Category Archives: Brotzu Lotion

Brotzu Lotion Countdown Begins

Update: April 15th 2018

— Dr. Brotzu’s entire presentation video is now available online. Keep in mind that this is not necessarily a summary from Fidia Farmaceutici itself. Hopefully, Fidia will update its website’s Brotzu lotion status later this year.

— The actual full presentation slides are available via the bellicapelli forums.


I first discussed the very interesting Brotzu lotion in early 2016. Since then, I have written several other posts in which I provided updates about the product, but all-in-all, there have been few major developments of note. Moreover, the product is supposedly not likely to benefit those who have lost most of their hair over five years ago. So its not a real cure for balding and hair loss, but nevertheless, a much needed potential alternative to existing hair loss medications Finasteride and Minoxidil.

The inventor of the product, Dr. Giovanni Brotzu, is now 83 years old. He is unlikely to make any further major breakthroughs at such an advanced age, although perhaps that is a moot point and the Brotzu lotion DGLA→PGE1 product is already as good as it can get for its particular chemistry.

Moreover, the patents for the Brotzu lotion and its potential future release are both in the hands of Fidia Farmaceutici (Italy) and not in the hands of the Brotzu family. The company last updated us in detail about the Brotzu lotion in January 2017 and concluded that:

We envisage the development of the potential product candidate being completed by 2018.

I am guessing that Fidia has its own researchers who are heavily involved with the product’s development, and Dr. Brotzu himself is now mostly an adviser.

Brotzu Lotion Status in 2018

Having said all that, the reason for this update is Dr. Giovanni Brotzu himself. Tomorrow, on April 14th, he is supposed to make an important presentation about his lotion at the Italian Society For Hair Science and Restoration’s annual conference. You can see a summary of this presentation on this page. When I translated the title, here is what came up:

Title of the Report: Liposomal solution containing DGLA, Equolo and Carnitene for the treatment of androgenetic alopecia.

If you live in Italy or are in the nearby vicinity, you can attend Dr. Brotzu’s lecture. More information after you scroll down in here. Questions will not be allowed.

  • There are a number of rumors online that the lotion could be released in the summer of 2018. I am skeptical that it can happen so fast, but that is probably why most people are so excited.
  • On Reddit Tressless, people have been going crazy about this since the beginning of this month. Eight of today’s top ten threads on there have the word “Brotzu” in their titles! Complete insanity.
  • Zero of the top ten threads on Reddit Tressless have the word “Aclaris” in their titles.  See my next blog post from later today for more on that.
  • Also make sure to follow the original still growing Italian forum thread on this subject as well as the gigantic HLT forum thread on this subject.

Brief Items of Interest, December 2017

There were way too many developments in the past month, at least half of which probably deserved their own post.

Wounding, Interleukin-1 (IL-1) and γδ T-cells

Wounding induced hair growth has been in the news a lot over the past several years.

At the end of 2013, I first discussed Dr. Krzysztof Kobielak and Dr. Eve Kandyba from USC in relation to their work on how the Wnt7 gene activates hair growth. Fast forward to this month, and both scientists are back in the news and (via a collaboration with researchers from UC San Diego and from India) published an important paper titled: “Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells“. Interestingly, one of the three most important words used throughout the paper and of primary importance to us (“wounding” or “wound“) is missing from the above title, although not from the complementing photo (see red area in the image further below).

These scientists found that wounding triggers interleukin-1 (IL-1), which in turn activates certain immune cells (called γδT-cells or gamma delta cells). These immune cells then awaken resting stem cells in the hair follicle so that they can then “multiply and travel to the wound site to repair the injury”. For our purposes, the hair follicle stem cell activation is more important than any kind of wound repair (i.e., hair > scar improvement).

Commentator “Omg” who has posted some great material in recent weeks (including the above — thanks) wrote that this finding is the biggest discovery of the past decade. I am not so sure. Note that the authors of this latest work are not affiliated with Follica (the widely discussed company that is developing a “wounding + favorable compound injection” related procedure to regrow hair); nor are they affiliated with Dr. Rachita Dhurat, who has published several groundbreaking papers related to wounding and hair growth. Makes this discovery from an entirely different group all the more exciting, and further validates the potential of wounding spurred hair regrowth.

Interleukin-1 and hair growth

Nanogel Encapsulated Dermal Papilla 3D Spheroids and Hair Follicle Regeneration

In 2015 I interviewed Dr. Malcolm Xing from Canada. In 2016, I discussed the same doctor’s new findings related to a novel improved “hanging drop” 3D cell culturing technique for the purpose of hair growth. Dr. Xing has constantly been trying to improve upon the renowned Dr. Colin Jahoda’s work.

This month, Dr. Xing and a team from China have published a new paper titled “Bottom-up Nanoencapsulation from Single Cells to Tunable and Scalable Cellular Spheroids for Hair Follicle Regeneration“. I am not motivated enough to try to make the sci-hub site work (I get mixed luck with that) to gain free access to this whole paper, since I do not want to then spend hours trying to understand the complicated science behind this research. I am, however, in no doubt whatsoever that any new development related to 3D spheroids and hair culturing is of utmost importance and warrants coverage on this blog.

More Good News from Aclaris

In November, I discovered an interview in which Aclaris Therapeutics’ chief scientific officer mentioned that in the  first half of 2018, Aclaris planned to commence phase 2 trials to treat androgenetic alopecia (male pattern hair loss) with topical JAK inhibitors. This was a huge development, since we are used to virtually all companies in the hair loss world postponing or delaying clinical trials. In contrast, Aclaris is doing the opposite and moving to phase 2 trials without even having done phase 1 trials! They probably got to skip phase 1 trials because they have tested the same JAK inhibitors (including oral and topical versions) for other conditions.

Several weeks after I posted the above pleasing development, Aclaris announced at an investor conference that they would start the above trials at the end of the first quarter of next year (i.e, end of March 2018). Yet again they surprise us with their speed, and do not want to wait will June 2018. The announcement can be accessed by going to their website and finding their latest investor conference presentations (often available in both audio and slide formats).

Thanks to “Royaume” who listened to the whole audio for us (albeit misinterpreted its favorable implication). Commentator “Malcolm” even felt like I should have devoted a whole post to this news, but I did not want to do so less than a month after my prior post on Aclaris. Moreover, past experiences make me think that Aclaris will delay its trial commencement target dates (like all other companies seem to do), although I hope I am wrong.

Follicum also Plans Phase 2 Trials in Early 2018

Even though Follicum has been present in the hair loss world well before Aclaris even commenced operations, the former has not moved along as fast as the latter. However, recently Follicum announced that they were planning to start phase 2 trials for their FOL-005 product in early 2018 in Germany.

Replicel CEO Update

Replicel’s CEO was interviewed by “Investing News” towards the end of last month. Key quote:

“There’s a possibility… that [our] hair products could have an early launch in Japan. Our partner Shiseido is funding a clinical trial in Japan that’s expected to release clinical data next year. It’s entirely up to Shiseido what they do in regards to this product. There’s certainly a possibility that they could decide if the data is positive, to launch the product in Japan and that would trigger… milestone payments and sales royalty revenue”.

Other Items of Interest

— I saw a number of comments and received several e-mails regarding the Brotzu lotion. It seems like they updated their EU patent page and several Italian hair loss forum members are claiming that the product is coming out in early 2018. For the time being I will refrain from writing a post on this, as it seems like there is a lot of speculation going on.

— A great thread with before and after photos on Reddit about the power of  the “Big 3” treatment of Finasteride plus Minoxidil plus Nizoral when effective.

PolarityTE starts using its SkinTE product on humans. No info yet on potential hair growth effects on the scalp, but still great to see usage in humans rather than mice so early in the process. Key quote:

“We are confident and believe that SkinTE will replicate its preclinical success and help patients regenerate their own full-thickness, hair-bearing skin”.