Category Archives: Nicotinamide Adenine Dinucleotide (NAD)

David Sinclair, NAD and NMN Supplements

Update: January 14, 2020 — Dr. David Sinclair is participating in a Reddit AMA on January 14th from 4-6 pm EST. Official link. He will cover NAD, NMN, NR and resveratrol supplements. Make sure to ask Dr. Sinclair (his Twitter) about his age reversing 80 year old father’s hair quality.

A recent interview with Dr. Rhonda Patrick is also worth a watch.

Dr. Sinclair talk at Google in September 2019:

Update: In September 2019, Dr. David Sinclair made yet another appearance on the Joe Rogan show. Besides discussing his new book “Lifespan” and NAD plus NMN, he also talked about metformin in greater detail. He also discussed HGH, rapamycin, caloric restriction and fasting for longevity. On a related note, make sure to read my past post on TA-65 and Telomerase.

Update: In January 2019, Dr. David Sinclair made an appearance on the Joe Rogan show. He discussed NAD and other supplements in there.

Update: In a recent Linkedin post, Dr. Sinclair said that his own regimen and NMN dosage was pretty simple: “I take 750 mg of NMN every morning, along with a gram of resveratrol and 500 mg of metformin.”

Joe Rogan and David Sinclair
Joe Rogan and David Sinclair discuss longevity, NAD and NMN supplements.

I first mentioned Harvard University’s Australian professor Dr. David Andrew Sinclair in several posts in 2016 and 2017. At that time, he presented some groundbreaking findings regarding anti-aging research in relation to increasing declining Nicotinamide adenine dinucleotide (NAD or NAD+) levels in aging humans. He is also renowned for his lab’s research on resveratrol. Make sure to also check out Dr. Sinclair’s AMA on reddit.

Nicotinamide Adenine Dinucleotide (NAD)

Nicotinamide Adenine Dinucleotide (NAD or NAD+) is a cofactor and coenzyme that is found in all living cells. Levels and bioavailability in humans decrease with ago. In December 2019, Dr. Sinclair posted a link to new research on real-time NAD biosensors.

NAD versus NAD+

Note that NAD and NAD+ are not exactly the same thing. The latter it the oxidized form of the former. It is also written as NAD+  via the superscript in technical articles. Time magazine had a lengthy article on NAD+ in 2018.

NAD versus NADH

Nicotinamide Adenine Dinucleotide (NAD) via Nicotinamide Riboside.
NAD Supplement from Tru Niagen.

Note that NAD+ and NADH are two different forms of the coenzyme nicotinamide adenine dinucleotide (NAD). NADH is the reduced form of NAD, while NAD+ is the oxidized form.

Dr. David Sinclair states that his team does not recommend people taking NAD precursors, since they have not yet been formally tested for safety.

However, on Amazon, it looks like NAD+ pills can be purchased legally, and they seem to be a form of Vitamin B3 (brand name Niagen). A company named Tru Niagen also sells them directly. A company named Alive by Nature also sells sublingual NAD+ and NMN online. Dosages can vary for most of these supplements.

Elysium Health is another popular company selling NAD+ supplements under the name “Basis”. The US FDA approval process for a new NAD or NMN related drug is extremely lengthy and expensive. So most companies are instead focusing on supplements.

Nicotinamide Mononucleotide (NMN) Supplements

Nicotinamide Mononucleotide (NMN) Supplement.
NMN Supplement.

While NAD itself is difficult to administer directly to humans, its precursors — nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) — are promising natural compounds to test in humans.

MNN supplements such as the one on the right are especially popular online and at GNC. However, make sure to read customer reviews in detail to make sure that there are long term benefits. Some people might just be experiencing placebo short term benefits. NMN supplements can come in pill, tablet, capsule and powder forms.

Nicotinamide Robiside

Nicotinamide riboside (also called Niagen) is an alternative form of Vitamin B3. It has been touted to reverse grey hair, wrinkles, hair loss and various other signs of aging. Thorne Research makes a popular combination version of nicotinamide riboside with resveratrol and cofactors.

NAD and its Precursor NMN

Human trials for both NAD and its precursor NMN have been underway in recent years. This will allow for more conclusive evidence in regards to both benefits and side effects in the near future. For now, it is wise to exercise caution when it comes to NAD and NMN supplement related potential side effects.

In regards to side effects, some cancer cells depend on NAD+ for sustained and rapid growth. So rather than increasing NAD levels to live longer, one may need to decrease them to fight cancer.

Dr. David Sinclair has formulated a capsule version of a precursor to NAD+ called Nicotinamide mononucleotide (NMN). This precursor is a naturally occurring compound that is found in small amounts in fruits and vegetables such as broccoli, cucumber, avocado and edamame.

David Sinclair, Resveratrol and Sirtuins

Dr. David Sinclair has all the credentials of a reputable and brilliant scientist. For well over a decade, he has promoted the benefits of resveratrol, which is found in small amounts in red wine, grapes, berries and other related fruits. Resveratrol switches on the well known anti-ageing gene Sirtuin-1. Both NAD and sirtuins are necessary for healthy aging, longevity and DNA quality.

Dr. Sinclair has conducted significant research on how sirtuins are modulated by endogenous molecules as well as pharmacological agents such as resveratrol. Other areas of anti-aging research in which Dr. Sinclair has participated include senolytics and caloric restriction.

However, many of Dr. Sinclair’s peers accuse him of being overoptimistic and impatient. Not always a bad thing in the hair loss world, where we typically have the opposite situation. The resvertarol angle has had some hiccups over the past decade and Dr. Sinclair seems to have shifted his focus to other anti-aging research in recent years.

Dr. David Sinclair and NAD Update

Yesterday, Dr. David Sinclair’s work on NAD and its anti-aging properties was back in the news in a big way (h/t Christopher and AndyOz). There are some very fantastical points made in the article, with the most striking being:

  • Dr. Sinclair is using his own NAD molecule. He has supposedly reduced his biological age by 24 years after taking the pill.
  • David Sinclair’s father is 79 years old, and has been white water rafting and backpacking since starting to ingest the molecule a year-and-a-half ago.
  • Dr. Sinclair’s sister-in-law is now fertile again after taking the pill. This despite that fact that she started to transition into menopause in her 40s. (My note: I assume this implies that she is in her 50s now).
  • Potential increase in human lifespan to 150 years of age.
  • The pill leads to a decline in age related hair loss. (My note: Ironically, I find this to be the most believable of all the above fantastical claims. Even though hair loss is as yet almost impossible to cure in most people. New hair growth in bald regions of the scalp is especially difficult.
  • Human trials still two years away, but Dr. Sinclair aims to release the product into the market in five years.

David Sinclair Companies

Dr. Sinclair is the co-founder of a number of biotechnology companies (Sirtris, Ovascience, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity). He is also the founder of Life Biosciences LLC, a longevity startup. And he is a scientific adviser to many companies, including InsideTracker.

Note: make sure to not confuse Dr. David Sinclair and Dr. Rodney Sinclair (who is also from Australia). The latter is a well known dermatologist and hair loss expert, who I have covered a few times on this blog.

Edit: I posted links to some critiques of Dr. Sinclair earlier above. A reader also posted this new one that is worth a read.

Huge Week for Anti-Aging Research in Mice

I have covered anti-aging research on this blog a few times in the past: partly because aging reversal can often imply hair loss reversal; and partly because I also cover medical items of interest once a month. This week was one of the best ever in anti-aging research, especially for mice (and their fur). A number of people have posted links about some of the below developments in the last post (with special thanks to commentator “Netshed” who was especially prolific), and several people have also e-mailed me relevant links.

Senescent Cell Destruction Results in More Youthful Mice

For many years, scientists have known that the quantity of senescent cells (i.e., aged cells that have stopped dividing) correlates with aging in humans. More recently, research has suggested that senescent cells also damage other nearby healthy cells. So, not surprisingly, some scientists have conducted experiments to see if removing these old senescent cells (ideally, without damaging other normally functioning cells) reversed signs of aging and increased life expectancy. A few experiments in mice have suggested the answer to be in the affirmative (e.g., this one from 2011 and this one from 2015). There is now even a name (senolytics) for the class of drugs that can kill senescent cells.

This week, a groundbreaking study (led by Dr. Peter de Keizer) from the Netherlands found that a drug that they developed to kill senescent cells causes dramatic improvements in mice health and essentially reverses their aging. For our purposes, the most important thing was that these mice saw regrowth of healthy fur/hair! Key photos below (green arrows on rightmost column show hair regrowth in almost all mice after FOXO4 peptide ingestion):

Mice hair regrowth from destroying senescent cells

The team behind this research plans clinical trials in humans in the near future. There are literally 100s of articles on this development, and various scientists from other countries have been quoted as saying that this development is potentially a huge breakthrough in anti-aging science. Two contrasting sources here and here.

Addendum 1: In case anyone got the wrong idea from my recent post on obesity perhaps benefiting scalp hair, this study is worth reading.

Addendum 2: Specially for Mr. “nasa_rs”: “JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age“.

David Sinclair Update

I have covered anti-aging Harvard-based Australian researcher Dr. David Sinclair (widely associated with resveratrol) once on this blog before here. In a new paper, him and his colleagues have found a way to protect a mouse’s DNA from damage via boosting NAD+ levels, and they are supposedly ready to test it in people. Dr. Sinclair in some ways is the Dr. George Cotsarelis or Dr. Ken Washenik of the anti-aging world. You decide what I mean by the above sentence.

Note that there is also a Dr. Rodney Sinclair who is a famous hair loss researcher that I have covered a few times on this blog. He is also from Australia.

Young Blood Without the Need for a Donor

In recent years, a number of scientists have been researching the fascinating subject of whether older people can be rejuvenated by the infusion of blood from the young! Billionaire Peter Thiel is especially interested. However, one major problem with this strategy for older non-wealthy people is that there might not be enough young healthy donors with the correct blood type willing to donate at reasonable prices. However, this week, scientists from Germany published research that could be a workaround for this problem. Just make old blood young again (in mice) via the addition of osteopontin protein and forget about the young. After all, “youth is wasted on the young”.