Category Archives: William Lowry

Pelage Pharmaceuticals Phase 2 Trials for PP405 Begin in June 2024

Update: May 6, 2024

Pelage Pharmaceuticals Phase 2 Clinical Trials Start in June 2024

Yesterday, a reader e-mailed a new link on Pelage Pharmaceuticals’ Phase 2 clinical trials for its PP405 inhibitor of mitochondrial pyruvate carrier (MPC). The Phase 2 trials are set to begin in June 2024 and will involve 60 participants. Half of these will take a PP405 0.05% topical gel once per day, and the other half will get a placebo vehicle  daily gel. The study primary completion date is December 2024, and actual completion date is February 2025.

Recruitment will likely start soon, and I assume it will be in the US based on the listed contact person and phone number. The contact e-mail is listed as clinicaltrials@pelagepharma.com. Please DO NOT call them now as the recruitment has not yet commenced and they might get annoyed.

If you are between the ages of 18-55 and have androgenetic alopecia, you can participate. However, the inclusion criteria for men and women is specific:

  • Males must have an AGA modified Norwood-Hamilton Classification score of Type III vertex, Type IV or Type V.
  • Females must have a Savin classification score of I-2, I-3 or I-4.

 

Pelage Pharmaceuticals
Pelage Pharmaceuticals Logo.

I previously wrote about Pelage Pharmaceuticals in my 2019 post related to the research of its President and co-founder Dr. William Lowry. The other co-founders are Dr. Heather Christofk and Michael Jung. I also covered the findings of Dr. Lowry and Dr. Christofk’s UCLA team in a 2017 post.

These UCLA researchers discovered two topical compounds (RCGD423) and (UK5099) that regrew hair in mice via different mechanisms. Both drugs involve an increase in lactate production. This in turn activates hair follicle stem cells and leads to increased and quicker hair growth.

Dr. Lowry’s patent can be found here. Patent and technology rights to both topical drugs have been exclusively licensed to Pelage Pharmaceuticals by UCLA.

Update: March 9, 2024

Earlier today, Pelage Pharmaceuticals gave a positive update on its novel small molecule PP405. Full summary can be read here. In Phase 1 clinical trials, PP405 reactivated dormant hair follicle stem cells and triggered hair growth. The company’s presentation was made by Dr. Christina Weng and titled: “Inhibition of pyruvate oxidation activates human hair follicle stem cells ex vivo”. Pelage will begin its multi-center Phase 2a trial of PP405 in mid-2024. It will recruit both men and women with androgenetic alopecia.

Their description of this unique hair growth molecule is as follows:

“PP405 is a potent topical mitochondrial pyruvate carrier (MPC) inhibitor that acts on the cellular metabolic pathway to upregulate lactate dehydrogenase (LDH).”

Stem cells are particularly sensitive to LDH, so this results in their activation and subsequent hair growth. PP405 demonstrates a statistically significant increase in Ki67 signaling in the hair follicle bulge. Ki67 is a well-established marker of stem cell proliferation.

February 27, 2024

Pelage Pharmaceuticals Raises $16.75 Million and Phase 2 Trials to Begin in 2024

Pelage Pharmaceuticals has raised $16.75 million in Series A Financing. More importantly, they will begin Phase 2 Clinical Trials for PP405 in mid-2024.

Phase I clinical data met primary safety endpoints. And they confirm that their was statistically significant stem cell activation in hair follicles after just one week of treatment with PP405.

Per CEO Daniel Gil, Ph.D.:

“Our scientific co-founders have uncovered a unique biological mechanism with the potential to reactivate hair growth in people with alopecia.”

The company will present translational data at the American Academy of Dermatology meeting in March 2024.

Recently, reader “Ben” made an very interesting discovery on Pelage Pharmaceuticals’ website. The following sentence at the bottom:

“Early Phase I clinical data shows statistically significant stem cell activation in the hair follicles after one week of treatment with PP405.”

This is super news. So their trials have started. I wonder if PP405 is RCGD423 or UK5099? I think it sounds like that latter. The company’s website homepage describes PP405 as:

“A novel, non-invasive, topical small molecule drug platform that activates stem cells in the hair follicles directly to stimulate robust hair growth. By targeting an intrinsic metabolic switch in hair follicles, Pelage’s platform is suitable for all genders, skin types, and hair types.”

In other recent news, Pelage appointed Dr. Qing Yu Christina Weng as Chief Medical Officer.

RCGD423

RCGD423 activates the JAK-STAT signaling pathway, which in turn leads to an increase in lactate production. This extra lactate activates hair follicle stem cells and results in quicker hair growth. The main 2017 study on RCGD423, lactate dehydrogenase activity and hair follicle stem cell activation can be read here. I also covered it in my earlier linked posts related to the work of Pelage co-founders Dr. William Lowry and Dr. Heather Christofk.

UK5099

UK5099, blocks pyruvate (a glucose metabolite) from entering cell mitochondria. This also results in an increase in lactate production in the hair follicle stem cells, and therefore accelerates hair growth. There is a 2015 study from China related to the application of mitochondrial pyruvate carrier blocker UK5099 and its effects on prostate cancer cells.

Lowry and Lowe

In 2017, I covered some important groundbreaking hair loss research from UCLA, led by scientists William Lowry and Heather Christofk.

These researchers discovered two topical compounds (RCGD423) and (UK5099) to regrow hair. Both drugs, via different mechanisms, increase the production of lactate. This in turn activates hair follicle stem cells and leads to increased and quicker hair growth. Dr. Lowry’s patent is here. Note that RCGD423, activates the JAK-STAT signaling pathway.

Dr. Lowry, Pelage Pharmaceuticals and UCLA

Update: January 2023 — Pelage Pharmaceuticals’ new site is live.

Earlier today, reader “PinotQ” posted an important update on progress regarding these compounds’ further development. The compounds and technology have been exclusively licensed by UCLA to Pelage Pharmaceuticals, a startup company founded by Dr. Christofk, Dr. Lowry and Dr. Michael Jung.

Moreover, 100 percent of the shares in Pelage will be purchased by Allergan (Ireland) per an agreement. I have covered pharmaceutical giant Allergan many times on this blog in the past, and they are heavily invested in various new hair growth product technologies.

Rob Lowe has Taken Finasteride for 30 Years. Via his veins.

Rob Lowe Hair Finasteride
Rob Lowe Thick Hair Due to Finasteride?

Actor Rob Lowe has been in the news this week after insulting Prince Williams’ hair loss. Mr. Lowe is 55 years old, and claims that at the first sign of hair loss 30 years ago, he stared taking a hair loss drug. Per the quote below, he took it intravenously via his veins! I assume he means finasteride injections.

Rob Lowe quote:

“The first glimmer that a single hair of mine was going to fall out, I was having that stuff mainlined into my (expletive) veins. And that’s what I did for the next 30 years.”

Prince William Hair Loss
Prince William Balding.

Almost everyone thinks that this drug that Rob Lowe took (and is maybe still taking) is Finasteride, usually given in the form of a pill. Donald Trump takes the same drug for his hair loss.

Dutasteride (Avodart) was not available 30 years ago (the younger Ashton Kutcher got lucky). I am not sure if it is a good idea to get Finasteride delivered through your veins, although Mr. Lowe has to this day maintained a very good head of hair and seems healthy.