Hair Loss Cure 2020 | Hair loss blog with the latest news updates.

In 2019 when I first discussed exosomes for hair growth, most doctors were injecting them into the scalp. Recently, I also discussed the rarer intravenous (IV) delivery of exosomes to tackle hair loss. Now I look at the topical application of exosome serums into the scalp, due to three such new products being in recent news.

Note that some injectable products from exosome suppliers to the hair loss market can also be applied topically. The method of delivery will depend on your doctor’s or clinic’s preference.

Calecim (PTT-6) Advanced Hair System with Topical Exosomes

Calecim PTT- 6 Topical Exosomes — Calecim (PTT- 6) Advanced Hair System: Topical Exosomes and Growth Factors for Hair Growth.

Recently, HairClone (UK) announced a partnership in which the company will work with an interesting new exosome containing topical product called Calecim Advanced Hair System (that comes with a Derma Stamp).

Edit: The manufacturer has now given blog readers a 15% off discount code “HLC2020“ for purchases of the Advanced Hair System kit.

Per their website, Calecim includes PTT-6^®, which contains over 3,000 proteins, including growth factors, cytokines and exosomes that signal cells to regenerate.

PTT-6 is derived from the secretion of cord lining stem cells isolated from the umbilical cord tissues of New Zealand red deer at birth. No deer is harmed during the extraction and harvest process of this rich source of stem cells.

The full list of ingredients is PTT-6^® and cord lining conditioned media (from stem cell derived fibronectins, glycoproteins, albumin, collagens and hyaluronic acid).

This Calecim topical serum is to be used with an included Derma Stamp for better absorption. A lot people underetrake at-home microneedling for similar reasons. This includes via dermarollers or dermapens or dermastamps.

Elevai Exosomes Combined with Yuva Biosciences Mitochondrial Technology

Elevai Topical Exosomes for Hair Growth.

Elevai Labs (US) recently gave a positive update regarding the company’s topical Elevai “age zero” Exosomes™ product range for hair loss. In a year-long study that the company conducted, patients who used Elevai empower™ exosomes in combination with in-office microneedling saw favorable results. The company also makes Elevai enfinity™ for at-home use in repairing your skin.

The 12-month results were assessed using imaging analysis and showed a cessation in crown inflammation, a reversal of miniaturized hairs, and a recovery of hairs from the dormant resting phase. the still on-going research study is being conducted in partnership with Carly Klein, president of the National Hair Loss Medical Aesthetics (NHLMA).

Note that I previously also discussed Elevai in my post on Yuva Biosciences and BosleyMDs new hair loss product related to mitochondrial upregulation. Yuva is partnering with Elevai to release a hair loss product that will combine Elevai’s proprietary PREx™ exosome technology with Yuva’s Y100™ mitochondrial technology. The two companies jointly filed for a combination patent in August 2024.

Ultimately, Elevai is developing a new hair and scalp care product line, called “Elevai S-Series Root Renewal System” that will be powered by exosomes and mitochondrial technology. According to company CEO Dr. Jordan R. Plews, they are in the process of conducting a follow-on study. This will further analyze the combination of Elevai exosomes and Yuva’s Y100 mitochondrial technology to address hair loss and thinning concerns.

In January 2025, Elevai’s skin and hair care business was acquired by Carmell (US). In March 2025, Carmell announced a rebranding and name change to Longevity Health Holdings. The company plans to launch a hair growth serum in the second quarter of 2025. Most likely, it will be the exosome and mitochondrial upregulation product that I discusses above.

ExoCelBio Evovex Serum

Another company that makes a line of topical exosomes is ExoCelBio (US) via its Evovex serum. The company website says that these exosomes are derived from the chorion of placental mesenchymal stem cells (pMSCs). Their Exovex™ serum Refine brand was launched in 2023 and has a concentration level of 75 billion exosomes per vial. Refine employs a high concentration of non-lyophilized, purified exosomes that results in fuller and stronger hair.

In May 2024, the US FDA sent a violation warning letter to ExoCelBio in relation to the company’s marketing and lack of a biologics license. This is not surprising, considering the new stricter FDA guidelines governing exosome products. In the US, exosomes are regulated as both a drug and a biologic. In Europe, you are not even allowed to use human-derived exosomes to treat hair loss.

Zishel Xomage

A June 2025 study that was co-authored by scientists from South Korea, France and Germany found the use of topical Zishel Xomage exosomes to significantly benefit hair growth. The product was applied to the scalp after microneedling. Note that Zishel makes both plant-based exosomes; as well as human adipose-derived mesenchymal stem cell based exosomes.

Skin Injury, Adipocyte Lipolysis and Hair Growth in 20 Days

No-one paid attention to the above mentioned new study till today. As is so often the case, this is due to coverage by the widely read Daily Mail in a catchy title that suggests a hair loss cure in 20 days. To be fair, they do mention in the title that it was in mice.

Spurred to do further research, I then realized that I had covered the lead author of this new study (Dr. Sung-Jan Lin of National Taiwan University) in a 2020 update to my post on the arrector piil muscle.

Moreover, all the way back in 2014, I covered Taiwan National University Hospital’s study on hair cloning (under the leadership of the same Dr. Sung-Jan Lin).

Even more interesting, one of the co-authors of this study is the renowned hair loss researcher Dr. Maxim Plikus. Giving it all the more legitimacy.

Getting back to the study, the scientists induced eczema (aka the injury or irritation) on shaved mice of both sexes. They did this by applying a chemical irritant called sodium dodecyl sulfate (SDS) to their backs. Lo and behold, in 11 days, the treated areas of skin started to sprout new hair from follicles that are just a fraction of a millimeter wide. At the same time, hair didn’t regrow on the areas of the mice without eczema. The hair also didn’t grow in other shaved mice that were never treated with SDS.

The researchers found that the irritant causes immune cells to move into the layer of fat beneath a mouse’s skin. This in turn signals fat cells (adipocytes) to release fatty acids which are then absorbed by hair follicle stem cells. Ultimately triggering hair growth. The intentional injury triggers adipocyte lipolysis, which in turn activates epithelial stem cells for hair regeneration through fatty acid metabolic signaling.

A new Fatty Acid base Serum for Treating Hair Loss

The most interesting part is what the researchers did next. They tested various monounsaturated fatty acids (MUFAs) on skin without the use of any chemical irritant. They created rub-on serums made of different fatty acids (such as oleic acids and palmitoleic acids) dissolved in alcohol. To my surprise, the researchers found that these fatty acids were effective in promoting hair regeneration, even when applied to the skin without any preceding irritant.

They have patented their serum and now plan to test different dosages of it on people’s scalps. Since oleic acids and palmitoleic acids are naturally derived fatty acids, they are safe and side effect free. No clinical trials will be required to sell this product as a hair loss cosmetic.

The Taiwanese team is already seeing promising results when applying it to human hair follicles in their lab. And Mr. Lin applied it to his thighs and gave the following quote:

“I personally applied these fatty acids, dissolved in alcohol, on my thighs for three weeks and I found it promoted hair regrowth”

Of course my gut feeling based on over 12 years of writing this blog is that this will not translate into any significant scalp hair regrowth in humans. Perhaps some minor hair thickening, as can be seen when using the best hair loss shampoos, some of which even contain plant-derived oleic acids and palmitoleic acids.