TA-65, Telomerase Activation and Hair Regrowth

TA-65 Reviews and Purchase Options

To purchase TA-65 –> TA-65 Telomerase Activation Capsules

To purchase a less expensive alternative –> Isagenix Product B Antioxidants Plus Telomere Support

Dr. Park’s Video on Hair, TA-65, Telomeres and Telomarase

Youtube is a never ending goldmine of discoveries. Some time last year, I stumbled upon a highly interesting video (published in 2012) from Dr. Ed Park titled “The Hair Show” and bookmarked it. I was impressed with Dr. Park’s breadth of knowledge about hair biology despite his not being a hair specialist or dermatologist. His instructive presentation is also interspersed with some really funny imagery. Among the more interesting items in the first half of the video were:

  • 3:30 = A diagram showing the dermal papilla, hair follicle matrix, keratinocytes and more.
  • 7:00 = A very useful table on hair throughout the body and what percent is in anagen (growth) phase verusus telogen (resting) phase in each region of the body at any given time. Also presented is duration of hair growth phase by region of body. Just prior to this table, Dr. Park also lists interesting facts about hair.
  • 10:30 = He talks about hair loss being a sign of aging. Kind of true, but not always. Some people go bald in their 20s, but live very long lives, implying hair loss is not necessarily a sign of aging throughout the body. Also, some people who die of old age still have a very full head of hair.
  • 15:00 = He talks about grey hair being a sign of the destruction of melanocytes (make sure you read my post on the cure for grey hair). He then gets in to DNA damage, TGF-beta, apoptosis and other issues that impact hair pigmentation. He includes some charts in there that are beyond my understanding.
  • 16:30 = Quote –>”I would stop looking at the whole issue of testosterone and male pattern baldness…dry hole so to speak. Androgens are not the “root” cause of baldness.” All of us hair loss sufferers are sick of medications targeting dihydrotestosterone, and none of us are going to get castrated to stop testosterone production. So this statement from Dr. Park cuts through the chase. Moreover, most of the new discoveries and research related to a hair loss cure that I have covered in the past 2.5 years do not involve targeting testosterone or DHT whatsoever. We have now moved beyond that area of research that has held us back for decades. Dr. Park make a great point, even though I am not sure if he knows of all the new research targeting other pathways to a hair loss cure.
  • 16:40 = He starts discussing telomeres and telomerase therapy, the main focus of the remainder of the video, and also the main focus of this post (see below the video for the remainder of this post). Note that Dr. Park has published a well reviewed book on this subject: Telomere Timebombs: Defusing the Terror of Aging.

Telomeres and Telomerase

Telomeres are repetitive nucelotide sequences (i.e., sections of DNA) at the ends of our chromosones that protect them from damage. In humans, this sequence is represented by the acronym TTAGGG (where “T” stands for thymine, “A” stands for adenine and “G” stands for guanine). As we age,  telomere ends become shorter each time cells divide, and this finally leads to cell death. People with longer telomeres tend to have longer lives than those with shorter telomeres. You can get the length of your telomeres measured at some labs if you want, but this is not a good idea for hypochondriacs and those susceptible to anxiety!

Telomerase is an enzyme that adds the TTAGGG telomere sequence to the ends of chromosomes. Telomerase in effect replaces the short bits of DNA known as telomeres,

Slowing Ageing via Telomerase Therapy

Many researchers think that that reversing the shortening of telomeres through temporary activation of telomerase may be a potent means to slow aging. Among the ways to do this would include drugs, gene therapy and metabolic suppression. Increasing telomere length could even reverse aging, although there is a lot of controversy behind this theory. In any case, for those interested in this subject, two of the leading experts in this area of research have both recently published new books:

  1. Bill Andrews — Telomere Basics: Curing Aging (also see this this inspiring video on Mr. Andrews)
  2. Micheal Fossell — The Telomerase Revolution: The Enzyme That Holds the Key to Human Aging…and Will Soon Lead to Longer, Healthier Lives

TA-65 — Does it grow back hair?  Does it darken grey hair?

The second half of Dr. Park’s video above delves into Telomerase activation and how it can regrow hair and reverse grey hair. He gives a number of examples of this and even has some real patient testimonial interviews in there, including a 112 year old called Soledad Mexia! Unfortunately, she died two years later, but it makes Dr. Park’s video seem a lot more legitimate to have such a testimonial of someone who can’t possibly have been bought to provide a fake positive testimonial. One caveat is that Ms. Mexia only took the pills for 3 days per the video and it seems hard to believe that she got some darker hair so fast. Its also impossible to see the darker hair in the video, but I believe her family members when they say so.

TA-65 Review:

TA-65

In the second half of the video, Dr. Park heavily promotes a very expensive and controversial product called TA-65. This product is manufactured by T.A. Sciences and contains a molecule called Cycloastragenol that is derived from a Chinese herb called Astragalus. There are numerous people (including respected scientists such as Dr. Bill Andrews) who believe in this product, but there are also a lot of nonbelievers. Amazon reviews (e.g, see TA-65 Telomerase Activation Capsules) tend to be mixed, and you have to be very careful about fake reviews on Amazon — especially for an expensive item such as this. More on the controversy behind TA-65.To be fair, there are also studies supporting the potential of TA-65:  see this 2011 study showing TA-65 being beneficial to mice and another study from 2013 showing some potential benefit in humans.

In any case, in both Amazon reviews and on Google searches for terms such as “TA-65 and hair growth”, you will see positive and negative testimonials. In my opinion, TA-65 is not worth purchasing unless you make at least $200,000 a year and can afford to blow away this kind of money. It is also likely that other much cheaper products that activate telomerase will come to the market in the near future. In fact the price of TA-65 has come down from $2000 per month several years ago to under $600 a month today. Moreover, a newer much cheaper telomerase activation product called Isagenix Product B Antioxidants Plus Telomere Support has been getting decent reviews.

Note that in a Quora question and answer session,  in response to the following question related to TA-65:

“Is the TA-65 yet proven to be effective in lengthening telomeres in humans?”

world renowned longevity researcher Dr. Aubrey De Grey stated the following:

“My information is that yes, there is clear telomere elongation. Whether that is a net positive for postponing age-related ill-health remains an open question.”

Footnote: Interestingly, Dr. Park interviewed Liz Parrish a few weeks ago. Below is the excellent video:

221 thoughts on “TA-65, Telomerase Activation and Hair Regrowth”

  1. Guess you have a point. Don’t worry. Everyone makes mistakes. I did hear recently and read on follicle thought that christiano said jak needs to be taken in high doses or need to be high concentration to grow, so even if it were to work you probably are right about chris. Far too low a dose.

  2. Dr. Christiano Sheds Light on JAK Inhibitors

    Dr. Christiano recently did an audio interview about her research on JAK inhibitors for hair growth. The interview covers most of the information we’ve already heard, and also brings forth a few insightful comments from the researcher. The question that everyone still wants to know is if these JAK inhibitors could be useful for common hair loss or androgenic alopecia. Her answer was: maybe. She did say that these JAK drugs were the most efficient thing she has seen for turning on the hair follicle growth cycle in a long time, which is promising. Dr. Christiano explained that at this point it is necessary for a company with resources to move the JAK research into clinical trials. However, she made it clear that it would be fairly quick and easy to determine whether these JAK drugs were effective for hair growth during initial trials, making them a safer investment. I personally believe that a keen company, perhaps a company like Kythera, will be knocking at her door soon enough to inquire about the JAK inhibitor work. One important tidbit that I picked up from the interview is that apparently the JAK drugs need to be at a high local concentration around the hair follicle to have an effect on it’s growth. This could mean that a topical solution with enhanced permeability would be a great choice for delivery.

    Finally, one thing I found interesting during the interview was that the interviewer mentioned that research on using JAK inhibitors for 3D cultured dermal papillae cells was eye opening and that he was very surprised no one was talking about it or mentioned it in the media. If you look back to my initial article, the terrific news about Tofacitinib promoting the inductivity of dermal papillae cells was highlighted and the picture of it’s results was shared.

    1. That’s the fundamental error of all researchers. This never-ending MAYBE… And is it with maybe that they want companies to invest on them? This people has to learn to talk the language of business, for Christ sake!!

      First thing.. they have to say IT WORKS.. obtain strong evidence that proves it works, like she did with Areata. But then why has nobody got interested in Areata? why? because it affects a very small percentage of people. If she had done the test for AGA and had got similar results she would get ALL THE MONEY she needs to fund her research.

      How can one not see this???

      1. and then they claim it’s so hard to get funding… talking like this, what do they want???

        Do you think your shit will will work for AGA as well, Mz. Christiano?

        I don’t know. Maybe… we now need some company to invest on our research to see if it will work, I can’t tell you that yet.

        lol

  3. So in theory when this is released for alopecia areta we may have to just apply it 3 times a day for example dependent on the dose.

  4. farhan. I was more concerned i got peoples hopes up rather than actually making mistakes. and i am aware hair loss is a bigger problem. why even relate them both. cheers…

  5. Is alopecia areta really cured now with jak ? Or not yet ? Or is it so expensive that only few can benefit ? What is the situation?

  6. Hey guys,

    Just another guy’s opinion, but optimism is always fun. Here is the most recent blog from Follicle Thought:

    For people looking to restore their hair through multiple transplants, particularly young people, good donor management is critical to the successful appearance of the individual. Donor hair management is evaluated by three major factors: the person’s age, the person’s degree of hair loss, and the person’s donor availability. These factors will determine what a hair transplant surgeon will recommend for surgery in regards to amount of grafts, hairline design, and areas covered. For example, a surgeon would most likely recommend a more conservative hairline and graft amount for a first procedure to a 24 year old man who had thinning in the front and the crown, compared to what would be recommended to a 40 year old man with only recession at his hairline. Overall, the general rule of thumb for hair transplants has been to be conservative because hair loss continues and donor hair has a limit to it. A practical and intelligent approach indeed.
    But what if we weren’t limited to a finite amount of donor hair anymore?
    It’s been dreamed about forever, talked about for decades, yet is extremely likely that we will actually have the capacity to create more hairs than what we started with within the next couple years. I mean like, within the next term of our next president. The two front runners to bring this technology to market would be Replicel and Histogen. Let it be stated clearly that of course, nothing in the future is guaranteed. But, if you’ve been paying attention to the world of hair regeneration technology and regenerative medicine in general over the past 8 years, you’d have a reason to believe that the current estimated timetable for the release of these products is highly likely.
    I’m not basing this discussion on just these two companies. They both do have a high potential to put an effective hair growth therapy on the market within the next 2 years, but of course there are others. Our scientific capacity as a whole multiplies every year, and every year there are more researchers actively working to crack the code of unlimited hair regeneration. The point is, things are changing and there is enough evidence to believe we will have a multitude of advanced hair technology within the next decade.
    So, what about donor management then? Does it still have the same significance that it did 10 years ago? As far as I can see it, the answer has to be “no.” I want to make a few points clear as I get into the heart of this discussion. First off, I definitely do not think that it is entirely responsible or prudent to completely throw the idea of donor management out the window because we seem to be a few years away from a regenerative hair technology. I will also acknowledge that it is a lot easier for me to have my stance on this subject than it is for a hair transplant surgeon who actually has to perform surgeries and is responsible for their patient’s outcomes. I simply wrote this article because I believe it is time to start having this discussion. Still, the notion that a 25 year old patient going in for his first transplant would have to be overly conservative with his choice of hairline and density because of “what he may look like in 20 years” does not seem completely in touch with reality to me. Even a conservative outlook would acknowledge that in the course of the next 20 years the world of hair restoration will be in a much different place than it is now.
    I wanted to hear the opinion of a professional who deals with this subject everyday. Dr. John Cole, a pioneer in the field of hair restoration had this to say on the subject:
    “Enthusiasm is contagious and stimulating. It is fascinating to think we are on the brink of major breakthroughs that will give us an unlimited number of hair follicles. Indeed we have numerous products directed at numerous different pathways of hair loss both from the perspective of hair regeneration to the reversal of hair loss. There are numerous products directed at the WNT pathway. We are bringing a WNT up-regulator product to the USA from Italy, which is known as Deltacrin.
    However, the question is whether we can be more aggressive with hair line location and with the hair we harvest from the donor area. By age 49 sixty-seven percent of men are a NW 2 or worse. Thus, when we design a hairline, the first thing to consider is whether we want to be married to a youthful hairline the rest of our life.
    From the perspective of donor area management, we are already more aggressive today than in 2005. We are going outside the traditional donor area for a variety of reasons. One goal is to focus on an even distribution of follicles throughout the scalp. This is best accomplished by harvesting outside the traditional safe donor area. We must remember that only three percent of men will lose hair higher on the sides of the scalp by age 60, so why not give them hair when they are younger and they can appreciate it. Another reason we are more aggressive is the use of Acell in the donor area extraction sites. We found that with a minimum depth FUE approach and the use of Acell to stimulate follicle stem cells, we could not locate 48% of the donor extraction sites. Without Acell, we could find all of the extraction sites. In one study we saw follicle regeneration of at least one hair in 42% of our extraction sites.
    There is plenty of reason to be optimistic about the potential for follicle regeneration and follicle resurrection. As suggested, the hair restoration surgeon cannot take chances with the future of young patients because there is no guarantee that current advances will create an inexhaustible supply of hair nor that the advances will work well in all individuals. Yes, it appears that advances are around the corner, but there is still no way to predict how many blocks away that corner is.”
    Dr. Cole made a great point about being married to a youthful hairline for the rest of one’s life. It is definitely something that should be considered before a surgery. For me, it wouldn’t be a deal breaker. If having a youthful hairline for the rest of my 20s, then 30s and 40s meant that I had to have the same hairline when I am 70, I would be OK with it. This is a great start to the discussion and please feel free to add your own below this article.
    In related news, Dr. Cole told me that is going to be pursuing adipose enriched stem cell treatments at his new clinic to be opened in Mexico. He also mentioned he is seeing good results from using sonication applied to PRP to release a higher concentration of growth factors into the PRP. I will be releasing more information about those subjects in the future.

  7. Fuuuuuuuuuuuuuuck why can’t they just release a freaking better hair liss treatment already! Shit! So tired of waiting and waiting and waiting. It’s freaking hair you doctors and researchers just make it grow again.

  8. I am so stoked, Mjones. Can you imagine if they can actually give us more hair than before?? Wouldn’t that be bad ass to have thicker hair?? Let’s dream baby!

    1. Ddog, 90% of my problems would be eliminated in my life if I got my hair back. I could go bsck to a normal relationship with a girl without her looking at me weird for blow drying my hair in the morning, adding rogaibe at night. The ability to jump in the pool or beach, or walk in the rain and not have to avoid getting my hair wet which shows baldness. It’s a fking pain everyday and we deserve better than this!

  9. I am farhan, I have been dealing with this shit since I was 19yrs old and now I’m 34. I’m exhausted of doing all these treatments etc. I just want a better treatment to restore my hair and fir it to stop falling out

  10. I have thinning hair since I moved to Australia.. I dont know if the change triggered it more quickly or it was just coincidence…for me it started when I was 25 and I am 30 now..Iam thinning but not bald…no one can tell im bald…as I had fue in India for frontal part…and other than that I used toppik to make it look thicker…I think I can hold few years…but deep down I know it is thinning..I see myself in mirror after shower and really feel bad..I dont use propecia ..once in a while I use minoxidil..but scared of shedding..

  11. I wonder if the cure isn’t out by 2020, the admin keeps changing the site date :’)

    which i hope isn’t the case or ill be depressed as!

  12. Selenium is known to increase telomerase, leading to longer telomere length in cells. Brazil nuts are a good source, but I’ve not yet looked into the dosage needed to boost selenium levels significantly or what is required to have a benefit to telomeres (suppliments might be necessary to have an effect). This article is a good reminder for me to do so!

    Also this article on lifestyle and telomere length is interesting:
    https://www.sciencedaily.com/releases/2013/09/130916203946.htm

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