Dr. Takashi Tsuji’s Hair Loss Cure will be Costly

For those of us who have followed hair loss cure research over the past decade, the number one person of interest is Japan’s Dr. Takashi Tsuji. He previously announced the aim of releasing a hair loss cure by the end of 2020. This was prior to the onset of the current global pandemic. Dr. Tsuji’s work is occurring at RIKEN’s major research center in Kobe, Japan. And he is partnering with locally headquartered Organ Technologies and Kyocera.

Update: November 8, 2020

Rumors of Dr. Tsuji’s Failure Exaggerated

Recently, we learnt that Organ Technologies had failed and was shutting down. A lot of people including myself were extremely disappointed. However, it seems like work at RIKEN continues. This month they published an interesting new study related to human skin.

More relevantly, in November 2020, Dr. Tsuji and his hair growth research was featured in a local NHK BS television broadcast. It was titled “Humanience-4 Billion Years of Plans.” Thanks to the various people who posted or e-mailed the above links. I sent the video link to “Fuji Maru” and hope he lets us know if it contains anything useful.

And today, to my utmost surprise, the most troll-like and negative commentator “jan” posted the most relevant link. Apparently, Dr. Tsuji and the RIKEN + Kyocera team’s patent was just updated. It is based on an April 2020 filing date, so probably just international approval formalities. Organ Technologies is still listed in there as a co-inventor.

Inventor(s):

TSUJI, Takashi; c/o RIKEN
TAKEO, Makoto; c/o RIKEN
OKAMOTO, Naokazu; c/o Organ Technologies
OGAWA, Miho; c/o Organ Technologies
MORI, Yutaka; c/o Kyocera
KISHIMOTO, Kyosuke; c/o Kyocera

Update: August 8, 2020

Takashi Tsuji Clinical Trials
Takashi Tsuji Human Clinical Trials in 2020.

Youngjet added a summary video of his attendance of Dr. Tsuji’s Zoom lecture. On Twitter and Youtube, he told me that human clinical trials will start in 2020 after approval from the relevant Commission for Regenerative Medicine. To be honest, this is disappointing news as I was hoping human trials already started earlier this year.

Youngjet’s prior video at the bottom of this post and past statements from Dr. Tsuji both indicated faster progress. In any case, trials in Japan will not take as long as in the west, especially in the autologous regenerative medicine sector.

Update: August 6, 2020

Dr. Tsuji replied to my email, and it seems like no new announcements in the August 5 presentation:

Dear Admin,

Thank you for your interest in our research. There was no updates because the lecture was for graduate school students aiming to get fundamental knowledge. For further information, please refer to our laboratory website for the latest news on the progress of our research projects. Our laboratory is striving to advance research with the aim of fulfilling the expectations to improve quality of life for many individuals. We thank you for your patience and continued support of our research activities.

Sincerely,
Takashi Tsuji
Laboratory for Organ Regeneration
RIKEN Center for Developmental Biology Research (BDR)

Update: August 4, 2020

Dr. Takashi Tsuji Zoom Events in August

By now, most readers know that Dr. Takashi Tsuji is participating in several Zoom and web based online presentations in August 2020. I have sent a few messages to Fuji Maru and to ハゲリーマンちゃんねるin case they can attend any of these events. I will update this thread if they or others send me any new information.

Dr. Tsuji will be presenting via a Zoom conference on August 5, 2020 (h/t reader “Karl” and “RolfLeeBuckler” on HLT):

Then, on August 24 and August 25, Dr. Tsuji and RIKEN will be making a  two-part web presentation.

  • Part 1 = “Of hair science front line: from the basics of innovation to beauty and health.”
  • Part 2 = “Overview of new products for FY2020.”

Also keep an eye on RIKEN’s Facebook page, and on Organ Technologies’ website.

Takashi Tsuji Web Presentation.
Takashi Tsuji Web Presentation in August 2020.

Update: June 26, 2020

New Interview

Recently, a number of readers have asked about Dr. Takashi Tsuji’s January 2020 article and interview in a Japanese magazine. Earlier today, reader “Lurker10” managed to purchase it from here and also posted it on Imgur! Keep in mind that all the information in this article is from prior to the Covid-19 pandemic. So there could be some delays in the work’s progression. Update: It seems like the interview mostly covered Dr. Tsuji’s historical hair loss research related work per reader comments and translations.

Dr. Takashi Tsuji in 2020.
Dr. Takashi Tsuji in his lab in 2020.

Baldness will be Extinct

Update: August 14, 2019 — English version of below video is now published. Title: “Baldness will be Extinct! The Time has Come!!”

July 22, 2019

In June 2019, Dr. Tsuji gave some interesting quotes to the Financial Times about the future importance of Kobe when it comes to medical tourism. Also in June, Dr. Tsuji gave an important 4 page interview to Beyond Health.

Dr. Tsuji: Hair Loss Cure in 2020 or 2021

Recently, a Japanese hair enthusiast named “Youngjet” posted a video regarding his attendance of a recent lecture in Japan by Dr. Tsuji. Five people emailed me or commented on here about the below video!

After you translate the video, it seems like Dr. Tsuji will release his cure in 2020 and/or 2021. It will initially cost 20 million to 40 million Japanese Yen ($190,000 – $380,000 per today’s exchange rates). Prices will then slowly come down over the next decade.

Perhaps Dr. Tsuji gave us two numbers (20 million and 40 million) because some people will have one session and some will have two sessions?

Note that as of 2019, they are already testing this treatment in humans. Favorable Japanese regulations probably allow for this possibility, even though clinical trials are yet to be completed.

Make sure to see the results of my 2016 poll on how much you would pay for a hair loss cure. Only 12.5 percent of you voted for over $100,000!

— The guy (“Youngjet”) in the below video has the following Twitter account.

— Another Japanese person named “Tonegawa” has more information on these developments.

Perhaps the most important screenshot from the above video:

Hair Loss Cure in 2020 or 2021.

Skin Regeneration, Wound Healing and Hair Growth

Two recent papers published important new findings in regards to wound healing and skin regeneration.

Wound healing via skin regeneration is often accompanied by hair follicle regeneration. Or even by brand new hair follicle neogenesis (e.g., Follica). Note that this hair growth after wounding phenomenon was even researched in the 1950s and 1960s.

On a related note, thousands of hair loss sufferers around the world are trying out at-home microneedling and dermarolling. Many of them have seen significant success, although one has to be careful with this type of scalp self-injury. On our hair loss chat, the most interesting recent discussion is around wounding depth levels.

Human embryonic and neonatal skin has the potential to regenerate after wounding. This includes fully functioning hair follicles. However, adult skin no longer has such regenerative capabilities. Researchers have been trying for years to find ways to coax salamander-like regenerative powers in humans. If not for whole limbs, at least for hair growing skin to cover baldness for our sake.

New Studies on Skin Regeneration and Wound Healing

1) In September 2020, a team that included Dr. Jeff Biernaskie published a study on the regenerative potential of dermal fibroblasts during wound healing. They identified a specific population of progenitor cells that reside within the dermis and which aid in wound healing.

Skin Regeneration Regulators
Skin Regeneration Regulators. Source: Bernaskie Lab GitHub.

The research is shared on GitHub. Also see Biernaskie Lab. According to the findings, Runx1, retinoic acid, and Hic1 control mesenchymal regenerative capabilities.

According to this summary, Dr. Biernaskie (whose work I have covered in the past) said that they have shown the following:

“You can alter the wound environment with drugs, or modify the genetics of these progenitor cells directly. Both are sufficient to change their behavior during wound healing. And that can have really quite impressive effects on healing that includes regeneration of new hair follicles, glands and fat within the wounded skin.” 

“It suggests that the adult wound-responsive cells do in fact harbor a latent regenerative capacity, it just simply needs to be unmasked.”

2) Also in September 2020, a new study from the University of Washington identified Wnt transcription factor Lymphoid enhancer-binding factor 1 (LEF1) as the key factor in adult skin regeneration.

LEF1 gene expression in fibroblasts has the potential in adult skin to repair itself like the skin of a newborn baby. This skin  can also grow new hair follicles.

Interview with lead author Dr. Ryan Driskell.

“We identified a genetic factor that allows adult skin to repair itself like the skin of a newborn baby.”

Hair, Skin and Wounding Interconnected Research

While researching for this post, I could not believe the number of diverse past posts that I have written on this blog that have focused on skin regeneration, wound healing and hair formation.

Regenerating hair follicle after wounding.
Wound induced single hair follicle neogenesis in a bald old man.

Renowned hair loss researchers such as Dr. George Cotsarelis, Dr. Luis Garza, Dr. Elaine Fuchs and Dr. Mayumi Ito have all also conducted frequent research on skin regeneration. I have discussed their work in past posts if you search for their names.

My gut feeling is that whenever there is a fully effective cure for hair loss, there is a strong likelihood that there will also be a cure for quality skin regeneration.

Skinregeneration.org

The authors of the second study that I linked to earlier have started a new site called skinregeneration.org. The site’s mission is to provide a platform for scientists to easily query large datasets that focus on skin wounding and scarring repair.

For further information, see the Driskell Laboratory site at Washington State University.

Skin Gun and Spray-On Skin

It seems like the technology to repair skin has improved significantly during the past decade. There is an especially unmet need when it comes to treating skin that has been burnt badly.

One of the technologies that I used to very curious about is the skin gun that was widely hyped in 2011. I have not heard much about this in recent years. RenovaCare acquired the technology in 2013. The company’s skin gun and spray-on stem cells for wound healing are trademarked under the names SkinGun™ and CellMist™.

Hair loss cure news blog. Hair cloning and hair multiplication developments for baldness.