2022 AAD Annual Meeting

— Yet another interesting conference will take place in Monaco from March 31-April 2 (h/t “Ben” yet again). It is the 20th edition of the Aesthetic & Anti-Aging Medicine World Congress.

Among the highlights (see full abstract here) will include:

  • An update from HairClone’s Dr. Paul Kemp.
  • Several presentations on exosomes for hair growth.
  • Several new reports of PRP reducing hair loss.
  • An interesting report form Dr. Pietro Gentile where he analyzes the benefits of hair follicle mesenchymal stem cell (HF-MSC) injections.
  • An update on ARTAS robotic hair transplants.

AAD 2022: Key Hair Loss Related Updates

Update from AAD2022.

— Baricitinib JAK inhibitor leads to significant hair regrowth in Alopecia Areata patients. Dr. Brett King video. Amazing before and after photos, but we have seen similar results from other JAK inhibitors in the past.

Baricitinib Hair Growth
Baricitinib Hair Growth in Alopecia Areata Patients. Before and After. Source: Dr. Brett King et al in the New England Journal of Medicine.

— At AAD2022, Alma launched an ultrasound based laser system called Alma TED™. It benefits hair growth via improving blood flow. Also see my recent post on sound therapy for hair growth. Some before and after photos here.

Update from the 2022 Oscars, where a hair loss issue leads to violence.


Introduction

American Academy of Dermatology (AAD) Logo

The 2022 American Academy of Dermatology (AAD) Annual Meeting will run from March 25, 2022-March 29, 2022 in Boston, Massachusetts. After being cancelled in 2020, this time it is an in-person event.

The AAD was founded in 1938 and currently counts most practicing dermatologists in the United States as members. In the past, I wrote about the 2016 AAD annual meeting and the 2018 AAD annual meeting. I also covered the lesser known Society for Investigative Dermatology (SID) conferences several times.

Make sure to follow on Twitter the AADmember account and the AADskin account for more information. #AAD2022.

2022 AAD Meeting Hair Loss Sessions

Unlike conferences focused solely on hair loss (e.g., WCHR, ISHRS, EHRS and AHRS), the AAD meetings include a wide range of dermatological conditions. Skin issues are of foremost importance.

Nevertheless, hair related sessions and posters (18 pages) are still numerous. The AAD hair loss sessions tend to focus more on existing treatments and recent developments and improvements in technology. You do not see much on long-term future developments.

Among the interesting presentations this time around include:

Disclosures and Corporate Affiliations

What I always find interesting in these conferences is the company affiliation disclosures. In some cases, hair loss product vendors provide fees to the presenters. In other cases, research funding and grants. And in other case, I assume just advisory support. Some of the “type of relationship” acronyms in the disclosure statements are not defined.

  • It is great to see Cassiopea so active. I still have hopes that Breezula will be at least as good as Minoxidil, while targeting an entirely different pathway.
  • Other hair loss companies that I have covered that are also mentioned as sponsors/funders/affiliates include AbbVie; Allergan; Almirall; Applied Biology; Follica and L’Oréal.
  • I find it interesting that low-level laser device manufacturers such as Capillus, HairMax LaserComb and Theradome are associated with so many of the researchers.
  • A number of smaller companies that I have discussed on this blog seem to be involved with a number of researchers. The most surprising of these is DS Laboratories.
  • The disclosure list of some of the scientists presenting is unbelievably lengthy. It is worth checking out Dr. Neil Saddick and Dr. Adelaide Hebert. Surprisingly, Dr. Ken Washenik only shows two companies (Cassiopea and Follica) in his disclosure list.

48 thoughts on “2022 AAD Annual Meeting”

  1. Nice to see that they are there are topical Finasteride and Low-Dose Oral Minoxidil presentations. In more recent years this saved my ass as prior treatments were waning. Funny after 20+ years on oral anti-androgens (fin/dut) and topical minox that now I’m on oral minox and topical dut (with minox) which has been very effective. We must get bridge treatments, even if it’s variations of what’s been around for years, while we wait (and wait, and wait) for the next big thing.

  2. If you want to travel back in time just go to these dermatology events lol. Same topics and treatments since 2002. Man you would think that even just one new treatment would have came out since 1996 that was fda approved to grow some hair lol. Big 3 till 3033 (not a typo) lol

  3. A cure for hair loss is like a cure for eternal youth, we’re a still 200 years away from it. You are bald and you will stay bald, let’s just keep on swallowing finasteride, at least we will shine a little less ” they really got us by the balls”.

    1. Maybe Breezula will come out by 2023 and give at least mild benefits? The company is still sponsoring hair researchers, and Winlevi is already out.

      The AAD conferences tend to not focus on new companies and research involving hair multiplication or cloning.

      1. Sorry admin but it has been proven over and over again that CB0301 is a piece of crxp that’s only effective for the first 6 months (with a loss of all gains from that point on), I’m shocked that you’re still hyped on this shxt. I advise you not to count on it, it’s been 20 years since they identified the molecule and its supposed “effectiveness” on baldness, if they take so much time to develop it it’s just because they know themselves that it’s ineffective, it’s going to end up like SM04554.

  4. The day will come when we can resurrect our dear departed ones, I will make sure that on my tombstone it is written … Resuscitate me only if you have found a definitive cure for baldness.

  5. You know, I see all these people with insanely thick hair. It’s too bad they couldn’t find a way to allow a transfer from one person to another in a FUE procedure. Heck, thick haired people could donate (for cash, of course), they could bank it, and then you go in for an FUE and they don’t have to take from your sides. Almost am infinite amount to use. Hair for all.

    I know, we have a better chance of defeating the Borg using a single photon torpedo from the USS enterprise.

      1. I’ll check out those past posts. Thanks.

        Seriously. I don’t think they’d have a problem getting people to give up some of their hair. Still would require an FUE for the recipient but I know I’d jump at the chance.

    1. That would not work because transplanting follicles from other people, with different DNA, would make the body reject them.

      1. Right now, you’re correct. But in the future it may be possible. People get heart transplants and kidney transplants. Of course there is a risk and the recipients take tons of medication to ensure their body doesn’t reject it but I can see this, one day in the distant future, being a reality for hair.

      2. It works under either of two conditions:

        — Via the recipient taking anti-rejection drugs.

        — Via the modified Dr. Kwon method I discuss in that post on allogeneic transplants. Only in mice for now.

        http://www.koreabiomed.com/news/articleView.html?idxno=4920

        Foreign hair is also not rejected as much as foreign organs such as kidneys and livers:

        “According to the team, hair follicles are independent organs present in the skin and have an “immune privilege” that is relatively free from immune rejection. As the brain and cornea also have this privilege, the team could reproduce the same state of hair follicles that existed in people’s bodies by removing the donor dendritic cells involved in direct antigen presentation.”

  6. I was just thinking how Athletes use local injections of human growth hormone to stimulate growth and recovery of damaged Soft tissue. Is there any research of injected growth hormone on the effect on the follicle environment? This would make intuitive sense. Probably wouldn’t stimulate new follicles but my hypothesis might be that it would help the dying derma papilla cells recover. And many of those cells exist in a dying stage before they are completely lost.

    1. CRISPR for hair, either for hair loss or hair texture/color won’t come before 2030 unfortunately. It will take about 10-15 years to make CRISPR safe, cheap and regulated for off-label use for enhancements.

  7. Haha! Love that you put the Oscar buzz on there.

    My take: Will is unhinged. Was the joke funny? No. Was it kind of rude? Yeah. But there have been way worse jokes in the past and if this is how Will reacts to a joke about his wife he has control issues. It’s the Oscars. It was a joke. If you can’t take it, you’re in the wrong industry. There were presenters in the past that would roast people like crazy. This was nothing in comparison.

    Also, it’s 2022. His wife didn’t need “saving.” Tarzan syndrome (must save Jane) and male ego kicked in there. I doubt Jada even cared about the joke and Will probably got in trouble after (from Jada) for doing what he did.

    1. I don’t agree. As a woman with hairloss, this impacts my life maybe way more than it would have if i had been a man. How do you think male look at us female with hairloss ? It is horrible to handle. If someone made a joke about my hairloss, i would be horrified. I would want to hide forever and never go out. Hair is definitely much more than boobs or breast. You almost never see women with alopecia in the media, Jada is strong for assuming it and i admire her.

      This joke was not okay.

      1. I never said the joke was okay (it was definitely insensitive), only that physical violence wasn’t the answer. She looks great without hair – far better than I do (I actually like that look for her).

        Still, we’re adults. If Will going to resort to violence each time a comment is said about his wife, I hope he’s prepared for jail (he’s lucky Rock declined to press charges). Also, if this is the avenue he wants to travel, he’s eventually going to come across someone who won’t be so easy to slap (Chris rock is hardly a tough guy but there are plenty out there tougher than Will). Tasteless joke but we can’t go around assaulting people when they say things we don’t like.

        Probably Will just had a moment. We all have them so I’m not saying he’s a terrible person only that he was wrong in his reaction to the joke (and of course Rock was wrong too for being insensitive).

    1. Yes, I added another Baricitinib link in the post update. Seems like this is an even bigger deal in comparison to past hyped JAK inhibitors (for AA).

    1. Thanks Ben. Added to this post. Doubt anyone will appreciate a new post on yet another conference!

      Looks like exosome treatments are still happening, but the US FDA has delayed things here. PRP is also not going away anytime soon.

      1. I keep seeing how great PRP is but it seems most of it is from those administering it (benefiting from the sale). Very few people that got it say anything positive, from what I can tell online (I don’t know anyone personally that did it).

        I appreciate the posts/updates, admin. Nothing moves fast enough but it’s good to see updates on some of this stuff.

        1. Agreed. But there must be at least 100 studies by now that show its benefits (albeit modest in most cases).

    2. I never fully understood hairclone. Maybe anyone can explain it to me again? When i read the article posted above, it looks like they extract hair follicle and inject the cells back into the scalp to thicken hairs? So i lose donor hair without gaining hair? And i have to repead this procedere sometimes?

  8. https://www.justjared.com/2022/03/25/donald-glover-debuts-shaved-head-on-red-carpet-for-atlanta-season-3-premiere/
    Well Donald glover couldn’t have gone bald that fast so I guess that was a good hair system back in 2018-2020 when he was blowing up.
    (I imagine he wanted to push through the high point of his career opportunities while he could. He’ll obviously still wear a piece for most roles like Sam Jackson but he has presumably “come out”. I think pieces will become more common now that they’ve become so high quality)

    1. I think some people can pull it off (the bald head/look). Looks good on him. Other people (like me), have a lumpy head and just can’t pull it off. It doesn’t look good and never will on me.

      I agree, the quality has improved but I mean, you have to go back to get it…something (refitted, reapplied?) every week or so, right? Kind of makes it hard to live and travel etc. Most don’t have the time for that – or the money. It’s not cheap on a reoccurring basis, from what I understand . I don’t think it’s something I would every do but never say never, I guess.

  9. I always wondered about why there is no news on Moogene (at least on their webpage), well I found there’s quite an active blog („Naver“ is a common software used for blogging in SK, just like „HanBio“ uses it too) run by them:

    https://m.blog.naver.com/PostList.naver?blogId=moogene2

    Summary: GMP facility opens in July and their hair loss treatment seems to become their first product with a market release in 2023. The treatment is called „HUTERA“ and I think they use Finasteride but with a completely different delivery (microbubble and lipid nanoparticles).
    •••
    As early as next year, a treatment for male pattern hair loss in the form of an application without side effects is expected. MoojinMedi CEO Yoon Tae-jong said, “Effect has already been confirmed, but it takes time to set up manufacturing facilities.” He explained, “We will minimize the side effects of existing drugs and maximize the therapeutic effect.”

    https://m.blog.naver.com/PostView.naver?blogId=moogene2&logNo=222637611961&navType=by
    •••

      1. Hey Admin,

        Tried topical finasteride, no benefit. Though, that’s what I expected. I think the lack of hype around topical finasteride exists for a reason.

  10. I once had thick, long, flowing hair that was the envy of girls in my high school. I was a football player and class favorite.

    That all began to change when I was 18, which was in 1985. Yes, 1985. I turn 55 next month. My receding hairline began at age 18. The change was slow and gradual at first. At around age 20, I began extensive reading and research in solutions. Even way back then, there were numerous “promising solutions and cures” there were always about 5 years away.

    By the time I was 25, I had no recourse but to begin shaving my head, which looked far better than the alternative. I still had a lot of hair even then, but I knew it would only become worse, so I grudgingly accepted it and shaved it all off.

    I also fully avoided the entire minoxidil and finasteride solutions over the years, because I’m not someone who wants “possible fixes”, “partial solutions”, or a potion that “may make it less worse in some cases”. Plus, the potential side effects were not something I wanted to risk. I’d rather just be bald, and I have been for 30+ years.

    Losing my hair has been the worst part of my entire life, by far. In some ways, it’s almost impossible to believe that medicine has advanced so far, yet male pattern hair loss remains uncured. Year after year, the solution has always been “5 years away” for at least 35 years. It’s laughable.

    Despite my hair loss, I’m still a good-looking, handsome guy. I wear hats and sunglasses up a lot. It frames my face much better. When the hats and sunglasses come off, I look very different, and not in a favorable way. Hair makes a huge difference to how my face was/is framed.

    Despite the whole male-pattern-baldness thing, I was able to find and attract two beautiful wives who saw past the baldness. I’m divorced now, but it had nothing to do with my hairloss. I’ve also had two beautiful girlfriends, both of whom I almost married. We broke up for reasons that had nothing to do with hairloss. So, yeah, it’s still possible to have good, healthy, loving relationships with great women, but the playing field is much, much smaller. For some women, they would absolutely never date a bald guy. I totally get it. I definitely understand why most women aren’t into dating bald guys, and I am not angry or bitter toward women who feel that way at all. Having said that, I certainly wouldn’t mind dating a bald woman if I was otherwise attracted to her, and she was sweet, loving, and best-friend material. I would date a bald woman like that in a heartbeat. Hell, I’ve even strongly considered dating blind women, who wouldn’t care in the slightest if I have hair or not. Seriously.

    Today, at almost 55, I am somewhere between a Norwood 3A and Norwood 5 — sort of elements of everything in between 3A and 5. I keep it shaved off, as I have for the past 30+ years.

    I’m closely following the Stemson Therapeutics, dNovo, and Shiseido/Replicel research. Each looks somewhat promising, as hundreds of other have for decades now. Eventually they will solve this issue, but guys… I’m virtually 55 now. I sometimes think that science will produce some type of genetically-engineered cloning of a youthful new body, crafted to our own specifications, and then transfer the contents of one’s brain (consciousness and memories and thoughts) into the brain of our new body before they will cure baldness. Seriously.

    But then, imagine a world with all of these beautiful, gorgeous people. Imagine a woman is sitting on a park bench crying and saying, “But Susan is a little prettier than I am. Her eyes are slightly bluer than mine.” Likewise, the guy next to her responds with, “I know what you mean. My brother’s johnson is 0.4 mm longer than mine, but at least I have nice hair now, but even his hair is a little better.” It’s all relative, I suppose.

    Years ago, I saw a poor guy sitting in a wheelchair in a lobby. He was completely a mental vegetable. He was conscious, but didn’t seem to know he was in the world. His head was tilted sideways, and drool was coming out of his mouth. This poor guy had a perfect head of hair and a perfect beard. Of course, a cognitive condition like his is infinitely worse than baldness, and I would much rather be bald than suffer that poor guy’s fate, but the irony of the human condition is incredible.

    Friends, I don’t think we’ll see a cure for baldness any time soon. I hope I’m wrong, as I’ve hoped that for the past 35 years. The perpetual dangling carrot of “5 years away” is always there, and you follow it, but you never reach it.

    Sadly, I would pay $250,000 for a perfect head of hair tomorrow, but then my focus would immediately be on the second most important thing I want to improve about myself, as most would.

    Okay… rant over! LOL!

    1. Great post, thanks John.

      I agree that they will always say it’s just around the corner. Medical science moves excruciatingly slow. I will say, though, that we have had some major advances in tech over the last 30 years. We’re at least getting closer to the goal, even if we’re not actually close. Will I see it in my lifetime? I have no idea. But while it’s okay to have hope (and I do have a little), we have to live our life – not wait to live until a cure comes. What you posted shows that one can still find love and happiness without hair. A good reminder.

  11. Just wondering if anyone has tried therapy 16 (rizn) with any kind of success, it’s been around for about six months now and is supposedly better than minox according to the company of course. Thanks for the input.

  12. Michael – I’ve been on RIZN since late August. I’m still on it & just re-ordered. I have gotten a response from it (otherwise I wouldn’t still be on it). But it appears that it either reversed some of the miniaturization in some frontal hairs or it lengthened the growth cycle. The results are not dramatic. I also still take finasteride & minoxidil foam. The RIZN improved my results on a marginal basis. The spray bottles last a long time for me. In a few months, I will be trying Revivv along with everything else to see if that helps. I can’t endorse that yet – it will just be an experiment.

    1. The website says natural (which I’m always skeptical about) but gives little info that I could find about what’s actually in it. Do you take the complex’s and the spray or just the spray?

  13. James1 – I just use the spray – I personally wouldn’t put any of those capsules in my mouth. I believe the spray contains Resveratrol. Based on posts I’ve seen from others on another site, many (of the posters) were not happy with the results and quit. I have seen enough improvement to continue. I actually have more confidence in Revivv since a dermatologist swears by it, but I won’t start on that until June. And I’m not expecting miracles from that either, just marginal improvement.

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