Of the hundreds of hair loss products and peptides that are based on natural hair growth ingredients, only several dozen are well known. Among these, there are four whose names end in “yl” or “il” that I have heard mentioned a few times recently. These four are:
- Redensyl™ is a trademark of Givaudan (Switzerland) that is produced by subsidiary Induchem.
- Capixyl™ is a trademark of Lucas Meyer Cosmetics (IFF — US).
- Procapil™ is a trademark of Sederma (Croda — France).
- Baicapil™ is a trademark of Provital (Spain).
Taken individually, I would not care much for any of these peptide based products. I do not believe that any of them can be as effective as Finasteride or Minoxidil. The later two are still the only ever FDA-approved drugs to treat androgenetic alopecia.
Redensyl, Capixyl and Procapil Combination
However, it seems like there are nowadays a number of compounded products on the market that include more than one of these four ingredients. I list some of these “combo” products later in this post. You can get both serums and shampoos containing these combination ingredients.
Last month, a reader e-mailed me a link to a 2019 Turkish study that analyzed Redensyl plus Capixyl plus Procapil (“RCP”) combination topical hair loss treatment. The surprising conclusion was that it grew more hair in users than topical 5% Minoxidil. One of the before and after photos with clear new hair growth is pasted below.
Note that this “RCP” product is currently reserved by the Turkish Patent Institute under the name “Procare”. In the above mentioned study, the description of making this combination product seems relatively simple.
On Amazon, laser hair growth device manufacturer iRestore makes a Redensyl based Anti-Hair Loss Serum. Average reviews currently stand at 3.8/5, but very few of those have any before and after photos. Redensyl stimulates stem cells and human fibroblasts from the dermal papilla to increase scalp hair growth. While Redensyl is side effect free, it is not officially approved to treat hair loss like Finasteride and Minoxidil.
Redensyl is made of a combination of natural botanical ingredients and plant extracts. It also contains Dihydroquercetin Glucoside (DHQG) and Epigallocatechin Gallate Glucoside (EGCG2). The latter has anti-inflammatory properties via the reduction of IL-8 release by keratinocytes. Redensyl is often described as a hair galvanizer that acts at the cellular level.
Capixyl is a biomimetic signal peptide complex (acetyl tetrapeptide-3) that is combined with a red clover extract rich in Biochanin A. Red clover is known as trifolium pratense, which has proven hair growth and hair density increase benefits. It does this via the inhibition of 5-α-reductase activity; reduction of inflammation and cytokines; and stimulation of extracellular matrix (ECM) protein synthesis in the hair follicle vicinity.
Procapil contains three plant-derived substances:
- Oleanolic acid, which is extracted from olive leaves. It inhibits 5α1 and 5α2 reductase enzymes, thereby reducing dihydrotestosterone (DHT) related hair loss.
- Apigenin, a flavonoid extracted from citrus peel. Aids in vasolidation and increases blood flow to the hair roots.
- Glycinehistidine-lysine peptides, which boost pro-matrix
metalloproteinase activity. This in turn benefits the metabolic
requirements of hair follicles.
Further reading: Reduction of Hair-loss: Matrikines and plant molecules to the rescue.
Update: Reader Tim pointed out that RevivHair Max Hair Stimulating Serum contains: Redensyl 5%; Acetyl Tetrapeptide-3, the active peptide in Capixyl; and Biotinoyl Tripeptide-1, the key peptide in Procapil. Moreover, it also contains Myristoyl Pentapeptide-17 (keratin stimulating peptide), often used to make eyebrows and eyelashes thicker.
Update: Reader George found an interesting hair regenerator serum product from Spain-based Redenhair. It contains 3% Redensyl, 3% Procapil and 2% Capixyl.
Baicapil Joins the Club
A lesser known but still popular product is Baicapil. It contains a combination of three key botanical ingredients: Scutellaria baicalensis, soy sprouts and wheat sprouts. Scutellaria baicalensis contains Baicalin, an important ingredient in traditional Chinese herbal medicine. Baicalin is thought to increase hair growth via increasing canonical Wnt/β-catenin signaling and activating dermal papilla cells.
On Amazon, there is a super expensive product called “More Hair Naturally 9: Advanced Stem Cell Therapy For Thinning Hair”.
It contains clinical strength Biacapil, Redensyl and Capixyl. It also contains mountain ginseng root, bamboo sprouts and stem cells from adult human fat cells.
— Also available on Amazon is United Pure’s Baicapil plus Capixyl based combination shampoo.
Interestingly, reader “Toccata” posted the below comment on this blog in January 2019:
“A few posts ago, John Doe mentioned a company — More Hair Naturally — selling a ferociously expensive, all natural, topical treatment. I noticed it shared a lot of the same ingredients as another topical I bought last year. The difference being I paid $17CAD for 60ml and they are charging $125US! for 50ml.
The topical I bought is: Multi-Peptide Serum for Hair Density.
It was a whimsical purchase that I thought would be for an occasional ‘whatever’ application. But now that I’ve looked closer at the actual studies of the ingredients, I might give this a legitimate daily 12 month trial run. I also microneedle and use Minoxidil so I won’t be able to make a reliable judge on its actual efficacy.”
I assume that Toccata did not see any miracle results with this potion, but nonetheless quite interesting.