Category Archives: David Sinclair

Anti-Aging, David Sinclair, Joe Rogan

David Sinclair, Lifespan and Longevity

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David Sinclair and Elon Musk conversation on lifespan.
David Sinclair and Elon Musk conversation on lifespan.

I have discussed the work of Australian-American Harvard Medical School geneticist, professor and longevity researcher Dr. David Sinclair a few times on this blog. In 2018, I even wrote an entire post devoted to his work on NAD, NMN, Resveratrol and Sirtuins. But too many new updates in that post have made it confusing. So I am now writing a second post on this esteemed scientist who has a knack for being mentioned in the global media on a daily basis.

I have covered the subject of anti-aging in numerous posts due to the fact that any technologies that reverse human aging will also regrow lost hair and re-pigment grey hair. In fact Dr. Sinclair’s Lab is also working on the latter two conditions. The most ambitious of Dr. Sinclair’s projects is a currently secretive drug candidate code-named SL-100 that aims for whole-body rejuvenation.

Life Biosciences: Phase 1 Trial of ER‑100 for Optic Neuropathies

Dr. Sinclair’s company Life Biosciences has been in the news a lot in recent months. They work on cellular rejuvenation therapies to reverse multiple diseases of aging,

Their current focus is on reversing various diseases of the eye that cause vision loss. In particular, optic neuropathies such as open-angle glaucoma (OAG) and non-arteritic anterior ischemic optic neuropathy (NAION).

In January 2026, Life Biosciences received FDA clearance for its Investigational New Drug (IND) application for its ER-100 gene therapy. More on this

“ER-100 originated from Life Bio’s Partial Epigenetic Reprogramming (PER) platform, which aims to restore aged or injured cells to a younger state by modifying the epigenome of cells, biochemical markers that regulate gene expression without altering the underlying DNA sequence.

Life Bio’s approach allows for the controlled expression of three of the four Yamanaka factors, the transcription factors OCT-4, SOX-2, and KLF-4 (OSK), and has demonstrated safety and efficacy in multiple preclinical animal models by local injection into the eye (intravitreally). ER-100 is the first ever cellular rejuvenation therapy using epigenetic reprogramming to receive FDA clearance to enter human clinical trials.”

In April 2026, Life Biosciences received $80 million in Series D Financing. This will allow for the completion of the company’s Phase 1 clinical trial of ER-100 and the continued advancement of its Partial Epigenetic Reprogramming (PER) platform across multiple therapeutic indications. The first patient in the clinical trial for ER-100 was dosed in June 2026.

David Sinclair on The Joe Rogan Experience

Earlier this month, David Sinclair was interviewed on “The Joe Rogan Experience” for a 4th time. In reverse chronological order, below are all of his past appearances on the world’s most popular podcast:

He talks about hair regrowth and grey hair reversal starting around 47:30 minutes into his latest interview with Joe Rogan.

He says that he takes sildenafil (Viagra) for his overall vascular health and also for better hair growth.

Lifespan

It seems like “Lifespan” is becoming Dr. David Sinclair’s main brand.

  • In September 2019, Dr. Sinclair co-published a book with Matthew LaPlante called “Lifespan” that has become extremely popular in logevity circles. It currently has an average rating of 4.6 out 5 stars based on 12,100 reviews. It seems like this is the second most popular book in the anti-aging segment after Dr. Peter Attia and Bill Gifford’s 2023 book “Outlive” that currently has an average rating of 4.6 out 5 stars based on 21,200 reviews.
  • In 2022, Dr. Sinclair launched a new YouTube show called “Lifespan with Dr. David Sinclair“. After not posting any videos on there from 2022-2025, he has been posting new content almost every week for the past three months.
  • In August 2026, Dr. Sinclair launched a new website called lifespan.com as well as his new magazine called LifespanTM. You can read the August 26 edition in full here.

What Supplements does Dr. David Sinclair take?

In a Tweet from August 3, 2026, Dr. Sinclair said the following:

“I take low-dose daily tadalafil (Cialis) for long-term organ health, especially the brain. Vascular dementia is the second most common and most preventable cause of dementia”

In a 2022 edition of his Lifespan with Dr. David Sinclair podcast that covered “NMN, NAD, NR, Resveratrol, Metformin & Other Longevity Molecules, Dr. Sinclair said that: he recently added Spermidine to his protocol; became vegetarian (while still fasting and eating just once per day); lost 15 pounds; and entirely quit alcohol. Dr. David Sinclair’s supplement list in 2022 included the following:

  • NMN (1g per day in the morning with yogurt).
  • Resveratrol (0.5 mg per day in the morning with yogurt).
  • Metformin (1g per day at night).
  • Statin (for cholesterol control).
  • Spermidine.
  • Vitamin D3.
  • Vitamin K2.
  • Quercetin.
  • Fisetin.

Interestingly, in a December 2023 Tweet, Dr. Sinclair mentioned that Resveratrol and Fisetin (both SIRT1 activators) induce the proliferation of hair follicle bulge stem cells. This in turn promotes hair growth. He certainly looks younger than his current biological age of 57, and he has no balding or grey hair.

Critiques

In my original post about Dr. David Sinclair, I linked to several articles that heavily criticized his past anti-aging claims. And some scientists have accused him of being a salesman with great marketing skills (who overpromises the results of unproven products).

In general, while I find his enthusiasm refreshing, I am not as yet a full fledged fan of Dr. Sinclair. I tend to trust scientists more if they are less active on social media and not too focused on promotional and marketing activities. But we live in a different era. And there must be a good reason that Harvard University (US) has kept the Sinclair Lab running for all these years and given Dr. Sinclair tenure.

David Sinclair, Anti-Aging, Joe Rogan, Metformin, Nicotinamide Adenine Dinucleotide (NAD), Nicotinamide Mononucleotide (NMN), Nicotinamide Riboside (NR), Resveratrol, Sirtuin 1

David Sinclair, NAD and NMN Supplements

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If interested, you can search for popular highly rated:

David Sinclair on the Joe Rogan Show

Update: In August 2026, David Sinclair made a fourth appearance on the Joe Rogan show.

Update: In June 2021, David Sinclair made a third appearance on the Joe Rogan show. Besides NAD and NMN, they also discuss intermittent fasting.

Update: In September 2019, Dr. David Sinclair made a second appearance on the Joe Rogan show. Besides discussing his new book “Lifespan” and NAD plus NMN, he also talked about metformin in greater detail. He also discussed HGH, rapamycin, caloric restriction and fasting for longevity. On a related note, make sure to read my past post on TA-65 and Telomerase.

Update: In January 2019, Dr. David Sinclair made an appearance on the hugely popular Joe Rogan show. He discussed NAD and other supplements in there. Also, in a recent Linkedin post, Dr. Sinclair said that his own regimen and NMN dosage was pretty simple: “I take 750 mg of NMN every morning, along with a gram of resveratrol and 500 mg of metformin.”

Joe Rogan and David Sinclair
David Sinclair discusses longevity, NAD and NMN supplements on the Joe Rogan Show.

I first mentioned Harvard University’s Australian professor Dr. David Andrew Sinclair in several posts in 2016 and 2017. At that time, he presented some groundbreaking findings regarding anti-aging research in relation to increasing declining Nicotinamide adenine dinucleotide (NAD or NAD+) levels in aging humans. He is also renowned for his lab’s research on resveratrol. Make sure to also check out Dr. Sinclair’s AMA on reddit.

Nicotinamide Adenine Dinucleotide (NAD)

Nicotinamide Adenine Dinucleotide (NAD or NAD+) is a cofactor and coenzyme that is found in all living cells. Levels and bioavailability in humans decrease with ago. In December 2019, Dr. Sinclair posted a link to new research on real-time NAD biosensors.

NAD versus NAD+

Note that NAD and NAD+ are not exactly the same thing. The latter it the oxidized version of the former. It is also written as NAD+ via the superscript in technical articles. Time magazine had a lengthy article on NAD+ in 2018. The NAD+ co-enzyme is largely synthetized through NMN. If interested, you can follow the developments of MIB-626, a NAD+ precursor that is currently in clinical trials.

NAD versus NADH

NAD+ and NADH are two different forms of the coenzyme nicotinamide adenine dinucleotide (NAD). NADH is the reduced form of NAD, while NAD+ is the oxidized form. NADH stands for nicotinamide adenine dinucleotide hydrogen.

Dr. David Sinclair states that his team does not recommend people taking NAD precursors, since they have not yet been formally tested for safety.

NAD+ Supplements

However, on Amazon, it looks like NAD+ pills can be purchased legally, and they seem to be a form of Vitamin B3 (brand name Niagen). A company named Tru Niagen also sells them directly. A company named Alive by Nature also sells sublingual NAD+ and NMN online. Dosages can vary for most of these supplements.

Elysium Health is another popular company selling NAD+ supplements under the name “Basis”. The US FDA approval process for a new NAD or NMN related drug is extremely lengthy and expensive. So most companies are instead focusing on supplements.

Best NMN Supplements

While NAD itself is difficult to administer directly to humans, its precursors — nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) — are promising natural compounds to test in humans.

MNN supplements such as the one on the right are especially popular online and at GNC. However, make sure to read customer reviews in detail to make sure that there are long term benefits. Some people might just be experiencing placebo short term benefits. NMN supplements can come in pill, tablet, capsule and powder forms.

Nicotinamide Riboside

Nicotinamide riboside (also called Niagen) is an alternative form of Vitamin B3. It has been touted to reverse grey hair, wrinkles, hair loss and various other signs of aging. Thorne Research makes a popular combination version of nicotinamide riboside with resveratrol and cofactors. Tru Niagen also makes popular NR supplements.

Also see this article on Nicotinamide riboside (NR) vs. Nicotinamide mononucleotide (NMN).

NAD and its Precursor NMN

Human trials for both NAD and its precursor NMN have been underway in recent years. This will allow for more conclusive evidence in regards to both benefits and side effects in the near future. For now, it is wise to exercise caution when it comes to NAD and NMN supplement related potential side effects.

In regards to side effects, some cancer cells depend on NAD+ for sustained and rapid growth. So rather than increasing NAD levels to live longer, one may need to decrease them to fight cancer.

Dr. David Sinclair has formulated a capsule version of a precursor to NAD+ called Nicotinamide mononucleotide (NMN). This precursor is a naturally occurring compound that is found in small amounts in fruits and vegetables such as broccoli, cucumber, avocado and edamame.

David Sinclair, Resveratrol and Sirtuins

Dr. David Sinclair has all the credentials of a reputable and brilliant scientist. For well over a decade, he has promoted the benefits of resveratrol, which is found in small amounts in red wine, grapes, berries and other related fruits. Resveratrol switches on the well known anti-ageing gene Sirtuin-1. Both NAD and sirtuins are necessary for healthy aging, longevity and DNA quality. Moreover, Resveratrol (RSV) may promote hair growth.

Dr. Sinclair has conducted significant research on how sirtuins are modulated by endogenous molecules as well as pharmacological agents such as resveratrol. Other areas of anti-aging research in which Dr. Sinclair has participated include senolytics and caloric restriction.

However, many of Dr. Sinclair’s peers accuse him of being overoptimistic and impatient. Not always a bad thing in the hair loss world, where we typically have the opposite situation. The resvertarol angle has had some hiccups over the past decade and Dr. Sinclair seems to have shifted his focus to other anti-aging research in recent years.

Dr. David Sinclair and NAD News

Yesterday, Dr. David Sinclair’s work on NAD and its anti-aging properties was back in the news in a big way. There are some very fantastical points made in the article, with the most striking being:

  • Dr. Sinclair is using his own NAD molecule. He has supposedly reduced his biological age by 24 years after taking the pill.
  • David Sinclair’s father is 79 years old, and has been white water rafting and backpacking since starting to ingest the molecule a year-and-a-half ago.
  • Dr. Sinclair’s sister-in-law is now fertile again after taking the pill. This despite that fact that she started to transition into menopause in her 40s. (My note: I assume this implies that she is in her 50s now).
  • Potential increase in human lifespan to 150 years of age.
  • The pill leads to a decline in age related hair loss. (My note: Ironically, I find this to be the most believable of all the above fantastical claims. Even though hair loss is as yet almost impossible to cure in most people. New hair growth in bald regions of the scalp is especially difficult.
  • Human trials still two years away, but Dr. Sinclair aims to release the product into the market in five years.
David Sinclair Companies

Dr. Sinclair is the co-founder of a number of biotechnology companies (Sirtris, Ovascience, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity). He is also the founder of Life Biosciences LLC, a longevity startup. And he is a scientific adviser to many companies, including InsideTracker.

Note: make sure to not confuse Dr. David Sinclair and Dr. Rodney Sinclair (who is also from Australia). The latter is a well known dermatologist and hair loss expert, who I have covered a few times on this blog.

Edit: I posted links to some critiques of Dr. Sinclair earlier in this post. A reader also posted this new one that is worth a read.

Update: July 2024 — Dr. Andrew Huberman and Dr. Peter Attia discuss NAD vs NR vs NMN supplementation and much more. The most popular NAD+ supplement on Amazon is sold by Tru Niagen.

Update: February 2024 — List of 13 supplements and drugs that Dr. David Sinclair takes for boosting his longevity.

Update: March 2023 — Dr. David Sinclair credits four habits that have made his biological age a decade younger. These include: supplements, intermittent fasting, less stress, and exercise. He now eats an entirely plant based diet.

Update: January 2023 — An important new paper from Dr. David Sinclair and his team at Harvard concludes that loss of epigenetic information causes mammalian aging. There is a loss in the cell’s ability to read its original DNA, so it forgets how to function. The team calls this the information theory of aging. And in a new Harvard interview, Dr. Sinclair states that the first person to live to be 150 has already been born.

Update: December 2022 — The US FDA recently announced that NMN can no longer be classified as a new dietary ingredients (NDI) supplement. This means that it is not allowed to be sold in supplement products anymore. However, the enforcement of this ban seems to be nonexistent at the time of this update. Edit: Amazon bans NMN for use as a dietary supplement as of February 16, 2023.

Update: April 2022 — In his interesting new Lifespan with Dr. David Sinclair Podcast, a recent episode covered “NMN, NAD, NR, Resveratrol, Metformin & Other Longevity Molecules.

Dr. Sinclair recently added Spermidine to his protocol; became vegetarian (while still fasting and eating just once per day); lost 15 pounds; and entirely quit alcohol. So we now know that Dr. David Sinclair’s current supplement list in 2022 includes the following:

  • NMN (1g per day in the morning with yogurt).
  • Resveratrol (0.5 mg per day in the morning with yogurt).
  • Metformin (1g per day at night).
  • Statin (for cholesterol control).
  • Spermidine.
  • Vitamin D3.
  • Vitamin K2.
  • Quercetin.
  • Fisetin.

In fact in December 2023, Dr. Sinclair mentioned that Resveratrol and Fisetin (both SIRT1 activators) induce the proliferation of hair follicle bulge stem cells. This in turn promotes hair growth.

Most importantly, the February 9 , 2022 podcast covered hair loss and grey hair in detail. It seems like the doctor trusts the studies that tout the benefits of laser hair growth devices and PRP.

David Sinclair, NAD and NMN Updates

Update: April 22, 2021 — NMN improves muscle glucose metabolism per new study.

Update: April 2020 — A new paper from China concludes that NMN is a promising molecule for therapy of various diseases. Likely via the targeting of NAD+ metabolism.

Update: January 14, 2020 — Dr. David Sinclair is participating in a Reddit AMA on January 14th from 4-6 pm EST. Official link. He will cover NAD, NMN, NR and resveratrol supplements. I hope someone asks Dr. Sinclair about his 80-year old father’s hair quality (the latter takes NAD supplements).

A recent interview with Dr. Rhonda Patrick is also worth a watch. AS is this Dr. Sinclair talk at Google in 2019.