Last year, by far the biggest news of the year involved two likely cures for alopecia areata (AA) in humans. One was the arthritis drug tocafitinib and the other was the cancer drug ruxolitinib. Both drugs are classified as Janus kinase (JAK) inhibitors, and it is likely that many other drugs from this family will lead to similar results when it comes to hair regrowth. If you read my two main posts on this subject from last year (see here and here), it should be quite obvious how exciting the news was based on the large-scale global media coverage at the time (and of course the miraculous before and after human scalp photos instead of the usual mice photos).
Unfortunately, the vast majority of men (and many women too) who have hair loss suffer from androgenic alopecia, also known as male pattern baldness (MPB). There are probably 100 times as many people who suffer from MPB as there are who suffer from alopecia areata. So the big news of last year was only useful to 1 percent of hair loss sufferers, at least for the time being.
While many people (including the famous Dr. George Cotsarelis) dismissed the potential for JAK inhibitors to work on people who have androgenic alopecia, I was not so pessimistic. In my posts from last year, I mentioned that MPB probably also had an immune system attack/inflammatory component to it (and JAK inhibitors seem to cure alopecia areata via stopping the immune system from attacking the follicles). My theory was partly due to the fact that I and numerous others get a lot of itching and dandruff while losing hair (especially if not using shampoos such as Nizoral). I was therefore very surprised that Dr. Cotsarelis was dismissing these developments so fast. It should be noted that all of his decades of work and numerous patents could go down the drain if JAK inhibitors were to cure MPB in humans without any major side effects, since this is one rare area of hair loss research that Dr. Cotsarelis has never touched.
Strangely enough, the two teams that discovered the cure for alopecia areata last year were both based in New York. One was led by Dr. Angela Christiano and the other was led by Dr. Brett King. The latter has credited the former with being the pioneer in this work.
My biggest reason for keeping faith in the potential of JAK inhibitors to also work on people with male pattern hair loss was the Bald Truth interview that Spencer Kobren did with Dr. Brett King. In the video, Dr. King mentions that a topical formulation of Tofacitinib would likely be tested on patients with Androgenic Alopecia. He clearly felt that JAK inhibitors could perhaps work on MPB patients too. If I had to rate the chances of a hair loss cure for MPB arising from JAK inhibitors after that interview from last year, I would have said 3/10. After the below groundbreaking developments of today, I will raise my rating to 5/10. The one big issue is whether these drugs can regrow hair that has been lost for more than several years. Also an issue is long-term side effects, but so far the oral JAK inhibitors do not seem to have caused any deaths, and the topical version of those inhibitors will likely lead to even fewer side effects.
Lo and behold, today Dr. Angela Christiano and her team published some findings (FULL TEXT AVAILABLE) that suggest a better than negligible chance of JAK inhibitors also working to treat androgenic alopecia. This time, they managed to grow hair on rats via a topical formulation of both Ruxolitinib and Tofacitinib. Below are the stunning pictures, albeit in mice this time (although it should be noted that they also grafted human hair onto the mice and achieved great results):
Image below from this Daily Mail article:
Some key quotes from Dr. Christiano per various articles from today:
“Male pattern hair loss follicles are stuck in the same state where these drugs seem to work.”
“What we’ve found is promising, though we haven’t yet shown it is effective for male pattern baldness.”
“JAK inhibitors seem to be among the very few number of compounds that produce hair growth very soon after their application.”
“But applying such drugs topically would be far safer.”
“Delivering it on the skin also seems to get more of the drug into the hair follicles.”
“Some topical agents induce tufts of hair here and there after a few weeks, but very few have such a powerful and rapid-acting effect.”
JAK Inhibitors Might Directly Affect Hair Follicles
The most interesting part of these experiments was that the mice grew more hair when the drug was applied topically to their skin versus when it was given to them to take internally. The research team thinks that this implies that JAK inhibitors might have a direct effect on hair follicles, in addition to the already known effect of inhibiting the immune attack. It should be noted that the precise terminology for this whole mechanism is “pharmacological inhibition of the JAK-STAT pathway/signaling”, with the STAT standing for “signal transducer and activator of transcription .”
JAK Inhibitors and Dermal Papilla Cells
I also found it interesting that the full published study has the following quote in the Abstract:
“We show that JAK inhibition regulates the activation of key hair follicle populations such as the hair germ and improves the inductivity of cultured human dermal papilla cells by controlling a molecular signature enriched in intact, fully inductive dermal papillae.”
A huge amount of hair loss research entails dermal papilla cells. I am not a scientist, but it seems like the above findings could also have ramifications for companies involved in 3D culturing of dermal papilla cells. In fact one of the co-authors of today’s groundbreaking paper is renowned hair loss researcher Dr. Claire Higgins, who has done quite a bit of work on 3D culturing of dermal papilla cells.
According to the NBC article on this development:
“Columbia University has filed patent applications relating to the discoveries reported in this paper, which are being commercialized through Vixen Pharmaceuticals, Inc., of which Dr. Christiano is a founder.”
This is interesting since some months ago I mentioned the fact that Dr. Christiano was supposedly starting a new company named “Rapunzel”. Perhaps she will have two companies devoted to curing hair loss: one for pharmaceuticals and one for work related to hair cloning and hair multiplication (i.e., cell culturing, stem cells etc…)?
I find this development encouraging since it makes more sense for Dr. Christiano to start a company devoted to this treatment only if she feels there could be at least some benefit to people suffering from MPB. Otherwise, she only has a market of 1 percent of balding people who have alopecia areata, and even that market would be split with other companies and doctors such as Dr. King that might make their own topical version of a different JAK inhibitor.
— The video from CBS does not embed very well in correct size, but is worth watching.
— Also see the video from Columbia University.
246 thoughts on “Ruxolitinib and Tofacitinib Could Also Regrow Hair in AGA”
What the f**k! good lord,
This is amazing!!
As I said in the post, 5/10 for now in my opinion:-) Need to see some human MPB patient photos next.
yeah, those MPB people with huge balls who try experimental drugs should go ahead if they like (I’m not encouraging anyone) to see how good is these JAK-STAT inhibitors. Too bad though, the drug seems to be expensive. So fewer people can try it.
Swiss temple might try this if he can get his hands on it.
can anyone cook this up? lol
Agree, we need to see photos of humans on this treatment..however we probably wont even hear about testing for at least six months is my guess.
admin, which treatment has the highest possibility to be the cure in your oppinion? Do you think such treatment work for scarring alopecia or people with third degree burns too? I dont know if hair follicles die or not by MPB but when im not mistaken, hair follicles are going to die for example by scarring alopecia.
Thank you very much for all the hard work youve been doing.
Are you saying you know of clinical trials?
This cheered me up when i first saw it. As a 22 year old who’s had receding hair since teens. I hope this comes out and works. To answer the writers question on this site. Christano was quoted saying theres no reason for it not to work on mob people. Mainly as where the hair is gone, the cells are in a suspended state, similar to people with alopecia. Just a waiting game now. Its still sad though. Minoxidil was expensive, dangerous and didn’t work much. The topical of it was very messy and just a pain. If this comes out i can only pray its cheap, is a proper cure that brings all the hair back. and of course if its topical, not messy. raining was a big fear when i applied minoxidil. But just have to wait :(
I would be interested in being in a study for mpb. Please send me any info to firstname.lastname@example.org
Admin, thx for this great news. What do you think, considering the fact that it’s topical solution, does it need to be tested in three clinical trials? Btw, you are doing a great Job, thank you!
Thanks Vedran. They have already used these drugs in oral form for cancer patients, arthritis patients, alopecia areata patients, psoriasis patients,vitiligo patients (see my post on that via a search for “vitiligo”) etc… so I suspect that the topical form might not need to go through all the clinical trials, but I have not done sufficient research on that. If this works to bring back lost hair too, I will do a lot more research on this for sure since I will want to take the drug myself….topical or oral!
Admin you really have a great blog and thank you always posting any interesting news and any product that might shine in the near future, keep up your great work. I visit your website daily God bless you
I’m with you on this one, meaning any clinical trial I will participate in if able. I want to try it as soon as it gets on the market. I hope I don’t lose contact with you or this site.
Did they ever send you info? Dude I’ll volunteering too!!!
They knew jack inhibitors would work on Aga and I have had discussion about this with “famous” forum members about it. The problems was they wont not release anything until they can make money off of their finding. Dr Cort has a cure but can’t patent it and now Dr Christiano has find a way to circumvent the pharma or has a collaboration agreement with them. So she can make money and then it will be released.
Admin, you were indeed optimistic about it.
Hello user always thought no one cares and I have always told them , they care about making money they just have to find a way to protect their investment through patents.
calm down, no one has a cure!
No one have a clue what the hell goes awry in MPB. Even god doesn’t know.
Another spencer cult member? That wants us to get FUT or propecia.
Spencer has interviewed both Dr. Angela Christiano and Dr. Brett King so lets give him his props. Too many people criticize him….he was even willing to interview Dr. Nigam:-) I feel he is very fair in his coverage.
I got a lot of negative comments and insults from brainless people who partook in this blogs chat, months ago.. simply because i defended that these drugs would likely work, every single human being knows that inflammation is a huge factor.. there are so many points which dovetail and make it clear that there is at least potential for this.. but no… people just said I didn’t know sh*t and that a commenter called NASA was also crazy… i’m looking at you “herro” and “x” .. time will prove it.. just like why so many anti-inflammatory things such as curcumin work quite well..
I gave up looking at this website due to NO Hairloss curess. What a pleasant surprise after being back for a quick look since the past few months.
I always thought these JAK type drugs would work WITH Skin Injury (been so long I forgot what they call that).
This is great news and I think it has a great chance of working. It has been mentioned that a few MBP’s have tried these drugs with no affect. However, the lotion should work better than pills PLUS the lotion needs to be in a special application that allows it to permeate the skin since these drugs are Large Molecule. Anyways I can at least take a breath after absolutely having no hope. This has made me happy. Lastly we should know fairly quickly (less than 1 year?) if this works on MPB then we can quickly get it.
You can either go in the history books as a savior but poor or Rich. I would pick to rather not make money and help billions (not millions literally billions ) of people with AGA. This condition is not seen as great threat to men as it should. Balding are causes for Suicide and depression among other things. Just give us the cure and let us be happy and healthy again.
So I think it all now goes down to PGE2! Someone really should give PGE2 a go, I think it’s even more important than PGD2 and it has been somehow disregarded in studying. Okay, let me tell you what I think:
1st) Remember about 30 years ago, benoxaprofen, was shown to completely reverse MPB in NW6 patients! well, guess what! benoxaprofen actually blocks 5-lipoxygenase which is down stream arachidonic acid, now in mast cells arachidonic acid have two important fates either turn to PGE2 or leukotirenes. Now when you block 5-lox, you tell the cells to produce more PGE2. No one studid benoxaprofen cause it was toxic, an no point in bringing it to the market. But this was the first proof for PGE2.
2nd) We all know about Cots and his findings on PGD2 (goes up) and PGE2 (goes down) in AGA.
3rd) JAK-STATs are major regulators of PGE2 in immune cells. Inhibition and activation of them, significantly changes levels of PGE2.
4th) well know that topica TOFACITINIB is very effect for the treatment of psoriasis, right?! guess what else is in clinical trials for psoriasis, yes! topical PGE2.
5th) We know sulfasalizine and minoxidil both have some effect on PGE2, and both have shown to increase it’s levels.
6th) swisstemples ( which no longer seems to be active ) used castor oil and UV, which both activate PGE2 (some of its receptors).
7th) now I think, someone really really should go and try topical PGE2 for MPB, I honestly think it’s going to be the next minoxidil.
What do you think admin?
Am going out to drink right now so do not feel like researching everything you wrote, but sounds very interesting and probably accurate! Will get back to it tomorrow.
I spent too much time in the past two days writing lengthy posts and really need alcohol!
Go have fun dude!!
dont’t you find swisstemples lack of activity on his blog, or lack of answering questions on the “ask” website quite suspicious? i don’t want to make crazy assumptions but….. he basically showed the most promising results i have ever seen in a while..
fgf11 this is all interesting and I always though that reducing PGD2 was the more significant angle. I guess no-one can tell for sure as yet, but thanks for all your research and analysis.
I do hope that topical PGE2 is not just the next Minoxidil, but much better.
What do you mean go try topical PGE2? Like it is on the market now?
Disclaimer: someone please send what I wrote here, to one of the doctors involved in these researches, and gives them a heads up. There is slight chance that they might have missed all the connections to PGE2, who knows!
Just found out that Nizoral (ketoconazol) is also a 5-lox inhibitor.
(Christiano talks about STAT5 phosphorylation in his article)
and that not only PGE2 synthesis is dependent on JAK-STAT
but PGE2 can cause activate STAT5 phosphylation.
and yeah, more importantly, we know about kerastem, huh? PGE2 also regulates adipogenesis, so maybe it somehow regulates fibrogenesis of bald scalp.
Anyways, I’m off to bed. If only PGE2 was cheaper and wasn’t used in abortion, I would have ordered it. But it’s hell expensive.
sorry i don’t understand all the scientific stuff. I’m currently using ketoconazole shampoo (2%) twice a week. Are you saying that keto shampoo is bad or good ? Should i drop it ?
No don’t drop it
Like you would need 10-50mg to apply every day on your head, based on the size of the balding area (since it’s topical you need much larget quanitity up to 200mg), 100mg of PGE2 posder is about 700$, from normal chemical distributors but if you buy the drug, the generics can be almost 30$ per 1mg, so each day it costs about 500$. it’s crazy expensive. Unless you can find it from a group buy or something?!
Well you seem very knowledgeable about hairloss. I have a few questions I hope you don’t mind. I just bought Nirozal shampoo and I was told to only use on the balding spot in my case a receding hairline, is that correct?
And what is the other stuff your talking about pze2?
1- On Wnt pathway and PGE2
(Interaction of PGE2 with its receptors E2/E4 stabilizes beta catenin through cAMP/PKA mediated phosphorylation. The synthesis of PGE2 has also been shown to be necessary for Wnt signaling mediated processes like tissue regeneration and control of stem cell population in zebrafish and mouse.)
2- On androgens and PGE2
[In this study we show direct inhibitory effects on prostaglandin E2 (PGE2) production by the androgens, testosterone (T) and dihydrotestosterone (DHT) ]
3- Lithium Chloride and PGE2 (lithium chloride is what follica bio by Cots is based on – he has patent on it and Swisstemples also use LiCl after derma-rolling)
Basically lithium chloride, significantly increase levels of PGE2.
(there are more papers on this topic)
Gentlemen, I have tofacitinib. I use it for vitilgo. I have a lot of it. I would be willing to test this out topically and post before and afters, if I can find a solution to mix it in that will penetrate the skin and get it to the hair follicles. Any ideas?
Maybe you can test it and see if a tablet will dissolve in ethanol. If so you can use DMSO to get it through your skin. Propolyene glycol may work too
Thanks Shane. I will probably try ethanol. It looks as if that alone may act as an effective skin penetrator. DMSO has some controversy regarding its safety, so I will likely stay away from it unless I feel the ethanol is not doing trick.
Wow Christopher! Do you mind telling how you got this? I thought only Dr. King had been working with this for vitiligo, but I suppose many other doctors might be prescribing it too. Just be careful with the oral version and monitor your side effects closely…I am sure you are aware of something that obvious:-)
Correct. I had a Dr. prescribe it off label for vitiligo. Side effects for the drug are usually very mild to none, although there have been a few very serious/deadly events. The vitiligo dose is half the dose used in the approved use and I’m sure once (if) a topical comes out the systemic absorption will be something like 1-3% of the dose currently given.
Ok, and please update us on how well the vitilgo is reduced! And post the update here too if you remember:
Christopher, if you can somehow contact me. leave your email, or something. I’ll send you an email. I have the technical knowledge on how to make topical solutions. Let’s make a two person trial, I’m willing to try this, and we can make maybe even publish it.
I thought u said there is no cure lol
Of course there isn’t.
It’s CALLED trying to find a cure.
If you used for vitigo then by using it you should see hair regrowth. It doesn’t matter if you take orally or topically. If is not working orally then it will not work. It is really bad news.
I believe there is a creme called Versapro that is used for transdermal delivery too
Christopher, id like to buy some if you have any extra and are willing to sell. I wanna test this out myself too
Shane, I can’t part with any at the moment. If it does end up fixing my vitiligo I can sell you some, however, be aware that the price of these pills is enormous and because, my condition is not a FDA approved use of the drug, I pay out of pocket.
I totally understand that man. I pay you every penny what they’re worth too. good luck brother and keep us all posted please
,hey Christopher I just had a thought. if you’re using this drug for a skin condition it’s possible that your doctor might be able to have it mixed into a cream for you at a compounding pharmacy. I had a doctor prescribe topical fin once this way. maybe this ask your doctor if it can be prepared and cream form
Looks very, very promising. The quality and density of hair is unlike the mere tufts all over, even if we’re talking just mice. The obvious challenge is the side effects as these are very powerful drugs that directly impact the immune system.
I have to say Dr Christiano inspires a lot of confidence. If anyone is to solve AGA, I hope it’s her
I agree with you 100%..
I have been very depressed until I saw her video ..
Baldness especially for women can shut one down
Why do those mice look they had been shaved??
Thank you for this great website, Admin.
I’ve been struggling with MPB since I was 19, when I started the process of 3 terrible HTs with strip scars. I’ve since had two other surgeries to attempt making me look presentable, but I’m still forced to wear a “hair system” to hide the humiliating plugs and large scarring in order to function in my career as a structural engineer. I’m now 35 years old and, after thousands of hours and thousands of dollars spent, my life has been severely impacted. Being forced to wear fake hair impacts my life decisions every day. I haven’t had a real relationship in years, and I don’t have children because it simply wouldn’t work with the embarrassing hours of hair maintenance effort to look decent for my career.
Anyway, I check your site every week for some hope of change! It’s great to know others are out there working on this issue so that no one else will have to go through what I’ve been through. Please keep up the good work of bringing us positive news! It’s greatly appreciated.
Sorry to hear about your scars Rick. Science is advancing very fast I believe and you have to remain hopeful and just try to save some money for when the cures arrive.
Thanks Admin.. keep up the good work! Let’s get this to (5+5)/10 (fingers crossed) (knock on wood)
Taught myself not to get my hopes up until I see pictures of a mpb man using this stuff and going from a nw6 to a nw2 with good density. However, christiano is a very intelligent woman who I have faith in since she suffers from baldness. I hope she brings us the cure and she makes millions. I would expect 10 yrs before this hits the market if it works. Buy if it works this could give us all our hair back. Let’s see if big Pharma and transplant industry will let this hit the market
I like the comment christiano mentioned at the end of the UK video. She said there are many drugs being studied that can grow hair for mpb but none of them have hit the market and it will take time and work being doing so.
They have a cure for baldness but it’s being blocked to hit market. It doesn’t get any more obvious
Duh! She clear says there are other medicines that regrow hair. No company will enter trials if they can’t patent it. Safety is not even the biggest concern at first. They need protection for their future income. If the cure is compound that occurs in nature it can be patented if it’s something with existing patent they can’t make money so again a dead end. You have to understand pharma wants to make money they’re not charities. They’re not actively pursuing cures, they’re aiming for residual income “maintainance” options.
Only an independent caring person, someone who is affected by this cruel disease that might put their ego aside and help us with a full blown cure. Hairloss is depressing and people with hair just say shave your head then or I wouldn’t be bothered by it. They don’t know that some of us can’t even date or are embarrassed to walk around with toppik. You can’t understand us if u r not in our position.
@mjones: You aren’t right. They can not do anything against medical progress . This is true . They have nothing to do. PROGRESS = MEDICINE. Hair Loss industry DON’T HAVE ANY PROGRESS IN YEARS! THAT’S LAMENTABLE.
There is much demand and people hate take Propecia and Minoxidil EVERY DAY. PATHETIC.
Many years without any progress in MPB . That’s the time. We are tired of this situation.
Great Blog. The best hair loss forum.
An unbelievable read, and free on the scienceadvances link posted by the admin. I don’t think I have ever been more encouraged that AGA could possible be cured within 5 years time. What is even better about this is it is likely something that would not have to be taken 24/7. It would likely be something that would be taken long enough to regrow all hair and then just taken as needed to maintain, and it is a topical which is great for reducing side effects and delivery to site of action. Amazing work admin.
Christopher be careful when you apply this stuff topically. Your health is first over hair. Hopefully this stuff will work wonders for you and you grow back thick hsir like those mice :) keep us posted
This drug will probably take years to hit the market but if Christopher can prove that it works with his experiment we can have some hope and use this stuff off label
Admin, medicine Jakavi, generic name is ruxolitinb, in Europe cost 2167,00 euro. Are you going to experiment with it?
Oral = No way.
Topical (homemade) = Perhaps in another year if I start seeing online anecdotes that it works with no side effects.
C’mon guys I’m sure many people have taken this drug orally that also had mpb. If it grew more hair the drug manufacturer would of been aware and all over it.
Dr. Christiano launched rapunzel to commercialize the 3d spheroid method and if you read the abstract of this latest paper she attempted to use this drug to see if it enhanced the gene expressin profile of the cultured dermal papilla, which it did but not quite to the level of an intact dermal papilla.
You raise a good point, but I wonder why she had to state this:
“Male pattern hair loss follicles are stuck in the same state where these drugs seem to work.”
Also, see my comment in the post under her new company section. Would it be worth starting such a company just to target the much smaller market of people who have alopecia areata? What happens when other companies (or Dr. King) also come out with their own topical version of some JAK inhibitor to target the small alopecia areata market?
Admin – Great Update on this particular topic.
Again, I do believe (no evidence of it yet) that these JAK Drugs will work for MBP. Why do I say that when there has been zero direct proof? Since there have been a few cases: 1) ~1980, Old man fell head first into a campfire and grew hair and there before and after pictures. He actually grew his hair back when he was a MPB before it happened. My guess is he was taking an Arthritis Drug, anti-imflamatory drug, along with Skin Perturbation (Dr. Costeligious sp.). Also 2 men took Beno (short lived arthritis type drug) and regrew their hair although both were sun worshippers and had severely burned their heads reportedly.
Therefore, there has been cases where MPB people regrew their hair it is just that the doctors never followed up on it since they just thought it was Unique Cases. Fast forward to today, these JAK type drugs reduce immflammation and maybe if it can be delivered in right doses into the skin we can get All Our Hair Back (maybe with skin perturbation).
I do not care about the Mumbo Jumbo or how it works just let me put that lotion on and have all my hair back. Please.
All is my opinion.
It is a great day that for the first time All Year we have a story with Real Hope. And if it really does work Bingo we litterally are months (my guess) from getting it from doctor prescription.
months? no way.
people were still bald in back to the future 2…
I second that..months???!
Here we have a drug ALREADY approved by the FDA, and of course it works on rats, yet they cannot try it on a single MPB person. What?!
What i was found intresting is, that normally scientists are testing their potentally treatments on bald mice but this rat seems to me like it has had already hair on its back. For this reason i think this kind of treatment could only regrow hair on people with low nw with hair follicles they’re not dead and for people with AA, because dr. Angela mentioned:
“Male pattern hair loss follicles are stuck in the same state where these drugs seem to work.”
I thought hair follicles are going to die with the time and the there is no more hair follicles they could be reactivated but hopefully i’m wrong.
Yes you are absolutely wrong.
hair follicles DON’T die!!
Dear friends, I found on diferent forums and news that Brevilin A is a powerful JAK inhibitor. Some shampoos already have it in formula, did Simeone experiment with it?
God bless this woman and her team!
I have a very good feeling this works and many other drugs to grow back thick hair but it’s thr buracracy that is holding it from release. I know it sounds like conspiracy theory blah blah blah but I mean it shouldn’t be this hard to grow hair. They will have to find a way where they can release this drug and still have ht industry make money. HT industry will lobby the sht out of it to stop it from destroying their business. The only way they can compete is by offering stem cell therapy that will grow back thick heads of hair. Everyone will rather put a topical everyday to grow all their hair back than go under the knife and scar up their head and get lousy results. If ht industry cones out with stem cell transplant then the topical drugs will have some very good conpetition. Just my thoughts. Fingers crossed we get a new treatment like samumed next year so we can grow some hair back stop loss until hair cloning or christiano s discovery drug comes to market
Wow, benoxaprofen sounds cool, a 75 year old grew his hair back:
cant we have a benoxaprofen topical?
Yup, also read this:
Please don’t ever try to acquire benoxa and don’t think about using it. It’s very toxic, ok?
That is correct, and in the post I linked, I mentioned that it was banned. I would not even take oral Ruxolitinib or Tofacitinib for now. If the topical version comes out, I might risk it even if they are allowed to speed through clinical trials.
Wasn’t phizer or someone already working on a topical form of this drug?http://www.jwatch.org/jd201304050000003/2013/04/05/coming-soon-new-topical-treatments-psoriasis
We only need it to work on one MPB and Game Over!!!
I am beginning to rethink my Skin Perturbation theory. Where I believed that a JAK type arthritis drug PLUS Skin Perturbation would be the cure for MBP. However, now thinking about it maybe that only works since when the skin is injured blood floods to the area and the JAK drug taken by those fortunate few who grew hair is able to become CONCENTRATED in the skin and thus it works.
Therefore maybe the Lotion form of Tolatinifib will work for MBP WITHOUT Skin Perturbation since the lotion form is more concentrated than when the drug is taken in pill form.
We seem to be so incredibly close, dare I say possibly 12 months or less away from a complete cure.
all is my opinion.
That would be nice:-) I would like nothing better than to stop writing blog posts regularly if the perfect cure was here in a year.
can you imagine that?
looking bakc on this website as a historical artifact for journalist in 100-200 years to study haha
Thanks. I excited reading your article.
ADMIN – You Need To Keep The Topic Alive of what research is being don on Tolafinitib Permanently in The Upper Part of Your Web Page – as I mentioned to do 1 year ago. As this is the only promise for ALL of hair back with a natural hairline, and fast.
Let’s Hope This Is It.
Finally – ADMIN you have done an incredible job over the years by providing facts to us of future possible breakthoughs. Thanks for bringing hope and allowing us to hang on for an eventual cure (whether this is it or not).
Thanks nasa_rs, and it seems like your persistence was correct.
I’ve read hundreds of papers and I think Seti is not going to be as effective, not because it is targeting a wrong thing but because it is used in a wrong way. Here is why I think setipiprant will be less effective than lowering levels of PGD2 from other ways. No one seems to have discussed this, when you block PGD2 receptor with Seti, what you do is that you cause a build up of PGD2 and subsequently 15d-PGJ2, but the problem is 15d-PGJ2 acts intracellularly, and no receptor has yet been found for 15d-PGJ2. But when you read the paper on PGD2, you see that 15d-PGJ2 is way more detrimental to hair follicles than PGD2, and in a course of 3 days completely blocked the growth rather than 7 days for PGD2. So I’m saying the most effective way is to target L-PGD2 synthase, as well as (PGD2 receptor with Seti). Now since the experiments was done ex vivo, they literally did not include 15d-PGJ2 in their experiments to see if it’s effect can be blocked through GPR-44. So it’s a black hole, one should genetically lower levels of PGD2 synthase, add PGE2 periodically and block GPR-44 to see an effective increase in hair growth. Admin let me know if you didn’t quite understand what I wrote here.
Hey fgf11, I would have to do several hours of research to figure out what you just wrote…but no need to explain. These are all just theories at present. Even inhibiting DHT close to 100 percent with Dutasteride has not guaranteed results, so I do not want to read too much into all this PGD2 inhibition version PGE2 increase theories until at least after the November Miami conference.
FYI — you should write a blog post for me one day! Your scientific knowledge seems greater than mine, assuming what you wrote above is correct.
pleasure, I might one day, if I find a worthy title. I happen to know a thing or two.
In other terms I wouldn’t go buy allergan’s stock
Hi all !
Great news ! It would be the best moment of my life when this drug gets on the market ! But , wait … hold on there … . We don’t know if this is safe, maybe it does create tumors afterwards. Be aware of the pharm-industry and their lies. Satan is in charge and gives always false hope.
Thank you .
Haha Joe love your ending. Do you happen to be Joe from Staten Island?
RUXOLITINIB AND TOFACITINIB… such horrible names, but if they can revert this mankind malady they are SO beautiful!!
I remember hearing, when Latisse was released, that Bimatoprost wouldn’t work for scalp hairs. Well, it works, maybe modestly but it does have some effect. It’s to be seen if they could perfect it in the latest trial.
Then this Ruxolitinib was proved to work miraculously to Alopecia Areata, It gave a full head of thick hair to a guy who had no hair. Again it was said that for Androgenetic hairloss it would have no effect cause it’s a totally different condition. Well well well… Let’s see..
THIS IS MY APPROACH
I WOULD LIKE TO SHARE YOU MY OPINION IF ANDROGENIC ALOPECIA IS RELATED TO GENETICS THEN HOW CAN WE REVERSE MINIATURIZED FOLLICLE TO GROWING ONES EVEN IF WE REVERSE IT HOW CAN WE MAINTAIN THEM AS GROWING FOLLICLES IN FACT THEY ARE STILL UNDERGOING THE SAME GENETICS FACTORS AND DHT EFFECTS THUS IT SEEMS THAT WE NEED TO TAKE A DRUG OR USE A TOPICAL SOLUTION DAILY TO AVOID MINIATURIZATION AGAIN THIS IF WE SUCCEEDED IN REVERSING THEM TO GROWING FOLLICLES, WHY HAIRS ON THE BACK OF THE SCALP ARE LESS SENSITIVE OR MORE RESISTANT TO DHT THEN OTHER HAIR SCALP, HOW CAN WE MAKE A NEW FOLLICLES FROM THIS KIND OF HAIRS TO TRANSPLANT THEM IN THE WHOLE SCALP AND THIS WILL BE A UNIQUE SOLUTION WITH A CONTINUED RESULTS WITHOUT USING TOPICAL SOLUTIONS AND TAKING DRUGS DAILY
Hey Fadi try to not post in all capital letters please!
What really calls my attention is this:
Why Dr Christiano did not take a n androgenic allopecia mouse when they were doing this investigation?
No patient taking this medication for other conditions noticed any hair benefits?
We need to test this on Christopher and other on-their-own-risk users of this site? Where is Christopher going to take a drug which costs over EUR 1500 each dose (at least in Spain) from?
All very strange, isn’t it?
Can anyone tell me if the topical cream is something i can make myself or something similar that’s already on the market? Also how can I be part of this study?
(Alopecia and Hashimoto – Thyreoiditis)
Hi Claudia, by alopecia, if you mean you have alopecia areata, you should consult with Dr. Christiano and/or Dr. King (both in New York). If your hair loss is due to your thyroid issues, they might still be worth a consult.
Hi Admin I’m 29 yo and I’m new on this site but I use finasteride 4 years.
I want to ask you what is your opinion about this two drugs, do you think that we can have cure in next 5 years maybe 2020?
Hi jere, I believe that the cure will be here by the end of 2020 and have said so a 100 times, including in the title of this blog:-)
These two drugs are already in use to treat many problems, but it remains to be seen how effective they are on MPB. In my post, I rate their chance at 5/10 — i.e., exactly 50/50 either way. Thanks for visiting the blog!
I just wanted to thank you for this blog its sometimes a pleasure reading news toughts and comments on it knowing that there are a lot of people out there who have and want the same.
Keep on with youre work and thanks again!
Thanks always appreciate the encouragement:-) I want a full head of hair so I am not going anywhere till the cure is here.
Fadi, What may be happening is DHT may be causing a lockout effect which over times keeps the follicle permenantly dormant. It needs to be woken back up to start working again. And then maybe applied as needed over time as the hair starts thinning again. No matter how much DHT is blocked in those susceptible, once the follicles go dormant you can castrate a male and he WONT GROW IT BACK. This to me is TELLING evidence that AGA and AA hairs are locked in the same state by JAK signaling. In one case, AA the JAK signaling happens via a swift immune response, and in the other, DHT causes the JAK signaling to go wrong in those with genetically predisposed hair slowly over time by increasing the dormant phase of the follicle (also why hair transplanted hair are immune to DHT.) What is needed is a kickstart in anagen signaling in the follicle. THAT IS THE KEY FACTOR. This looks like it has an unbelievable shot of working on AGA. Read the article and look at all the pathways JAK disruption effects (SHH, Wnt’s, progenitor cells directly after stem cells depleted in AGA scalp, positive signaling between dermal papilla and stem cell niche.) I have an overwhelming feeling that this is going to be the cure. May be taken for a long while to start with to regrow full head of hair, and then only taken as needed when the DHT miniaturizes the hair again over time.
Confusing, It is often assumed that hair that is lost in pattern balding somehow “dies” after a certain period of time, and is therefore gone for good, rendered incapable of re-generation. This assumption is also erroneously reinforced by certain doctors, and other hair specialists. The following case study published in a reputable peer reviewed journal, along with numerous anecdotal accounts we have received over the last 10 years convincingly refute this assumption. This particular study gives an account of a 73 year old man who had been completely bald since 28 re-growing a full head of hair at age 73 ( 45 years of slick baldness) after 6 years on oral Spironolactone, effectively shattering the assumption of “dead” hair follicles. Source
Department of Internal Medicine, University Medical Center of Southern Nevada, University of Nevada School of Medicine.
This 73-year-old white male has been bald since the age of 28. He developed nonA-nonB-induced liver cirrhosis and had been treated with spironolactone for the last 6 years. For the last 3 months, his hair had started to regrow over the scalp. This might be related to the antiandrogenic effect of spironolactone.
I’m personally fine taking a topical to get back to my teenage hairline. That is essentially a cure to me. Obviously transplanted full head of resistant hair is more of a cure but that may be a good amount of years after some topical like this comes out as a cure.
what kind of topical solution?
It’s been a long time that I follow every study about Xeljanz ( tofacitinib ). First everybody told that Tofacitinib was just for Alopecia Universalis and it could not work for androgenic alopecia. Now the same people say that could cure androgenic alopecia.
I have androgenic alopecia and I am tired to wait years by years. I would like to try tofacitinib as treatment.I have good feeling about that beacause I know there is a true connection between male pattern baldness and our immune system and specialy with our stem cells. However I do not enough money to buy tofacitinib. Then If someone want to make the test but is afraid of possible side effect, I am ok to try it. I could take picture of my scalp every weeks to show you if xeljanz works or not. I am not totally bad and I am in good condition. So if you people are ready to try it without having any side effects just Make it together !!!
Hey Cornille, why don’t you just keep bugging Dr. Christiano and Dr. King to have you as a test patient/volunteer when they start testing the topical? I do not think you should trust some topical version that an amateur on the iternet makes (or that you make yourself) to work correctly…not to mention you will have no idea what kind of dosage to take, how to monitor side effects etc… I just do not want people reading this news to take crazy risks. No major side effects from such dangerous drugs are worth it just to reverse hair loss…I would rather wear a wig.
I can not apply as volunteer to Dr Christino ans Dr King because I dont live in the US.
By the way thank you very much for your advise
Sorry I forgot…although it you are somewhat wealthy, flights from Paris to New York are probably not too expensive. Too bad the Concorde is no more!
Dear ADMIN sorry if I’m boring but do you really think that this two drugs really can wake up/ regrow all lost hair in people who is norwod 7?
What say dr Cristiano, t she think about this?
I’m just scared if all this just fake hope.
Hey jere, no you are not boring me.
I am not confident that they will, but I do not put it past the realm of possibility. The only thong we can do is to wait for Dr. King or Dr. Christiano to give us more updates.. plus closely follow the news in the November conference in Miami. I will cover that in detail in November.
None replied to my questions thou… ¡ (
Why Drs. Christiano/King did not take an androgenic allopecia mouse (or non allopecia arreata mouse) when they were doing this investigation?
No patient taking this medication for other conditions noticed any hair benefits? How long have these drugs been on the market? No bald patient noticed any hair improvement?
Where is Christopher and other users going to take a drug which costs over EUR 1500 each dose (at least in Spain) from?
As the admin said, I think that people shouldnt put their health under seriuous risk by doing self drug tests.
All very strange, isn’t it?
There is no AGA mouse. Mouse do not have AGA’s. Their hair growth works differently, they grow hair in waves. Early in 1950’s they found this out. It’s like it starts somewhere under their belly, and like waves the hair grows to other sides of the body. That’s why when they published that plucking experiment on a reputable journal such as cell ( I guess) I was shocked, because it was already known for a long time that plucking works in mice. Simply put, hair follicles talk to each other in mice, but in humans it doesn’t seem like that. They thought that there is an inhibitor signal present, that gets void when another signal comes and tell the hair follicles to grow and this activating signal dissipates to surroundings and creates a wave, but this is not how it is in humans, and scalp. Body hair and pelage in mice is almost 50% percent different from human scalp. Now there are knockout mice, like ptgs2 knockout mice or other mice that have no hair but that is a far cry from an AGA model of humans.
Sorry to be a pessimist, no WNT activators will work for hair in AGA patients. Histogen and any other company working on that (WNT signalling, any of 15 or so WNTs, or Beta-catenin stabilizers) will also go bankrupt. I’m sorry but that is the bitter truth. True to god, I would like that to work, but it wouldn’t. It’s too narrow of a shot.
So I just want to put a topic to rest: Big Pharma/ HT industry stopping a cure coming to the market. The numbers just don’t add up if someone actually has a cure and I’ll lay out my argument below based on statistics from statisticbrain.com/hair-loss-statistics/. Before sharing this though I will also admit that they probably will try to stop a cure from coming but really their attempts to block it will be futile as the numbers aren’t in their favor. And please remember my notes below are NOT fact, they are just observations.
Given that 35 million men in the US alone suffer from MPB. Given that 800k worldwide seek treatment it leaves a huge market looking for an applicable solution. Let’s say a company did find a cure and offered it at a very modest price: $5,000* for “the cure”. “The cure” is miraculously a one time treatment and you get back to a NW 1 or 2 (the crowd cheers!).
In the States alone, assuming that every male gets “the cure”, the company would be poised for a lump sum of $175bn income. Obviously if they cure us of MPB we wouldn’t need any more treatments but every year new patients would become available unless gene modifying somehow becomes available. So $175 billion (bn) broken up over a 75 year lifetime = $2.3bn/ year.
I want to note that these numbers are for the United State’s men alone. Obviously this would be marketable world wide and if “the cure” is able to treat women as well (21 million in the US) it would add $105bn or $1.4bn/ year based the US alone – worldwide I have no clue what the numbers are but say if only 10% of people suffer from MPB worldwide over their lifetime (which I think is a very conservative number) we are looking at a around 700 million people, $7.5 trillion or 46.7 billion/ year potential based on a cure that you only need once priced at $5,000.
Pharmaceuticals are definitely powerful and definitely have money to throw around but we are talking about having to pay off a company trillions of dollars to sell their cure and lock it up/ keep them coming to market. And that’s if only one company has a cure.
I want to note that these numbers are based on a perfect 100% sale rate which is wildly ludicrous based on a few observations:
1. Not everyone will care to get the treatment.
2. Very few people on earth are able to afford a $5,000 procedure let alone a cosmetic procedure (the global median salary is around $1,250USD)
3. This is assuming a cure that only takes a one time treatment to bring back ALL your luscious locks. I personally think that would be amazing to have but is probably not on the plate anytime soon.
*4. And this is where the asterisk * came from. I read a comment one day that I thought was nice and it went something to the tune of: someday treating your MPB will be as ubiquitous as getting braces. I used the price point of current braces which lies around $5000 total cost. This number is totally made up based on a “nice feeling” I had when reading that post.
Obviously the price and how many people that are suffering that would elect the treatment would vary wildly but I could easily see a company making a $1 billion/ year based on a single one time treatment that has an endless clientele for the foreseeable future (new people experiencing MPB). Blocking that kind of revenue is hard especially when there are many opportunities out there. More importantly, if a company (like merck) were threatened by it they could potentially buy it up and not adding it to their product line would not make any financial sense considering that propecia only makes roughly $400 million yearly which is sure to decline in the future as more and more treatments come out (you can’t stop progress).
So there you have it… my thoughts in a long post on the subject.
Basically, when you look at propecia sales it’s roughly 400 millions, but however, do not forget that many people buy proscar, and divide it by four for their hairloss. which is roughly another 300 million dollars. given existence of generics now, I would say a rough estimate of 100 million or something. So finasteride alone, can be considered top 15 best selling drugs in the world.
roughly an annual sale of 1 billion dollar, so any drug that can have less side effects and keep the hair is a block buster, and among top 10 drugs in the world
Totally…. I guess I was just trying to make a point that the money involved in a cure now heavily outweighs anything that Merck can throw at it. Given the fact that only a certain percentage of people are willing to take the pills and they are making $1bn/ year off of them… imagine what the revenue/ profits would be for a cure with no sides with better results. I just don’t think that you can stop it from happening.
It is similar to the oil industry trying to stop renewables – of course they are going to try and might have some success at doing so in the beginning but eventually the better solution will win out based on financial figures (renewables will eventually become cheaper/ more cost effective than oil and a new cure will be more profitable than merck can/ is willing to payoff).
In the end this is a hard puzzle to solve but it will be solved. I just don’t think big pharma trying to stop it is what is holding it back. I have a lot of hope for the coming years. As the admin says the technology is jumping in leaps and bounds now and with the new regulatory system in Japan it really seems like we are in the front row for watching them find a cure*… might take some more time but my guess is that we see it in our lifetime.
*My idea of a “cure” is not a one time injection that takes me back to a NW1 or 2 (I actually prefer to be at NW 2, currently at a 3) after 6 months. It would be a treatment that would take 1 to 4 years to get you back to NW2 depending on your loss. I just imagine us waking back up our follicles in a similar process to how they fell asleep, slowly growing the hair back from the perimeter of what we currently have (yep… that’s my not-based-on-any-science theory).
Stem cells are a far shot, no hair cloning will be available in at least 30 years or something. That’s for sure. Replicel will go bankrupt. There is no doubt in it, unless they manage to bring some kind of therapy for other diseases. Stem cells, as in a sense of creating a new hair follicle, will simply not work anytime soon. But drugs are close, I would say we will have a drug replacing fin in about 3 to 8 years, and that will probably give us something on average like [30% to 60%] increase in hair counts, but it will be a far cry from cure. A cure, will probably come from prevention, as in, there will come a drug that will 100% stop hair from shedding and people prone to it should take it. Now, this is something that WILL happen in future, like about ten years or so (I’m making up these predications clearly) but this is how things will go, so take home lessons are 1) no cloning anytime soon, FOR SURE. 2) a good therapy (mixture of drugs) will come but no one knows how effective it will be (probably somewhere around 60%) 3) a preventive medicine for sure will come in future.
I here you fgf.
I’m not making any predictions, especially in regards to hair cloning. If you think that hair cloning is the only solution then I might agree with you on that.
My opinion is this: If a solution increases my hair count 30 to 60 percent I would be very excited.
I think one of the things I am interested in seeing is if that solution – replicel, histogen, fak, whatever (not saying which will work and which won’t just dropping names) – if that solution is compoundable (it can be used multiple times) even if it has diminishing returns ie. 1st time 30-60%, 2nd time 15 – 30%, 3rd time 5 to 10% etc. (I think it would go something like that anyway considering the fact that you would eventually only need a certain amount of hair to get back to your desired NW) I think that many would consider that a huge advance.
Really as I said before I think that my idea of a cure isn’t a one off grow all of your hair back kind of deal. I would be happy stopping my hair loss. I would be thrilled seeing my hair loss reverse at the rate I lost it and I would be ecstatic if I could grow it back at twice the rate.
The thing is, I don’t think we are designed like rats and as we have seen our hair follicles are obviously much more complicated. We need to have modest expectations and I appreciate your outlook on things. I know that having a solution work compounding, working out from the perimeter, is about just as equally likely as it working all over the head but to me it makes sense to at least have something that builds our hair back instead of instantaneously (within 6 months) to see a full head of hair growing back.
Have fun camping!
A drug that cures baldness, I mean CURE, will be the first place Top drug ever created in the world. Second place will be a thousand miles behind it… No doubt. It is even common place to anyone knowing that the one person/company who can make a bald person hairy again – this can be called a miracle in all peoples minds, be sure – well, every one thinks/knows that whoever puts an end to this problem will be the richest mtf..krr on earth. It will really be BIG pharma!!
men… you keep discussing what the treatment will be, how it will be performed, when it will be available, the results, etc…
c’mon… Nobody knows and this discussion is empty.
fgf11, are you a prophet now?
c’mon, let’s talk things we know, let’s focus on what is the subject of this post, you think you know more than these researchers sometimes. ow my God.
News don’t say the same….Why? hahaha Propecia is the past. That’s all folks…
That’s all i’m so sorry. We need a new treatment better than this type of treatment based only in DHT. And minoxidil have shedding and poor results. Pathetic. And Hair Transplant industry needs to improve with something new.
Take care FGF11 and Curious (TBT users).
This conspiracy theory is so naive.. you did put well, but was too conservative in the numbers of hair loss sufferers worldwide. 10%?? you know that a very conservative figure is 50% of men over 50 years of age have some degree of hair loss. We know that it is more than that, just look around and you will easily see. I would put this number around 70-80% of men over fifty are Norwood 3 to 7. No doubt… it’s the vast majority. Men that never lose no hair during their lifetime are about just 10%. All the rest loses hair, some slower some faster, but lose. I think these numbers translate more or less similarly everywhere.
The actual potential of this market is immeasurable!! it is so big that none has a clue of how much money it can amass. It is HUGE, HUGEST than anything you can imagine.
what big pharma could have an interest in blocking a cure?
finasteride has hundreds of brands, you can buy it or even have it made to you by a pharmacy that manipulates remedies.
Minoxidil same thing. Rogaine today is just one more brand among many others.
Snake oils sellers don’t count. Those are just small parasites.
Hair transplant doctors?? c’mon.. are you serious? these poor creatures would just go find another occupation.
The cure doesn’t exist yet because it is really hard to get to, but we’re coming close.
Julian, I’m with your point.
fgf11, what do you (and us) get from your unfunded pessimism? Please do not write depressive personal points of views that sum nothing but irreal calculations to an intelligent discussion.
Making a “cure” takes from the $$ hustle of scum hair transplant doctors, crappy drug$ on the market now, etc. They will try try lobby against a cure as long as they can.
I guess that is the point I was trying to make… the potential is huge. I’m not sure in regards to it being 50% though. The thing is we live in a bubble in regards to how we see the world. I happen to live in Mexico right now and the amount of people that are balding at any age is relatively low… definitely higher with older men but it is also more common to see an old man here with a full head of hair. At the end of the day I think you are right though. People affected by MPB is in the upper 50% worldwide. But again as I said before the amount of people able to afford a $5000 for a cosmetic procedure might bring the number of people who access it down a lot.
Either way the potential for making a ton of money is HUGE.
Curious, you live in Mexico. You should know that most Mexicans descend from indians… indians don’t bald, they live 100 years without losing a single hair… look for pictures of indians, you’ll never see a bald indian. You’ll see photos of very very very very old almost mummies indian chiefs with much more hair than you’ve ever had in your life.
So, off course in Mexico the percentage of balding men is little, almost nothing. Because their indian genetic heritage is still strong.
5000, again you keep arguing over a figure that you don’t know. Why 5000? because is what putting braces is? what’s the connection? Maybe it will be more 10.000, maybe 2.500, maybe it won’t be possible.. WE DONT KNOW. This assumptions are crazy, man.
Curious… take a look at these:
And those are no wigs, real hair.. I have indian blood.. I wish I had more.. lol.
Relax man… If you read the original post you will see first and foremost that I call the numbers ludicrous and secondly I chose the number $5000 for a specific reason which I also admit was done on a whim… please don’t jump down my throat about it, I was trying to make a point that the industry is going to explode if they find a cure and money will be rolling in cash money. The other point that I was trying to make is that companies can’t assume a 100% consumer buy-in rate because unless they provide it for free the majority of the world will not be able to afford it as at the end of the day it is a cosmetic procedure/ treatment and as I mentioned before the median global salary is about $1,250/ year.
Responding to your rather no so correct (politically or otherwise) comment of Mexicans. Obviously you aren’t an anthropologist and my guess is that you have studied very little of Mexican people/ culture/ history. So here is a little lesson for you. So you can better understand the reasons why my guess of somewhere more like 20 to 30% of all men here (that number may be low) are affected by MPB and while it may come at a later age for a larger percentage it is just as common to see any age with some kind of MPB just like the states.
Mexico by it’s own constitution is defined as a “pluricultural” nation in recognition of the diverse ethnic groups that constitute it and where the indigenous peoples are the original foundation. About 15% of Mexico’s population is considered to be indigenous, which is much bigger than the US which is about 1%. If you open a history book about much of Latin America you will find that Spain invaded and colonized countries from around the 16th century to the 18th century until Mexico finally fought for and declared it’s independence in 1821. Before the Spanish you will find that there were many different indigenous ethnicities – including some of the most famous: Aztecs and Mayans. But during the time of the Spanish Empire, they intermingled with the indigenous populations along with bringing over black slaves creating various mixed races.
Thanks to a quick wikipedia search: they did a study in 2011 on mitochondrial sequencing or mitochondrial DNA and found that “Native American mtDNA in Meixcans is higher than was expected on the basis of autosomal estimates of Native American admixture of this (Mexican) population ~ 30-46%.
So yeah… the genetics for Mexicans does have a 30 -46% chance of being from indigenous descendants But that leaves 54 – 70% that doesn’t which would be a bit obvious in making assumptions about MPB in Mexico if you spend enough time here – yes, there is less MPB but it is still prevalent.
I’m not trying to bust your balls Julian, just relax a little man and read my entire comments… it is just a very non-scientific observation regarding a conspiracy theory that people toss around too often.
Ps. my guess is that there is MPB in indigenous communities as well… I have no scientific proof of this but saying that it doesn’t exist or that they don’t bald is probably wildly incorrect. While the numbers are probably low based on what little observation I have, my guess is that it does exist.
Now calculate his with propecia before patent expiration for years one day a pill. That will be more than the $500 you’re thinking of just FYI
I don’t believe in conspiracy theories
Won’t come back to the comment section until two weeks, sorry for leaving too many comments admin. Off to camping and enjoying life.
Hate to state the obvious but does anyone know WHEN they will start the Topical trials on humans?
That is what we need to know before everyone runs off to buy or not buy the product. Thanks.
No Nasa, nobody knows, not even they know. Apparently it is one of the hardest things in life to take something that was tested in mice, proved safe and efficacious, and then to put it on the head of a man. Apparently it would be the hardest thing on earth to find a bald volunteer desperate to get his hair back to give it a try on this.
So, they may have the solution ready but don’t know because they have to wait I don’t know what else to start human trials.
Unfortunately, not everyone is like Liz Parrish.
That’s a good question for Hellouser to ask Dr. Christiano at the Conference in Miami. To try to get more from her about these recent discoveries involving JAK inhibitors.
Admin, check this out :) http://timesofindia.indiatimes.com/tech/more-gadgets/Chinese-firm-makes-worlds-first-3D-blood-vessel-bio-printer/articleshow/49537328.cms?
what do you think? Guess we are coming closer and closer to the cure :) I appreciate your job maintaining this blog!
Thanks Luiza. Yes the 3D cell/organ printing news keeps making waves almost every week. Hope they are able to test this on humans soon.
hey admin what do you make of this?
Yes saw that on the forums and found it very interesting. Might write a post on that at some point, but not sure yet as there is lots to cover in the next few weeks. Thanks.
also Admin, what are your thoughts on these quotes? (My interpretations)
“Male pattern hair loss follicles are stuck in the same state where these drugs seem to work.” (MPB follicles stay small where these drugs are applied)
“What we’ve found is promising, though we haven’t yet shown it is effective for male pattern baldness.” (It doesn’t seem to be working with AGA/MPB)
am I wrong?
egghead, I think your first interpretation is wrong. She is basically saying that MPB follicles seem to be in the same type of resting state where the follicles in the current study are. So if the topical medication worked in the current study, it might work on MPB patients too.
Your second interpretation is also wrong. She is saying neither yes or no. They have not done any tests on MPB yet to be able to prove or disprove.
Admin, you really have made a very good point in there:
“I was therefore very surprised that Dr. Cotsarelis was dismissing these developments so fast. It should be noted that all of his decades of work and numerous patents could go down the drain if JAK inhibitors were to cure MPB in humans without any major side effects, since this is one rare area of hair loss research that Dr. Cotsarelis has never touched.”
Dr. Cots.. You may hate that, but Dr. Christiano may have been smarter than you!! Lol…
Admin, did you ask maybe dr. Christiano will it work on people who have mpb, and do you know maybe some people who want try with this two drugs?
LOL “maybe some people” maybe 90% of people want to try it . it’s expensive and $100,000 won’t stop “maybe some people” from spending it to try it out
jere, she has never replied to my e-mails. Think I have e-mailed her three times in the past. She probably got 10,000 e-mails this week lol
Millions of people want a new treament…That’s the real truth. 2016 and our treatments are Minoxidil and Propecia. NO RESULTS AND A LOT OF SIDE EFFECTS. What’s this? Pathetic.
Again, The Researchers need to try these Lotions on MPB Humans Now!!! They might not even try these for years believe it or not. But it has to be the right drug that will properly be absorbed/penetrate the skin otherwise it will not even have chance to work.
I wish we knew of Upcoming Trails and actually know the results once information about it is available.
I think this will be a real cure.
Am I maybe crazy?
Huge, Huge News, I think…
The last paragraph states:
“In the new study, the researchers found the two drugs woke follicles up by blocking enzymes that caused them to stop growing hair. While the drug combination has not been tried in humans, human hair follicles grown in a dish and grafted onto the mice grew longer than the mice’s own hair. The study is published in Science Advances.”
EVEN BETTER MAYBE WE CAN GRAFT RAT HAIR ONTO OUR HEAD
Good idea… to do the contrary.. lol
I posted the aforementioned above this comment.
I am perplexed about the part of the article where it states essentially that, human hair transplanted on the mice grew longer.
Not sure if that means it was MPB hair that was induced in the mice and that the mice were on Tofacitinib and yet the hair instead of falling out Grew????
Admin well done
Thank you all for your comments it’s amazing how I feel like partying already even when there are no promises of finding the drugs in pharmacies within the next two years
Well a bald African lady is no joke . The braid and weaves are now a thing of the pass and that is sad.. For the past 8 years I wake up depressed and sleep upset .. I have hyperthyroidism and that itself is a sad terminal illness..
Im up for trials definitely .. And hope il get the chance .. Can’t wait
Again well done and thanks for answering the million questions
Keep the faith Ola! Thyroid can be controlled and better cures will surely come there too. I can imagine how hard it is to be an African woman. Double whammy:-( But life is improving for women, black people, gays, transsexuals etc… gene therapy will improve it even more, but perhaps 10 years or more away.
Interesting comment I found about Tofacitinib:
“The big news of this new paper is that JAK inhibitors are even more versatile in function than previously thought,” says Amy McMichael, professor of dermatology at Wake Forest Baptist Medical Center, who was not involved in the study. “Not only do they have a burgeoning role in treating inflammatory conditions, but there appears to be a direct effect on stem cells that can impact hair growth function.”
I am almost positive that this is going to work since it blocks specific Enzymes. I know everything grows hair on Rats but this time it is my guess that it will work. Also the lotion form of the drugs work better than the pill form.
Curious, I know Mexico was colonized by Spain, man.. and therefore there’s an immense Spanish influence there, otherwise that wouldn’t even be their language, just to start with.
I pointed that, and you partially agreed with me, that the indigenous influence is greater there, or at least, in some parts of Mexico is greater, than in other places, countries. Even the States, which has a very rich indian heritage, particularly in its western states, as you’ve mentioned, is only 1% indigenous populated.
My point off course was purely empiric, but even so you tell me that about almost 50% of the Mexican gene pool is indigenous (30-46% according to your research) so its influence should be greater than most places, countries, alright? which in my empirical opinion, may account for its MPB being less prevalent than what should be expected.
Now, I can bet with you that you will never find a indian, I mean a pure indian man, bald, you’ll never will see one, not even a thinned hair indian! the ones that you may see are head shaved, that doesn’t count, obviously. Show me a picture of a bald indian and I’ll pay you a round of beers, or whisky, or anything you want to drink.
As for the price you proposed, I know your intention was just establishing a value in order to give us a hint of the real size of this market. I just think it is still underestimated, even your figures, no matter how much it costs. It just has to exist and we’ll know it.
But you’ve seen my photos? I find that incredible.. very old men with all the hair they’ve ever had. They don’t lose hair. It’s fantastic!! Dht, Pgd2… all this crap, does nothing to them, how come??
They are Warriors even inside their cells!! brave people!! truly admirable!
I’m not sure why you keep misinterpreting what I am writing. I don’t think we are disagreeing outside of some small things.
First and foremost I am making statements based on complete guesses (outside of the info I gave you on the demographics of Mexico which I did a little research for). Most of these claims are made because people somehow still think that big pharma is trying to stop a cure/ treatment from happening and I completely disagree with it, the numbers don’t make sense.
In regards to Mexico, I was trying to lay down a school of thought that MPB suffers are less here (but not by some huge number) and so our thinking that the same % of MPB sufferers in the States is going to be the same around the world is incorrect. Again I don’t know what that percent is but I was roughing numbers for the sake of making an argument. I was being conservative in that 10% of the world suffers from MPB (I honestly think that number to be low.
In regards to your statements about the indigenous population in Mexico, no it is not 30 to 47% of the population. As I mentioned in the same post the indigenous population in Mexico is about 15%, still a high number. 30-47% of those tested in the study I mentioned were noted to some mix of indigenous genetics or more specifically mitochondrial DNA.
That aside, when I went out to get some things for my Halloween costume today I took note of who I was seeing and how many I was seeing with MPB… The numbers were significant. I’d say somewhere around 30% at least. Most of them were older men (60%+ were 40 years and up based on visual appearance) but that seems to be par for the game.
As for your bald native american:
Now where is that beer? I accept payment in Lagunitas, Alesmith, Ballast Point and Russian River. In fact, I’ll buy the beer if you ship it here.
ps. Yes, it is amazing that some cultures are seemingly immune to balding… those bastards… lol
Curious, It’s not that I don’t want to pay the bet but I wouldn’t say these indians are bald or balding eigther, they just have a big, tall forehead. They might not be pure and have white blood, which would account for their finer hair, or it is just a characteristic of them, since childhood, having that kind of hair and features. It happens too.
I’d expect a Norwood 3-5 indian at least… lol
find one like this and I promise I’ll let you drunk!
Lol… Okay, well someone is a bit delusional. I’m not really going to make you pay up on your offer but if you don’t think these 2 guys aren’t at least NW3, you are blind – in fact, although it is hard to tell from the photo my guess is that the first photo is at the very least half way to NW4 if not all the way and then some.
With that said… if anyone mentions my MPB I’m going to tell them that I just have a big tall forehead LOL- I’m easily a NW3 and have more hair on my head than the second picture.
Found this on The Huffington Post Newspaper article:
“Christiano told The Huffington Post in an email.
The next step would be to conduct clinical trials, according to Christiano. Because the JAK inhibitors that the Columbia researchers tested are already FDA-approved, they could take less time to reach those in need, she said. However, it could still be four or five years before the drugs are commercially available for treating hair loss.”
it could still be 4 or 5 years before the drugs are commercially available for treating hair loss.” – apparently you will need to change the name of your website to hairlosscure2016.com.
2016 + 4 or 5 years = 2020-2021
Admin – apparently you will need to change the name of your website to hairlosscure2016.com. I think the cure is finally, Finally, here. We just need proof that it works on MPB then we can get a prescription from the doctor for the specific lotion form and then, Hair Is All Back. It will truly be a miracle.
Guys, let’s be real…this will not be available any time soon. If you had a cure for baldness worth bilions $ you would not go in publicil and discovery it just like that. I mean, there must be some compound beside JAK inhibitor, and second thing is they are not sure that will work on people with androgenic alopecia. There is still so much to research until human trials start. This is a good news, but let’s not be overexited, otherwise disapointment will be big.
Ha! Someone will find me and harm me if I ever become that optimistic..especially if the cure does not become publicly legally available by Dec 31, 2016.
Admin, the don’t know if it will work on humans, it is all about speculations for now. But from experience I know what means when scienties says “there is so much work and reasearch to do before the human trials”… It could be a realy long timeline. Do you agree?
But if Tofacitinib is ALREADY FDA Approved then IF is is proven to work in lotion form for MPB then why not by the end of 2016? (once trials are known for MPB)
Please consider a fact the Doc. Angela C. has alopecia areata, and she is wearing a wig….and cure for AA has been discovered last year….what she is waiting for??? I don’t want to be negative but that is a fact!
If it is a cure then it is a cure as simple as that.
Still need them to try it on Humans with MPB as we already know it will grow hair on genetically engineered hairless rats to prove that it works on Humans with MPB. My guess, and only a guess, is it will work if used in the right Topical Method. Hurray!!! I hope.
The drug is ALREADY FDA approved to be taken Internally. Simply making it into a topical solution, however they do it, and using it as prescribed by a Doctor as they can write a prescription for other uses.
What you have to realize is the drug is ALREADY here and in the Pharmacies. But we do not take it internally just put the lotion on our skin. It will take another 5 years to formally get it approved for hair growth but I already will have 5 years growth of hair as I am not waiting. I strongly say months after they prove it works on Human MPB that everyone will use it prescribed by their doctors.
All is my opinion.
how the F are you going to turn it into a lotion and apply it the same way in the studies IF they prove it works in men.
You get a Doctor to provide you with a prescription. They are allowed to use currently FDA Approved drugs for Other Uses. One member of this group is already trying it not sure if he has the Correct Lotion Form of it.
great news but what do you think???
When will start human trials?????
always 5 years, always delays, always nothing new….
the same history again and again…
Tsuji team: delayed
what do you think???
— This might come first FYI:
— All new trials might be faster now due to the the new US and Japanese regulations.
— Replicel/Shiseido trials have not been delayed by much. Perhaps a year at most? I lose track.
— Histogen, I gave up hope. Now they are back and presenting at the Miami conference. I am still skeptical , but good to see them still interested in hair loss.
— Yes the Christiano news plus the development of a topical for MPB might still take a few years…but these oral JAK inhibitor drugs are already FDA approved so maybe things can progress faster?
Overall, far more optimistic news today then ever before in my opinion.
Follicum Applies for Human Trials in Germany
One of my favorite companies in the game right now, Follicum, is getting ready to test their wonder peptide for hair growth in human beings. Here’s the news right off Follicum’s website from October 15, 2015:
Follicum has filed a clinical trial application to start a clinical Phase I / II a study to both the the BfArM (the Federal Institute for Drugs and Medical Devices in Germany) and to the Research Ethics Committee. Follicum’s intention is to initiate the study at year-end 2015/early 2016, provided that the application is accepted.
The news release mentions that Follicum will investigate some efficacy parameters during this Phase I/II trial, which is generally a safety study. They plan to release their results from this study in 2016. Also, Follicum will be presenting information at this year’s World Congress for Hair Research in Miami.
Pantheon Company Contains Ex-Aderans Researchers
Pantheon, a company out of China that is lead by Dr. Wu Xunwei, who is formerly of Aderans Research Institure, is working on hair regeneration therapies. For those not familiar with Aderans, it was a major hair biotech company that worked on hair cloning for over a decade but failed to make significant progress and closed its doors in 2013. Pantheon’s website is not entirely clear when translated to English, but the basic concepts are laid out. Pantheon is working on producing a functional cellular based hair regeneration treatment. They show pictures of human skin grafted onto the backs of mice which are growing human hair follicles. The interesting thing is that the research team of Pantheon contains several ex-Aderans researchers, and amongst them, many combined years of hair R&D experience. It’s a good addition to the pool of known companies working on hair growth technology.
Follicept Mod • 15 days ago
It’s been a tough 3+ weeks, but no one has taken a single day off from work. We appreciate all of the posts of condolences and sharing their experience of the loss of our beloved Devon.
I have no plans to replace Devon because that is impossible. I am waiting patiently for another brilliant young person to join us and lend his/her own specialness to our company and our efforts.
We continue to get interest from companies in China, Italy, South Korea, and elsewhere for manufacturing and sales of Follicept in North America, EU, and Asia–then eventually everywhere.
However, we must be patient and respect that the FDA has a mandate to evaluate whether Follicept can be marketed and sold as an OTC product or whether it should be considered a drug. This takes time. You’ve waited a long time to an alternative for mediocre hair growth products. Wait a bit longer.
Jeromo • 5 days ago
Steve, sorry for writing about conspiracy theories here but this actually fits into them. Because of the fog surrounding Devons cause of death, the delaying of second clinical trial and lack of reports from subjects, its starting to look like your team has been targeted and ordered you to silently slowly cancel the research. Whether by companies producing Minoxidil / Finasteride, government or someone else, i dont know.
However we have all seen new hairs sprouting in Devons temple after he started using the cure more frequently and we thus know for sure that this cure works – but needs to be applied more frequently.
In case you have not seen Devons body (could be a wax figurine), there is a slight chance that he is well and alive but was “made” to disappear or paid handsomely to do so, internet is full of hoax assassinations and people photographed to be alive but whom were claimed to die in crashes and explosions.
I dont mean to make fun of Devons disappearing, im just putting forward a possible explanation and i wish he is still alive. We all hope that there is no conspiracy and that you will develop and market this working cure. We can always search for the patent, buy IGF-1 and produci it ourselves at home anyway.
Are you serious with your comments Fadi?! I think people like you make all hair loss sufferers seem delusional and out of touch. There is no conspiracy. Just shut up, or get a degree and help contribute.
This guy is a p.. in the ass. c’mon
We know Tofacitinib grows hairs on Humans with AA type hairloss but if it can grow hair on people with HPB simply by users putting on a lotion form of the drug. Then, there is no reason why we could not get the product the second we know it works from a Doctor who can legally prescribe the drug for other uses (even if it is not officially approved for hair growth).
I really think this is it. Not False Hope but Real Hope and we should know in 2016 then I get a doctor’s prescription for it.
We must send email dr Christiano and ask her about this, all of us.
We just need to know WHEN they are starting Human Trials for people with Male Pattern Hairloss. Then what the results were once the trial is over.
After that (if it works) all we need to do is to go to a doctor and ask for a prescription for it in The Lotion Form. Then can you imagine we get all our hair back after 3 weeks. And I am going to let my hair grow extremely long.
your rushing to awesome conclusions faster than the slow not awesome world we live in dude, just saying get more facts before you plan how long your going to grow your hair
This will take them at least 5 years to get this into the market for people to buy. It has been about 1 year since they announced that it worked for AA type hairloss. That means AT LEAST another 1 year before they announce if it works on Male Pattern Hairloss then ADD more Studies then all the other FDA requirements, easily 5 years.
I am not waiting. As soon as I know it works and I can get a doctor to approve me for the exact same lotion then I am going for it.
I really hope this will be the baldness cure, but at the same time im not getting my hopes up. I only started noticing baldness last year and after the full year on FIN im now almost a norwood 4. :c by the time this comes out EVEN if it works for mpb ill already be bald as hell.
Not to mention, im sure alot of people have been prescribed these two drugs already, and out of all of them there are like 3 documented cases of it regrowing hair. Id love for this to work, but I feel like its going to just be the next gen rogaine. Not trying to be pessimistic, I just have seen too many “breakthroughs” “fall through” to get really pumped yet. being almost bald at 24 sucks. .
Hi admin and Everybody
I have had a look on the study and read it but there one point I do not understand.
For the study, How do they know that Ruxolitinib and Tofacitinib works ? I read the mice were juste shaved. Then, isn’t normal that hairs regrowth after been shaved ?
Thank everybody for your repply ;-)
Those were indeed shaved mice. They are confident because they believe these JAK inhibitors will work equally on AGA humans by inducing the hair follicles into anagen (growth) phase. It is my understanding that such JAK topical will have to be applied daily.
I think there is ample reason to be positive about this latest discovery. The rapid growth in a matter of days and the upregulation of follicle inductivity tick all the right boxes for this to be a “cure”.
I hope we hear more about this in the upcoming hair congress.
Admin: Are you attending the hair congress in Miami?
But if they think it work same on AGA human why havent they simply tested on bald mice like always they do. Thats weird
No due to personal and professional commitments, but really wish I could.
Thanks Admin for this great blog. I’m norwood 7 and eagerly waiting for a real cure. Hope it is real.
I just dont understand the delay then. We have two drugs already FDA approved for CONSUMPTION, that we cant just slap on someones head to see if itll work? If it regrew hair in mice in 10 days, then itd take about, what, a month? Two max to see if this had any effect at all on mpb? Why the “possible 4-5 years?” We could literally know by this time next month if it showed any chance of helping mpb. Also, if I was Christiano and had AA, i would not wait to try this. These drugs have been known since 2014 to help AA patients no? Soooo why isnt she using?
yeah waiting sucks man especially their trials wich always have delays after delays
I Am 30 years old and it has been 10 years that I am looking for a cure. I think that when they will find THE treatment I will too old and I wont care about my image !
About the mice, I am still a bit sceptic because when you see them on the pic, they are shaved and you can see some small dark spots like you can see it on the scalp from a man who had shaved it.
On a really bald scalp you just see anything…exept a perfect shinny skin. I hope I am wrong dude !
This is speculation but the doc… she might be content with her solution of a wig for now (and what a wig it is). The other thing is that she might already using it, which my guess she is, and it doesn’t work from one day to the next… And even if she is, it takes time for hair to grow. You can’t magically grow a long length of hair over night… it takes years even when you aren’t balding. And with that wig, my guess is that she likes to have long hair (again just speculation).
Regarding trials… common sense will bring you to the conclusion that doing any kind of trial takes time and money. The time it takes, if you want to be taken seriously, is to make sure you are measuring things properly and have accurate, scientific ways of proving what you are setting out to do. The other side is money. I’m not sure how much this drug costs but my guess is that it takes a certain amount of money to make it into a topical. Yeah they can pump pills into someone that have immunologic side effects isn’t something you want to be playing around with. Science takes time.
That aside, my guess is that they are already trying it on humans… they just don’t want to come out and say so. But they will still need to do real full trials that are in accordance with FDA regulations and all that.
Admin, you pointed something out about Cotsarelis that’s interesting. He dismissed these drugs as being beneficial and you pointed out (quite reasonably) that he may have an ulterior motive for doing so.
The way I see it, the way I’ve seen it for quite some time now, is that this is a race. This recent piece of news ups the ante. In particular for Follica – a controversial topic I know, still after all these years.
I’ve always felt they might just be on to something with the wounding method and the numerous anecdotal evidence of wounding and people regrowing hair. Couple of things of note…this story broke on one of the forums recently that may affect Follica:
But perhaps more interestingly, after Luis Garza’s RNA discovery, Cots filed a new patent (Follica related I’m given the mention of Fgf9) and then Follica popped up again last month for the allowance of a US patent. Don’t think these were coincidental. Also worth checking out is this interview with Garza in relation to his discovery;
That “really excited” part has me excited. Also, Follica have been hiring again on the qt. David Tharp and Stephen Muniz not to mention the addition of Washenik to the Advisory Board. At the congress next month, Follica have 4 people from their board presenting.
I can’t help but get the feeling something is going on. I could be way off but next couple of months could prove very interesting. Man the best man (or woman) win the race. The sooner the better!
Hey Mike great analysis! I did not know about 4 people from Follica presenting next month! Yes it does seem like a race hereon. Also see my next post — not anything groundbreaking, but something I had forgotten to follow in the past several months due to all these recent developments.
Topical tofacitinib shows promise as a novel treatment for atopic dermatitis on the basis of a highly positive phase II randomized clinical trial.
The key extract from the link:
“Oral tofacitinib is Food and Drug Administration–approved as Xeljanz for the treatment of rheumatoid arthritis and is currently under FDA review as a potential treatment for moderate to severe chronic plaque psoriasis, with a regulatory decision anticipated in October 2015.
The atopic dermatitis study was funded by Pfizer. Dr. Bissonnette is a consultant to and recipient of research grants from more than a dozen pharmaceutical companies, including Pfizer.”
Seems like topical tofacitinib could be on it’s way alot sooner than you think. I read a month ago that Pfizer was trialling this in 2013 for Psioarisis (I have eczema that comes and goes). Could this be used for the scalp potentially? Seems to have efficiacy in being absorbed into the skin.
Hey guys and admin.
I did some quick research this morning, googling: natural JAK inhibitors and I came across a couple of interesting articles.
The first was a BTT thread that lead to this product:
I know… looks like another snake oil but the important think I got from it is that it has Brevilin A with targets JAK activity. Along with other hits in the search Brevilin A seemed to be the top hit. Whether it works, is effective or even natural… I’m not sure on any of those.
So I searched for Brevilin A and found this study: http://www.ncbi.nlm.nih.gov/pubmed/23704931
I’m personally awful at deciphering medical studies and data but the interesting thing I found was in images, specifically figure 3. In that figure it shows a timeline up to 120min and in that timeline it shows that STAT3 is reduced to 1/10 within 2 hours which to me seems amazing.
What I take away from that is IF (super speculation happening), STAT3 is involved somehow and if removed hair will begin to grow/ repair/ reverse MPB it will happen almost immediately (within a couple of hours). That isn’t to say that you will have your hair back within a couple of hours but more along the line of – the effect will start to take place within a couple of hours and your damaged hair follicles will start to repair themselves.
Please don’t take this as scientific proof/ advice or anything of the sort. I am just surprised that the medicine works almost as quickly as tylenol and that JAK s or more specifically STAT3 are relatively easy and quickly shut down. I’d love to see how long it lasts though… if it starts to rebuild/ comeback after 2 hours just as quickly, it would be a pain to have to constantly put it on every 2 -4 hours. My guess is that they could create some sort of medicine that releases slowly over time if that is the case – something that they already have now for pills.
Please feel free to pick apart my theory, just don’t accuse me of claiming any scientific fact – this is purely speculation.
Great research Curious!
I am very skeptical of this now because the mouse grew back that was shaved not lost to AGA. Plus, Cots said this won’t work on humans and I believe him. I think christiano just needed some publicity to attract funding. She should have used an aga mouse at least. If you added rogaine to that mouse it would have grown hsir fast. I hope I am wrong. She has been working on hsir since 1999 from what I remember and hasn’t done anything. At least Cots started a company, sold a drug to kythera, developing a wounding device and discovered numerous hair loss studies like pgd2 etc. I think he is way ahead of christiano.
Yes Cots is the king of hair loss research and to be honest I do not think that two drugs are going to do a lot
I think you guys are forgetting – or didn’t read the study – the control mouse did not grow any hair during the very short period of time the other mice grew thick hair. These drugs certainly have a substantial impact on growth. Sounds like more so than minoxidil, at least. It is exciting.
Even if something came around with the benefits of FIN without the side effects, I think it would be a good leap forward. I will admit, that is interesting and a good theory Curious. I think if nothing else, JAK inhibitors will be beneficial for hair regrowth, similar to rogaine, but probably alot more powerful. It may end up only working for those in very early stages to maintain what they have though. Yes, it did manage to grow hair very quickly on the mice, but as people are saying, they were shaved and not really bald. I don’t see how it “kickstarted” their follicles into anagen phase, when 90% of the hair on them was already in anagen phase since they didnt have AGA.
It has already worked to Regrow 100% of hair on the AA type hair loss victims who had not had hair in decades.
These two drugs can be promising to hair loss cure but I’m more concerned about the side effects of these drug especially for tofacitinib. Tofacitinib may have serious infectious side effects as well as can create tuberculosis. After googling I learned that it weakens our immune system by prohibiting ZAK enzymes, so any minor decease can lead us to dead. So I just want to ask one question that if these two medicines become cure for hair loss, then should we go for it after knowing that it can kill us. I think these will be worst of propecia. Propecia has sexual side effects but that doesn’t kill. Dear admin, what is your opinion about that ?
Not if used as a cream
You are talking about oral use of the product. The side effects appear to be virtually non-existent as a cream. They noted that the cream works better on hair anyway.
These Drugs have a powerful affect on growing hair. Hair grew within 10 days on Rats thus the hair was already there but Dormant and these drugs immediately got the hair to regrow. [my guess the rats were not shaved but were genetically engineered to have repressed hairs as in bald]. I say the Cure is Here… my opinion of course.
” When they rubbed the compound onto the skin of bald mice for five days, new hair sprouted within 10 days, the team reported in the journal Science Advances.”
“The hair that came in came in beautifully and in a few weeks and very thickly,” Christiano said.
“Some topical agents induce tufts of hair here and there after a few weeks, but very few have such a potent and rapid-acting effect.”
I say MBP is Now in the Past. These drugs work to WAKE UP dormant hair follicles. And that is what DHT does it puts hair into a resting state. Now these drugs will wake up these dormant hairs and after 3 weeks a full set of hair. Amazing. Simply amazing.
Just need final proof that it works from the scientists, and then to have a doctor prescribe.
All is my opinion.
guys if you still haven’t donated yet .. please do so .. we are only 400 something dollars away from our target .. let’s get Hellouser to the 9th World Hair Congress this November…
I love your optimism but the fact you state all these claims and then finish with all is my opinion sort of contradicts your validity. Just my opinion of course.
There is NO complete cure right now for male pattern hairloss BUT we have reason to believe that these new drugs COULD completely give back a person’s hair. There is no proof yet that they work just incidental evidence that they will work. The test should be done this year (probably going on right now) and then we will know if there will be a 100% cure or 0%.
I say, All is My Opinion since I am not in the medical profession nor am I an expert in the field.
It does cure hair loss but does it regrowth new hair in a bold area? If it does that’s a great news and how we can found out this medicine is launched
It is not yet confirmed whether it’ll work with AGA or not. There is some experiments on it & we’ll know soon whether it is worth or not.
Ok. My comment asking about Oclacitinib as a JAK inhibitor was deleted. Was this an accident ? If not why ?
It is a JAK inhibitor available cheap and is used for pet dermatological treatments. I wanted to ask if there is any research done on effect for MPB.
I did not delete anything…maybe you posted it under another post?
Hi George, you have two comments on Oclactinib in the last “brief items of interest” post that are still there. Nothing deleted:-)
hey fgf11, i could use your help regarding this :)
can you contact me?
then we can start our test :)
I think people shouldn’t get too hyped. I believe it will work and cure male pattern baldness. But do you know what that means guys. Expensive. The pill form now is over £3,000!!! The topical a hairless cure? Be prepared to spend more than what you did on minoxidil. The only way we won’t spend a shit ton of money is if christiano or anyone who has been affected by this shitty hair loss experience takes pity, empathises and makes it affordable. But I’m not holding my breath. It’s a sad world we live in. Lets hope everything comes up roses. I’m 22 and shouldn’t have hair like I do. No man should.
Another success with using JAK inhibitors for hair loss. Can’t wait to get my hands on some!
just a short question: WHERE to get topical ruxolitinib or topical tofacitinib?
I have alopecia areata (barbae) and would do everything to try that!!
Please help – thank you
I don’t think there is a topical released ansi otherwise id be trying it. There are only pills, but the pills are linked to cancer etc. The topical however doesn’t affect the body but does regrow all hair and blocks the body from destroying hair. Unfortunately it isn’t on market If you were to take the pills anyway its like 2000 for a month. its absurd. Its a waiting game I’m afraid
ok, unfortunately I thought that it isn’t marketed yet.
http://www.selleckchem.com/products/INCB18424.html on that page you can but the chemical compound, and with knowledge how to create a cream, you could use it.
i have no pharmateutical knowledge, but I ask myself, if nobody try that up to now?
If ruxolitinib and tofacitinib works in AA, why can’t we have them in the market? I went yesterday to the doctor and I can say he didn’t know a lot about it. So, if those drugs are so hopeful, why dermathologists don’t know them?
I sent an email to doctora Christiano but she didn’t answer me. Does anyone know if she continues her trials in AA? And could anyone say when can we find the cure for AA on the market (I’m from Spain)?? Thank you.
i have alopecia universalis
im trying it on my own risk by making a simple compound from tofacitinib tablet,for 2 months now.
i use it on my eyebrows2-3 time a day.(all the body is almost hairless 80%)
first time applying the cream ive notice itching stoped and skin changed the texture and feels much better.
after few days started to see baby hair,the hair continue to grow and gets black,still it is very thin though.
please if someone have the knowlage on how i can make the compound better so it can observe properlly in the skin.
that will be helpfull,the therapy takes a while because the skin is not observing it enought,and also the small 5mg dose in the tablet.
i dissolve the tablet in water,adding propilyn glycol,base cream and soap to connect betwin the water and oil.
So far no side effects and feeling is great(:
any ideas how to make it more efficancy?
Can You explain how You you’re cream?i have alopecia areata since i’ve 1year…
I don’t know guys but I think its just a lie to make us hope for it and feel positive, because you know this problem is a huge depression so they want to calm us down and say ( the solution is coming anyway).. This is a big discovery if its right, but they just stopped saying anything about it anymore.. That can’t be, something is wrong and obviously its a lie.
Hair growth oil when will it come to out
We r waiting
I’m from France and i would know where are the research about topical cream tofacitinib please?i suffer of alopecia areata since i’ve one year!!!and i have 28 years old today…please thank You lot
Hello I Amit from India. I have alopecia. can I use
ruxolitinib and tofacitinib?
Hi, any updates on DIY tests for MPB? Looks like it’s possible to buy a ready made solution in DMSO for topical use here:
Not sure how strict controls are in that ordering process, but it looks like a simple “i agree” type thing. Any news from someone daring enough to have tried it already? Also, if I where to go ahead and test it for myself, what kind of quantities do you think would be reasonsble? I’m not sure I understand the dosage of that solvant.
Several companies overseas offer tofacitinab citrate at $44 per gram. The topical formulation partial details are found on the web. The side effects of the use of this compound are unknown topically. I will update after some experimentation and blood tests. I will state my final protocol if efficacious.