bio, they also plan to mass-cultivate these cells and then inject them into patient scalps.

In 2023, Canada-based Acorn Biolabs started offering hair follicle banking services. They are combining this with a personalized autologous secretome hair growth product derived from your own stem cells.

In 2024, Shiseido (Japan) started offering its groundbreaking dermal sheath cup (DSC) cell multiplication and implantation procedure. This process took a decade to develop and went through all three phases of clinical trials. The first step in this treatment entails hair follicle extraction and storage, though I do not think they store your follicles for the long term.

And in 2025, a Thailand-based company named Medeze claimed to have started offering Asia’s first hair follicle banking and cultivation service.

Medeze Hair Renaissance: Follicle Banking and Cultivation

Medeze launched its hair follicle banking service in 2025 under the name Medeze Hair Renaissance. They state that this is Asia’s first hair follicle cryopreservation bank. The company plans to offer hair follicle analysis, isolation, cultivation and long-term preservation for up to 60 years. The company set itself a target of getting 500 clients in 2025 and up to 5,000 clients by 2030.

Medeze calls its hair regeneration technology “HairFolico”. They claim to be able to culture 50 million cells from 50 extracted hair follicles in just 30 days, and package them for future use. The entire process is carried out in a CLEANROOM CLASS 100 laboratory, which adheres to the highest standards for cleanliness and sterility.

Per a recent interview of Medeze Group CEO Dr. Veerapol Khemarangsan with Frost & Sullivan, the company is partnering with Shibuya Company of Japan and implementing the world’s first robotic culture system.

“Human scientists cannot work efficiently under these conditions, so our robots will manage the culturing process entirely.”

The company has built a new five-story biobank in the Philippines that is a vertically integrated facility with labs and cleanrooms. They have also expanded in Oman and Laos. Moreover, they have already conducted various clinical trials in Thailand for stem cell related applications. Including for degenerative disc disease, skin rejuvenation and anti-aging. They are also working on NK cell therapy for stage 4 colorectal cancer.

In July 2025, CEO Veerapol Khemarangsan participated in the 9th Scientific Meeting of the Asian Association of Hair Restoration Surgeons (AAHRS). The meeting was held in Bangkok (Thailand) and his presentation was titled:

“Development Methods for the Cultivation & Cryopreservation of Dermal Papilla & Dermal Sheath Cells Derived from Hair Follicles”

Thailand is among the world’s leading nations when it comes to medical tourism and cosmetic procedures. It is home to a number of highly respected hair transplant surgeons such as Dr. Damkerng Pathomvanich. In fact, around two decades ago, “Dr. Path” was already a big advocate of using oral Minoxidil to treat hair loss rather than topical Minoxidil. Something that only caught on in the US and Europe a few years ago.

As is typical for so many of the new Asian companies that I have covered on this blog, the potential hair multiplication claims seem exaggerated. However, I am always hopeful that one of these Asian companies will be able to proceed with their clinical trials much faster than what we are used to in the West. And it should be noted that 60 percent of the world’s population resides in Asia.

Veradermics VDPHL Tablet for Hair Loss

Veradermics Logo
Veradermics.

Veradermics (US) is working on a new extended-release oral Minoxidil tablet to treat androgenetic alopecia (AGA). The product is called VDPHL (as well as VDPHL01) and is currently in Phase 3 clinical trials. The top half of this post contains new updates in reverse chronological order. Also see my past posts on immediate-release low-dose oral Minoxidil and sublingual Minoxidil.

Update: February 4, 2026

Veradermics just completed a successful IPO that raised $256 million. It is now listed on the New York Stock Exchange under the ticker “MANE.”

Update: October 16, 2025

Veradermics Raises $150 million in Series C Financing

Yesterday, we heard that Pelage Pharmaceuticals (US) raised a massive $120 million in Series B Financing. In 2026, they plan to begin Phase 3 trials for their hair growth product PP405.

Today, we have news that Veradermics has raised an even larger $150 million in an oversubscribed Series C Financing. And this is after they raised $75 million in 2024 from Series B Financing. Such numbers are unheard of in the hair loss world. Veradermics is already conducting multiple Phase 3 trials for their hair growth product VDPHL.

For context, in 2021, the esteemed RIKEN and Dr. Takashi Tsuji of Japan were finding it difficult to raise $5 million and even asked me to help them with the goal. And in 2025, Yunce Biotech (China) is finding it tough to raise just $2 million to move forward with their hair cloning work. See the most recent comments from reader “Jan Miedza” in that Yunce post. And in late 2024, the much hyped Stemson Therapeutics (US) folded because it could not raise sufficient funds. Many other hair loss companies that I have discussed on this site in the past folded due to lack of funds to proceed with tedious clinical trials and approval processes.

In the earlier mentioned press release from Veradermics, they do not mention any other ingredient besides extended-release oral Minoxidil in this VDPHL01 tablet. The do provide some great before and after hair growth photos from their Phase 2 trials:

Veradermics VDPHL Hair Growth
Veradermics VDPHL extended-release oral Minoxidil. Before and after hair growth photos.

VDPHL Clinical Trial Updated Links

Enrollment links:

VDPHL01 Phase 2 Trial

  • 70 patients (male and female).
  • Start date = 2024-07-08.
  • Completion date =2026-08-28.

VDPHL01 Phase 2/3 Trial

  • 480 patients (males only).
  • Start date = 2024-11-06.
  • Completion date =2026-07.

VDPHL01 Phase 3 Trial

  • 552 patients (females only).
  • Start date = 2025-07-25.
  • Completion date =2027-03.

Update: September 29, 2025

Early Study Finds Extended-Release Minoxidil Grows More Hair

An optimistic summary of the results from the 20-person Phase 2 trial of VDPHL01, with the volunteers taking 8.5 mg VDPHL01 twice daily for 4 months. In the control groups, 33 patients received 5 mg immediate-release oral minoxidil once daily for 6 months; and 34 patients received 1 mL of 5% topical minoxidil solution twice daily for 6 months. Investigator Global Assessment (IGA) was the primary outcome that was measured, and the IGA ratings were made by blinded investigators.

The summary contains an interesting quote from Dr. Jerry Shapiro (who it is mentioned has a financial relationship with Veradermics):

“A longer time to sulfate is what we want, so if we keep the drug in the blood longer, there is greater sulfation and more activity.

Make sure to read my past post on Minoxidil sulfotransferase boosters and why Minoxidil requires sulfation in order to grow your hair.

Also of note, VDPHL:

“Offers an opportunity to maintain drug levels above those needed for therapeutic effect, but below those associated with cardiac adverse events.”

Update: September 21, 2025

Veradermics Extended Release Minoxidil for Hair Loss: Superior to Topical and Oral Minoxidil

Veradermics presented its smaller 20-person Phase 2 trial results at this month’s EADV Congress in Paris. A post about this on Instagram is causing some excitement. It has two slides in there, and I will paste the main points below:

  • The doctor Congress attendee who made the Instagram post states that “Extended release oral minoxidil has superior increase in hair density compared to topical minoxidil and oral minoxidil. Phase 3 trials are underway.” So this confirms that VDPHL is extended release oral Minoxidil, even though Veradermics’ pipeline page still does not declare the key ingredient.
  • 82% of VDPHL01 patients achieved moderate to great improvement versus just 20% of topical Minoxidil or low-dose oral Minoxidil users.
  • There is superior efficacy (3.5 times higher IGA scores) in a shorter time frame (4 months versus 6 months) compared to “competitors”).
Veradermics VDPHL Tablet for Hair Loss
Veradermics VDPHL tablet for hair loss. Pipeline screenshot from company website.

Update: January 2, 2025

Veradermics Phase 2/3 Clinical Trial Enrollment Link

Veradermics Phase 2/3 US clinical trial enrollment link is live. Their 40 plus locations are pretty widely spread across the country. Please note that we are not certain of the active ingredient(s) in this tablet. From the company’s patent, I previously guessed that it is an extended release oral Minoxidil, plus hopefully some other surprises (see bottom of this post). But it could end up being something totally different too.

The study involves 13 visits to a clinic over the course of 12 months. Participants will either get the new treatment or be part of the placebo group (that will still also get a tablet).

Update: December 11, 2024

Veradermics Raises $75 Million for Phase 2/3 Trials

Veradermics just raised $75 million in Series B financing (h/t “meko”). They have also initiated a Phase 2/3 trial for their lead candidate VDPHL01 for the treatment of androgenetic alopecia (AGA). The trial will enroll 480 patients across 44 sites in the US. Note that Veradermics also has an ongoing 20-patient Phase 2 trial for VDPHL. The company plans to report topline data from that Phase 2 study in the first half of 2025.

August 9, 2024

Veradermics VDPHL Tablet: Phase 2 Trials Begin

Veradermics is a US-based startup that is working on a new tablet to treat androgenetic alopecia (AGA). They just started Phase 2 clinical trials for VDPHL01 in male subjects with AGA. Only 20 patients are enrolled, and the completion date is listed as August 1, 2025. The trial will take place at Therapeutic Research’s center in San Diego, California. Note that VDPHL likely stands for Veradermics Pattern Hair Loss.

The tablet does not impact hormone levels as do dihydrotestosterone (DHT) inhibitors finasteride and dutasteride. Thus avoiding potential side effects. Veradermics’ CEO is a young dermatologist named Reid Waldman.

Modified Release or Extended Release Oral Minoxidil

The mechanism of action (MOA) and key ingredient(s) in this tablet are both confidential. However, when I searched through the company’s patent, it seems like the drug candidate will be a “modified release” oral minoxidil tablet. In the patent, they use the term “extended release (ER)”. Note that they do not use the term “sublingual minoxidil” anywhere in the patent.

Other Potential Ingredients in VDPHL

In the patent, they also have a massive list of 191 claims. Within that section, all of the following drugs are listed 11 times each:

  • Setipiprant (11 times).
  • Valproic acid (11 times).
  • Cetirizine (11 times).
  • Medrogestone (11 times).

For long time readers of this blog, setipiprant (and Kythera) will ring a bell. It caused so much excitement a decade ago. I cannot believe that the very optimistic 9-yr old audio interview with Kythera’s CEO is still online. Setipiprant is an oral antagonist to the prostaglandin D2 (PGD2) receptor.

I covered valproic acid and hair growth in detail in the past. Follica also has a patent that covers valproic acid and hair regrowth. Valproic acid activates the Wnt/β-catenin signaling pathway.

Cetirizine is a PGD2 inhibitor that has been shown to benefit hair growth even when used topically.

I have never covered medrogestone on this site before. Per Wikipedia, it is a progestin that is an agonist of the progesterone receptor and a weak anti-androgen. Progesterone is a female sex hormone that has beneficial properties towards hair growth.