Mallia Therapeutics, CD83 and Hair Loss

It seems like MalliaBioTech will now be known as Mallia Therapeutics (Germany). The company was officially founded in June 2023.

Update: July 11, 2023

Mallia Therapeutics Secures Seed Funding

Mallia Therapeutics (previously MalliaBioTech) finally has a website (h/t “Ben”). Moreover, the company just announced that it has raised seed funding. They now plan to raise Series A funding prior to beginning clinical trials.

The company is developing a soluble CD83 (sCD83) based  topical treatment of hair loss.

This sCD83 has an immune-modulatory function and induces hair growth via a dual mode of action:

  • It induces an anti-inflammatory environment around the hair follicles via regulatory T cells (Tregs). These interact with follicular stem cells and activate hair growth.
  • It directly binds to follicular stem cells and induces the formation of new hair follicles. So sCD83 not only prevents hair loss and accelerates growth, but also induces the growth of new hair.

Moreover, this treatment will supposedly work for both androgenetic alopecia (AGA) and the less common alopecia areata (AA).

Key quote (slightly reworded):

“The company is led by world leading experts in the field of CD83, with more than 60 CD83-related publications and 20 years of relevant experience.”

November 4, 2021

A new biotech company in Germany named MalliaBioTech is working on a topical hair loss treatment based on the CD83 molecule. Thanks to “Marcus” and “James” for sending me several of the below links.

CD83 and Hair Loss

On October 27, the Friedrich-Alexander University (FAU) in Germany published an important page on their site titled:

“FAU project wins funding for remedies against hormone-related hair loss.”

An soluble CD83 based active ingredient newly developed at FAU leads to new hair growth. The FAU researchers from the Department of Immunomodulation and the Department of Dermatology at the University Hospital Erlangen received the m4 Award for this project on October 21, 2021.

So far, this CD83 (see gene card) based active ingredient has not shown any side effects in pre-clinical studies. The video of this work can be found in this article.

Mallia Therapeutics CD83 Hair Growth
CD83 hair growth before and after. Screenshot from Mallia Biotech video.


The research team is led by Dr. Alexander Steinkasserer, who I e-mailed for more information. His co-researchers include Dr. Dmytro Royzman and Prof. Dr. Carola Berking. Their new company is called MalliaBioTech, and it received EUR 500,000 via the m4 Award. It is officially called the m4 Award from the state of Bavaria.

“The new product has the potential to conquer the large unfulfilled market of hair loss.”

In contrast to existing hair loss treatments Finasteride and Minoxidil, this topical treatment based on a soluble form of the CD83 molecule:

“Stimulated the formation of new hair follicles and thus induces new hair growth.”

While the current pre-clinical work is in mice and yet to enter human clinical trials, this research represents yet one more new method to tackle androgenetic alopecia. We read about at least five such major new hair loss cure related discoveries every year, so reader skepticism is warranted.

When I first heard about CD83 for hair growth, I assumed it would be for alopecia areata. This is due to the frequent use of the word “immune” in tandem with CD83. However, the new German research clearly indicates that this treatment will work for hormonal hair loss (aka male pattern baldness).

26 thoughts on “Mallia Therapeutics, CD83 and Hair Loss”

    1. Translation from the video:

      Prof. Steinkasserer was actually researching for proteins to treat MS. They were surprised when they found out that the protein induced hair growth in mice. The animals got a higher hair density. Further research showed that they even created brand new hair follicles. 3 times more new hair follicles than the untreated mice. Right now they are testing the CD83 in humans. If they get the same positive effect of it, clinical trails might start in 4 to 5 years. Its gonna be topical.

      That is everything important I guess. On the screen they show the hair follicles which are growing at the moment, induced by the protein.

      I hope my English is good enough.

        1. Yeah but serioiusly everything does grow hair on mice. Its actually difficult to find something which doesn’t haha.

          Its already strange that they still get money to research for growing hair on mice.

          I hope so much that riken will be fast… But since they don’t even have found a partner for clinical trials…

          1. This is great news because hair follicle neogenesis is a conserved process between mouse and humans. Traditional hair growth in mice is usually hair elongation and shaft thickness. Those are indicators researchers look for because Mice do not have androgenic alopecia . so it’s very very exciting that this molecule was able to induce hair follicle neogensis which is something we rarely if ever see .

            Who knows… maybe just like finasteride… the best hair loss treatment twill once again come as an unexpected result while being tested for other morbidities.

      1. Hi Georg – I don‘t think that Dr. Steinkasserer said they are testing in humans (that’s completely unrealistic right now and would be almost equal to a clinical trial) but something like „Humansystem“ (it‘s hard to understand). So in my opinion he means a traditional „in vitro“-testing, which is the logical next step.

        I would add one thing: they said that completely new follicles emerged, and that in pretty big numbers – so I think we are talking about neogenesis.

        The 4 – 5 years seem to be a very conservative timeline for a topical. I would expect something like 2 years maximum. See Samumed or Follicum. That’s why I find it very alluring, but completely uninteresting from a standpoint of availability.

    2. They figured out that the molecule triggers new hair follicles to grow IN MICE. They think first trials might be possible in 4-5 years.

  1. Promising. I wish it wouldn’t take a decade or more like I’m sure it will to find out if it works on humans and, if it does, get it into our hands. These things take forever. Still, it’s good news. Something to add to the list of maybes.

  2. “Clinical trails might start in 4 to 5 years”. Meanwhile, no hair transplant surgeons are willing to test FDA approved veterporfin on a patient.

    1. Verteporfin has very limited potential use. Basically it’s only use would be to improve donor areas by stimulating follicle neogenesis post extraction. It doesn’t have a topical application. Right now there are a number of well known modalities for this such as ACell, PRP, PRF, etc. There are very few patients that would be willing to undertake the use of verteporfin for this, especially if they will also be paying for the surgery themselves. Most Hair transplant surgeons are interested in doing Hair Transplants for profit, not research.

  3. If this company said their treatment was contagious like covid they could fast track it and come out with a billion doses sent globally in less than a year lol. I don’t have hope for this company especially when they said 4 years till trials. Why even bother put a press release out of trials are half a decade away lol. Stupid. History repeats itself with mpb industry. The only hope I have is a company out of nowhere that we know nothing about comes out with a drug side effect of massive hair growth and they commercialize it. Just like min and fin. All the drugs that were created for mpb have failed miserably. Happy Friday all:)

    1. Well this situations seems similar. The researchers were testing a molecule to treat MS and stumbled across hair neogenesis albeit on mice.

  4. I understand how the process works, but really, there are thousands (perhaps hundreds of thousands) that would sign up for testing right now – and sign whatever was needed. Heck, they’d do a video staring whatever these folks wanted to ensure they couldn’t sue etc. Do the testing on humans already! I’ll never understand why it takes six to ten years to get to human trials. The red tape and approval process must be insane in some countries. It’s sure there is good reason for it but come on.

  5. Got this in my alerts:

    New website online. Haven’t had the time to read it all yet, but looks good so far. A clear, informative and official communication tool (in form of a website) builds a lot of trust imho.

    Admin, maybe you can break it down for us.

    1. Thanks Ben! They are yet to begin Phase 1 trials, but I still republished the post with the update. Interesting based on the team’s relevant and long-term CD83 experience.

  6. Me likey. Also of course hoping for more than 3x new hair follicle growth (3 x 0 is still 0…exaggerating a bit but you know what I mean).

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