Category Archives: PGD2

Brief Items of Interest, August 2016

Hair loss news first:

Update: Histogen gets funding from China and also targets the Chinese market.

Kyocera updated its article on the biggest news of this year in the hair loss world.  They plan to conduct clinical research in Japanese fiscal year 2019 (i.e., between April 1st 2018 -- March 31st 2019) and put the technology into “practical use” in 2020.  Interesting quote:

“While various methods are under evaluation, Kyocera’s piezoelectric technology is of particular interest as a means of discharging small amounts of viscid cells in a precise manner during the cell processing process.”

PGD2 inhibitor Fevipiprant could be a miracle treatment for asthma.  I am still hopeful that Setipiprant will be better than expected when it comes to treating hair loss.  Worth listening to Kythera CEO’s interview here if you haven’t already.

— More evidence that enhancing the β-catenin signalling pathway in dermal papilla cells allows faster and denser hair growth.

— New findings from a Stanford University (US) and A*STAR (Singapore)’s Institute of Medical Biology collaboration:  Wnt signalling plays a critical role in hair follicle stem cell maintenance. Interesting quote:

“Compounds, particularly those which have already been established to be Wnt activators, can now be tested against cultured HFSCs to see if they do stimulate hair regrowth. The scientific community may also be able to culture HFSCs more efficiently by tweaking Wnt signalling to the optimal levels.”

New interview with Replicel CEO Lee Buckler.  Important part is around three minutes in.

— New article that covers Dr. Christiano’s company Rapunzel as well as other relevant subjects including Samumed, Vixen/Aclaris and Dr. Joseph Greco.

— Hairlosstalk is interviewing Dr. Gail Naughton of Histogen this week.  Unfortunately the questions are already finalized, but its still worth a gander through this thread.

— New study from China: “Hair follicle and sebaceous gland “de novo” regeneration with cultured epidermal stem cells and skin-derived precursors.”

Cellmid to enter US hair loss treatment market.

— Dr. Cole’s office sent me an update on PRP and ACell recently.  I think they sent out a mass e-mail on the subject since its contents were also pasted in here.

— Joe Tillman discusses his Dr. Cooley PRP treatment results.

Healeon Medical is starting a new clinical trial in Honduras that will “evaluate the safety and efficacy of the use of a biocellular mixture of emulsified adipose-derived tissue stromal vascular fraction (AD-tSVF) and high density platelet-rich plasma concentrate (HD- PRP) as compared with adipose-derived cell-enriched SVF (AD-cSVF) + AD-tSVF and HD- PRP concentrates in treatment of androgenetic alopecia (AGA) and Female Pattern Hair Loss (FPHL).”

— Dr. Jeffrey Epstein is conducting the “first ever FDA-approved study in the US on the use of fat-derived stems cell for the treatment of hair loss in men and women.”  If you are near Miami, perhaps worth a visit.

On a less serious train of thought:

Eat curry to prevent hair loss.

— He says that black guys do not always pull off the bald look.  I still think he pulls it off.

UK celebrity funnyman divorcee gets a hair transplant to prepare for online dating so as to not look like a thug.

When Homer Simpson got hair due to a miracle drug call dimoxinil.

Our lack of body and scalp hair may have allowed our species to thrive.

And now on to medical items of interest:

— Last year I discussed the inspirational Zion Harvey after he got a double hand transplant.  He had lost both his legs, both his hands and his kidney to a childhood infection.  One year after his double hand transplant surgery, here is the result:

Chinese scientists to pioneer first human CRISPR trial.

— “Bio is the new digital.”  Great article from Taiwan that is a must read after translation.  Boston is to biotech what Silicon Valley is to information technology.  In the hair loss world, it seems like New York and San Diego (see here) are far more important than Boston, but perhaps we will see some surprises from Boston soon?!

— Two stories on aging in the Economist in the past week.  Here and here.

Excellent article on human enhancement.

Dr. David Sinclair’s presentation on ageing and lifespan extension.

— At least androgens have some benefits such as telomere length extension.

Dr. George Church on the future of genetic engineering.

Gene therapy cure with a money-back guarantee.

— Using a patient’s own stem cells and a 3D printer, scientists have genetically engineered a “living hip” that will cease pain.

— Cornea cells successfully grown and implanted to cure blindness in animals.

Peter Thiel is a fan of parabiosis.

Update on Dr. Frankenstein.  Full body transplant scheduled for December 2017.

— Scientists just created nanorobots to travel the bloodstream and fight cancerous tumors.

PGD2 Inhibitors/Antagonists: the Next Big Trend at Hair Clinics?

Of all the numerous groundbreaking developments that have occurred in the hair loss cure research world during the past 3 years, Kythera Biopharmaceuticals and its Setipiprant prostaglandin D2 (PGD2) antagonist (inhibiting) product have easily been among the five most exciting developments to look forward to.  For a better understanding of the link between male pattern baldness (MPB) and PGD2, this 2014 paper from the famous Dr. Luis Garza and Dr. Ashley Nieves is excellent reading as is this 2012 paper from Dr. Luis Garza, Dr. George Cotsarelis and others.  In the simplest of terms, prostaglandin D2 levels are elevated in balding scalps, and inhibiting PGDcould prevent baldness from progressing.  In order to do this, you target the PGD2-GPR44 pathway (since PGD2 binds to the GPR44 receptor).

What excited me even more so than the research behind this subject matter is the following 2015 audio interview with Kythera founder and at-the-time CEO Keith Leonard.  When I first heard it, I felt like he really knew what he was talking about, was sincere and was very excited about the “elegant” science (via research from Dr. Cotsarelis and his team at the University of Pennsylvania) behind this product.   Unfortunately, it seems like Mr. Leonard is no longer with Kythera. Moreover, when I checked Kythera’s website today, the pages with a listing of board of directors and management were opening as blank placeholders.  I would not read too much into Mr. Leonard’s departure, as the release of Setipiprant is still at least several years away in a best case scenario. To learn more about Kythera and Setipiprant, read my post from 2015 in its entirety.

Private Clinic Made PGD2 Inhibition Products to Treat Hair Loss

What made me think about this subject matter this week after several months of forgetting about it was an interesting new article published three days ago coming from India.  Apparently a local clinic named Hairline International Hair and Skin Clinic” is now offering PGD2 inhibitor therapy for hair loss.  The article is full of typos, bad science and ads.  Just like my take on the recent development from the Bahamas from a few weeks ago, my immediate reaction is that this Indian clinic’s product is likely to be totally ineffective and a sham. Nevertheless, this development is not surprising at all considering that so many hair loss forum members have been experimenting with similar homemade products for several years now (see links in next section).  So perhaps such a product is not too difficult to manufacture/compound?

Are we about to see more hair loss clinics offer proprietary products that inhibit PGDor is this just a one-time thing that will spread to very few other places?  A decade ago, very few hair loss clinics offered lasers or platelet-rich plasma therapy to treat hair loss, but now both are commonplace worldwide.  Can PGD2 inhibition therapy follow a similar path?  With PGDtherapy, I do wonder how much the patent held by Kythera negatively impacts the chances of other competing proprietary products from hair loss clinics becoming popular and legal, especially in the US?

Homemade (“ghetto”) PGD2 Inhibition Products to Treat Hair Loss

There is a good chance that Setipiprant will significantly aid patients with androgenetic alopecia.  The only problem is that clinical trials for Setipiprant will not be completed for several years. So not surprisingly, many people on hair loss forums are creating their own versions of Setipiprant/PGDinhibitors and testing them, or purchasing them from oftentimes sketchy vendors. The vast majority seem to have tested these “ghetto” products with no groundbreaking results to report.  However, as is always the case with such experiments, a majority of people are probably not even remotely correct in getting correct ingredients, dosages, vehicles and more.  In any case, I will leave you with some links to the said hair loss forum threads further below.

Also note that I plagiarized the “ghetto” term from “Swisstemples” who I have mentioned on this blog several times before.  He has what seems to be an excellent page on his site regarding “The Postaglandin Protocol.”  He also has a page on things to buy and use (where he uses the term “ghetto protocol” that includes some products to combat PGD2.  I do not take any responsibility if you do what he suggests and get nasty side effects.  I would never try any of this myself unless I had a really good chemist friend.

Note that people use various essentially synonymous terms for the products that they are trying in some of the below links, including “PGD2 receptor antagonist”, “PGD2 blocker”, “PGD2-GPR-44 receptor antagonist” and “CRTH2 receptor antagonist”.

— An excellent poster from the 9th Congress for Hair Research last year  (thanks “Hellouser”) can be found here –> “CRTH2/DP2 Antagonists Reverse Hair Growth Inhibition Caused by PGD2.” Main authors are Cotsarelis, Hsieh, Nace and Zheng.

— 51 page and growing HLT thread titled “dedicated Setipiprant log.”  Seem to be overall negative results, but I have only read 3-4 of those pages.

— BTT thread on homemade  PGDinhibitors.

— HLT thread on whether anyone is still on PGDblockers?

— HLH thread on OC000459, a CRTH2 antagonist.  Also see Oxagen.

Ramatroban (a PGDreceptor antagonist) that many people seem to have purchased from iron-dragon.  I have no idea about safety and legality issues.

— Note that Kane from China was offering his version of Setipiprant in the past, but I do not know the current status.

— Seems of interest regarding CRTH2.

PGD2 Regimen — Cetirizine + Water.

— An interesting recent HLT thread on CRISPR type gene therapy to fix the three single nucleotide polymorphisms (SNPs)  — rs545659, rs634681, and rs7167 — that have been found to be responsible for this PGD2 sensitivity.

Resvertarol and PGD2?  Not sure about this one.

Quercetin and PGD2  video.  Not sure about this one either, but many other hair loss forum posts on this subject.