Electricity and Hair Growth

No matter how many years I research hair loss, virtually every month still brings a major surprise. The latest eyebrow-raising story concerns electricity stimulating hair growth, and comes to us from UW Madison.

New Studies on Electrical Stimulation for Hair Growth

Update: March 2022 — Related new study from Junji Fukuda titled “Electrical stimulation to human dermal papilla cells for hair regeneration”.

Update: April 2021 — South Korean scientists find that micro-current stimulation can promote hair growth.

Baseball Cap to Zap your Scalp and Stop Hair Loss

Update: These scientists from UW Madison have now formed a company called Rise Technology. They are developing a battery-free wearable electric cap that stimulates scalp hair growth. The cap will be called “GrooHair”.

Per their website:

“This device builds on the principle of converting biomechanical energy into low-intensity alternative electric fields. This electric field stimulates the segregation of KGF and VEGF growth factors, which effectively activate the hair follicles in the scalp.”

Electric Stimulation for Hair Growth.
Electric Stimulation to Grow Hair. Source: ACS Nano, Wang et al.

Yesterday, an article in Futurism discussed a new baseball cap invention that mildly electrocutes your scalp and leads to hair growth. Moreover, the cap is powered by small head movements from whoever is wearing it. i.e., no battery or electricity needed. Of course I initially laughed off this whole concept. However, upon further examination, there is some logic to this story.

The scientist who made this invention is Dr. Xudong Wang who leads the University of Wisconsin-Madison’s nanoscience and nanotechnology group. His lab has done an especially large amount of work in the bioelectronic and energy harvesting sectors. This weeek they published a paper in which they discussed how they increased hair growth in mice via electrical stimulation.

“Self-Activated Electrical Stimulation for Effective Hair Regeneration via a Wearable Omnidirectional Pulse Generator.”

This work was published in ACS Nano. It was also covered in New Scientist magazine and Science Daily, all fairly reputable magazines. Dr. Wang’s team aims to conduct human clinical trials in the near future.

Their actual invention makes use of something called the triboelectric effect. In the cap, small nanogenerators passively gather energy from day-to-day body movements. These nanogenerators then transmit low-frequency pulses of electricity to the scalp skin. This electric stimulation and electrostatic field causes dormant (or telogen) hair follicles to wake up.

Note that there already exists a battery powered hair growth stimulation device called Niostem. And on a somewhat related note, electricity charger powered low-level laser therapy (LLLT) devices such as the Hairmax laser comb.

Dr. Wang is a world leading expert in the design of energy-harvesting devices. Among the inventions that his lab is most famous for include electric bandages that stimulate wound healing; and a weight loss implant that uses electricity to trick the brain into thinking that the stomach is full.

Note that this work was only proven in mice, and supposedly in one human (Dr. Wang’s father). The cap will not regrow hair in completely bald men, but it may regrow recently lost hair as in the case of Mr. Wang’s lucky father.

Prior Work on Electricity and Hair Growth

Moreover, all the way back in 1990, Canadian scientists discovered that they can help restore thinning hair by stimulating the scalps of balding men with a pulsed electrical field. The lead research was a Dr. Stuart Maddin. Their theory on how this works was that:

The turning on and off of the electrical stimulus at the electrodes causes the alternate polarising and depolarising of the (root and follicle) cell. This opens electrically sensitive calcium channels in the cell membrane, allowing calcium and other positively charged ions to enter the cell where they will stimulate the production of DNA and, from there, protein (and hair) synthesis.

Interestingly, reader “bw” found the following page on an electrical scalp stimulator for hair follicle regrowth. The article cites Dr. Maddin’s work.

This phenomenon of electrical stimulation of scalp for hair growth is known as electrotrichogenesis (ETG).

Preparation of Hair Beads and Hair Follicle Germs

I have covered hair regeneration research by Yokohama University’s Dr. Junji Fukuda a few times in the past. He is highly respected in the world of hair loss research.

Preparation of Hair Beads and Hair Follicle Germs

Last month, Dr. Junji Fukuda and his team published a groundbreaking new study titled: “Preparation of hair beads and hair follicle germs for regenerative medicine“.  The team managed to generate new hair follicles from stem cells in far higher quantities than ever before in mice. This news was widely covered, including in today’s Guardian newspaper.

The researchers’ approach entailed use of a collagen gel in combination with spheroids formed from epithelial cells. This resulted in something called bead-based hair follicle germs (bbHFGs). These germs generated hairs more efficiently than previous approaches. A hair-raising protocol per one headline.

The success of this approach will potentially lead to the preparation of microtissues with high trichogenic ability upon transplantation. A key necessity in future hair follicle germ creation and transplantation from stem cells in humans.

Past research from Dr. Fukuda is here. The researchers next step is to “find a way to expand the number of hair follicle stem cells“.

The below post on earlier work from Dr. Fukuda was written in February 2018.

Large-Scale Production of Hair Follicle Germs

I have covered Dr. Junji Fukuda and the Fukuda Lab several times on this blog in the past. Their important hair related research takes place at Yokohama National University in Japan. Most recently, this was just two weeks ago in relation to their latest paper titled: “Spontaneous hair follicle germ (HFG) formation in vitro, enabling the large-scale production of HFGs for regenerative medicine“. It was published towards the end of 2017, but seems to now be dated as 2018.

Junji Fukuda: Hair Follicle Germs (HFGs) Preparation.
Junji Fukuda: Hair Follicle Germs (HFGs) Preparation.

At the time, I decided that this development was only worth a cursory mention in my once a month “brief items of interest” post. My decision was clouded by the fact that this research only entailed work on mice (see bottom part of image on left, courtesy Yokohama National University). We are all a bit bored/tired/frustrated with that of course.

However, earlier today, Dr. Fukuda and his team’s work was covered in the Science Daily publication. Key quote from Dr. Fukuda:

“This simple method is very robust and promising. We hope that this technique will improve human hair regenerative therapy to treat hair loss such as androgenic alopecia,” adds Fukuda. “In fact, we have preliminary data that suggests human HFG formation using human keratinocytes and dermal papilla cells.”

Perhaps this really might end up being a major development, even in humans.

Tsuji, Shiseido, Ohyama and perhaps now Fukuda? I have never been to Japan, but it looks like this may change in the future.