Tooth Loss Cure 2030

Almost a decade ago, I first covered research from RIKEN (Japan) in relation to hair regeneration and tooth regeneration. Both of these projects were being led by the same person: the renowned Dr. Takashi Tsuji. I have since written about Dr. Tsuji’s hair related work in numerous blog posts.

In 2023, I briefly mentioned another Japanese Dr. Katsu Takahashi and his tooth regeneration company Toregem Biopharma. In this post, I will discuss new updates from both Dr. Takahashi and Dr. Tsuji in regards to tooth regrowth.

Tooth Regrowth and Regeneration.
Tooth Regrowth and Regeneration by 2030.

World’s First Tooth Regrowth Medicine in 2030

Earlier this month, it was announced that the world’s first tooth regrowth medicine will be tested in humans in Japan in September 2024. The clinical trials will begin in September at Kyoto University Hospital, and will last for a year. The research is led by Dr. Katsu Takahashi, head of the dentistry and oral surgery at Kitano Hospital. Most importantly:

“The researchers hope to commence sale of the medicine in 2030.”

The initial safety focused clinical trial will involve 30 males between the ages of 30 and 64 who are missing at least one tooth. However, do note that this particular teeth regrowth technology is meant for children who lack a full set of adult teeth due to congenital factors. i.e., a condition known as anodontia. In the next stage of the trials, the medication will only be administered to those between the ages of 2 to 7 who have at least four teeth missing from birth.

Anodontia is a congenital condition that causes the growth of fewer than a full set of teeth. It afflicts just 1% of the population Interestingly, 1% of the population also exhibits the converse of anodontia: hyperdontia. The latter is a congenital condition that causes a higher than normal number of teeth.

Dr. Takahashi and his team’s drug based teeth growth treatment entails blocking the function of the uterine sensitization associated gene-1 (USAG-1) encoded protein. This protein limits the growth of teeth in some individuals. They published a paper in 2020 that was titled: “Development of tooth regenerative medicine strategies by controlling the number of teeth using targeted molecular therapy.” More information from Kyoto University here.

They also published findings in mice in 2008 that connected USAG-1 and its bone morphogenetic protein (BMP) antagonist action, Wnt signaling modulation, and the subsequent creation of supernumerary teeth.

With this same technology, it is hoped that humans will be able to regrow teeth for a third time in their lifetime (as opposed to just twice, the current norm). Many animals such as sharks and certain reptiles continuously regrow teeth over their lifetimes. Dr. Takahashi believes that the ability to grow a third set of teeth was lost over time in humans, but we still have the “buds” for a third set. His team has already successfully managed to grow additional teeth in ferrets. Key quote:

“We are hoping to see a time when tooth-regrowth medicine is a third choice alongside dentures and implants.”

OrganTech: Next Generation Tooth Implants

In 2023, Dr. Tsuji and his team’s research and development activities were officially subsumed into a new company called OrganTech. This came after a past failed attempt via Organ Technologies (established in 2008) due to fundraising issues. OrganTech’s main focus is hair and teeth regeneration. In the Summer of 2024, OrganTech plans to begin clinical trials in relation to its next generation teeth implants.

According to the company:

“We were the first in the world to succeed in the functional regeneration of teeth with complete regeneration of biological functions (regenerating periodontal fiber, enabling orthodontic treatment, and restoring perception), by harvesting epithelial and mesenchymal stem cells from the tooth primordium of a mouse’s teeth which is in the fetal stage, creating a regenerated tooth germ using the organ germ method (Nature Methods, 2007), and transplanting them into areas where the teeth have been lost (PNAS, 2009).”

On OrganTech’s website, they mention that the company’s new next-generation tooth implants will recover the periodontium surrounding the implant. This will make it possible to recover all the physiological functions of native teeth.

Carbonic Acid Shampoos for Hair Fortification

In recent years, I have read a lot about carbonic acid shampoos for scalp health. These products supposedly help:

  • Unclog pores.
  • Reduce sebum levels.
  • Improve scalp blood flow and oxygenation.
  • Balance scalp pH levels.
  • Add moisture and volume to your hair.

You are probably not going to regrow hair in totally bald areas from these carbonic acid shampoos. However, anything that can reduce scalp oiliness and itching can only be beneficial to the overall hair growth environment.

Testosterone and its derivative dihydrotestosterone (DHT) besides causing hair loss: also raise sebum levels; increase acne outbreaks; and cause scalp inflammation and itching.

Carbonic Acid Shampoos

There are few popular carbonic acid shampoos on the market today that have many reviews. Among the main ones are Simfort, Fortero and Vanidox. This is in sharp contrast to the wide range of dandruff shampoos and hair growth shampoos made by renowned brands.

Simfort Shampoo

Simfort Carbonic Acid Shampoo
Simfort Carbonic Acid Shampoo.

In Japan, an extremely popular deep scalp cleansing shampoo is called Simfort Sparkling. They have sold over 150,000 of these since product release. The 6-pack costs $230 while a single bottle costs $65. It currently has 2,300 reviews on Amazon with an average rating of 3.7/5 stars.

According to the product description, the “expansion power” of this shampoo is a dense 8,000 ppm concentration level of carbonic acid. A single bottle of this hair fortifying product contains 150ml of foam. It can be used by both men and women.

Simfort is made in Japan and distributed by Seiseidou America. Do not confuse the latter with Shiseido and its Adenovital shampoo. Note that this product is based on a sulfate, paraben and cruelty-free formula.

The full list of ingredients in Simfort is very lengthy. Besides carbonic acid, it also contains keratin, numerous natural extracts, protein, rosemary oil and more:

Simfort Ingredients
Simfort Ingredients.

According to the company website, carbonic acid help unclog hair pores, minimize excess sebum levels, increase blood circulation and repair hair follicles.

The Simfort shampoo (with almost 2,300 reviews on Amazon) does all of the above by:

“Absorbing deteriorating proteins that sebum plugs are made up of. The reaction between the carbonic acid and the plugs won’t get in the way of our shampoo doing the other half of its job: gently cleaning your scalp and outer layer of hair.”

Fortero and Vanidox

Other somewhat well known brands of shampoo that contain carbonic acid (carbon dioxide dissolved in water) include Fortero and Vanidox.

Vanidox is fortified with biotin, collagen, argan oil, peppermint oil and tea tree oil. It currently has 3,170 reviews on Amazon with an average rating of 4.2/5 stars. Vanidox carbonic acid shampoo is made in the US and is paraben free, sulfate free and never tested on animals.

Fortero contains seven rare ingredients in rice bran protein, algae extract, charcoal powder, citrus lemon fruit extract, paeonia suffruticosa root extract, scutellaria baicalensis root extract and swertia japonica extract. It also has rosemary oil, green tea and lavender oil.

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