Category Archives: Shiseido

Dermal Sheath Cup Cells, Shiseido

Shiseido News

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My post on Shiseido’s Phase 3 clinical trials for hair loss has the latest updates as of 2024. The company’s technology entails culturing dermal sheath cup cells (DSCs).

Also check out the Japanese company’s very popular Adensoine based Shiseido Adenovital shampoo.

Shiseido Logo

Shiseido Cell Processing Facility
Shiseido’s Updated World Map. Kobe Cell Processing and Expansion Facility.

Shiseido Hair Regeneration

The company has two pages on its site in related to hair regeneration:

  1. Hair regenerative medicine.
  2. New research areas.

Shiseido collaborates with University Hospitals (Japan) on a clinical study in regards to hair regenerative medicine technology in Japan. The company also used Replicel (Canada)’s technology via a licensing agreement pertaining to the Asia/Pacific region.

This technology entails culturing dermal sheath cup cells (DSCs). These represent the source of hair dermal papilla cells, which play a critical role in the growth of scalp hair.

For a patient with hair loss (male of female pattern baldness), these DSCs are implanted via injection into the balding scalp skin. The cells then rejuvenate damaged hair follicles and promote the growth of healthy hair.

Make sure to also read my 2014 post on Shiseido’s at-the-time new research facility in the Kobe Biomedical Innovation Cluster (KBIC). This location is also home to RIKEN’s hair research center.

RCH-01, Replicel, Shiseido

Shiseido Opens New Hair Regeneration Research Facility

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Japan’s Shiseido will open a new hair regeneration related facility in Japan on May 1, 2014 in the Kobe Biomedical Innovation Cluster.

Shiseido New Hair Regeneration Center

More details from the company’s press release.

The company plans to open the Shiseido Cell-Processing and Expansion Center (SPEC) on May 1, 2014. The center will be located in the Kobe Biomedical Innovation Cluster in Kobe, Japan. It will
centralize research and development in regards to hair regenerative medicine, with an end goal toward commercialization.

Shiseido is now also using Canada based Replicel’s RCH-01 dermal sheath cup cell related technology. See: Replicel and Shiseido complete collaboration and technology transfer.

The Japanese government has in the past year made major announcements regarding its support and encouragement of stem cell related research via favorable laws and funding. It will therefore not be surprising if the first hair cloning or hair multiplication type cure comes from that country.

It should be remembered that Japanese car companies and electronics companies significantly improved upon western inventions in those fields. So it would be fitting if a Japanese hair regeneration company significantly improved upon a Western based hair regeneration technology too.

Company History

Having said that, it should also be noted that Shiseido also has its own highly experienced team of hair loss research scientists. And a very lengthy history in the hair loss sector.

  • Shiseido was founded in 1872 as Japan;s first Western style pharmacy.
  • In 1898, the company launched “Euthrixine Hanatsubaki Perfume”.
  • In 1915, the hair tonic solution “Flowline” was developed by the company’s scientists.
  • In 1982, “Medicated Flowline” was released.
  • In 2005, Shiseido released “Medicated Adenogen,” which contained adenosine, a bio-related component, as an active
    ingredient.
  • Since its release in 2021, the company has sold over 2.3 million units of “The Haircare Adenovital Scalp Essence” throughout Asia.