Category Archives: PGD2

Brief Items of Interest, August 2016

Hair loss news first:

Update: Histogen gets funding from China and also targets the Chinese market.

Kyocera updated its article on the biggest news of this year in the hair loss world.  They plan to conduct clinical research in Japanese fiscal year 2019 (i.e., between April 1st 2018 – March 31st 2019) and put the technology into “practical use” in 2020.  Interesting quote:

“While various methods are under evaluation, Kyocera’s piezoelectric technology is of particular interest as a means of discharging small amounts of viscid cells in a precise manner during the cell processing process.”

PGD2 inhibitor Fevipiprant could be a miracle treatment for asthma.  I am still hopeful that Setipiprant will be better than expected when it comes to treating hair loss.  Worth listening to Kythera CEO’s interview here if you haven’t already.

— More evidence that enhancing the β-catenin signalling pathway in dermal papilla cells allows faster and denser hair growth.

— New findings from a Stanford University (US) and A*STAR (Singapore)’s Institute of Medical Biology collaboration:  Wnt signalling plays a critical role in hair follicle stem cell maintenance. Interesting quote:

“Compounds, particularly those which have already been established to be Wnt activators, can now be tested against cultured HFSCs to see if they do stimulate hair regrowth. The scientific community may also be able to culture HFSCs more efficiently by tweaking Wnt signalling to the optimal levels.”

New interview with Replicel CEO Lee Buckler.  Important part is around three minutes in.

— New article that covers Dr. Christiano’s company Rapunzel as well as other relevant subjects including Samumed, Vixen/Aclaris and Dr. Joseph Greco.

— Hairlosstalk is interviewing Dr. Gail Naughton of Histogen this week.  Unfortunately the questions are already finalized, but its still worth a gander through this thread.

— New study from China: “Hair follicle and sebaceous gland “de novo” regeneration with cultured epidermal stem cells and skin-derived precursors.”

Cellmid to enter US hair loss treatment market.

— Dr. Cole’s office sent me an update on PRP and ACell recently.  I think they sent out a mass e-mail on the subject since its contents were also pasted in here.

— Joe Tillman discusses his Dr. Cooley PRP treatment results.

Healeon Medical is starting a new clinical trial in Honduras that will “evaluate the safety and efficacy of the use of a biocellular mixture of emulsified adipose-derived tissue stromal vascular fraction (AD-tSVF) and high density platelet-rich plasma concentrate (HD- PRP) as compared with adipose-derived cell-enriched SVF (AD-cSVF) + AD-tSVF and HD- PRP concentrates in treatment of androgenetic alopecia (AGA) and Female Pattern Hair Loss (FPHL).”

— Dr. Jeffrey Epstein is conducting the “first ever FDA-approved study in the US on the use of fat-derived stems cell for the treatment of hair loss in men and women.”  If you are near Miami, perhaps worth a visit.

On a less serious train of thought:

Eat curry to prevent hair loss.

— He says that black guys do not always pull off the bald look.  I still think he pulls it off.

UK celebrity funnyman divorcee gets a hair transplant to prepare for online dating so as to not look like a thug.

When Homer Simpson got hair due to a miracle drug call dimoxinil.

Our lack of body and scalp hair may have allowed our species to thrive.

And now on to medical items of interest:

— Last year I discussed the inspirational Zion Harvey after he got a double hand transplant.  He had lost both his legs, both his hands and his kidney to a childhood infection.  One year after his double hand transplant surgery, here is the result:

Chinese scientists to pioneer first human CRISPR trial.

— “Bio is the new digital.”  Great article from Taiwan that is a must read after translation.  Boston is to biotech what Silicon Valley is to information technology.  In the hair loss world, it seems like New York and San Diego (see here) are far more important than Boston, but perhaps we will see some surprises from Boston soon?!

— Two stories on aging in the Economist in the past week.  Here and here.

Excellent article on human enhancement.

Dr. David Sinclair’s presentation on ageing and lifespan extension.

— At least androgens have some benefits such as telomere length extension.

Dr. George Church on the future of genetic engineering.

Gene therapy cure with a money-back guarantee.

— Using a patient’s own stem cells and a 3D printer, scientists have genetically engineered a “living hip” that will cease pain.

— Cornea cells successfully grown and implanted to cure blindness in animals.

Peter Thiel is a fan of parabiosis.

Update on Dr. Frankenstein.  Full body transplant scheduled for December 2017.

— Scientists just created nanorobots to travel the bloodstream and fight cancerous tumors.

Brief Items of Interest, May 2016

Hair loss news first:

There have been a huge amount of hair loss related news items of interest in the past month.  Several of them probably deserved their own blog posts.

— I did not realize that GSK was launching Dutasteride in Japan via the brand name Zagallo (to treat male pattern hair loss) and that this plan was delayed in late 2015.  I did, however, cover the favorable Japanese clinical trial results last year that are mentioned in that first link.  Now comes word that Catalent’s French plant has been cleared to restart production.  So there is a very high chance that Dutasteride will finally be approved to treat hair loss in 2016 (one year later than I was hoping), 14 years after being approved to treat enlarged prostates in men. (Edit: in fact the drug was already approved for hair loss treatment in Japan on September 28th 2015, and even approved in South Korea around 2010!  Hopefully the US and EU will finally follow suit in 2016.).  It would be the third ever drug to be approved to treat hair loss, almost 20 years after the second one (Finasteride/Propecia) was approved and almost 30 years after the first one (Minoxidil/Rogaine) was approved.  Make sure to read the Dutasteride testimonials post and related comments.  FYI — If you are worried about Finasteride (Propecia) side effects, do not even consider taking Dutasteride. The side effects from the latter are guaranteed to be worse for most people.

— Since quite a few of the reader comments to my past few posts have mentioned Kerastem, I am giving high importance to Christopher1’s thread on hairsite regarding his Kerastem treatment in Switzerland.  He had the treatment in early February of this year for $8,000.  Unlike his well covered failed experiment with topical JAK inhibitor tofactinib, this time he went to a professional clinic (more reliable in my opinion) to get the Kerastem treatment. Per his latest post from three days ago (which has surprisingly still not received any replies), he has good news to share and I quote:  “After having brought you some bad news about my Jak inhibitor trial, I finally have some good news for you. It’s not great, but it’s very good.  My hair has stopped falling out. It stopped about three weeks ago, which was a bit over 2 months after my Kerastem treatment.”  Note that this is only one data point and there has been no regrowth and we do not know how long this cessation in hair loss will last.  The rest of his post indicates that this is the first time in 15 years that his hair has stopped falling out.  I find Chrisopher1 to be a highly reliable and sincere person, or else I would not mention him to start off a blog post.

— Scientists at NYU Langone Medical Center in New York recently found the molecular pathways responsible for creating the color of skin and hair.  They found that a signaling pathway known as Edn/EdnrB interacts with other pathways (in particular, with the Wnt signaling pathway), which in turn causes the proliferation of melanocyte stem cells (McSCs) that are involved in the earliest stages of skin and hair pigmentation.  This suggests that targeting Edn/EdnrB signaling in McSCs can be a therapeutic approach to promote hair pigmentation retention.

— A new paper from China titled “Wnt/β-catenin signaling pathway activates melanocyte stem cells in vitro and in vivo.”  Research was done in mice.

— An update on research at Japan’s Yokohama University under the leadership of Dr. Junji Fukuda.  Translation required, and yes, it is in mice only for now.  Short interview with Dr. Fukuda in there that is partially lost in translation.  Thanks yet again to our wonderful Japanese blog reader and commentator “nosyu” who updates me regularly about developments in Japan that are not covered by the English media.  The Fukuda Lab lists hair regrowth as one of its key areas of research.

— Update on Thorn Medical’s further plans in the Bahamas.

Topical methyl vanillate (a plant derived natural ingredient) increases hair count and hair mass index by inducing Wnt10b mRNA expression in the scalp.  According to the study, methyl vanillate has recently been shown to activate the Wnt/β-catenin signaling pathway, which has become a key target in the treatment of androgenic alopecia by numerous researchers in recent years.

— I was not planning to cover this public relations type piece on Dr. James Harris, but I liked the ending: “And when Harris predicts the future of his profession, he sees stem cells and growth factors – not plucking and planting.

More good publicity for Samumed and its CEO Osman Kibar.

— I am always impressed by hair loss sufferers who go through impressive regimens and post regular updates.  The latest example is “westonci” on HLT who is supposedly going through the whole of SwissTemple’s prostaglandin protocol that I have mentioned on this blog several times before.

— Talking about PGD2, an interesting new study from South Korea just came out today and provides yet more evidence that prostaglandin D2 (PGD2) and its nonenzymatic metabolite, 15-deoxy-Δ-prostaglandin J2, inhibit hair growth.

— For those in the United Kingdom, Dr. Steven Edgar is now prescribing topical Finasteride in the UK (his e-mail address is in that thread).

— An interesting new hair product from a company named “Reason to Believe” will soon be produced in North Carolina, based on the Alpha Keratin 60ku patent.  Hard to tell how good this product will be and how long it will last (I doubt it is permanent).

Can protein shakes lead to hair loss?

— “Baldy Viking” has some videos on dermaroller and onion juice!  I just saw only part of one of those…seems interesting and not entirely crazy.  I have become more of a believer in natural treatments for hair loss having at least some minor benefit.

— An interesting story of an Irish woman’s battle with alopecia cicatricial related hair loss since age 21.

Yet one more distraction for Dr. George Cotsarelis.

— In celebrity news, Rosie O’Donnell discusses her hair loss; it seems like golfer Jordan Speith may have had a hair transplant; and Charles Barkley has asked basketball superstar Lebron James to stop painting on his hair.  Search this blog for my past mentions of Lebron James if you are interested in this kind of news.

And now on to medical items of interest:

CRISPR breakthrough is most clever yet, and increasingly relevant to humans.

Scientist turn skin cells into heart cells and brain cells just using drugs.

Regenerating brains of the dead.  A more interesting take from my favorite Daily Mail.

Japan OK’s gene editing of eggs.  As long-time blog readers know, the Japanese have already fast tracked clinical trials for newer regenerative medicine and stem cell treatments, and earlier in this post I mentioned that Japan could be the first country to approve Dutasteride for hair loss treatment.  Everything is moving along fast over there and I am glad that we have both Shiseido and Dr. Takashi Tsuji based in that country.

— As expected, the first ever penis transplant in the US got widespread global news coverage yesterday.  I first heard about it via the radio in my car yesterday, then via a text message from a friend (wonder why?), and then again today via my yahoo homepage. Bill Gates must be horrified at global priorities.

— Now just imagine if this really happens in 2017?  I doubt it, but it would be absolutely ridiculous if that came to fruition before a hair loss cure.

— Alzheimer’s cure getting closer:

— Five-year update on face transplant recipient.

— MIT scientists and others create an artificial second skin:

— Histogen is also involved in skin care products via its growth factor technology in case people forgot.  Here is an update.

Doubling lifespan of embryos in petri dishes.

Maybe vitamin supplements are useful after all?

Biohacking in Brooklyn.

— I am a bit skeptical about Liz Parrish and Bioviva, but since I have mentioned her a few times before, here is an update and some reddit comments on the subject.

Rapamycin and more to make your dogs live forever.