I discussed Liz Parrish and BioViva in October of last year. While there has since been a great deal of skepticism surrounding Ms. Parrish’s self-experimentation as well as scientific credentials, I am still very interested in her approach (in particular, getting treated in developing countries so as to escape US regulations). She could really help speed up scientific progress. Moreover, anti-aging work (especially in regards to telomerase) has the potential to help hair loss sufferers too.
BioViva and Sierra Sciences
After some significant negative publicity earlier this year, Liz has received some positive feedback recently and she has visited a number of countries.
Shortly thereafter in May, the relatively well respected Dr. Bill Andrews (who I have covered on this blog before if you do a search) of Sierra Sciences announced that his company would partner with Liz’s company BioViva and open an anti-aging clinic in Fiji:
Also in May, Bill and Liz co-presented at this year’s 10x Medical Device Conference:
It really got out of hand in Russia and Liz became a glamour girl:
There is a chance that this company might end up being one of the craziest scams that the biotech world has ever witnessed, but it is nevertheless great to see the popularity of ant-aging treatments in Russia. The country is the only one besides the US to have its own Cryonics facility.
TA-65 contains a molecule called Cycloastragenol, which is derived from a Chinese herb called Astragalus (Huáng Qí). You can read the reviews through 2019 and purchase T.A. Sciences TA-65 via here –> TA-65 Telomerase Activation Capsules.
Youtube is a never ending goldmine of discoveries. Last year, I stumbled upon a highly interesting 2012 video from Dr. Ed Park titled “The Hair Show“. It is embedded below, along with my detailed analysis following the video. Dr. Park also published a 2018 video on 11 years of telomerase activation therapy.
I was impressed with Dr. Park’s breadth of knowledge about hair biology, despite him not being a hair specialist or dermatologist. His instructive presentation is also interspersed with some really funny imagery.
Among the more interesting items in the first half of the video were:
3:30 = A diagram showing the dermal papilla, hair follicle matrix, keratinocytes and more.
7:00 = A very useful table on hair throughout the body. Including what percent is in anagen (growth) phase verusus telogen (resting) phase in each region of the body at any given time. Also covered is duration of hair growth phase by region of body. Just prior to this table, Dr. Park also lists interesting facts about hair.
10:30 = He talks about hair loss being a sign of aging. Kind of true, but not always. Some people go bald in their 20s, but live very long lives. This would imply that hair loss is not necessarily a sign of aging throughout the body. Also, some people who die of old age still have a very full head of hair.
15:00 = He talks about grey hair being a sign of the destruction of melanocytes (make sure you read my post on the cure for grey hair). He then discusses DNA damage, TGF-beta, apoptosis and other issues that impact hair pigmentation. He includes some charts in there that are beyond my understanding.
16:30 = Quote –>”I would stop looking at the whole issue of testosterone and male pattern baldness…dry hole so to speak. Androgens are not the “root” cause of baldness.” All of us hair loss sufferers are sick of medications targeting dihydrotestosterone (DHT) and not curing hair loss. And none of us are going to get castrated to stop testosterone production. So this statement from Dr. Park cuts through the chase. Moreover, most of the new discoveries and research related to a hair loss cure that I have covered in the past 2.5 years do not involve targeting testosterone or DHT whatsoever. We have now moved beyond that area of research that has held us back for decades. Dr. Park made a great point, even though I am not sure if he knows of all the new research targeting other pathways to hair regeneration.
16:40 = He starts discussing telomeres and telomerase therapy, the main focus of the remainder of the video. Note that Dr. Park has published a well reviewed book on this subject titled: “Telomere Timebombs: Defusing the Terror of Aging”.
Telomeres versus Telomerase
Telomeres are repetitive nucleotide sequences (i.e., sections of DNA) at the ends of our chromosomes that protect them from damage. In humans, this sequence is represented by the acronym TTAGGG (where “T” stands for thymine, “A” stands for adenine and “G” stands for guanine). As we age, telomere ends become shorter each time cells divide, and this finally leads to cell death.
People with longer telomeres tend to have longer lives than those with shorter telomeres. You can get the length of your telomeres measured at specialized labs. Probably not a good idea for people who are hypochondriacs or suffer from anxiety.
Telomerase is an enzyme that adds the TTAGGG telomere sequence to the ends of chromosomes. Telomerase in effect replaces the short bits of DNA known as telomeres,
Slowing Ageing via Telomerase Therapy
Many researchers think that that reversing the shortening of telomeres through temporary activation of telomerase may be a potent means to slow aging. Among the ways to do this would include drugs, gene therapy and metabolic suppression. Increasing telomere length could even reverse aging, although there is a lot of controversy behind this theory. In any case, for those interested in this subject, two of the leading experts in this area of research have both recently published new books:
Micheal Fossell — “The Telomerase Revolution: The Enzyme That Holds the Key to Human Aging” .
TA-65 — Does it Grow Hair and Darken Grey Hair?
The second half of Dr. Park’s video above delves into Telomerase activation and how it can regrow hair and reverse grey hair. He gives a number of examples of this and even has some real patient testimonial interviews in there, including a 112 year old called Soledad Mexia! Unfortunately, she died two years later.
However, this case and testimonial makes Dr. Park’s video seem more legitimate. One caveat is that Ms. Mexia only took the pills for 3 days per the video. It does seem hard to believe that she got some darker hair so fast. It is also impossible to see the darker hair in the video, but I believe her family members when they say so.
In the second half of the video, Dr. Park heavily promotes a very expensive and controversial product called TA-65. This product is manufactured by T.A. Sciences and contains a molecule called Cycloastragenol that is derived from a Chinese herb called Astragalus. There are numerous people (including respected scientists such as Dr. Bill Andrews) who believe in this product. But there are also a lot of nonbelievers.
In any case, in both Amazon reviews and on Google searches for terms such as “TA-65 and hair growth”, you will see positive and negative testimonials. In my opinion, TA-65 is not worth purchasing unless you make at least $200,000 a year and can afford to blow away this kind of money.
It is also likely that other much cheaper products that activate telomerase will come to the market in the near future. In fact, the price of TA-65 has come down from $2000 per month several years ago to under $600 a month today.