Hair Loss Cure 2020

I first covered UK based HairClone in 2016 in this very post (original version at the bottom). Then I interviewed the company’s accomplished CEO Dr. Paul Kemp several times.

Note that Mr. Kemp was previously CEO of Intercytex and has decades of experience in the regenerative medicine and hair space.

I wrote another post on HairClone’s hair follicle banking service in 2019 and updated it in 2021.

Update: March 9, 2023

Last week, one of our readers mentioned that HairClone had updated its website. I contacted Dr. Kemp and he confirmed that the refreshed site was launched on February 27th, 2023. And they also have a new logo. Moreover, the company plans to start its delayed cell expansion service no later than 2024.

HairClone to Start Cell Expansion Service by 2024

In my prior update from 2021, I mentioned HairClone’s goal of commencing its cell expansion service in 2022. However, this was delayed in the aftermath of Covid and fundraising related issues. Several days ago, Dr. Paul Kemp e-mailed me an update and I am pasting his email below:

“Sorry for not replying sooner but I have just returned from annual leave. Yes we have freshened up the website and created a new logo that was inspired by our goal of rebuilding miniaturizing hair follicles. It was launched Feb 27th.
Our banking service continues to increase and we now have had 3 years of successive growth. We have also shown that our cryopreservation technology, as well as preserving the Dermal Papilla (DP) cells that we will use in the treatment we are developing, is also able to cryopreserve the other cell types from the hair follicle such as melanocytes, epithelial cells and bulge stem cells which could be used in other Regenerative Medicine therapies.
Though we are focusing solely on androgenic alopecia at this time, the follicles we are banking remain the property of the patients so this is a valuable way that patients could store considerable numbers of various cell types in a simple outpatient surgical procedure.
As always, we are re-investing revenues from banking to advance the therapy but are still limited by our ability to bring our technology to the clinic by our funding of the GMP manufacturing process needed to use the DP cells in the clinic.
We have developed an effective and reproducible system to increase the number of DP cells over 1,000 fold and have been able to carry out most of the technical transfer stages of this process to a licensed contract manufacturing facility. But we need additional funds in order to complete this technical transfer and enable the manufacturing facility to produce cells for clinical use.
We are looking to increase the number of Banking Associate Clinics that we work with both in the Americas as well as Europe and Asia and we are working to raise new equity funding in 2023. Our aim is to obtain the funds needed and start offering our cell expansion service no later than 2024.“

Update: October 15, 2021

I always assumed that HairClone’s actual hair cloning or hair multiplication procedure was still years away. They have yet to even start human clinical trials. However, when it comes to autologous hair cell multiplication and transplantation, the UK has less stringent guidelines when it comes to testing in humans. Clinicians can offer unlicensed procedures prior to clinical trials. Japan also has some similar favorable regulations.

What an incredible surprise to then find this encouraging new below interview of Dr. Paul Kemp! He is one of the keynote speakers at the upcoming ISHRS 2021 conference. His presentation will be titled:

“The Evolution of the Promise of Hair Cloning: How Hair Cell Cloning will Fit Into Your Practice.”

HairClone will offer its cell expansion hair multiplication services on a select basis in certain clinics in the UK starting in early 2022. Dr. Kemp has consulted with regulators and they are very supportive of this step. It is a way to ensure that future expensive and lengthy clinical trials have a much greater chance of success.

“What we are planning to do early next year is offer a cell expansion service.”

— Paul Kemp (at 15.:50 into the below video).

Watch this video on YouTube

September 8, 2016

During the past few months, there have been a few new companies entering the hair regeneration sector. Today, I learnt about yet another new entrant into the field named HairClone that warranted its own post. As yet, I do not consider HairClone anywhere near as important as the established entities such as the RIKEN/Kyocera/Tsuji partnership (Japan); or the Shiseido/Replicel partnership (Japan).

HairClone

I will briefly analyze HairClone via its positives and negatives:

Positives

The renowned and widely respected researcher Dr. Claire Higgins joined HairClone’s advisory board on August 30th, 2016.
HairClone will be hiring more scientific advisers besides Dr. Claire Higgins in the near future. Would be great if they tried to get Dr. Roland Lauster into the team.
A recent Tweet suggests monthly update meetings with PhD students.
HairClone has devised a unique and creative strategy to get funding that includes: crowdfunding; giving people who fund the company’s research preference when the actual treatment comes out; allowing investment in equity; offering leading hair transplant clinics around the world membership opportunities; and most interesting of all, hair follicle banking and storage.

Negatives

By far the biggest negative is that this is still way too early in the game and who knows when trials will commence, and whether the company will succeed with its dermal papilla focused cloning technology in the first place. Or even if they manage to get sufficient funding.
Related to the above, when Solomon interviewed Dr. Claire Higgins earlier this year, she generally sounded pessimistic about new treatments and said the following about cloning. Update: Solomon corrected me in the comments and said she was only talking about cell injections. But I think she sounded pessimistic about the hair cloning time-frame in the whole interview:

“I think the future (but it’s not in 4 years or 5 years away, it’s like in 20 years) is to promote direct conversion of fibroblasts into papillae. But something like this will take decades. We don’t know how to do that yet.”

I am hoping that Dr. Higgins will change her prediction to 10 years if her lab and research work gets significantly more resources as a result of HairClone. Thankfully, she said that she was not exactly sure about Dr. Tsuji’s work. Neither did she list Shiseido’s trials in Japan in her list of ongoing trial examples. So maybe she is just entirely focused on her own work and not following others too much?

Twenty years would be too big a gamble to invest in a company such as HairClone. I hope Dr. Bessam Farjo has other ideas and is hoping for much faster completion of clinical trials. And hopefully he is not only relying on Dr. Higgins’ dermal papilla related work.

Note: The company website has some typos, flow issues and seems somewhat haphazardly put together at the moment. It even includes “hello-world” and placeholder type pages.

Note that the increasingly popular low-dose oral Minoxidil for hair loss (taken via ingesting pills or tablets) acts a bit differently compared to sublingual Minoxidil (taken via dissolving under the tongue). Read the bottom half original version of this post for more details.

Sublingual Minoxidil for Hair Loss Updates

Update: February 2023 — A HRN forum member named “Viney” is posting excellent details with photos of his hair regrowth from sublingual Minoxidil and Dutasteride. He sees a dermatologist at Sinclair Dermatology (Melbourne, Australia).

Update: January 2023 — I posted something on Twitter about sublingual Minoxidil possibly being more effective than oral Minoxidil. Below are the interesting responses from Dr. Corralo and Dr. Bhoyrul:

Update: December 2022 — Also see this thread on Twitter in relation to the same subject.

Update: September 2021 — A clinical trial of 40 male and female patients receiving sublingual Minoxidil (SM) for androgenetic alopecia just ended. Per the summary, SM produced a dose-dependent increase in mean terminal hair count of the frontal and vertex scalp and an improvement in hair density. There was no affect on blood pressure. Quote from reviewer Dr. Mirmirani:

“The authors suggest that sublingual Minoxidil (SM) may have better bioavailability and fewer hemodynamic effects by avoiding first-pass liver metabolism. Although the data in this study are positive, it will take more to convince me that it is significantly better than oral Minoxidil (OM). Very few of my patients on low-dose OM for hair loss discontinue the medication due to side-effects. The other consideration is cost. OM it is an inexpensive, generic drug, that is covered by medical benefits.”

Update: March 2021 — An excellent video presentation on sublingual Minoxidil from Dr. Bevin Bhoyrul from Sinclair Dermatology:

Watch this video on YouTube

Update: July 2020 — Also from Sinclair Dermatology comes a case series report of 64 patients taking sublingual Minoxidil (0.45 mg per day) for pattern hair loss.

April 9, 2018

Sinclair Dermatology

Earlier today, a reader named Chris posted a very interesting video about a new hair loss treatment from Australia that entails putting some kind of dissolvable listerine-style strip underneath the tongue. Chris asked me for my opinion about this treatment.

At first, I thought that this seemed like an obvious scam since the title of the video includes the word “breakthrough” in it. Moreover, the video does not even mention what ingredients are in the sublingual strip or patch itself.

However, since the famous Australian dermatologist Dr. Rodney Sinclair appears in the video, I decided to conduct further research. Dr. Sinclair (associated with “The Hairy Pill“) is an extremely well respected researcher in the hair loss world. In the above video, he is honest and clearly says that this treatment will not bring back hair in totally bald scalps.

Having said that, so far it seems that the results from this treatment on people who have moderate levels of balding have been very positive. And this got me curious about what magic concoction was in the strip itself?

Clinical Trial for Sublingual Minoxidil

I did not have to conduct much further research to figure out what this new potential breakthrough hair loss cure entailed. On Dr. Sinclair’s blog, the latest post from today discusses a new clinical trial they are conducting that is recruiting both men and women. Volunteers will be treated with low-dose oral Minoxidil that will be given as a sublingual tablet (which will dissolve under the tongue).

I would not be surprised if the tablet is actually the strip/patch that was shown in the video I posted earlier. It would be very uncomfortable to put an actual tablet underneath the tongue and wait for it to dissolve, unless the dissolution happened very rapidly. On the other hand, a strip would be much easier to keep in place underneath the tongue for a longer period of time.

I discussed oral Minoxidil for hair loss in detail last year. While I often use topical Minoxidil foam, I would not take the oral version as I do not want more body hair as a potential side effect. However, oral Minoxidil clearly seems to be a superior option to topical Minoxidil when it comes to hair growth benefits. Partly due to the sulfotransferase issue.

If you live in Australia or in the nearby vicinity, perhaps it is worth volunteering for these trials. Today I finally learnt the definition of “sublingual”.

Also make sure to read my post on extra strength Minoxidil 15 percent for other alternatives to regular dosage store-bought Minoxidil foam.

HairClone to Offer Cell Expansion Service by 2024