Hair Loss Cure 2020

A few months ago, I heard about a relatively new company named Replenology. It is headquartered in Canada, and produces a natural hair growth product with 21 key hair growth pathway targets.

Replenology Hair Growth — Replenology supplement, serum, shampoo and conditioner.

This week, someone on our chat mentioned Arbor Life Labs and its ALRV5XR hair growth product.

Upon further research, I discovered that Replenology^® is Arbor Life Labs’ branded version of its ALRV5XR hair regeneration product.

Replenology: 21 Hair Growth Pathways

I am very skeptical about natural and botanical products for hair growth being able to reverse baldness. However, countless studies have proven that natural products are able to make existing hair thicker and stronger. In some cases, even reverse recent hair loss (at least temporarily).

In recent years, things such as propolis, sandalwood and seaweed have all been in the news for their hair growth properties. The most famous natural product to benefit scalp hair is saw palmetto via its modest dihydrotestosterone (DHT) blocking activity.

While their Instagram is not updated regularly, I found Replenology’s website content to be of high quality. In particular, their amazing “21 to Grow” brochure (the product targets 21 factors or pathways that contribute to hair loss). The active natural ingredients (expand below image) target different molecular pathways that promote hair growth. Although I am still skeptical, kudos to this company for making such a great effort. Make sure to also read my past post on natural DHT blockers for hair growth.

Over 200 Ingredients

The number of ingredients in Replenology’s product portfolio (capsule supplement, follicle serum, shampoo and conditioner) easily exceeds 200. The below screenshot only lists the active ingredients. See a more complete list here.

Replenology ALRV5XR Active Ingredients — Replenology ALRV5XR active ingredients for hair growth.

Hair Follicle Health

The Replenology formulation targets seven key area of hair follicle health:

Growth factors.
Circulation.
Anti-androgens.
Follicle protection.
Hair stem cell stimulation.
Immune regulation.
Nutrition.

Among the natural ingredients include ones that reduce DHT; inhibit PGD2; inhibit the COX enzyme; inhibit the interferon (IFN) class of cytokine proteins; increase good (when it comes to hair growth) interleukins (IL-10) and decrease bad ones (IL-1 and IL-6); and block the negative effects of TNF-α and TGF-ß on hair cells;.

The formulation also further activates the Wnt/ß-catenin pathway to increase cell proliferation; influences the SHH (Sonic Hedgehog) pathway and induces the anagen (growth phase) of resting hair follicles; inhibits the bone morphogenic protein (BMP-4); stimulates the noggin protein; activates mTORC1 (target of rapamycin); activates FGF-7; inhibits FGF-18; activates hepatocyte growth factor (HGF); activates insulin-like growth factors (in particular, IGF-1); activates vascular endothelial growth factor (VEGF).

It is hard for me to believe that one oral supplement (even if combined with topical shampoo, conditioner and serum) can do all the above. Especially beyond a modest efficacy level. At present, you cannot find Replenology products on Amazon, so no reviews and ratings on that site.

In any event, I am glad that someone has finally tried to come up with an all-encompassing hair loss product. Something that I implied in my 2019 post on “creating the ultimate hair loss drug cocktail“.

ALRV5XR from Arbor Life Labs

Arbor Life Labs completed separate safety and efficacy clinical trials for male and female androgenetic alopecia patients in 2020. Both trials entailed 46 subjects each. The treatment entailed a dietary oral supplement of ALRV5XR, a hair follicle serum, a shampoo and a conditioner.

The company’s current pipeline indicates that ALRV5XR trials are complete. This is probably because you do not need three trials for natural products.

Arbor Life ALRV5XR Pipeline — Arbor Life Labs’ ALRV5XR hair growth product clinical trials and pipeline.

The Phase 1 trial results were discussed (separately, for men and women) in the prestigious Lancet journal in 2021. However, note that the lead author Mr. Peter Feldman is also the co-founder and CEO of Arbor Life as well as CEO of Replenology.

September 11, 2021: Safety and efficacy of ALRV5XR in men with androgenetic alopecia: A randomized, double-blinded, placebo-controlled clinical trial. Also in ScienceDirect in October 2021.
June 23, 2021: Safety and efficacy of ALRV5XR in women with androgenetic alopecia or telogen effluvium: A randomized, double-blinded, placebo-controlled clinical trial. See the PR News article from October 19, 2021 (included a before and after photo).

The findings indicate that ALRV5XR caused new terminal hair growth in both men and women. Arbor Life’s patent for ALRV5XR is pending, and is titled as:

“Botanicals as Wnt/β-Catenin Activators, Molecular Pathway Regulators, Tissue Regenerators and Health Biomarker Regulators.”

New Hair Loss Chat

September 20, 2020

Recently, one of this blog’s readers encouraged me to create a hair loss chat on Discord. After a day of hesitation, I started the chat last week. So far, it has been going great with no spam. I initially only invited people who emailed me useful intelligent information at least a few times over the years.

I now want to invite other serious people so that we can get at least 100 regular participants. If you are interested in joining, please post a comment in this post under your existing username. If possible, also use a legitimate email address. Thereafter, email me using the same email address and let me know your blog username and why you want to join the chat. Also your city/state/country location. If you do not post comments on here but have a solid posting history on any of the hair loss forums out there, let me know too for verification purposes. If all seems ok and I feel like you will not spam the chat, I will send you an invite link. My e-mail can be found in the contact us page. Make sure to check your spam folder for my reply in case it goes there.

Initial preference will be given to those who have made mostly useful comments on this blog in the past. These do not have to be scientific comments. As long as you have been courteous, I am okay with your participating in the new chat.

For the most part, this chat will help people looking to compare their existing hair loss treatment regimens with others and make improvements. Including by using newer products, delivery mechanisms and alternative or esoteric ingredients. I hope to benefit from this information too.

I would not recommend joining the chat just to always vent. Nor just to always complain about delays in future hair cloning and hair multiplication related prospects and trials. Some venting and complaining will be acceptable. The moderation in the hair loss chat will be strict. If anyone posts dozens of emotional comments in a day with nothing useful to say, they may get banned.

If anyone looks like they are there as a hair transplant surgeon representative or are primarily there to promote specific products, they will be banned. If anyone keeps repeating that there will never be a hair loss cure, they will likely get banned. Any excessive cursing or insulting of other chat participants will be grounds for being booted.

I am sure that 100 percent scientific and technical discussions can get dull and dissuade those who are not interested in chemistry and biology. So I will give some leeway for off-topic comments. At least in the general chat channel. I will rarely have more than a few hours a week of time to devote to the chat. So if you join, please try not to message me privately unless absolutely necessary.

Discord Channels

In chats on Discord, you can break things into channels to separate key subjects of interest. Among the hair loss related subjects that most interest me at present include:

The related subjects of At-Home Microneedling, Dermarolling, Wounding and Follica. I may start microneedling myself if motivated enough by success stories.

Oral Dutasteride for hair loss reviews. Also mesotherapy and topical Dutasteride.

Topical Finasteride. Especially Polichem’s P-3074.

Oral Minoxidil.

Dr. Takashi Tsuji and Riken.

Exosomes.

Breezula.

Please do not be disappointed if you are not invited immediately. I want to be selective initially and see how it goes. I do not want to waste my time again by accepting spammers, trolls and overly negative people.

October 31, 2014 — Hair Loss Chat

I recently installed chat functionality on this site. I initially allowed anyone to post, but due to spam, you now have to register. If popular, I might pay to get a better chat on the site in the future. The current one is based on a free plug-in.

Also, if people are keen, I can arrange a once a week fixed chat time when many people show up at the same time. I cannot promise to be there each week. Please post recommendations on the time and day when you prefer to chat under the comments to this post. Try to post Eastern US time preferences to keep things easy for me. I am located in the Pacific zone.

Replenology: Arbor Life’s Branded ALRV5XR