Bimatoprost Results are Finally Out

At the beginning of this year, I published a detailed post on Allergan’s Bimatoprost product.  In that post, I stated the following:

My feeling is that Bimatoprost may result in slightly superior results to Minoxidil, but nothing extraordinary.

***I am pleased as well as slightly disappointed to say that I was probably correct (read the rest of this post).

At the end of January 2015, Allergan was supposed to have finished its phase II clinical trials regarding using Bimatoprost to treat scalp hair loss.  However, those results have not as yet been published, although…

Allergan Finally Releases Some Information on its Results of Treating Hair Loss with Bimatoprost

On November 4, Allergan published two interesting pdfs on its website that can be downloaded.  On pages 16 and 17 of one of those pdfs, there is a surprising and unexpected summary of the initial results of using Bimatoprost to treat people with hair loss.  I am assuming that these results are from the earlier mentioned clinical trials. (Note that the pdf also includeds some information on Allergan’s more exciting Setipiprant product to treat hair loss).

It seems like Bimatoprost 1% and Bimatoprost 3% both result in slightly superior hair growth in comparison to Minoxidil 5%, based on an “Expert Panel Review” and based on an “Investigator Global Assessment.”  Hopefully the experts and investigators involved in those reviews are unbiased and not employed or funded by Allergan.

Funnily enough, Bimatoprost 1% has slightly better results than the higher dose Bimatoprost 3% according to the “Expert Panel Review”, although the “Investigator Global Assessment” finds the opposite to be true as one would have expected.  When it comes to actual volunteer opinions based on non-scientific self-assessments, Minoxidil results seemed to be slightly better than Bimatoprost results.

We Have Become Spoilt & now Expect a new Hair Loss Medication Each Time There is a new Version of the Iphone or Galaxy

The overall mood of hair loss forum members regarding this news has been slightly pessimistic per my analysis.  On the one hand this is very surprising considering that to date there have only ever been two FDA approved drugs to treat hair loss on the market (Finasteride and Minoxidil), and Bimatoprost will match or slightly exceed the results of one of those two (Minoxidil) and work via a different mechanism.  Just a few years ago, millions of people around the world were delighted that Minoxidil (Rogaine brand) was finally released in a foam version.  The old liquid version was extremely irritating for many people and often dripped down people’s foreheads.  Last year, women were also pleased that Rogaine had finally released a 5% version for females.  All in all, there are numerous people out there who find Minoxidil to be very useful to slow their hair loss progression and sometimes even halt it entirely.  I hope that Bimatoprost finds similar success.

On the other hand, I am not surprised at all by the pessimism.  In today’s extremely fast paced world where groundbreaking medical and technological advances are announced on a weekly basis (and popular smartphone brands come out with new versions of their bestselling models almost every year), many hair loss sufferers expect a 100 percent foolproof hair loss cure immediately, or at the very least, a new hair loss drug every six months!  Nothing less is worth getting excited over.  While not particularly impressed by these results, I am still pleased that we could finally have a third FDA approved weapon in the fight against hair loss, and one that acts via an entirely different mechanism (prostamide F2α analog) to Finasteride or Minoxidil.

Other Notes

— Even if Bimatoprost does consistently produce superior results to Minoxidil with no significant side effects, we are still at least 2-3 years away from actual product release.  However, lower dose versions of Bimatoprost have already been in use for eyelash growth (via the brand name Latisse) for a few years now.  I am guessing that some hair loss forum members will continue to try to make their own higher dose versions and play around with topical delivery mechanisms for the scalp, although the current cost of Bimatoprost makes it very prohibitive at higher doses for the vast majority of us.

— In my post on Allergan from a month ago, I was thinking that it was worth buying the company’s stock.  Since then, AGN has gone up by 10 percent!  The main reason for this is due to the fact that the world’s largest drug company, Pfizer, has recently expressed interest in purchasing Allergan for around $120 billion.  The primary reason given is that Pfizer would then benefit by drastically lowering its tax bill by adopting Allergan’s headquarters in Ireland (US corporate tax rate = 35%, Ireland corporate tax rate = 12.5%).  I think that the two pdfs that Allergan has just published give even more reason for Pfizer to acquire Allergan.  However, it remains to be seen if the US government will allow Pfizer to get even bigger than it already is and at the same time pay far less taxes to Uncle Sam.

— Allergan plans to commence further clinical trials for Bimatoprost on scalp hair in the first quarter of 2016.

270 thoughts on “Bimatoprost Results are Finally Out”

  1. So basically we have to wait 2-3 years from now to just get our hands on a drug which has superior result to Minoxidil ?! Everyone please rise and take your hats off in honor of these great scientist who brought us such a great treatment, after that somebody please do me a favor and shoot me in the head !!!

  2. Admin or someone can answer the question? Thank you guys
    1. bimatoprost is gonna be in the market in 2016?
    2. you think is better than min or fin?
    3. what do you think about swisstemple? he regrow almost all the hair in temples, i just saw it. how long is gonna take to hit the market? looks like the ‘cure’

    Thanks in advance

      1. I don’t see much sense in releasing a drug that will just enhance slightly the results of the the ones that already exist (after some 20 years, amazing isn’t it?). It had to be more impressive!

        The kind of change that would revolutionize the bio tech medical world is a drug that yields the kind of results achieved in the AA experiment. That was BIG!!

          1. I think their plan is to have Big and Seti complementing each other. doesn’t make sense to release what is effectively an inferior minoxidil at a dearer price.

  3. You see, there is alot of info now about regrowing hair. There are alot of young students that will make secretly a solution. The hair-industry is allready lost. To much info was giving away.


    1. I don’t think it will show anything. I mean if he had great results, he would have shared them. I’m an expert when comparing photos and nothing I see on his pics is really interesting. He always had some darker fuzz on the temples.

  4. I knew to never get my hopes up for this crap. Or any treatment to be exact. It has to be a stem cell based solution to have any chance of kick starting decent hair growth. Latisse is meant for the eye lashes not scalp. The funny thing is this will be released in 2018 as the next best hair loss treatment and marketed like crazy for those who are dumb and have no clue about the industry like we do. We are just .000000001% whike the remaining will go out and buy latisse and make allergen tons of cash. Big Pharma is lookinh at dollar signs not our feelings or happiness in life. Let’s cross fingers for samumed and histogen. And hopefully cotsarelis will finally release his wounding treatment in 2016 as a big surprise. We need something new and great asap! I got my hair cut yrsterday and was about to cry on the drive home. It just gets worse and worse every month. We don’t deserve this!

    1. Tofacinitib should be a 100% cure (need confirmation that it will work for male pattern hairloss as it is already proven to work for AA type hairloss). It is already FDA Approved and we could easily get it from a doctor IF it works and no side affects from the lotion form (should not be any but need confirmation).

      The 100% cure might be here just need more tests. Hang on.


          It is not a PROVEN cur YET but there is a chance that Tofacinitib can cure male pattern hairloss. No I have no direct evidence but the research they are doing this year should let us know if it works. And, I think it will work not that is not wishful thinking but BENO from the 1980’s apparently grew complete hair on two men who had male pattern hairloss and BENO was a JAK Type drug just like Tofacinitib. And we also know for a FACT that Tofacinitib can grow 100% hair for AA type hairloss.

          It is sad that they have not done any tests yet for male pattern hairloss using Tofacinitib in a lotion form but again they more than likely will this year (2016) then I believe the results will be Very Positive.

          1. That’s because this is the hardest thing to do in the world!!!: rubbing a little of this thing on a bald scalp for some weeks and see what happens.. No, that is extremely difficult!!!

          2. I know you really believe that it’s a cure, but it’s simply not.

            It’s not even able to cure minority of people with alopecia areata, let alone androgenetic alopecia.

            Yes, there have been few cases, I know.

            But alopecia areata is still a disease with no drugs in the market, so let alone AGA.

            Also I don’t think, BENO, was a JAK inhibitor. It was used for arthritis, but It was actually 5-lox inhibitor, something like, ketoconazole.

            I just felt that I should comment, as you keep repeating it.

            But if you want a more scientific version why it’s most probably not a cure, let me state it here. You know activation of anagen, is different from miniaturization (which is what happens in AGA).

            STAT3 inhibitors tell telogen hair follicles (which are normal physiologically to enter anagen) but the same call wouldn’t work in AGA as dermal papillae in AGA is not capable of inducing matrix cells and Secondary hair germ cell to create a shaft.

            Imagine it like this, a huge guy with huge muscles is told to lift a weight, let’s say 100 kg. This guy can lift the wait as soon as he is told to do that. But a small weak guy is told to lift the weight, and he tries to do so but he can’t. because he is smaller and is weak. The weight is the hair shaft. Different guys are the dermal papillae in normal and AGA patients and the call is stat3 inhibition.

            AGA is not a disease of hair cycle, so I doubt STAT3 inhibitors would work on it.

  5. nasa_rs, may your words become true! I personally believe it works too.. in human tissue grafts it did work already, a good indication I suppose. It just has to be tested ASAP in my opinion in a small open label trial, same way they did in the AA experiment. If really proves to work, then they may conduct a complete trial, then it will be easy to get funding, once they are sure it is a breakthrough, a real one!!

    1. BENO from the 1980’s apparently grew complete hair on two men who had male pattern hairloss and BENO was a JAK Type drug just like Tofacinitib. And we also know for a FACT that Tofacinitib can grow 100% hair for AA type hairloss.

      If it is proven to work then we litterally can walk to our doctor and get a prescription for the lotion form (assuming the lotion form is available) and 3 weeks later ALL our hair back.

      I could be wrong but I believe it will not only solve but be a complete 100% solution to male pattern hairloss.

  6. We have Tofacinitib that has proven to grow 100% hair back on AA type hairloss. Yet, people keep waiting for these Minoxidol type cures to hit the market. Amazes me.

    The 100% cure is probably here it is just a matter of doing a test with a lotion form of Tofacinitib on a male pattern hairloss person to find out if instantly if Male Pattern Hairloss is a thing of the past and that the Nightmare is Finally Over.

  7. “The surprise was when we started using the drugs on alopecia areata patients, when we used them topically the hair grew back much faster and more robustly than it did orally,” Christiano told NBC News.

    [I do not care if this is Off Topic since the topic is about growing back all of our hair and Again I say Tofacitinib will grow back 100% of our hair if used in a lotion form and I say the cure is here]

      1. ITS RIGHT THERE! lol..
        Theres RUX RIGHT NEXT to a proceed to check out button.

        If only we all had a rich friend that knew how to “get a perscription” that also knew someone who could turn the drug topical… we could see what happens before christiano and the government regulatory mud.

          1. LOL this is some serious sh*t that makes propecia look like some sort of child play. I know they say a topical will greatly reduce its effects as it’s not systematically absorbed. I still wouldn’t mess with this stuff.

          2. athmane.. really? I heard the opposite pretty sure christiano said topical is more fast and more effective.. multiple times over.

    1. We can make fund & buy this drug & test on someone who agree to be volunteer. I can provide 100$, if needed then more. I just want the cure. God help us please. We should go for make a fund. What do you think guys ?

      1. As it is already fda proved then I think it will not cause any major effect if we can make it a topical lotion with someone expert.

    2. egghead – you are correct. Dr. Christiano has clearly stated, and it is one of my posts where I directly pasted a quote from her, that she was surprised that the topical form is much better than the pill form.

  8. So…What’s your options egghead? Minoxidil and eat Propecia with pathetic results, no grow long hair and sexual serious side effects? That’s not a treatment come on… We want our hair back…Bald people needs a decent treatment.

    Awesome blog.


    1. So…What’s your problem Paul Pheonix? I’ve never support minox or fin…., “no grow long hair and sexual serious side effects?” Oh haha, you don’t speak english! …learn english before you talk to someone buddy…

      That’s not a treatment come on… (duh no shit!.. oh wait you dont speak english “Yes obviously”) We want our hair back…Bald people needs a decent treatment. Yes Obviously



      1. Paul Pheonix Unbeknownst misconstrued prejudices discombobulate our auspicious yet already discursive premonitions please refrain from your lathy apportionment

        1. Sorry for my English…Don’t be offensive.I’m not American…You haven’t answered my question? Since we are in the same boat, let us think in the same way…no? haha…
          What’s your prediction? Watch…Only wait (HLC 2015 in Miami) you will be surprised….



    1. Nice to email them. But if they have any credibility they would already be doing research on those drugs.

      I am hoping a Pharmacist who gets his hands on the proper lotion form tries it and lets the world know the results. If it works then I am next.

  9. Right now, the only thing we can pin our hopes on is SM04554. The company itself – Samumed – has an excellent track record both in its clinical trials and also the fact it’s highly specialised in its field. Unfortunately, they will be only discussing their phase 1 results at the hair congress.
    Certainly one to watch very closely.

  10. Athmane personally I’m not so excited about Samumed because I don’t think WNT or FGF5 or IGF or addressing any of those can really directly reverse AGA. Benificial? Sure, a cure? no way .But we’ll see as always hope I’m wrong about that.

    Also to my understanding topical Rux Tofac is “more” effective than oral/endogenous in christiano’s words

    1. I am not into the science side egghead, but the way this company is “breezing” through its clinical trials coupled with its specialisation in this pathway signalling field tells me they hold great potential. They have just finished their phase, hence my assertion they are our best hope in the near future
      No doubt JAK inhibitors hold great potential, but then again with the muddied waters of clinical testing and FDA approval, how long till we have a functioning product on our hands. It’s still a long way away.

      1. I think it is interesting, fellas. If Tofac/Rux works, remember it is already FDA approved, but not for hair loss. That doesn’t entirely matter. Avodart is not approved for hairloss, either, but it is used quite a bit. Don’t worry about the FDA approving it so much. If efficacy can be shown, we can get it prescribed.

  11. I am very hopeful that Rux/Tofac can help. When it comes to baldness, I guess I just don’t understand the pathology. If it was merely DHT that caused us to lose hair, then why do we all begin losing hair at different times. Some people start in their 30s, but some start at 18. If it was merely just our hair has a sensitivity to DHT, wouldn’t we all start going bald around the time our bodies started producing it? What about the guys that don’t start until they are 40? Sounds like there is something that happens to the follicle that freezes it. Hopefully, that means that there is a topical that can take the follicle out of its state of gridlock. Maybe I just don’t understand? I am sure you guys know.

  12. from what i understand Ddog DHT has nothing to do with hair loss anymore it’s actually something way more down stream PGD2 PGE2 PGE2ep3 VEGF IGF-1 PTGDS FGF5 WNT progenitor cells (CD) . DHT and TGF-B have long been the ‘culprits’ but they have been claimed to be more upstream and we need DHT to maintain erections, heart health, and various other vital functions.

  13. It’s complicated, isn’t it? The whole DHT thing never really seemed to fit to me because all males have DHT, but go bald at different times. Why would that be if that in fact was the culprit? I have heard of some guys that start going bald at 50. They didn’t just start producing DHT then. Also, if it was a DHT thing, anti-androgens should be the saving grace. They are not. In fact, it doesn’t even work for everyone, despite being successful in lowering DHT for everyone. That seems to be a sure sign that other things are happening.

    1. Ddog, you should know that some very few lucky men never lose hair throughout their entire lives, not even in their 90s… Some races have a very small to even none incidence of the baldness gene, I’ve already discussed that with Curious, maybe you’ve seen it. That is complicated. But it is a fact that androgens (most specially DHT) have a strong relation with inducing hair loss in genetically predisposed people. It is a kind o gene, let’s call it the baldness gene, that is inherited, that should be sensitive to the androgens, or to other substances (such as PGD2) which are affected by the androgens. I mean, it’s tricky.

      As you know, castrated men never go bald. That had been observed in very ancient times, actually. That because they didn’t produce androgens anymore. So, the relation is obvious, what has been recently discovered is that it is not a direct relation, but something that acts, as you put it, downstream in the chain of signaling to the cells. Some men might have this gene more and others less expressed, given their ancestry, and this variation may influence how strong, and faster, their hair loss will show. Therefore, some will bald earlier and faster and others will bald at a later age.

      1. It is interesting though the Eunuchs that are castrated with male-patterns baldness fail to regrow hair though. They stop losing hair, but do not regrow, despite now knowing that the follicles are still active. There is something going on there besides DHT keeping the follicle in optimal hair growth condition. We know it isn’t dead, so what’s up? Why is it dormant?

        1. Their hair is still locked in the dormant face of the hair cycle even without DHT continuing to act on the hair. DHT starts the lockdown, but it is continued without it. Hence why I think topical JAK inhibitors actually have a huge chance of fully restoring hair in AGA

        2. Once they are dormant, miniaturized, it becomes very hard to reverse their state, as all of us know. That’s why it is so important to try to prevent and take anti-androgens or minoxidil even before the hair loss starts.

          But the good news is, it IS REVERSIBLE, it has been proven already. The miniaturization is totally reversible.

          The bad news is, we still don’t know how to revert it.

  14. If you really want the 100% cure then look at the Before and After pictures of the AA type hair loss after using Tofacinitib and Rux.

    They grew ALL their hair back.

    Why am I going to pay attention to any other cures when I have one Proven to grow 100% of hair back. Yes AA type hair loss is different, or is it? The scientists do not know squat about hair loss as they keep discovering new things by complete accident. Just imagine, up to about 3 years ago they did not know that the Hair Follicle in a bald person was still there that the hair follicle was just miniaturized. And waiting to return to its full glory as it will for me by the end of 2016.

    1. Couldn’t agree more, Nasa_rs….

      “Why am I going to pay attention to any other cures when I have one Proven to grow 100% of hair back. Yes AA type hair loss is different, or is it? The scientists do not know squat about hair loss as they keep discovering new things by complete accident.”

      1. All that exists and works, moderately but works, today… Minoxidil, Finasteride and Bimatoprost, all of them!! you know it, was discovered by serendipity!! complete luckiness!!!! lol

  15. It really does show that the scientists really know very little about hairloss. I am really not sure why that is, but they stumble upon treatments when researching other things; however, it seems to me that there is a better chance now than ever of finding a solution. I think the internet is helping with this a lot. People can share information at a rate that was unheard of 8 years ago. Not just regular people, but scientists as well. American culture seems to be more focused on youth/hair than ever as well. The timing may be right. Seems a lot of the hairloss researchers are at an age where they are finally going bald as well. They have a dog in the fight, finally. lol

  16. It seems that to awaken the hair follicles that don’t work properly anymore, we need something radical and it seems that Ruxo/Tofa… are the ones!! What they did to the AA patients was nothing short of extraordinary, a complete cure – NO HAIR TO ALL HAIR BACK! it restored all hair where it was missing, to whoever wants to see it!

    Can it do the same to other types of alopecia, particularly the Androgenic??

    these more recent experiments STRONGLY suggests that YES, it can!!

    It only remains to be tested and, hopefully, prove to be true to what was observed in the last study.

    A question… is this topical tested now the same used in the AA patients? is it the same formula? If some of you have connections with HELLOUSER please send him this question.

    1. Stop spamming. I think you alone have increased the recent comment threads by nearly 50 comments saying the exact same thing. We get it, you are excited but there is no need to read the same thing over and over that you think this is the cure and that all remains is to be tested. We got it, thanks for the input.

          1. fgf11, you’ve made a good point and great analogy to weight lifters back there.

            But, maybe… the drug not only tells the weak skinny HF weight lifter to lift a very heavy weight but more than that, it gives him more muscles and power to make it strong enough to be able to lift it.

  17. The article that states JAK inhibitors helped the old men regrow their lost hair was from 80’s. Why…WHY on earth has no researcher ever thought of experimenting with this stuff on MPB?
    Why hasn’t dr. Christiano thought of using the mighty JAK inhibitors earlier? She must have been aware of that article and its findings, no?

  18. Hello Admin, and commentators all, and thank you Admin for another wonderful insight.
    Any effort toward a better understanding of how to modify the way hair follicles get shrunk by AGA is welcome and appreciated.
    We as a group of interest and potential investors/customers maintain the point that hair follicle cells retain the property to progressively affect hair follicle size and functionality, and accordingly, topical solution will barely be able to delay miniaturization, not to mention fibrosis. If we think about a solution that will turn miniaturizing hair follicle into “healthy” ones, like the ones in back/sides of the head, how could a topical substance ever be able to accomplish this? Editing the genetic material in each and every hair follicle will do this. And this is the most difficult of the solutions, which is one of the reasons why it has never been found yet. Still, if any progress can be reasonably reported and measured, we’re all ears.

    1. Sounds like gene therapy is where we go from here. Still, does this mean that AA does not miniaturize? The hair just falls off even though the progenitor cells are perfectly fine ?

    2. By the way, Androgenic Alopecia, you haven’t really explained why a topical would fail to accomplish healthy hair follicle maintenance. You just basically asked a question like it is obvious and already understood.. It isn’t. Tell us why.

      Editing the material in every follicle certainly would be the ultimate solution, but is it the only one? I think Bio-Viva’s tissue re-engineering looks really promising in terms of keeping hair youthful, just like the skin.

  19. What’s good news is, people are living much longer and are going to be demanding a high quality of life well into old age. We’ll want to remain youthful amd sexually attractive for as long as medical advancements will allow us and I feel (and hope) that this will drive research to find solutions to quality of life problems like AGA. I have hope!

  20. It’s funny yet sad that the next best topical for hair loss is going to produce the same results as rogaine. Actually I have seen pics of rogaine where it did much better than latisse lol. As for side effects, you could expect discolored skin. I use latisse with no results and will end it once my little bottle runs out. I applied it to my temples and it actually caused my temples to thin out so now I just put it on my jaw line to promote beard growth haha. I still have hope for follica and samumed. Everything else has just been slow moving and delayed. Fingers crossed christiano found the cure with jak inhibitors because if she did she deserves a Nobel prize. One last thing, is it that FREAKING HARD TO GROW HAIR lol wtf. I mean 30 yrs since rogaine and we are producing the same results lol. Just sad

  21. This is worth repeating. Beno, the drug from the early 80’s, appeared to have caused two male pattern bald men to regrow their hair, as thick on top as it was on the sides according to the newspaper article. Plus an old man fell into a campfire and later regrew his hair. My guess is he was on a JAK type arthritis drug.

    Why no doctor followed up? Lack of information as no internet back then. Also know one knew hair could grow back they just thought that when people lost hair they would never get the hair follicle back since they did not know it was only miniaturized. They simply thought of it as a Lucky Gene thing.

    Now we know from Dr. Christiano and the new JAK Type drugs that 100% Hair can be regrown even after decades of it being gone.

    I still say these JAK type drugs will regrow hair on Male Pattern Baldness men. Since, how else could you explain the two guys from the 80’s on Beno (JAK type drug) and the campfire guy REGROWING their hair on their bald heads???

    It was due to the JAK Type drugs!!! And guess what, we have better JAK Type drugs (than Beno) today in the form of Rux and especially Tofacinitib.

    The cure should be here. Been saying it for 1 year and the Admin knows I have been saying it for 1 year. I really, really think these drugs will work on MPB,

  22. Hey Nasa I think you make a good point and the evidence is there to bacj up your claims. Now the big question is if it cures baldness do you think this will get released in a couple years or do you think it will take fda 10 yrs to bring it out. You know all the competition in the hair loss world will fight this from hitting the market since it will DESTROY them lol. I hope in 6 months we find out it works and by the end of 2016 we can get it off label somehow. Just for once let modern science help us hair loss suffers

  23. Shouldn’t take years if someone shows it can work. As I mentioned previously, avodart is not FDA approved for hairloss. It doesn’t matter.

  24. Ddog. I agree but only christiano will know the exact topical formula for hair loss. Doctors can prescribe jak but will they know the correct formula and topical carrier ? That’s going to be the challrnge. You Know christiano will have that topical formula sealed, vaulted, surrounded by 6000 heavily armed guards with laser guns haha cure for baldness is worth billions!I wouldn’t be surprised if she keeps the mpb results of jak super confidential until she is ready to commercialize the product.

  25. I hope she isn’t and she helps us out. I mean she should be the last person to hide a working cure since she suffers from hsir loss

  26. Ddog Mjones: making a drug solid to topical does not involve high tech secrecy. It’s something an 19 yearold chemist can do.

    It doesn’t matter whether it’s FDA approved for XYZ .. you can still buy DUT (which is avodart) at inhouse for example and like avodart isn’t approved for hairloss.. you just buy that shit on the internet dude really? who the fuck cares about waiting around for stephen ostroff to take a dump.

    Furthermore there are already patents for TOF and RUX .. there called Novartis’ Xeljanz (TOFAC) and Pfizer’s Jakavi (RUX). If anything hair loss scientist at pen state university are at the very least looking at Novartis and Pfizer stocks because IF this RUX and TOF story works in AGA you can expect those two stocks to carry.

    Also Ddog I’m prety sure AA hairs don’t minaturize it really is an exotic situation much different from androgenic alopecia.. but the story about BENO and campfire bro is really really inspiring for people with AGA.

    edhel: I know WTH, this is the worst teaser EVER. “People, we found a potential cure for AGA were not sure yet, it worked on a human with AA last year with better than perfect results, we know it worked on a guy with AGA in the 80’s with BENO, It’s FDA approved already and has a strong saftey profile, but even better it’s more effective topically and safer and might be quicker to market since it’s already approved … but here is the catch were still staying silent on whether we will test it on men with hairloss thank you for your attention.” lol jesus, has anyone thrown their chair out their window yet?

    1. No No No NO NOOO…

      I had the exact same doubt. I’ve posted it some many times here. Nobody cared.. Well, somebody told me to stop asking everybody, being lazy, and do my research…

      My neglected doubt: Do the hair follicles in AA also miniaturize or they just stop growing hair completely but keep their size normal? I wanted that asked to Dr. Christiano at the congress…

      But, I did my research and found, don’t remember where, that YES, hair follicles in AA also miniaturize!!!!!

      The causes are different but the consequences, to the hair follicle, are very similar, all suggests.

  27. I must say guys, I was really really cynical last week but I learned alot in the past few days that makes me realize the cure is already here.

    Swiss temples proved Dr. Cots theory works….

    I realized it’s dumb to wait and see if Swiss Temples hair gets any thicker because growing hair on the front is not scientifically possible…. according to the PHD’s behind propecia. I’m sure many of you already familiar with that quote.. Temporal hair is not possible to reverse. he did it waaaay up in the front.

    Furthermore these guys are taking Setipiprant already.. shits not even out yet.. explain that.. RUX TOFAC are ALREADY out there. Think about it… Swiss temples uses UV lamps to sunburn himself to get pge2 …Campfire bro burnt his scalp… and 2 AGA victims grow back on Beno JAKs 30 years ago….

    I would say were getting close but swiss temples shows were already here just look at the picture and think about it

    I don’t care how pessimistic or smart you are that’s incredible even for 8 months. those hairs were lost 9 years.. Now this dude is on Seti ….and then on the side is RUX and TOFAC are already on the market .. I know i’m sounding repetitive maybe sensational but I think this is seriously history in the making for tens of thousands of years it’s all like happening right the fuck now.. is that not mind blowing

    1. Swiss results are promising, I agree. But two things in his protocol is scary,
      But few things to consider, UV will goddamn cause cancer. it’s the root cause of almost all melanoma’s.

      Read this:

      So even if it’s legit, it’s actually more dangerous than hair loss.

      also Sulfa has lots of sides.

      1. true i thought of this, I’m not taking no damn sulfa, and skin cancer and UV isn’t life threatening my grandfather has had skin cancer for 35 years and is 92 right now, also essential fatty acids play a role in that from what I understand.

        I’m not saying anything other than I mistakenly or unmistakenly see a correlation between a guy growing his hair back after burning it on a campfire and a guy that is defying medical science from Merck’s propecia research citing you can’t grow back frontal hair by inhibitting DHT… which he clearly has grown back .. so you can’t say it’s the DUT he’s on…

  28. Basically, STAT3 inhibition has been know for a LONG time that it can induce anagen. Actually, lots of drugs are known to do so. Also, as you know when hairs fall in Alopecia areata it usually happens very fast, and it’s different from AGA, as it’s more chronic. So basically, the reversal, or a drug will act acutely in AA but not AGA.

    Also minoxidil or PGF2a will never be a cure, because they make hair follicles stronger without addressing what is going wrong in AGA. So imagine, they can make eyelashes stronger, I mean their effect is general. They can make any kind of hair stronger, but as long as they are not addressing what is going wrong in AGA they can’t be a cure. Imagine it like this, some one who suffers from a familial condition that has elevated cholesterol levels, ( this is actually a case in science, it’s called familial hyper cholestrolemia) these people usually die from a heart attack when still young. Now imagine, we go and research that exercise causes later onset of atherosclerosis. Now, this is good for heart, and it’s scientifically proven. Now we tell these patients to go and exercise like crazy, but they still die. May be the tend to live for a couple of more years but exercise is not the answer. Now the sick is AGA, exercise is PGF2a or MINOXIDIL and normal guys are normal hairs.

    The only cure can come from what address what goes wrong in AGA. only few things can do that, one is stem cell biology, which is years away. I mean decades. One is using CRISPR/CAS9 technology to topically alter genes responsible for AGA, but since it’s a complex disease. It’s not possible to do that. No GWAS studies have been able to completely identify genes responsible for AGA. So we are a decade from that too. The other way is to topically use siRNA’s to silence genes such as 5alpha reductase and PGD2 synthase of GPR44. This is now possible, but we still will face issue as we don’t know what genes to target.

    Also facial/cranial hair follicles are embryologically derived differently from body hair follicles so body hair transplantation would never work. As it would be easier to clone hair follicles than to make that work (as in make it look normal).

    Now, what can we do then? I’ll write a comment in future, about what is a practical scientific way towards a cure for hair loss soon, If I find time.

  29. fgf11 i appreciate your realism i feel like I’m losing mine.
    but how do you explain this

    growing that hair lost from 9 years ago and in 8 months growing it back that thick… explain that..

    Also explain Benoxaprofen and the two guys with AGA reversing hair loss.

    not to sound like the opimist police but you gotta lotta splainin’ to do.

    if you think were 30 years away from a cure explain all that… and also explain why your even paying attention to forums if you absolutely know what you said, and finally explain the “practical scientific way” towards a “cure” for hair loss soon”.. and all the other international PHDs have totally been outwitted of this grand master plan you have.

    1. hey my friend, how old are you?

      When did I say it’s 30 years away? I DO believe it’s not.

      When I say you can’t fly by flapping your arms I don’t mean you can’t fly at all.

      Also when I say practical way, I didn’t mean I know something other researchers don’t.

      I found this blog randomly but I guess my presence here no longer means anything.

      Have a nice life, everybody

  30. Ddog and Mjones, I mean the best, not to sound condescending i think both of you guys are smart, i think Fgf11 and Nasa_Rs are twice as smart as me but christiano can’t hide anything from anyone, rux and tofac are already patented by pfizer and novartis which type in Pfizer stock on google and lookat their market cap… Mkt cap 207.7B.. thats B for billion. if you were going to make money off this discovery you simply buy a bunch of Pfizer or Novartis stock to front run the trade and release the news on main stream media showing a bunch of guys with AGA cured and then sell in 10-20 years..

    I’m telling you man there is no conspiracy big foot and elvis are really gone this time.

    1. I am not one for conspiracy theories, either. Not sure why I got lumped into this, ha! I was saying that I believe a cure would be released, if there was one. At least a viable treatment that could halt baldness would be legit – other than castration.

  31. I would normally say that it would take 5-10 years to bring it to market. That being said, if topical JAK inhibitors can be shown to cure AGA I think the market demand would be so unbelievably large that it would make it to market much faster than 5 years. The key question in 2016/2017 that should be answered is; are AGA and AA follicles both locked in the same state of no growth and dormant follicles, one being caused by the immune system, and the other being caused by bodies reaction to DHT over time? If yes we should have ourselves a cure.

  32. The bigger question is how the fk did baldness ever start and why did it evolve in the human species. Why couldn’t ass hair fall out or the sides of our head? No its got to be the top so we look ridiculous.

    Pfizer Novartis better fast track this shit and release it. How much longer do we have to wait to grow back hair. Another 10 yrs? Either do it or don’t and stop torturing us with possible cures.

    1. I agree, all of the teasing, bs headlines about something new being discovered and the cure being 5 years away are insulting to our intelligence.

  33. i heard there was a theory abuot it being a vitamin D theory, most likely it was a gene mutation millions of years ago and women didn’t care enough to ostracize it out of our ancestors

  34. Tnx for the post by the way admin, one of my friends is actually allergic to minoxidil in both forms, and so he’s thrilled that an alternative is coming soon!

  35. skip to main content
    Cassiopea – link to home page

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    Product Pipeline

    Home / Activities / Product Pipeline / Breezula

    Breezula™ is the brand name of our anti-androgen-containing composition for the treatment of AGA. Breezula™ is topically delivered to the scalp to reduce the hair miniaturization process that, if not controlled, shrinks the follicle, causing hair thinning and, ultimately, hair loss. Breezula™ is currently undergoing a Phase II proof-of-concept clinical trial in the United States.
    Product Description

    Breezula™ is a different formulation of the same API contained in Winlevi™. Breezula™ contains a 5% concentration of this API in a lotion designed to penetrate the scalp.
    Mechanism of Action

    AGA is caused by the overexpression of androgens. These androgens in turn cause excess sebum production that clogs the hair follicles of the scalp, impairing the growth of the hair shaft. The hair becomes thinner and eventually falls out. At the same time, the follicle shrinks progressively and eventually becomes unable to produce new hair.

    Breezula™ acts at cutaneous level on the scalp. It antagonizes the negative effects of dihydrotestosterone, the androgen that is the major contributing factor in AGA, on the dermal papillae, small structure in the skin that nourish the hair follicles. Breezula™ also reduces the skin’s production of prostaglandin D2, a hormone-like compound that, in elevated levels, can inhibit hair growth. Finally, Breezula™ helps to control sebum secretion, ultimately reducing hair miniaturization and dermal inflammation.

    Breezula™ does not interfere with the hormonal and, in particular, androgenic profile of patients; libido and sexual behavior are unaffected in clinical trials to date.

    Because the API of Breezula™ is the same as that of Winlevi™, both product candidates have the same safety profile. Although Breezula™ has a higher concentration of this API, because the scalp is less permeable than facial skin, the systemic penetration of the two product candidates is substantially the same.
    Clinical Trials

    Breezula™ is currently undergoing a Phase II POC trial in the United States.

  36. Breezula™

    Breezula™ is the brand name of our anti-androgen-containing composition for the treatment of AGA. Breezula™ is topically delivered to the scalp to reduce the hair miniaturization process that, if not controlled, shrinks the follicle, causing hair thinning and, ultimately, hair loss. Breezula™ is currently undergoing a Phase II proof-of-concept clinical trial in the United States.
    Product Description

    Breezula™ is a different formulation of the same API contained in Winlevi™. Breezula™ contains a 5% concentration of this API in a lotion designed to penetrate the scalp.
    Mechanism of Action

    AGA is caused by the overexpression of androgens. These androgens in turn cause excess sebum production that clogs the hair follicles of the scalp, impairing the growth of the hair shaft. The hair becomes thinner and eventually falls out. At the same time, the follicle shrinks progressively and eventually becomes unable to produce new hair.

    Breezula™ acts at cutaneous level on the scalp. It antagonizes the negative effects of dihydrotestosterone, the androgen that is the major contributing factor in AGA, on the dermal papillae, small structure in the skin that nourish the hair follicles. Breezula™ also reduces the skin’s production of prostaglandin D2, a hormone-like compound that, in elevated levels, can inhibit hair growth. Finally, Breezula™ helps to control sebum secretion, ultimately reducing hair miniaturization and dermal inflammation.

    Breezula™ does not interfere with the hormonal and, in particular, androgenic profile of patients; libido and sexual behavior are unaffected in clinical trials to date.

    Because the API of Breezula™ is the same as that of Winlevi™, both product candidates have the same safety profile. Although Breezula™ has a higher concentration of this API, because the scalp is less permeable than facial skin, the systemic penetration of the two product candidates is substantially the same.
    Clinical Trials

    Breezula™ is currently undergoing a Phase II POC trial in the United States.

  37. Breezula™

    Breezula™ is the brand name of our anti-androgen-containing composition for the treatment of AGA. Breezula™ is topically delivered to the scalp to reduce the hair miniaturization process that, if not controlled, shrinks the follicle, causing hair thinning and, ultimately, hair loss. Breezula™ is currently undergoing a Phase II proof-of-concept clinical trial in the United States.
    Product Description

    Breezula™ is a different formulation of the same API contained in Winlevi™. Breezula™ contains a 5% concentration of this API in a lotion designed to penetrate the scalp.

  38. Breezula™

    Breezula™ is the brand name of our anti-androgen-containing composition for the treatment of AGA. Breezula™ is topically delivered to the scalp to reduce the hair miniaturization process that, if not controlled, shrinks the follicle, causing hair thinning and, ultimately, hair loss. Breezula™ is currently undergoing a Phase II proof-of-concept clinical trial in the United States.

  39. Safety

    Because the API of Breezula™ is the same as that of Winlevi™, both product candidates have the same safety profile. Although Breezula™ has a higher concentration of this API, because the scalp is less permeable than facial skin, the systemic penetration of the two product candidates is substantially the same.

  40. Mechanism of Action

    AGA is caused by the overexpression of androgens. These androgens in turn cause excess sebum production that clogs the hair follicles of the scalp, impairing the growth of the hair shaft. The hair becomes thinner and eventually falls out. At the same time, the follicle shrinks progressively and eventually becomes unable to produce new hair.

    Breezula™ acts at cutaneous level on the scalp. It antagonizes the negative effects of dihydrotestosterone, the androgen that is the major contributing factor in AGA, on the dermal papillae, small structure in the skin that nourish the hair follicles. Breezula™ also reduces the skin’s production of prostaglandin D2, a hormone-like compound that, in elevated levels, can inhibit hair growth. Finally, Breezula™ helps to control sebum secretion, ultimately reducing hair miniaturization and dermal inflammation.

    Breezula™ does not interfere with the hormonal and, in particular, androgenic profile of patients; libido and sexual behavior are unaffected in clinical trials to date.

  41. Dr. Christophe Guillemat SCT


    Dr. Christophe Guillemat of the CFS Barcelona clinic has finally released the name of the innovative procedure he is currently R&Ding. It’s being called the Stem Cell Transfer. I can say for sure that he is sincere in his work and taking the time to prove with clarity that this procedure will work as expected. Ultimately, he is looking to create a method of stem cell extraction from donor to recipient area with complete donor regeneration.

    1. Hi Fadi, im from Spain and i’ve been following the SCT from the begining, this tecnique it’s supposed to be ready from the last august and always the same shit ” mmmm we are not sure if its gonna work, so we need to do more trials and the next september we’ll know if we can use” so , we need to wait till september..

      in the other hand if its work is a kind of cure, cause is like a FUE (without little scars) but maybe unlimited , anyway if is not unlimited you can cover a NW5 with all the donor area

        1. if the SCT works:

          1. you dont loss hairs from the donor area
          2. if works how is suppose to work maybe is a unlimited donor (in the best case)
          3. hairline will be natural, because is the cell what is transplanted not the hair follicle
          4. everyone happy for the whole life after 1 or 2 interventions
          5. you guys will never need to put creams and lotions on your head or take pills anymore

          Cross finger for this solution.. i dont know why, but this time i think we’re close to have a better ‘cure’ than the currents treatments we have nowday..

  42. @DDog, as per the hair loss researches we witness, to get non-miniaturizing follicles out of miniaturizing ones, proper DNA material would need to be edited in the hair follicle cells; a topical solution, created with the current technical advancements, able to indefinitely “edit and maintain” DNA changes seems quite improbable to us, but that’s just a point of view.

    Editing the DNA material in every follicle DOES seem to us the ultimate solution, and at this point you could ask “ok, how do we reach the inside of each head follicle?”
    The answer is…we are not sure. But we do think it is not “with a regular scalpel”, it will probably be “with and editing tool attached to a micro-precision robot arm, yet to be developed”. And that is another very interesting point: some of the IT/electronic people in the hair loss community group, and out there, would probably love to take any part in it, as we do.

  43. Certainties, facts!!:

    Hair miniaturization has been proven to be reversible!!

    AA hair follicles also miniaturize.

    Jak-stat inhibitors have been proven to revert the their miniaturization.

    1. But anyways, it should be tested, I think.

      What intrigues me is that AGA miniaturized hair follicles that were implanted in immune deficient mice reverted to normal size and function again!! that was verified in an experiment from 2003, 12 years ago!!! So, it is reversible!! there must be something else!

    2. I’m still optimistic about JAKs Julian, AGA may cause hair follicle to miniaturize and loose contact with arrector pili muscle but who knows, maybe if JAKs can take the hair follicles out of their misery and reverse the miniaturization the contact can be made again. As far as we know , no AGA patient has ever grow the long lost hair back so we don’t really know what will happen if the follicles start going back to the normal state, beside this arrector pili muscle issue is not only related to JAKs, correct me if I’m wrong but if you look at it in that way other potential treatments like what Histogen and Shiseido are working on right now will not work as well since both JAKs ( if they work) and stem cell therapy can only help for the rejuvenation of hair follicles. Anyway I’m tottaly agree with you,these drugs must be tested and if they work, well we all can be in peace again.

    1. Why do you keep bringing Cots up? I am not really sure what he has done practically besides be in the media. You know that the dudes in the media the most are seldom really the top researchers in their field? They are either just the loudest, or the most marketable. I wish he were legit, but as other members of the forum have already stated, the dude has basically tried to say he has a great treatment, but is losing hair quickly like the rest of us. That is like Jared from Subway talking about how great the sandwiches are for him, and still being overweight.

  44. Government of Japan will start clinical trial after 4~5 years.
    I also hate always after 5 years.
    But First plan of government did not involve hair regrowth in 2012.
    Second plan that revised first plan involved hair regrowth and planted to start clinical trial after 7 years.
    Second plan was released just 2 months ago,but today third plan was released.
    Hair regrowth of medical science is so fast the past few years.

    Sorry, bad my English.

    1. nosyu is that 4-5 timeline related to shiseido ? Replicel Youtube first video says they are aiming for 2018 (2 years) am i wrong?

  45. I just cannot get it pass me that those two guys from the 80’s got their hair back after using Beno. They had Male Pattern Hairloss not AA type hairloss. Also it has been mentioned that AA type hair loss is miniaturized hair follicles just like in Male Pattern Hairloss. Obviously it might be caused by a different reason but looking at it factually it would only make sense that Tofacinitib will work, and adding that human hair grew longer and stronger from grafts on rats when the lotion form of the drug was used.

    Why could’nt they have used a human graft of male pattern hairloss skin on the rats as a preliminary test? They absolutely could care less about us but it is too late the Genie is out of the bottle and it strongly looks like the Cure is Here Now just needs to be tested on Male Pattern hair loss.

    We just need proof that the topical form of Tofacinitib works and that it is safe. Then we simply get a prescription from our doctor. Done.

    My most controversial statement – I think we will be growing all our hair back by the end of 2016!

    The only problem will be the cost. It will be very expensive BUT only for the first few years then the cost dramatically falls.

    This is the year I get my hair back, period. I do not care what the naye sayers say and I am not overly optimistic. I strongly believe the lotion form of the drug will work but for whatever reason I think they will hide it from us as they want to do more tests for the next 5 years to line up their products. I am not waiting.

    1. Nasa_rs I’m 100% in the same thought…i just think in the hypothetical universe where RUX TOFAC was filmed in front of the world to grow back AGA 100% in 3 weeks it would still take a long ass time to get to market.. I don’t know why I just believe it would be forever

  46. We are spoilt ?! Im sorry to say this but are you losing IQ with hair admin ? The foam has the same or less results than the first minox. We dont have an improvement regarding hair loss treatment since decades. Lets consider it an improvement . With this pace our grandchildren will not make it to see the cure. We are not rushing finding the cure because we live in a fast paced world as you say . We simply want to grow our hair back before we die. Otherwise we are wasting our time reading your blog and following the hair loss news in general . i dont think there is a bald man with a single brain cell who is worried about baldness a century from now

  47. yeah julian I remember throwing cold water on someone on this blog last year doubting the idea of JaK inhibitors on AGA but I didn’t know about BENO.

  48. Didn’t you see the link I posted, right??.. it’s interesting but you people always get away from the subjects. Always somebody comes with something that has nothing to do with, always repeating the same thing, as Curious has already called our attention.

    I posted an important find, for me at least, I didn’t know that.. and probably most of you. It really is important when comparing AA to AGA because it may be the root reason why one drug that works for AA may not work for AGA.

    I will put it again here, maybe now you bother..

    1. Julian, that sucks. Sounds to me like once the arrector pili muscle becomes detached from the follicle, we are done. It is irreversible at present. In AA hairloss happens suddenly whereas with AGA it happens gradually. Accordingly, in AA, the arrector has not had time to detach, whereas overtime, the arrector becomes detached in AGA; hence, the marked difference in the ability to treat it. Ahhhhhhh….

  49. I’ll make it easier:


    Hair follicle miniaturization is the hallmark of male pattern hair loss (MPHL), female pattern hair loss (FPHL), and alopecia areata (AA). AA has the potential for complete hair regrowth and reversal of miniaturization. MPHL and FPHL are either irreversible or show only partial regrowth and minimal reversal of miniaturization. Hypothesis: The arrector pili muscle (APM) attachment to the hair follicle bulge, a recognized repository of stem cells may be necessary for reversal of hair follicle miniaturization.

    Materials and Methods:

    Sequential histological sections from MPHL, FPHL, AA, and telogen effluvium were used to create three-dimensional images to compare the relationship between the APM and bulge.


    In AA, contact was maintained between the APM and the bulge of miniaturized follicles while in MPHL and FPHL contact was lost.


    Contact between the APM and the bulge in AA may be required for reversal of hair follicle miniaturization. Maintenance of contact between miniaturized follicles in AA could explain the complete hair regrowth while loss of contact between the APM and the bulge in MPHL and FPHL may explain why the hair loss is largely irreversible. This loss of contact may reflect changes in stem cell biology that also underlie irreversible miniaturization.

    1. Our only hope is that Swiss_temples, and the dude that fell into the fire have already shown that AGA is reversible, and this research is not complete.

  50. Julian yes, agreed but were talking about BENO being similar to RUX and TOFAC and immunodifficent mice with AGA human skin in the news 2 weeks ago… we get it there is a 50/50 chance here, but because of the two 1980’s BENO AGA males reversing their hair loss … we are kind of ignoring the suspicion that it won’t work – not changing the subject but ignoring the other side of the glass.

  51. guys i’m a dork, i gotta go. I’ve been spending a lot of time on this site. admin everyone supports you, i’ll come back and poke around but I’m gonna f off ~ it was good being with you.

    I just realized it’s mostly foreigners debating with each other, conspiracies, and guys with airy speculative input name dropping alphanumeric chemicals.

    Peace bitches <3 one love

  52. egghead, don’t leave the forum. This is the best hairloss discussion board there is. Can’t lose people. What else are you going to do during work? Certainly helps me kill time. I spend less time on the NFL pages. lol

  53. I’m still optimistic about JAKs Julian, AGA may cause hair follicle to miniaturize and loose contact with arrector pili muscle but who knows, maybe if JAKs can take the hair follicles out of their misery and reverse the miniaturization the contact can be made again. As far as we know , no AGA patient has ever grow the long lost hair back so we don’t really know what will happen if the follicles start going back to the normal state, beside this arrector pili muscle issue is not only related to JAKs, correct me if I’m wrong but if you look at it in that way other potential treatments like what Histogen and Shiseido are working on right now will not work as well since both JAKs ( if they work) and stem cell therapy can only help for the rejuvenation of hair follicles. Anyway I’m tottaly agree with you,these drugs must be tested and if they work, well we all can be in peace again.

    1. That’s what I said. Nobody knows how this whole process really work, it’s all mystery still.. I HAS TO BE TESTED, cause in human grafts it did work!!

      About the miniaturization, it’s reversible, in AGA.. already proven!! something is missing to know how to do it, just that!
      Maybe Jaks can do the job, it has to be put to practice!!

  54. Egghead feel free to leave if you want a life BUT again the solution is here for us at the end of 2016 and I am simply going to stay on top of the latest news. As I am not waiting one second longer for the cure.

    To me BENO proves that AGA is curable as it cured it for two people. Easy for us now to say why didn’t they follow up to figure out why these guys grew hair but the doctors were not doing hair research they were doing Arthritits research. An accountant is not going to investigate an Engineer issue when they happen to see a part made different. Same with those doctors.

    The cure is here it is that simple. It HAS grown 100% hair back for AA type hair loss. Those with all these why AGA is not easily curable are WRONG. I have to admit I will never follow another cure as life needs to go on. But I am going to follow Tofacinitib for a for 6 months to find out about Experiments as I know, I know this is it.

    2016 Goodbye Baldness:) It is almost all over.

    For all these other cures go ahead and follow the various Peach Fuzz cures not me. this is it. I get ALL my hair back in 2016. Guranteed for me. I know I am right but I do need Final Proof that the lotion works. I also wonder if they did not try AGA skin patch on the rats and have kept that a secret. They would need to know so that they can know how much business they can expect in selling products, lining up investors and contracts with drug companies.

    That is pure speculation but I do think they would have said that it does not work on AGA as to keep the tremendous hopes from being built up. But they never said that, they simply said it may work. I am just guessing, but I think the know it will work. But if BENO worked why not Tofacinitib, especially considering we know it works for some types of hairloss.

  55. Egghead, just saw that Spanish ht clinic link you sent. That’s great news if he can give unlimited donor supply! He is one of the few ht doctors that realizes the future of ht is in stem cells. I still believe ht doctors are terrified that a cellular treatment will knock them out of business if they don’t hurry up and get unlimited donor regeneration or a stem cell treatment like Aderans to work. They see sishedo and samumed and histogen that could possibly take their business away. Well histogen could supplement ht especially for bald spots and hair line.

    If jak inhibitor work then this will destroy ht, sishedo, Cots etc. Pay 3 thousand bucks a year to keep your hsur. I’m assuming you apply jak inhibitors to scalp for one month to grow back all your hair then you reapply topical a year later once hairs start to miniaturized again. Just a wild guess

  56. One month supply of jak inhibitors cost around 2 to 4k a prescription from what I seen on the forums. I don’t think you will have to buy treatment each month since the growth results happen in 10 days

  57. Nasa_Rs you say things exactly the way i would have.
    I’ll still be looking at this blog, …(like i am right now) it is the best.

    I’ve got nothing more constructive to say.. other than i totally agree with you, swiss temples is fascinating and on the edge of my seat with Rux,

    to be honest.. if I met a few dudes that taught me how to turn TOFAC into topical and knew another dude from a lab that would ship it online I would be the first independent guinea pig. Wouldn’t mine snapshotting that for you guys at-fucking-all. But I don’t have any academic background in that…

  58. Ddog That is pure guessing on how I think tofac and ruxo would work.

    Egghead. No clue if they are already testing rux. I hope they are behind the scenes and that it works

  59. Mjones, I know that is speculation. I just thought it would be a good time to see how much everyone would be really wiling to spend per year to keep their hair. It would be tough.. but I think I could manage $10,000.00. But it would have to be all of my hair!!!

  60. It really sucks. I remember being 5 or so with Rogaine was released. I was really young, but I remembered thinking, “That’s awesome. This is a treatment, so they will have something by the time that I am older where I will not have to worry about hair loss.” So weird the state of things practically hasn’t improved at all since. They understand hair loss a lot better, but that hasn’t turned into any valuable treatment options.

  61. Ddog I remember I was about the same age when rogaine cane out in the 80s. My dad and uncle both bought it and were psyched. They got zero results and just excess ear and nose hair lol. They were like don’t worry son by the time you lose your hair they will have a cure lol. Well 30 yrs later and Jack shit. Just latisse that shows the sane results of rogaine. This is why I believe in conspiracy theories because I find it unbelievable that they don’t have anything better.

  62. I think 2016 is the year… for yes or NEVER.

    tsuji team
    2020??? for me … 2016 or never!
    admin what do you think???

  63. Hair congress coming up. I know some people are super pumped. I think that the information presented will probably leave a lot to be desired. Never in my life have I ever been really excited about something, and had that thing match my expectations. I am sure a lot of you guys can probably say the same.

  64. Lately at work people have been telling me I look tired which confused me because I get plenty of sleep and look relatively youthful for 31…but when I asked a friend why she thought i looked tired she said it was because my hair looked flat/just out of bed on top. I told her it looks like that because it’s desperately thin/sparse up there now and I desperately try to hide it. It’s getting to the point I can no longer hide my hairloss and I may have to shave my head. Ugh.

  65. It is very sad. I am slowly coming around to seeing myself with a shaved head in 5 years or so. It may not be so bad. It just sucks because it is saying goodbye to how you looked in your youth. It is tough stuff. If not for hair loss, men don’t really age until they are much older. Curing baldness would be very close to finding the fountain of youth for men.

    1. Couldn’t agree more. Everything else is manageable; don’t smoke, dont drink to excess, don’t stress, eat right, stay fit, limit sun exposure…but hairloss is the one thing I cannot control damnit!

      1. That’s the thing, we’re always told not to smoke, not to stress and overeat, to stay fit.

        But even if we do those things, hairloss still comes in and destroys your appearance and self-image. It’s just not fair, but that’s life I guess.

  66. I agree with sets. If they don’t show anything impressive at the congress then we are shit out of luck and everything is just hype from researchers looking to get money. I’m the most pissed off at histogen. She said 2015 release and she just let us all down

  67. Btw in the movie Idiocracy they had baldness cures everywhere lol not sure if you guys have seen this movie but it pretty much shows how everyone in the future is stupid. It’s good to see that they think baldness will be cured then

  68. I firmly believe the miniaturization of the follicles can be completely reverted as it was already done using mice with deficient immune systems. Miniature hair follicles taken from MPB donors were implanted in the skin of these mice and they were regenerated, they grew back to their normal size and produced normal hair shafts. That was in a 2003 experiment. That proves their state can be reverted once some conditions change.

    I would like to know if the opposite that what is usual in hair transplantation was done, what if this would be repeated. I mean, if a miniature hair follicle was taken from the top of the head and implanted somewhere in the back of the head, where the hair follicles are healthy. I wonder if they would grow big again, like what happened in the mice back in 2003.

    I really have this doubt now.

    1. You are interesting in that on one hand you say a cure for AGA is probably not going to be the JAK type drugs then on the other hand you provide proof, the 2003 experiment, as to why it should work.

      I simply know it will work, just a real strong gut feeling and sometimes that is right. I would absolutely say it is going to work, beyond absolute. I just wish they would let us know when the experiments happen for AGA and what the results are. Instead, we will have to wait, and wait, and wait.

      I am telling you I am not waiting beyond 2016. Somewhere some pharmascist or someone involved in helping in the experiment will rub some lotion on their head for 3 weeks then we will know. That is all it takes. It should only take 3 weeks for us to know Why Do We Have To Wait Years. Really, that is all it takes is 3 weeks yet it will take at least until year end of 2016 for them to let us know, at least.

      Alright I am back to reality. If anyone knows in the next few months of someone who is getting the same lotion that they put on the rats and is trying it let us know.

      1. I’m not saying it probably won’t be the Jaks, nasa. It has to be tested, I hope it will be the sooner the better! The only way to know is testing them! No one can say it won’t work, nor even the God Cotsarelis, because nobody knows exactly how they work, how they stimulate the follicles to grow that fast, you know.

        Safety is established right? also, efficacy in animal model and human tissues grafted to animal models?

        So the next step is testing it in a HUMAN model.. see what happens… So fkn easy, isn’t it?

    1. I suppose this Pili muscle is the one responsible for making our hairs bristle we chill, for example. I wonder if this structure isn’t damaged in hair transplants and if it’s that that makes the transplanted hair looks a bit different, not really that natural, because of the absence of this muscle attached to the follicles.

  69. Also would like to know what Dr. Christiano thinks of all that. If she knows of this difference between miniaturized hair follicles from AA and AGA. If she thinks Ruxo.. or Tofa.. could act in some way to reestablish this junction…

    1. If she is familiar with the study from 2003 that proved hair follicle miniaturization to be reversible??

      That I would like to ask Cotsarelis too.

  70. You guys are going to get mad at me again but I have a gut feeling they have a cure. It’s freaking hair lol. It can’t be that hard for them to rub a tonic that makes miniaturized hsir to become long thick again. I just don’t buy it that after all these years they can’t do it. It’s just like technology. The Internet was secretly used in thr govt in the 70s and 80s. Then BAM! AOL cones out of nowhere with the biggest technological advancement in history. I think the same thing will happen very soon. Out of nowhere they will release a remarkable treatment that will make a Norwood 5 a Norwood 2. The reason why all these rich people are still bald including prince William is that if they all of a sudden grow back their thick hair people will ask how the fk did he do that? It will come out for everyone just like the Internet. Released at the sane time. It will be pricy for sure though.

  71. mjones the ultimate question is are the scientist every other scientist in the world with 100% disclosure of their findings rapidly progressing our understanding. OR are they hiding 90% of it to safe guard their sponsors and teaching each other 10% of what’s going on. IF SO we are not growing optimally and that is the reason why it’s taken 30 years of minox and fin.. that is not a conspiracy that is just flat capitalism holding hands with science.

  72. I don’t know Egghead. I just find it strange that 30 yrs has gone by and the results are the same as rogaine. At this point they should have a treatment that grow at least two Norwoods of thick hair. Latisse phase 2 results are just pathetic and embarrassing and that was probably their best result. Whatever happen to that Korean adipose stem cell injection treatment study that actually grew back thick hair? That is the results I find acceptable. Not photo shop images from allergan lol. What boggles my mind is that whoever cones out with a true effective treatment will make billions! Wake forest research seems to have a secret treatment for hair rejuvenation. Same place samumed did their studies. Samumed phase one showed increase hair growth and dramatic slow down in hair loss in just 14 days. Plus samumed has been moving quickly with their trials, no delays or funding issues. I wouldn’t be surprised if they rolled our phase 3 in march 2016 and wrap that up by Nov. My gut tells me they have something good and they are doing their trials in thr USA. they are looking to release this here in the states not oveseas.

    1. That’s phase1 results and doesn’t make for good reading. Hopefully they’ll give a glimpse on their phase2 results. Needs a monumental improvement.

  73. so.. it was true… they were taking so long to show bims results because they really were shit and not innovative at all? wow… this is just bad guys…. bim+ seti was supposed to be the holy grail according to many…

  74. Sammumed doesnt put any photo of their first trial? and, the first trial has been just for 14 days? i’m a bit confused, can someone explain me?

  75. Guys, my first post here. Thank you for a quality forum.

    We need to test Tofacitinib! No time to loose. We can’t wait.

    Here is my idea on how we get Xeljanz from Turkey and make our own topical solution. I need your help as I am myself not

    able to travel.

    I believe a lot in the potential for topical JAK inhibitors for MPB. JAK is the group name for drugs like Tofanitinib and

    Ruxolitinib that we’ve heard so much about lately. The main JAK taken by the AA-community (Alopecia Areata) is Xeljanz. It

    has proven mighty effective for many with AA. People who haven’t had a single hair for years now sport a full head! So far

    the AA-guys have taken Xeljanz orally. Quite heavy doses with possible side effects. They need to start taking it

    topically as well IMHO thus reducing possible side effects drastically.

    Why would JAK work for MPB?
    In AA as in MPB the follicles are still alive, just dormant/miniaturized. Most likely in a way that is very similar in the

    two diseases even if the reason for the abnormal state is different. In AA it’s the immune system who terrorizes the

    follicle and in MPB it is very likely DHT that shuts it down. Point is the JAK inhibitor seems to wake dormant follicles.

    Why not in MPB as well? this needs to be tested. Note that AA has not had an effective drug for just as long as MPB. Its

    no short of a miracle what this drug really does to AA-patients.

    What we need for a 2-month test
    1 pack of Xeljanz 5mg, 56 pills.
    6 x 60 bottles of Minoxidil solution (not the foam)
    5 x 20 ml empty vials (buy at pharmacy)
    1 mortar (borrow your moms)

    How to make the topical solution
    1. Grind one Xeljanz pill in the mortar.
    2. Mix it with 10 ml of minoxidil solution in a clean vial. Let it rest for 10 minutes.
    3. Shake well.
    Importnat! Grind a new pill and make a dose every morning so that the effective components of Xeljanz are fresh. Make a

    new 1-pill-batch every day. Don’t mix all pills at once as the effective parts of the Xeljanz could possibly start to wear

    off when dissolved in a solution.

    How to use
    Let the mix rest for 20 minutes and then apply half of it on your test area and massage properly for a few minutes until

    your skin has soaked it up.

    Why do we need the Minoxidil
    Because we need a vehicle for the JAK to penetrate the skin and reach our follicle. Minoxidil solution does that, plain

    water wont. If really want to you can find a different vehicle that does not possibly skew our experiment (because if we

    see an effect of my recipe it could potentially be just the Minoxidil, however unlikely that is…) but as this is test is

    not being published in Nature I would use the Minoxidil myself. If we see results we will all know it’s from the JAK.

    How to get hold of Xeljanz
    The price in Turkey for 56 tablets Xeljanz (Tofacitinib) is 1700 Turkish lira which is about 600 USD. A flight from US to

    Istanbul in Turkey is around 500 USD. When in Istanbul (in my opinion one of the world’s most beautiful cities btw) go to

    a large pharmacy and show your American prescription for Xeljanz. What? I have no prescription! Well… use your

    imagination on how to produce that piece of paper. The drug name on the prescription should read Xeljanz 5mg. Most likely

    the pharmacist won’t even ask for a prescription. Prescription is not necessarily needed in Turkey to buy drugs, money is.

    And the pharmacist for sure won’t call the US to double check if/when you show your prescription document. My

    recommendation would be to stay 3-4 days if the pharmacy need to order home the pills.

    Read more about getting Xeljanz in Turkey in an AA-forum:


    Visit a Turkish pharmacy guide:

    Who goes first?

      1. sam this would be definitely doable … all it takes is a trip to turkey. If you guys actually do this or need someone to do this over the holidays let me know whats going on… I’ve been piping this idea for the last 3 days. Even if you don’t do it I’m going to do this whenever i get the money together myself.

    1. Well, not bad idea, but from my point of view, minoxidil show some ‘good’ results, so maybe is better if we mix it with ethanol or another vehicle, just my opinion, cause of this way, we are 200% sure is the Jak

  76. Bimatoprost results are pathetic for 2015 and Samumed phase 1 results dont’t do anything. Only their massive phase 2 will enable us to judge their drug.
    However, I have never believed that any drug maybe holy grail for this disease. The cure I am waiting for is the cell solution and I think that’s the only way to end this nightmare of programmed ugliness. Before the ultimate cure we have few options like HT. Or even concelears or hair pieces. I would never let the others get to know that I am suffering from this hideous genetical humiliation. FDA drugs like minox and fin are pathetic: the first one doesn’t do anything or has effects for about one or two years, the second works of course, but inhibiting an important hormone DHT for X years seems to be an aburd for me.
    Histogen and Replicel may be in Japan in few years, it wouldn’t be full cure, but it will be a total breakthrough if Replicel may stop hair loss progression. I think that total cure will come from cell projects realised by scientists like Christiano, Lauster, Ohyama and the other. All of them will be present in the congress, so I hope they will realase some important information about their projects actual state. According to Christiano (and her Rapunzel Company) they will start clinical trials in about two years ( statement from NYT article).

  77. If christiano is starting trials in 2 years that means she will need at least 8 years for clinical trials to market. That’s 10 more years . Man fuck this shit. I give up. Just going to shave it off and accept it. Tired of waiting and waiting for bs results from over hyped treatments. They just can’t do it. Human race will be plagued with this disease forever

    1. Me too mate. I’ll shave it off and be done with this sh*t. Let’s face it, nothing will see the light in the next decade and I am giving them some leeway
      These researchers have been at it for decades and they have bugger all to show for it. They just spin this “cure is 5 years away” to get more grant money and line their pockets. Same goes for these small time biotech start ups.

      Shaving it and I’m signing off. So long fellas!

        1. What progress Ddog? It’s all speculation and a lot wishful thinking on our part. Life’s too short to worry about this sh*t. I’ve set up some Google alert on “baldness cure” just in case though! LOL.

      1. The problem with shaving it as a bald man, is it doesn’t look as cool/hip as a buzz cut. People can still tell that you are bald! Not the best option. I would just hold on to what you have. Look at Bill Murray. He has been going bald since he was 23, at least. People still think he is cool as ice. Never shaved his head.

  78. “The trial treated male subjects topically once daily for 14 days with either 0.05%, 0.15% or 0.45% SM04554 or vehicle; subjects returned 14 days post­treatment for final evaluation. Safety data, including pharmacokinetics (PK), electrocardiogram (ECG), laboratory parameters, application site assessments and vital signs, were collected throughout treatment, with subject­reported efficacy outcomes collected at end of study.”

    Sounds good!!

  79. “SM04554 appears to be safe, well­tolerated, and potentially efficacious. These results will help guide future AGA trials using this treatment.”

    Nice to know!!

  80. @mjones: That is true, but only under the western legislations. Cell therapies in Japan have the possiblity of the temporary approval DURING phase II, after the collection of safety and efficacy data. If the trial begins in 1/2 years it is really possible to have the therapy in Japan in about 5-6 years. And that therapy from Christiano or Lauster wouldn’t be a treatment, but would be the cure. You are lucky that you can just shave and accept it, I can’t. And it’s not the matter of looking good, that’s the problem of existential identity, the problem of identifying ,,myself” with its physical presentation. In my case, it’s out of question to function properly in the life. What is more: I will be public person in the future and the problem of appearance is also crucial.
    If Samumed will work for the regrowth and slowing/stopping the process, that would be huge, but we will know only after phase II results. Their attitude shows that they are very sure of the success, so I assume it will be available in max 2 years (its phases are quite short). Then, I would make HT on the front and I will take Samumed on the crown until something new will come for example CB or Seti.

  81. The only thing we need is One trial for Male Pattern Hairloss using Tofacinitib. Then we should immediately be able to get it.
    Just wish a researcher would do one study, just one.

      1. We NEED THIS STUFF TO WORK IF IT DOSENT THEN WE ARE ALL going to stay bald. lost my girlfriend faild in uni, i dont go out anymore i dont see friends. Life is shit without hair……

        1. Question to Dr. Christiano:

          I’m pretty sure Hellouser will ask her that one, cause it’s so obvious… but here it goes:

          When are you planning to start trials of topical Tofa../Ruxo… in humans to access their results? Is there a timeline already?

        2. Hang in there. One day, your hair will be back. Imagine how frikken awesome it will be to watch it come back and to look like you again.. That is a bad ass thought. One worth hoping for.

  82. We need the results of the JAK Inhibitors used on MPB asap. No one can tell for sure whether they work or not without testing the damn drugs.

    No need to wait for FDA. I have no trust in them. Just google” Vioxx Recall – Merck and FDA Scandal” and you’ll see what I mean.

  83. All these researchers can blow me! Japan laws are bs. Sishedo hasn’t started their phase 2 yet. Who is going to fly to Japan every 3 months to get histogen done or other treatments that require constant monthly or tried monthly use. I only have hope for samumed at this point. If jak inhibitors worked for mpb then why is christiano still working on stem cell shit? If jak is the cure I highly doubt she would pursue another 10 yrs of trials for stem cell. She would cash in on jak inhibitors. Too much bs going on and it’s stressing me out. I am going to find a hot wife, continue to make good money and forget this shit. Later

  84. The last two years they found out hair follicle don’t die they just shrink and are very velous. Nice job Havard grad scientists of the hsir loss world. I knew that shit in the 90s when I looked at my dad Norwood 7 scalp under bright lights and I can see thousands of very fine wispy transparent hairs there that just can’t grow past that stage. It took these retards 30 yrs and millions of dollars to find that hsir is still there. You guys expect a cure from these idiots? Haha. In 30 yrs they will say all we needed to do was inject vitamin D to the scalp to kick start growth. Hsir should be the easiest thing to cure because it doesn’t involve any internal surgery. It’s right their on thr scalp for anyone to look at or take a microscope to see even better. Sorry for the rant guys but I’m fed up with the constant 5 to 10 yr shit

  85. … guys we could crowd fund our own TOFAC human experiment… seriously were all pissed off enough to get it done all we have to do is buy the plane ticket get the “perscription” and mortar,ethanol … TOFAC is way cheaper than RUX too.

  86. One last thing, samumed is testing their treatment on high Norwoods 4 5 6. This shoes that they are pursuing growth as their main effort goal. Not maintenance . They are a sponsor of the hair congress which shows they are working on an effective treatment. If it didn’t work then I doubt they would be a sponsor.

  87. Mjones, your the rich one why dont you do it!
    You drive a benz dude beast that shit out for us
    or give me the money I’ll do it for you give you my drivers license lol you can meet me in person so you can beat the shit out of me incase you dont trust me.

  88. you guys wanna start fucking with the real deal or waiting a few weeks for peach fuzz compounds like Bim and Rogaine XR foam?

    Let’s get the gat damn show on the ROAD, TOFAC turkey 3 week results.. one of us needs to get our balding ass on that plane PRONTO… whats the alternative?? wait 9 years for clinical phase 1a to put out a paper indicating yawn% growth.

  89. Unfortunately great IQs doesn’t have interest in hair loss biology, those things.. If a mind like Stephen Hawking’s got an interest in solving a problem like that, I’m pretty sure it was solved by now!

    All we’ve got are strong willed average or a little above average minds dealing with it, so it takes time.. lol.. but we got to be very thankful to them anyway, cause they want to help us, everyone.

  90. guys I’m dead up serious I will fly to Turkey and test TOFAC on myself for all of us to see if you guys want to help. If someone else wants to do it I can crowd fund $200 … you guys definitely have the money to do it alone

  91. I think a pretty good damned hacker could be very helpful in attempting to decode those signals between cells, hormones, follicles, chromosomes, growth factors, these complicated pathways that we know are what regulates, stimulates or forbid everything.

    We needed a guy like Alan Turing in this endeavor:

  92. “We can only see a short distance ahead, but we can see plenty there that needs to be done.”

    Turing on the challenge of machine intelligence, 1950

  93. I am going to telepathically communicate with the shape shifting reptilian grays to beam me up to their space ship where they hold the real cure for hair loss. I will then hijack their space ship and land it here in the states grow everyone hsir back on this forum starting with the admin since he takes time out of his day to write this blog. Once the hsir loss companies find out about my space age alien cure for hair loss I will burn the cure in front of all these companies that promised us 5 to 10 years. They will see me destroy a billion dollar cure they want to own. The feeling of happiness and joy will enlighten me whike I watch them suffer. Plus I will inject then with Norwood 8 level baldness so they can live in this hsir loss nightmare like us. Then we can say “use your 5 to 10 yr away treatment to cure your hair loss” hahaha

    Egghead what is Rogaine RX foam? Is that a new foam product rogaine us releasing lol?

    1. lmao

      good plan bro!

      …rogaine xr foam is another hypothetical granny shot to the market ..another dud from the future that the brilliant minds at the highest levels have concocted smoking crack with their lab mice.

  94. Some researcher or pharmascist must be trying out the Lotion form of Tofacinitib. We just need to see the Before and After pictures after 3 weeks. That’s it.

    We just need ONE Public Experiment of Tofacinitib Lotion on a bald head daily for 3 weeks.

    It has to work. Not my will buy by logic. It grows on Rats (everything grows on rats); it grows on AA Type Hairloss to give 100% hair; No Public Experiment for regular baldness (dang it). I almost do not care either way just do the experiment and let us know.

    This is the thing that keeps me around as it does not need to take years just a few weeks to know if it works and I am waiting for someone with a half way decent experiment (with photos) to let us know.

    Also I think Dr. Christiano already has some evidence that it works since coming out with those rat pictures with hair would crush her with publicity and if she later said it does not work for regular baldness then she would know that billions of people would be upset. All is My guess.

    1. Lastly, why would she continue with cell research if the Lotion form of Tofac worked? One reason, over the long run it would be better to have a Natural Treatment over a Drug Treatment. Two, the drug may not work on ALL types of baldness.

      This whole hair thing for me comes down to one thing: does Tofacinitib Lotion work? If it does not then Fine, I am through. If it does work, praise god, I am done.

      We will know either way hopefully within months to the end of 2016, and I have to know ASAP the second it comes out.

    2. I think jak inhibitors as tofacitinib has great potential to hair grow and if it works then i think it will take more time than only three weeks use to fully grow all hair. The patients of 80’s who were treated with beno, grew their hair after 7 months use of beno. So I think only 2-3 weeks will not be sufficient to fully hair grow with tofacitinib. It may require more time to use, maybe months.

  95. Nasa, I love your optimism, but it does make me afraid that it really is just optimism. As you said, everything grows on rats. I read in another article, I can find it for you if you want, that rats are actually a poor model for testing baldness because their hairloss/baldness is fundamentally dissimilar. I found that disheartening since it seems like that is all that we test on. With the JAK inhibitors, really the only source of optimism we have is the evidence you mentioned about the guys regrowing hair in the 80s. We haven’t seen pictures of those, so we don’t know about the quality regrowth, right? Scientifically speaking, why would JAK inhibitors regrow all AGA damaged hair? Does anyone know this? They are anti-inflammatories, right? But it seems unlikely that this plight is caused solely by inflammation, you know? I want to believe. Help me! lol

    1. forget about rats. how do you explain their effect on AA? Dr. Christiano had said that MPB follicles are stuck in the same state where these drugs seem to work. So ? MOST OF THE TIME scientists don’t have a clue about why or how a drug works. They just give it to the patient and patient gets better. That’s it. They only have theories. So I think JAK inhibitors are definitely to be tested on MPB

      1. I explain their impact on AA by saying that AA is an immunodeficient disease, and JAK drugs seem to treat issues with the immune system whereas it seems that AGA has a complex genetic pathology.

        1. Immunodeficiency has a lot to do with genetics traits, just like AGA.
          AA and AGA follicules might be affected via the same miniaturizing pathways. Follicules are miniaturized in both situations right? Maybe it takes the activation of one single pathway to miniaturize a hair follicule and if these drugs deactivate this pathway then voila! You get your hair back just like those old men from the 80s and AA patients treated with JAKs.

          1. The activation of this pathway might be due to DHT sensitivity determined by genetics, or crazy antibodies targeted at hair follicule. But it might be boiling down to one single pathway to miniaturize the follicule. What if JAKs deactive this pathway?

    2. Regarding BENO and the regrowth of the two guys. The article specifically stated that the older man had hair as thick on top (after it grew back) as what he had on the side of his head. Remember this was just a curiosity story not anything about Hair Loss Research per se.

      Also, we know that Tofacinitib HAS grown 100% hair back on AA Type baldness on Humans. The lotion form of it on the rats the was recently in the news stated that it worked much more Effectively as a Lotion (on rats) than in Pill form. Also that the human skin grafted on rats where topical lotion was put on Grew Longer and Thicker. That means that human hair will grow Longer and Thicker if we use the lotion form of the drug. The BIG question is does it work on AGA – I have no idea just speculation from looking at a few scant stories.

      But I just wonder if maybe it was AGA skin she put on the rats and she is just keeping quite about it just saying that hair grew longer and thicker.

    1. To many desperate Pharmacists and others out there. Someone is going to try this Lotion Form afterall someone probably made the formula for Dr. Christiano.

  96. heres the bottom fucking line gentleman read it over a few times

    1. TOFAC/RUX is a JAK BENO is a JAK, BENO worked on two guys with AGA in the 80’s

    2. AA and AGA are different but both miniaturize follicles JAKS work on human with AA last year.

    3. Human AGA skin was on those immunodeficient mice in the news we all saw.

    4. They haven’t said when or how long we will know till they test topical RUX/TOFAC on men with AGA. PERIOD

    Again, we know JAKs HAVE worked in the past on men with AGA, the mice had AGA human skin on their backs, …

    5. Were the only english speaking community in the world (internet) talking about this.

    6. Theres a dude say’s we can get it with bs perscription in Turkey for $600 using ethanol as vehicle.

    K? that’s the state of affairs right now

    1. Wait until some researcher tries it Do Not Buy Anything From Turkey. As Either your hair will still be Gone from a fake formula or your Money or your health.

  97. Ive only been balding these last two years. So two years ago I noticed and started doing research on how to prevent it. Ive been excited about propecia, RU, CB, seti, and bim because I thought at least one of them would help. I dumped an ass load of money into RU with 0 results. I popped a propecia pill for a year with nothing but accelerated loss as im now almost a norwood 4 and sexual sides. Practically no one even talks about CB anymore so I doubt its of any help since its like a glorified RU. Barely hear anything on replicel or histogen anymore.

    This whole hairloss treatment thing is a joke now. I actually started to have high hopes for tof and rux, but I just dont see it working anymore. Julians post about why it may not work was actually pretty damn depressing, but he is probably right. I don’t mean to be pessimistic, my whole image revolves around my long hair, but this just sucks. How long did we have to wait to just hear that BIM is barely better than rogaine? Now we can wait over a year just to hear some results from tof and rux when we could know in 3 weeks. So sad that in 2015 people are still plagued by this stupid cosmetic defect. We can work out, run, eat healthy, stay clean and hydrated and it doesnt matter we lose our hair anyway. Just wish I knew one way or the other if tof and rux would work, even if it was a few years out. At least then I would know I could just get a hairpiece and hide it for a few years until its out. Now ive no idea wtf to do.

  98. I would say your best bet is just to get fit as possible if you are vain, like the rest of us. It is the only thing you can control. At least, you will be good everywhere else when there is a solution.

  99. their testing topical RUX on humans with AA right now

    business wire

    simple google search this was on the 2nd… c’mon guys really am I the one that has to do this basic ass shit? Is this a “obvious reasons why we should all be sad” forum or “avante garde let’s get some shit figured out” forum.. PHG …those guys, they fucking test shit 10 years before it’s done going through clinical bulls hit… I wish I was invited in there.. fuck sake. let’s elevate the dialogue guys

    1. I totally agree. We all need to figure it out. My self i will buy the TOFAC and keep it with me until i see some result online then i will do it to my scalp. Maybe if this is real cure it would be expensive in the futer when they releas the JAK to the people.

  100. I still have faith in Ruxo and Tofa, based on what has been shown mainly the grafted skin’s results… if it doesn’t work, the secret is in the rat’s blood!.. lol…

    I think they have to test it!! Fast!!

  101. Just a quick question for the like’s of Julian, Egghead, Ddog, MJones etc.. the regular posters on this site.

    Do any of you have a regimen of sorts? Any of you on fin or anything similar?

  102. I tried taking FIN, but developed sides pretty quickly. I guess I need DHT, go figure. I did PRP/Acell.. I feel I actually benefited in quality of my current hair. Glad I did it.

  103. The bald Richie I have been on propecia for 14 years. I added rogaine foam in 2014 when my hsir started to thin again around 2013. I upped my dose from 1mg to 2 MG of propecia in 2014 as well. It stopped by scalp burn and tightness but hair still thinned. Propecia was a success for me till 2013. It kept my Norwood 1.5 in tact for 12 years. I must add every male in my family is a Norwood 5 to 7. Now I am diffuse losing hair . Temples miniaturizing to a Norwood 2.5. Rogaine thickened up the hsir a bit but accelerated thinning in my hairline which blows. Now I am just watching my hsir get worse each month which blows because I thought I had this hair loss beat for 12 yrs. I took a protein whey isolate shake for 6 months in 2013 and that is when I noticed my hsir loss increasr. My dht levels increased due to that shit and messed up my propecia balance of hormones. I always wonder if I didn’t take that protein shakes if my hair wouldn’t have started falling out. That’s my kick in thr balls story.

    1. Thanks for your responses guys. As a 21 yr old with nw2 (been receding since 17-18) it’s quite depressing seeing everyone with full heads of strong hair around me. Recently i’ve notice a bit of loss on the crown and was wondering whether to jump on fin or not (very worried about the sexual sides and potential risk of prostate cancer). Have you ever encountered anyone whose suffered permanent ED as a result of it. And what would any of you recommend? Should i go see my GP, a dermatologist a HT doctor? A HT is definitley on the cards at some point if i can get the money together.


  104. Bald be rich. If you are losing lots of hair in the shower, thinning on crown and hsir line then I would recommend getting on 1mg of brand name propecia once a day. Don’t cut pills, don’t take some indian made finasterude crap. See a dermatologist asap. Buy country life Maxi Hair vitamin and take that once a day with a 1,0000 iu vitamin D. Exercise 3x a week with a day of cardio. Do scalp massages before you go to sleep and don’t smoke and drink no more than 3 to 5 drinks a week. Don’t take rogaine. This is what I did at age 20 and kept all my hair for 12 yrs with minor temple recession and minimal density loss. First go to your dermatologist. You might get some sides from propecia but it will fade away once your body adjusts to it in 3 to 5 months. As long as you exercise, eat healthy and not stress about sides you will be just fine buddy . Let me know if you have any other questions. I know how it feels to lose hair at an early age so I am here to help you kid

    1. The only useful thing for his condition is finasteride, the rest are useless. The most shocking thing you said is do not take rogaine, this is the only FDA aproaved medicine to regrow hair. If it works with you it may not work with him so be careful giving wrong advises as it may distroy people life.

      1. Being approved by FDA means nothing. Check out the Vioxx Scandal. THE WORST DRUG DISASTER IN HISTORY

        in 1999, FDA approved Vioxx, a non-steroidal anti inflammatory drug, for use BUT in 2004 MERCK withdrew the drug from the market after a study revealed the drug more than doubled the risk of heart attacks and death!! By that point, more than 38,000 deaths were related to Vioxx use.

        Merck was accused of misleading doctors and patients about the drug’s safety, fabricating study results to suit the company’s needs and working together with FDA to keep the drug on the market and quiet the health concerns

        And you know who is the manufacturer of Propecia, right?

  105. Kjouri, I recommend him not to take rogaine because he said he is a Norwood 2 probably thick hsur with some minimal loss. Propecia will thicken your and possibly grow some back since he is young. I just don’t want him taking rogaine and being dependent on it with minimal results. He should use propecia as first line if attack for 1 yr to see how it goes. I think it will work for him. If not he can add rogaine foam. I don’t want him to go through drastic hair shed from rogaine . That will freak him out. He doesn’t need that right now. That’s just my advice

  106. I think this is the post of most comments here. I think this forum is becoming popular day by day & it’s really worth of it. I believe this is the best forum in internet nowadays about hair loss discussion & research.

  107. You guys taking finasteride arent worried about the long term sides? When I started taking it my libido dropped very quickly. On other forums people kept telling me to stick it out and it would go away. But then you see other posts from people that took it for like 8 years side effect free, and then all of a sudden it hit them hard and they can’t recover from the sides. After almost a year of no libido, I got too scared and just quit.

  108. I took Propecia and noticed significant changes down there in a week. I know some people will say I am crazy, but trust me when I say I never had any issues down there before – strong in that department. I didn’t want to believe it. I tried manually to see if I could get an erection, and much to my surprise.. It wasn’t happening. Fortunately for me, it came back after I quit in ten days, and now there are no issues. It was easily the scariest thing I went through in my life. I was bummed because I thought the people who had issues on it were crazy, depressed, or did not take care of their bodies. I am a workout junkie, so I thought my hormone levels would be fine, and I would have no side effects. Bummer. By reading how many people have problems with the medication, I seriously doubt the side effect percentage is really 2%. I wonder how many times, sides go unreported. I know my dermatologist didn’t report my issues to Merck. No one will ever know, statistically.

  109. @ DDog.

    You arent crazy. I dont believe propecia only has a 2% risk of sides either. I have read about and know too many people that got sides. Mine showed up very quickly too, and I also am a workout junkie that has NEVER had a problem down there. Going 3 times a day witha chick was not uncommon for me. After about a month it barely would stay up. Gf and I ended up breaking up so I didnt care at first and hoped it would go away. It didnt. Not until I stopped popping the pill. Then it took about 3 weeks to normalize. I had brain side effects too though. More forgetful, i always felt at a loss for words or couldnt think of thr word I wanted to say. Idk if it was the FIN or not, but its gotten a lot better since stopping.

  110. FYI Allergan Q2 2016 Earnings call
    ( ): “So we actually have two hair growth programs. One is bimatoprost, where we’re looking at a Phase 1 local PK [pharmacokinetics] study with bimatoprost for hair growth, and we’ll get the results for that later this year.

    And we also have setipiprant, which is the CRTh2 antagonist, where we plan to start Phase 2 studies later this year. The CRTh2 program came out of some academic work showing changes in prostaglandin D2 expression in male pattern baldness, and the CRTh2 receptor is the receptor for prostaglandin D2. So we have genetic validation of the target in male pattern baldness. And it’s that genetic validation that we’re exploiting with the compound that we acquired from Kythera along with Kybella.

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