Category Archives: FOXO4

FOXO4, Anti-Aging and Hair Growth

I previously wrote about FOXO4 in a post in March 2017 that covered Dr. Peter de Keizer and his groundbreaking findings. In brief, interference via a newly created modified FOXO4-p53 peptide caused senescent cell apoptosis (death) in mice. Subsequently, the mice became younger and healthier. Most importantly, the mice regrew thick and robust coats of fur.

In the above study, the FOXO4 peptide was created in a D-retro inverso (DRI)-isoform conformation and named FOXO4-DRI. The anti-aging and hair growth related findings of this work were widely covered by the media in 2017. Dr. Keizer thereafter started his own biotech company called Cleara Biotech.

Senescent Cells

I have written about senescent cells (undesirable) and senolytics a number of times in the past. In an interview with Dr. de Keizer, he mentioned the following:

“If you remove the senescent cells, it means the (neighboring) stem cells can differentiate again, supporting tissue rejuvenation.”

Also make sure to read my related post on NAD, NMN and Resveratrol for aging reversal.

Hyperbaric Oxygen Treatment

Earlier this week, an anti-aging breakthrough from Israel was widely covered in the media. Apparently, giving pure oxygen to older people while in a hyperbaric chamber increased the length of their telomeres by 20 percent. More details here.

This development is impressive because it resulted in both:

  1. Telomere Elongation. And:
  2. Senescent Cell Reduction.

There have already been other methods via which people have increased their telomere length, including TA-65, exercise, diet and caloric restriction. However, this new hyperbaric oxygen treatment (HBOT) protocol led to elongation of telomeres at higher rates in comparison to existing interventions.

Using FOXO4 for Hair Growth

I was not planning to write about the above findings from last week as there did not seem to be any connection to hair loss.

However, earlier today, reader “egghead” posted a new link to the same story. More importantly, he made an astute observation in regards to the video at the bottom of the just mentioned Aljazeera link. He watched it entirely, and found an example of hair growth from FOXO4-DRI in the second half of the video.

Unfortunately, I cannot embed the video here, but below is the most relevant screenshot:

FOXO4-DRI Hair Growth.
Using FOXO4-DRI for hair growth.

FOXO4-DRI

Apparently, many people have been taking commercially available versions of the FOXO4-DRI peptide. Both for longevity reasons and, in rare cases, for hair growth. The above screenshot is from someone named Darren Moore and you can read his story on his site. Also see this article on his before and after hair growth.

Although Darren initially regrew his hair and it became darker, it seems like he lost most of the gains per this interesting 2019 video about him. During a brief perusal of Darren’s blog, I noticed that several commentators posted that they saw darker and fuller hair when taking FOXO4-DRI. There is also a 29-page group buy thread on this subject on the longecity forum.

I am surprised that people trust this untested and expensive chemical. It is even on sale on Amazon. Who knows if there are any long term side effects. In an interview on Linkedin, Dr. Keizer stated the following:

“We have now also received emails from people from America, for example, who have already bought the drug, the anti-aging substance FOXO4-DRI. You can now get it on the market in China. For a thousand euros you can buy ten milligrams and that is enough for a third of one treatment.”

I am not sure how the product that Dr. Keizer and his team developed (and patented) can be replicated by these Chinese labs. Even US companies such as Bucky Labs sell FOXO4-DRI for “scientific research use”. I assume all commercial versions of the drug have minor differences.

My Thoughts

I would not take this product in the hopes of re-growing my hair. Too little anecdotal evidence for that as of right now. Not to mention that the price for a full dose treatment is quite prohibitive. However, this whole FOXO4 subject matter is worth following in the coming years.

In an e-mail, Dr. Keizer told me that they were certainly not going to ignore hair growth results during their future research. However, cancer treatment and anti-aging remain their top priorities.

Perhaps localized senescent cell destruction in the scalp region will be possible via topical products in the future? Maybe this could then regrow hair via enabling nearby hair cells to function properly again?

Brief Items of Interest, June 2017

Hair loss news first:

— Apparently, there is a small subgroup of people who suffer from hair loss due to a condition called hypohidrotic ectodermal dysplasia (HED), which also adversely impacts nails, teeth and sweat glands. While studying this condition, the well known Dr. Sarah Millar and her team at the University of Pennsylvania recently found that “lower levels of Wnt10A may contribute to male pattern baldness in some individuals”. Later, they go on to state that “small molecule drugs that activate the beta-catenin pathway downstream of Wnt10A could potentially be used to treat hair thinning and palm and sole skin defects” in some patients suffering from male pattern hair loss. I have covered Wnt signaling and various associated proteins and genes (especially Wnt10b) a number of time on this blog in the past when relevant to hair growth, but it seems like this is the first post that has covered Wnt10a.

— Someone from the Netherlands emailed me yesterday with an interesting new story on a well known Dutch news site about an American guy named Darren Moore who is testing FOXO4-DR to regrow his hair. This self-experimenter’s website with frequent updates is here and he also has his before and after scalp photos on there. For more about the FOXO4 peptide and its killing of senescent cells, see my recent post on that subject. The Netherlands based researcher (Dr. Peter de Keizer) who did that groundbreaking work has warned people about the above experiment and its possible dangers in the Dutch newspaper article that I linked to at the beginning of this paragraph.

Besides the health ramifications, I am obviously very skeptical of one-off anecdotal reports, even though I do mention them if interesting. Note that Mr. Moore’s site has two links from where to purchase FOX-O4 from, but I would not recommend getting the product. It is extremely expensive and potentially highly dangerous as elaborated by Dr. Keizer (and worth repeating again). I would also like to first make sure that Mr. Moore is in no way affiliated with the websites that sell this product before taking him more seriously. Having said all that, I am now probably going to eagerly anticipate his diary updates over the next several months:-) I like that he posted a photo of himself with Liz Parrish, another self-experimenter that I have covered on this blog several times before.

Samumed continues to garner great publicity. They must surely be the most successful hair loss cure focused company of all time when it comes to getting media attention? Their big coup came last year via a cover page on Forbes magazine with some great photos such as the below inside:

— Like last year, Aclaris Therapeutics is presenting at various investor conferences and lets all of us see their slides and listen to their audio after registration. This time I have not listened to any live or recorded audio as yet (I waited for 30 mins on one day, but it never started at the announced time). For those who are patient, it is always worth hearing the audio out till the end, when attendees often get to ask questions. In their latest slides, Aclaris still maintains that are doing pre-clinical work related to topical JAK inhibitors for androgenetic alopecia. No announcements on when they will start phase 1 trials as yet.

— Wasabi found to benefit hair growth.

Baldness, how close are we to a cure? Not a bad effort, since most such articles are highly inaccurate and badly researched. Nevertheless, the author does not even mention the leading prospects for a cure or treatment such as Follica, Histogen, Replicel/Shiseido, Samumed and Tsuji.

New ADSC and hair growth study from Japan.

And now on to medical items of interest:

— Limitless lab-grown blood tantalizingly close.

— A drug that creates a real sun-tan (and subsequently, protects against skin cancer, rates of which have been rising rapidly).

— 3-person babies for older women having trouble getting pregnant.

— Progress in the cure for multiple sclerosis, a very debilitating auto-immune condition.

Defibrillator carrying drones.