Redensyl, Capixyl, Procapil and Baicapil

Of the hundreds of hair loss products and peptides that are based on natural hair growth ingredients, only several dozen are well known. Among these, there are four whose names end in “yl” or “il” that I have heard mentioned a few times recently. These four are:

  1. Redensyl.
  2. Capixyl.
  3. Procapil.
  4. Baicapil.
  • Redensyl™ is a trademark of Givaudan (Switzerland) that is produced by subsidiary Induchem.
  • Capixyl™ is a trademark of Lucas Meyer Cosmetics (IFF — US).
  • Procapil™ is a trademark of Sederma (Croda — France).
  • Baicapil™ is a trademark of Provital (Spain).

Taken individually, I would not care much for any of these peptide based products. I do not believe that any of them can be as effective as Finasteride or Minoxidil. The later two are still the only ever FDA-approved drugs to treat androgenetic alopecia.

Redensyl, Capixyl and Procapil Combination

However, it seems like there are nowadays a number of compounded products on the market that include more than one of these four ingredients. I list some of these “combo” products later in this post. You can get both serums and shampoos containing these combination ingredients.

Last month, a reader e-mailed me a link to a 2019 Turkish study that analyzed Redensyl plus Capixyl plus Procapil (“RCP”) combination topical hair loss treatment. The surprising conclusion was that it grew more hair in users than topical 5% Minoxidil. One of the before and after photos with clear new hair growth is pasted below.

Note that this “RCP” product is currently reserved by the Turkish Patent Institute under the name “Procare”. In the above mentioned study, the description of making this combination product seems relatively simple.

Redensyl, Capixyl and Procapil Hair Growth Treatment
Redensyl, Capixyl, and Procapil Hair Growth Before and After Photo. Source: Karaca N, Akpolat ND (2019). J Cosmo Trichol 5: 140. doi:10.4172/2471-9323.1000140

Redensyl

iRestore Redensyl Serum.

On Amazon, laser hair growth device manufacturer iRestore makes a Redensyl based Anti-Hair Loss Serum. Redensyl stimulates stem cells and human fibroblasts from the dermal papilla to increase scalp hair growth.

Redensyl contains a combination of botanical ingredients as well as Dihydroquercetin Glucoside
(DHQG) and Epigallocatechin Gallate Glucoside (EGCG2). The latter has anti-inflammatory properties via the reduction of IL-8 release by keratinocytes. Redensyl is often described as a hair galvanizer that acts at the cellular level.

Capixyl

Capixyl is a biomimetic signal peptide complex (acetyl tetrapeptide-3) that is combined with a red clover extract rich in Biochanin A. Red clover is known as trifolium pratense, which has proven hair growth and hair density increase benefits. It does this via the inhibition of 5-α-reductase activity; reduction of inflammation and cytokines; and stimulation of extracellular matrix (ECM) protein synthesis in the hair follicle vicinity.

Procapil

Procapil contains three plant-derived substances:

  • Oleanolic acid, which is extracted from olive leaves.
    It inhibits 5α1 and 5α2 reductase enzymes, thereby reducing dihydrotestosterone (DHT) related hair loss.
  • Apigenin, a flavonoid extracted from citrus peel. Aids in vasolidation and increases blood flow to the hair roots.
  • Glycinehistidine-lysine peptides, which boost pro-matrix
    metalloproteinase activity. This in turn benefits the metabolic
    requirements of hair follicles.

Further reading: Reduction of Hair-loss: Matrikines and plant molecules to the rescue.

Redenhair Hair Serum
Hair Serum containing Redensyl, Procapil and Capixyl.

Update: Reader Tim pointed out that RevivHair Max Hair Stimulating Serum contains: Redensyl 5%; Acetyl Tetrapeptide-3, the active peptide in Capixyl; and Biotinoyl Tripeptide-1, the key peptide in Procapil. Moreover, it also contains Myristoyl Pentapeptide-17 (keratin stimulating peptide), often used to make eyebrows and eyelashes thicker.

Update: Reader George found an interesting hair regenerator serum product from Spain-based Redenhair. It contains 3% Redensyl, 3% Procapil and 2% Capixyl.

Baicapil Joins the Club

A lesser known but still popular product is Baicapil. It contains a combination of three key botanical ingredients:  Scutellaria baicalensis, soy sprouts and wheat sprouts. Scutellaria baicalensis contains Baicalin, an important ingredient in traditional Chinese herbal medicine. Baicalin is thought to increase hair growth via increasing canonical Wnt/β-catenin signaling and activating dermal papilla cells.

More Hair Naturally 9
More Hair Naturally 9: Hair Loss Treatment.

On Amazon, there is a super expensive product called “More Hair Naturally 9: Advanced Stem Cell Therapy For Thinning Hair”.

It contains clinical strength Biacapil, Redensyl and Capixyl. It also contains mountain ginseng root, bamboo sprouts and stem cells from adult human fat cells.

— Also available on Amazon is United Pure’s Baicapil plus Capixyl based combination shampoo.

Interestingly, reader “Toccata” posted the below comment on this blog in January 2019:

“A few posts ago, John Doe mentioned a company — More Hair Naturally — selling a ferociously expensive, all natural, topical treatment. I noticed it shared a lot of the same ingredients as another topical I bought last year. The difference being I paid $17CAD for 60ml and they are charging $125US! for 50ml.

The topical I bought is: Multi-Peptide Serum for Hair Density.

It was a whimsical purchase that I thought would be for an occasional ‘whatever’ application. But now that I’ve looked closer at the actual studies of the ingredients, I might give this a legitimate daily 12 month trial run. I also microneedle and use Minoxidil so I won’t be able to make a reliable judge on its actual efficacy.”

I assume that Toccata did not see any miracle results with this potion, but nonetheless quite interesting.

57 thoughts on “Redensyl, Capixyl, Procapil and Baicapil”

  1. Re: Capixyl

    I’m a chemist that formulates cosmetics. 90% of what you’ll find in Sephora comes through my lab. We use red clover extract in eye lash serums as a natural and less expensive alternative to Latanoprost. It’s just as efficacious.

    1. Hello @Rick+C.
      Very interresting ! On what pathway red clover extract works ??
      Did you tried to formulate a topical for hair with pretty good results ?

    2. > Comparing a crappy natural extract which has nothing to do with prostaglandins (might even decrease its expression) with a full pgf2a analogue? Really?

    3. @ admin, there is a reddit post of someone claiming their doctor told them to take Redensyl instead of minox. There then people published they compared it to 1% minox. Idk, but I can post the link if allowed or one can just type in the keywords.

      1. Srsly? what type of doc? lemme guess: dermatologist?

        Someone should come out and explain how redensyl is supposed to work.

        Redensyl is according to their study composed of almost no actives: https://i.imgur.com/rQj46h4.png

        And then in lotions they dilute it further to 1-5% depending on the product.

        Same with the iRestore study they show on Amazon. 7-10 days invitro, probably with pure redensyl, where you have no further dilution, and can bath the hair follice 24/7 in it. I could also get into minoxidil timeframes and concentrations but the data is so old, what a waste of time.

        I won’t even bother looking into the others. All nice sounding trademarks with little to nothing behind it. These kind of studies are usually poorly done under conflict of interest.

      2. Sure, post the link. If the comment does not get approved, it went to spam. Let me know and I can bring it out of the spam folder.

    1. There’s that ‘The Ordinary Multi-Peptide Serum for Hair Density’ Admin linked above. It has Redensyl, Capixyl, Procapil, Baicapil, AnaGain, Caffeine, etc.

      Honestly, I used it occasionally, no more than half of one bottle and just kinda forgot about it, no idea at all if it’s good.

      The Minoxidil I used never moved my hair for better or worse in either direction (still NW4) but my scalp peeled which would periodically force me to stop topicals. I just bought the foam version so perhaps now I can truly commit to this Microneedling + Minoxidil unimpeded. Here’s hoping for a miracle.

      1. Sorry. Didn’t mean to hint there has been one. I just meant we all know how many disappointments there have been in the last few years when it comes to potential breakthroughs.

        It kinda feels inevitable that there is one coming from Tsuji, and I think if it does come, it will be the final hammer blow for most people who were hoping for something other than the self inflicted, slow chemical castration we’re currently undertaking with big pharma skittles.

        1. I dont think it will fail, I think its going to be delayed. With the whole virus, trials all over the globe are cancelled because they can’t examine test subjects in person, so they have to redo the trial. Usually when you emailed Shiseido or replicel or any failing company they responded. Kyocera, organ technologies and all 3 of Tsuji’s emails are dead ends. They won’t respond. Maybe thats a good thing. Try emailing apple about a top secret project. You think they’re going to return the email?? Thats what we sound like. I will say this. They should of released an update like they stated a year ago. So I agree with you on that

        2. I don’t think it will fail. Dr tsuji’s thing is unlike any other hair method that has failed in the past. You wanna why replicel failed it’s because they Didn’t clone the actual follicle and then transplant it to the bald area. If you watched the 2012 video from replicel and You thought that you could grow a full head of hair, you might as well give all your money to a Indian scammer then lol.

        3. “..it will be the final hammer blow for most people who were hoping for something other than the self inflicted, slow chemical castration we’re currently undertaking with big pharma skittles.”

          This made me laugh pretty hard. That said, I *wish* that worked for me. My hair loss seems to be autoimmune (hypothyroidism), and naturally I’m allergic to PPG (liquid minox was an absolute disaster, foam minox seems to have no effect). :/

  2. Hey Rick, how can someone like me get access to the Red Clover extract as a liquid? Does it darken eyebrows as well?

    1. would love to have a link for a high dosed red clover extract product for eyelashes aswell

      any side effects similar to those noted when using prostaglandine analogue ?( darkening of upper eyelid/ or fat atrophy)

      thanks

      Admin do you know if winlevi is still going to be released next year thanks again

  3. Everyone is focusing on the clover now! The main point of the article was that there are products on the market that combine 2-3 of the 4 mentioned trademarked peptides into one potion. The Turkish study described a not too difficult process of combining 3 of the peptides. Interesting.

  4. Reviserum max stimulating serum includes these ingredients, including 5 percent redensyl. (It also contains saw palmetto, just as a warning to anyone sensitive to dht suppression).

    1. Thanks, but I thought it only included 1 of these 4 ingredients. Will recheck. They followed me on Twitter after I published this post!

      1. No problem. I haven’t posted the link, but it looks like I was mistaken and it contains 3 out of the 4 (it doesn’t contain Baicipil).

  5. If this stuff would really work it would already be something bigger than what it really is… I keep my hopes up for Tsuji

  6. I don’t know why we are talking about capixyl again when years back it has been proven to be BS on multiple forums.

  7. You missed Kopexyl, my doctor in Brazil has always prescribed me this one with Minoxidil plus Prohairin. I’ve never even looked them up online util now haha

    1. Have Stemson and Rapunzel been fully tested and ready for release? Can’t find anything on their website which says how far they are along with their product. These both look like they could take ten years minimum?

      1. When Stemson secured funding from Allergan (June 27, 2019), their press release said: “The investment will advance Stemson’s final product development in preparation for human clinical trials…..” So they appear to have reasonable promise but are still pre-clinical.

      2. Stemson announced last year officially that clinical trials were planned and filed for end of 20 or beginning of 21. Given current circumstances, I would assume it will be some time next year.

      3. I have low hopes for Rapunzel.

        Scientifically top for over 20 years (Christiano, Jahoda) but they are the furthest away from commercialisation. They love to do research, development not so much…

        10 years is reasonable, but imho starting from the first solid reearch-publications of Terskikh which were around 2015. The final paper went public in 2018, where they proofed a robust and safe mass-production of follicles.

        We shouldn’t forget that the research of these technologies always started much earlier; the first papers regarding cell-therapies from Tsuji were in 2007 (!), specifically hair was in 2011 and 2012. So OrganTechs research is 10 years old.

        Oh by the way, Paul Kemp is also going strong. I couldn’t see any postponement in his endeavors, reading his latest newsletter. He in fact is my favorite in terms of being the first to go commercial, his therapy will be already in (limited) use next year. Introduced new researchers, got the funding. Competition is crucial, also for Tsuji!

        1. Don’t lower your hopes too much for Rapunzel; they have a pretty solid plan using the robotic hair restoration surgery already in use:

          “Using 3D-printing approaches, our goal is to engineer HFs as follicular units that can be integrated with surgical robots and facilitate effective hair transplantation surgery. […] Adaptation of this new technology by hair researchers, hair restoration surgeons and the pharmaceutical and cosmetic industries will have overwhelming implications in the maintenance and regeneration of this complex human tissue.”

          — According to their study they can generate 5000 hair follicles from a small 0.5 cm2 tissue sample. And they know how to grow it in the proper direction. But they do need our impatience behind them. Jahoda published this 36 years ago! https://www.nature.com/articles/311560a0

          “The eventual application of this work to human hair replacement techniques can also be envisaged.” —1984

          1. Well that proves me right, doesn’t it? That’s what I said: they are researchers, not developers. They are researching now for almost 40 years and gained a gigantic amount of knowledge, but developed nothing which would be of help. Which is almost a shame.

            On the other hand it says one thing for certain: how incredibly far ahead Jahoda has been, pure genius. Imagine they would have started seriously developing in 1984? Man, we would have had an additional weapon for 20 years now!

            Rapunzel won‘t happen. I hope they prove me wrong.

        2. The technology is proven. They used human hair cells on animal trials. At this point its not a matter of if but when. When you multiply cells they lose their ability to perform the same functions. Proteins denature, etc. So maybe they had an issue where they couldn’t take one hair follicle and multiply it 10,000 times. I read an article from 2019 that organ technologies and Tsuji discovered the right number to be 7,000. After that the cells stopped working normally. And keep in mind they discovered a cell multiplying technique that multiples cells, 7,000 times. The most people could do before was 2. They just used a scaffolding technique which is brilliant. Price will definitely be for rich in beginning. But people don’t understand. Nobody wants to be the first to use this because nobody knows if it produces cancer or not. So if it WORKS, then it will get fast tracked for fda approval in U.S and other companies will do the same thing. Like I said matter of when not if. Like I said, I’ve been research hair for 5 years now, in med school. In my opinion this gets released in 2023, 2024 other companies start launching stuff, 2025 real results come in, 2026 global release.

          1. Hahaha! See you back here in 2026 with the next installment of “Don’t worry guys, just 5 more years!”

  8. Does it make new hair appears in completely bald areas or it just increase the density? Is it equally efficacious in temple region?

    1. Older people are more likely to be bald. Older people are also more likely to die from Covid.

      Also, bald people have higher rates of heart disease. People with heart disease are more likely to die from Covid.

  9. Question for admin and anyone else:

    On various forums, I have seen people say that they use various treatments to attack hairloss from various angles.

    At the moment, I can’t take finasteride (trying for baby) so I would like to try other options. What should I be looking at?

    – I got oral minox from derm (just started. Low dose)
    – I have foam minoxidil.
    – I have Nizoral.

    What else should I add to my regimine? Oral treatments are preferable, but I’m open to anything that could lead to visible thickening.

    1. Stay with minoxidil and nizoral, if I were you I wouldn’t take oral minox..
      I stopped taking finasteride for six months and nothing happened.

  10. I have a oil that contains Redensyl but not Capixyl. Capixyl had worked great for me lately. Will the Redensly work as good as Capixyl? Is it okay to shift from Capixyl to Redensyl?

  11. Hi
    I have been using The Ordinary Multi-Peptide Serum for last few weeks.
    based on the product info their serum contains
    REDENSYL™ complex (with Larix Europaea Wood Extract and Camellia Sinensis Leaf Extract), Procapil™ peptide complex (with Biotinoyl Tripeptide-1), CAPIXYL™ peptide complex (with Acetyl Tetrapeptide-3 and Trifolium Pratense Flower Extract), BAICAPIL™ complex (with Scutellaria Baicalensis Root Extract, Triticum Vulgare Germ Extract and Glycine Soja Germ Extract), AnaGain™ (Pisum Sativum Extract) and High-Solubility Caffeine (1% net Caffeine by weight).

  12. Same. Have been using The Ordinary RCP serum + microneedling for ca. 2 months at this point (2 bottles). I can’t say for certain given the short time frame, but IMO all of these peptides are trash.

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