Category Archives: Senescent Cells

Huge Week for Anti-Aging Research in Mice

I have covered anti-aging research on this blog a few times in the past: partly because aging reversal can often imply hair loss reversal; and partly because I also cover medical items of interest once a month. This week was one of the best ever in anti-aging research, especially for mice (and their fur). A number of people have posted links about some of the below developments in the last post (with special thanks to commentator “Netshed” who was especially prolific), and several people have also e-mailed me relevant links.

Senescent Cell Destruction Results in More Youthful Mice

For many years, scientists have known that the quantity of senescent cells (i.e., aged cells that have stopped dividing) correlates with aging in humans. More recently, research has suggested that senescent cells also damage other nearby healthy cells. So, not surprisingly, some scientists have conducted experiments to see if removing these old senescent cells (ideally, without damaging other normally functioning cells) reversed signs of aging and increased life expectancy. A few experiments in mice have suggested the answer to be in the affirmative (e.g., this one from 2011 and this one from 2015). There is now even a name (senolytics) for the class of drugs that can kill senescent cells.

This week, a groundbreaking study (led by Dr. Peter de Keizer) from the Netherlands found that a drug that they developed to kill senescent cells causes dramatic improvements in mice health and essentially reverses their aging. For our purposes, the most important thing was that these mice saw regrowth of healthy fur/hair! Key photos below (green arrows on rightmost column show hair regrowth in almost all mice after FOXO4 peptide ingestion):

Mice hair regrowth from destroying senescent cells

The team behind this research plans clinical trials in humans in the near future. There are literally 100s of articles on this development, and various scientists from other countries have been quoted as saying that this development is potentially a huge breakthrough in anti-aging science. Two contrasting sources here and here.

Addendum 1: In case anyone got the wrong idea from my recent post on obesity perhaps benefiting scalp hair, this study is worth reading.

Addendum 2: Specially for Mr. “nasa_rs”: “JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age“.

David Sinclair Update

I have covered anti-aging Harvard-based Australian researcher Dr. David Sinclair (widely associated with resveratrol) once on this blog before here. In a new paper, him and his colleagues have found a way to protect a mouse’s DNA from damage via boosting NAD+ levels, and they are supposedly ready to test it in people. Dr. Sinclair in some ways is the Dr. George Cotsarelis or Dr. Ken Washenik of the anti-aging world. You decide what I mean by the above sentence.

Note that there is also a Dr. Rodney Sinclair who is a famous hair loss researcher that I have covered a few times on this blog. He is also from Australia.

Young Blood Without the Need for a Donor

In recent years, a number of scientists have been researching the fascinating subject of whether older people can be rejuvenated by the infusion of blood from the young! Billionaire Peter Thiel is especially interested. However, one major problem with this strategy for older non-wealthy people is that there might not be enough young healthy donors with the correct blood type willing to donate at reasonable prices. However, this week, scientists from Germany published research that could be a workaround for this problem. Just make old blood young again (in mice) via the addition of osteopontin protein and forget about the young. After all, “youth is wasted on the young”.

Brief Items of Interest, February 2016

Hair loss news first:

— Thanks to commentator “nosyu” from Japan for posting a link with news from today regarding hair and skin focused Japanese company Adjuvant Cosmetics, the renowned Dr. Takashi Tsuji (RIKEN Center for Developmental Biology) and Organ Technologies getting into some kind of partnership agreement.  The Japanese to English translation did not work well enough for me to gather all the details. Make sure to do a  search on this blog for Dr. Tsuji to read past posts that I have written about him.

— Since I started writing this blog, of all the researchers and companies involved in the hair loss world, Replicel has by far and away provided us with the most regular updates.  This past month has been no exception.  Here is a new video with Replicel’s CEO Lee Buckler starting his presentation at 16:11.  The presentation was part of the Japan External Trade Organization (JETRO)’s “Investing in Japan” conference in Toronto, Canada that took place on January 29th 2016.  The focus of the conference was on Japan’s booming regenerative medicine market.  Lee also discusses Replicel’s partner Shiseido.  From the same conference, here is a pdf of Lee’s presentation.  And finally, here is a new letter from the CEO.

— The latest issue of Nature Biology has an interesting article titled “Biotechs target stagnant baldness market.”  Only half the article is visible for free online, but you can find some hair loss forum threads where people are posting links to the full article.  Some of those links came up with security warnings on my browser, so I am not posting them here.  My favorite and at the same time least favorite sentence from the article:  “It’s been 25 years since Propecia (finasteride), from Merck of Kenilworth, New Jersey, was approved by the US Food and Drug Administration (FDA) in 1992.

— Study from Japan suggests that COL17A1 (collagen gene) could be a new target for therapy in preventing hair loss.

Kerastem clinical trial page was updated at the end of January 2016.  Go under the locations section of that page to see if there is a clinic near you where you can volunteer.  US only for now it seems.

Excellent new article summarizing latest hair loss treatment options.  One of the co-authors is the famous Dr. Antonella Tosti.

Polichem (which is working on a topical Finasteride product called P-3074) was purchased by Spain’s Almirall.   Also see this new positive study from Italy on P-3074.

— Did Dr. Bernard Arocha just perform the first ever documented ARTAS beard transplant?

Irish men are increasingly opting for hair transplants.  Is a reduction in alcohol consumption next?

And now on to medical items of interest:

Partisanship in the US hurting 21st Century Cures Act.  Thank goodness for Japan, Canada and probably some other countries by now.

— I have discussed Dr. Anthony Atala and the Wake Forest Institute for Regenerative Medicine several times on this blog before.  This week, both were widely covered by the media due to the completion of their 3D bioprinter that can make bone, cartilage and muscle (a culmination of 10 years of work it seems)!  Full journal article here.  No mention about hair in there, but a Canadian team’s 3D bioprinter related article from 2014 mentions the eventual feasibility of adding hair follicles to the new skin.  Some quotes from Dr. Atala here.

UK scientists get gene editing go ahead.  Now western scientists may become less prone to criticize the Chinese too much as they did last year.

Oldest heart transplant recipient dies 33 years after getting a new heart.  Amazing story.  In another article I read, his son said that he died from kidney problems and still had no heart problems.

— If you have older family members that you want to live longer, you might want to try to find a sketchy doctor who can help remove their senescent worn out cells without government approval.  Or ask Liz Parrish for advice on South American clinics.

A major boost for cryonics.

A major boost for cancer treatment.

— This week “New Scientist” had an interesting article titled “First fully approved off-the-shelf stem cells launch in Japan.”  You have to register to read it, so here is the pasted version.