Nanofat and Adipose Tissue Hair Growth

I have written numerous posts in relation to fat cells (adipose tissue) and hair growth. There is clear evidence that adipose-derived stem cells (ADSC) on the scalp impact hair growth. The latest trend at hair clinics entails combination nanofat and platelet-rich plasma (PRP) hair growth treatments.

Nanofat Injections for Hair Growth

Nanofat Injection Hair Growth
Nanofat for Hair Growth.

During several of last year’s hair loss conferences, a number of presentations entailed nanofat injections into the scalp. Most of these fat and adipose-derived stem cell related topics are classified under “stem cell” treatments for hair loss. Note that adipose-derived stem cells (ADSCs) are mesenchymal stem cells (MSCs)

Nanofat injections have been used for many years when it comes to regenerative medicine applications. Usage in hair loss sufferers is more recent. A 2020 study from China found human-derived concentrated nanofat promoted hair growth in mice. The mechanism of action entails activation of dermal papilla cells via the Wnt/β-catenin pathway. Also of interest, a clinical trial from China that tested nanofat grafting for treating androgenetic alopecia ended last year. I am guessing that the results will be published this year.

Perhaps the first study to find benefits from nanofat in male pattern hair loss sufferers came from Italy in 2017. These gains in hair growth lasted even 12 months after initial treatment. The fat was obtained via liposuction using the Tulip Nano device. Also from Italy, Dr. Piero Tesauro is a leading practitioner of nanofat transplantation.

In the US, doctors are increasingly offering combination treatments that include PRP and nanofat. According to Dr. Cheryl Karcher:

“When nanofat is used for hair restoration, she injects it first. She then injects the patient’s PRP on top of it to act as a fertilizer for the nanofat.”

However, in the same article, Dr. Robert Singer warns that there is as yet no safety or efficacy data surrounding nano-fat treatment for hair growth. It should be noted that the somewhat related SVF/Kerastem treatment has shown promising results.

Dermal Adipose Tissue Promotes Hair Growth and Pigmentation

Also of interest, a January 2021 study found that dermal adipose tissue secretes hepatocyte growth factor (HGF). This in turn promotes both human hair growth and hair pigmentation. Among the co-authors of this paper include Dr. Ralf Paus (see Monasterium) and Dr. Maksim Plikus (see Plikus Lab).

What was especially interesting to me in this new 2021 paper was a link to a 2019 paper. Apparently, autologous fat grafting to the face can in rare instances lead to unwanted hair growth (hirsutism). Further evidence of the connection between adipose cells and hair cells.

Fat Grafting Hair Growth
Hirsutism from facial autologous fat grafting. Source: Karger.

Hair Loss Lawsuits Galore

Every now and again, I read about class action lawsuits against major hair loss product manufacturers. It seems like 2021 will be a record year for such legal actions.

Merck, Propecia and Lawsuits

The most famous of these entails various class action lawsuits against Merck (US) (the manufacturer of Propecia). The initial accusations against Merck pertained to Propecia causing persistent long-term sexual side effects in men. Despite the company settling the lawsuit with most litigants in 2018, further class actions continue to stack up to this day.

The latest allegations state that Propecia causes depression and suicide in males. This story was covered by many major news sources in February, 2021. However, these issues were already in the news for several years. I have not tried to find out if suicide rates in men taking Propecia are higher than in those not taking the drug. I also wonder if some of these suicides occur due to the fact that Propecia is not stopping hair loss in some desolate men? Or causing serious sexual side effects in some, in turn leading to depression? I would also guess that depression in balding men and women is higher than in those without any hair loss.

“Annual US prescriptions of finasteride for hair loss increased to over 2.4 million in 2020, more than double the number in 2015”. Source: IQVIA.

At the same time, these drugs do alter hormones. In particular, Dihydrotestosterone (DHT) is drastically reduced in men taking Propecia or generic finasteride. Moreover, finasteride affects both estrogen and testosterone levels. Albeit by a small amount in most users. Hopefully topical finasteride may lead to fewer side effects.

Out of respect to families affected by these tragedies, I will delete any comments in this post that seem insulting or demeaning. Voicing some support or skepticism about this issue is fine.

I wonder if such lawsuits against Merck were what prevented GSK (UK) from obtaining US FDA approval to sell Avodart (dutasteride) as a hair loss drug? Almost everyone agrees that dutasteride causes more side effects than finasteride. As of 2021, dutasteride is only approved in Japan and South Korea to treat male pattern hair loss (androgenetic alopecia). In the rest of the developed world, it is approved to treated enlarged prostates in older men.

Gorilla Glue Lady

My favorite story from 2021 is probably the Gorilla Glue lady Tessica Brown. It is also the biggest story in the hair loss world so far this year. Luckily, it had a happy ending. Many sources reported that Ms. Brown would be suing Gorilla Glue, but this is not true as of the time of writing this post. She received a lot of backlash on social media when people thought that she was going to take legal action against Gorilla Glue.

Unilever and Tresemmé

TRESemmé (owned by UK-based Unilever) is a very famous brand of shampoos. I have used it many times in the past, and always liked the product. However, in January 2021, a class-action lawsuit was filed against Tresemmé. Apparently, some Keratin lines of this shampoo contain formaldehyde-releasing preservative DMDM hydantoin. It is alleged that this ingredient caused hair loss, scalp irritation and burning in many women using the shampoo. Unilever faced similar allegations against its Suave range of products in 2012, forcing it to recall the offending items.

Sanofi-Aventis and Selsun Blue

In 2021, Sanofi-Aventis (France) is facing legal action from several parties in relation to its Selsun Blue dandruff shampoo. The plaintiff alleges that the product contains chemicals that cause scalp irritation and hair loss. In 2020, Sanofi-Aventis faced another lawsuit claiming that the company’s Selsun Blue line of natural dandruff shampoo is, in fact, not natural.

While I have reservations about most such lawsuits, I do find it undesirable that most hair loss shampoos contain so many harmful ingredients. Even something as popular and effective as Nizoral shampoo contains ingredients that often dry out the scalp. A recent NY Times article on declining sperm counts blames endocrine disruptors (including ingredients in plastic bottles and shampoos) as contributing factors. Hormone disrupting phthalates should be avoided in hair and beauty products. Parabens and sulfates are also undesirable.

DevaCurl Lawsuit

In 2020, curly hair line DevaCurl was in the news almost every month due to a class-action lawsuit that was heavily promoted on social media. Perhaps the biggest reason was this video from Ayesha Malik:

Monat Lawsuit Resolution

Also in 2020, Monat finally seemed to have resolved continued lawsuits that first commenced in 2015. Consumers have complained that Monat products cause hair loss, itching, sores and skin lesions. Monat is a multilevel-marketing company, renowned for its natural hair and skincare products. The company is now banned from making false or misleading claims about the health benefits, safety or performance of its hair and beauty products.

Hair loss news blog. Hair cloning for baldness.