The Bald Truth Show: Live Today

I have discussed “The Bald Truth” show many times on this blog. Usually when I catch an episode of relevance to a new post that I am writing.

The show’s hosts are Spencer Kobren and Joe Tillman. Spencer has been involved in the hair loss world for 25 years, and in 2000 even authored a book on hair loss. He is also the founder of the American Hair Loss Association.

I have covered Joe several times on this blog, and he has had an unbelievable 10 hair transplant surgeries. Ranging the gamut from bad surgeries; to repair surgeries; to crown and scar improvement surgeries; to a minor body hair transplant procedure. You can find Joe’s before and after photos and videos on his site.

I will republish this post each Friday the show is on. The post will only remain on top for half the day. You can click on the below video to go to the actual YouTube broadcast with the live chat and comments.

The Bald Truth™ August 12th, 2022

Hair Transplant Mentor™ Presents Spencer Kobren’s The Bald Truth with Joe Tillman.

  • 3:00 PM Pacific
  • 6:00 PM Eastern
  • 10:00 PM GMT

— Call in from North America: 1-888-659-3727
— Call in from the UK/EU: 0203-3724-683

TGF-β and Hair Growth

This past month was the most important one of the year in the hair loss world. First came the major finding of SCUBE3 signaling and hair growth from researchers at the University of California, Irvine (UCI). Several weeks later, a team from the University of California, Riverside (UCR) released findings that TGF-β is the key protein that governs hair follicle growth and death.

A lot of people confused the above two studies. For one, those two universities are less than one hour drive from each other. Also, in the SCUBE3 study, there was a connection made with TGF-β (aka TGF Beta).

Interestingly, the lead authors of the above two studies (Wang and Plikus) even collaborated in a 2017 study relating to hair growth pattern differences around the body.

TGF-β Governs Hair Follicle Fate

The actual study can be found in Biophysics Journal. A lot of media picked up on this news, including the prolific hair loss news covering Daily Mail. In a rarity, even WebMD wrote about these findings.

Key quote from study co-author and mathematical biologist Dr. Quixuan Wang:

TGF-beta has two opposite roles. It helps activate some hair follicle cells to produce new life, and later, it helps orchestrate apoptosis, the process of cell death.

Also according to Dr. Wang: When a hair follicle kills itself, it never kills its stem cell reservoir. If the surviving stem cells receive the signal to regenerate, they can divide and develop into a new follicle. I am sure we have heard something similar many times in the past.

Long-lost dead hair follicles can certainly regenerate under the right circumstances. Unfortunately, one potential side effect of such future treatments is unimpeded cell growth proliferation that could lead to cancer. Hence the need for lengthy human clinical trials.

For some reason, TGF-β is called a chemical rather than protein (or cytokine) in most of the articles and headings. The UCR researchers found that when the TGF-β chemical is in high concentration levels, it kills hair follicles. However, when the levels are “just right“, it causes them to grow new hairs.

If the levels of TGF-Beta can be controlled, it will be possible to prevent chemical buildup and further hair loss. In a best case scenario, it might also be possible to re-activate follicle stem cells and stimulate hair regrowth.

Note that transforming growth factor beta (TGF-β) is one of the growth factors in PRP.

Will these Mathematicians cure hair loss? I certainly hope so, since I have a bias towards the subject as a past Math major.

TGF Beta 1, 2 and 3

Note that there are three different isoforms of transforming growth factor beta (TGF-β) in mammals:

  1. TGF beta 1.
  2. TGF beta 2.
  3. TGF beta 3.

A 2019 study from China titled: “New Insight into the Relationship between TGF-β Superfamily and Noggin in hair cycle” contains a great diagram and table that explains the impact of each of the three on the hair growth cycle. I am pasting it below.

TGF-β Hair Growth
TGF-β family and the hair growth cycle. Source: IOSR Journal of Dental and Medical Sciences. Author: Xiuhong Jiao.

Hair loss treatment and cure related news updates.