Category Archives: Gene Modification

DIY Genetic Engineering to Cure Hair Loss

For the past five years, the revolutionary CRISP/Cas9 gene editing technique has caused much excitement as well as trepidation all across the scientific universe. Both emotions reached a new crescendo two months ago, when a renegade Chinese scientist genetically edited human babies for the first time ever using CRISPR technology. Aldous Huxley’s 1932 book “Brave New World” was truly ahead of its time.

Gene Editing (Modification) versus Gene Therapy

Gene editing (aka gene modification aka genetic engineering) involves alteration of existing genes. This can in the future perhaps enable humans to develop various superman-like capabilities. In contrast, gene therapy is the process of replacing existing defective genes with new normal and healthy ones. Having said that, gene therapy is starting to incorporate some of the tools of gene modification.

In 2017, CRISPR based gene editing was performed in an adult human for for the first time in the US. Thereafter, both the US and Europe started gene editing clinical trials in 2018.

Genetic therapy treatment has a much longer history, with 2,335 gene therapy clinical trials having been undertaken in close to 40 countries between 1989 and 2015.

DIY Gene Modification for Hair Loss

A number of do-it-yourself (DIY) self-experimenters in various countries have been experimenting with editing their own genes and DNA in recent years. None have as yet announced their doing this for hair growth or hair loss prevention purposes. Some (or even all) might obviously be frauds trying to get fame and make money from product sales.

At the same time, there could very well be hundreds of others by now who are DIY modifying their genes without publicizing it anywhere. Note that while most self-experimenters are undergoing gene therapy treatments, some are  trying out the more difficult gene modification procedures. There are various online biohacking and genetic engineering groups where you can read about strategies and testimonials.

Sooner or later, it is inevitable that someone will try to replace or modify the genes responsible for hair loss if such genes can be fully categorized; or cut out the gene responsible for dihydrotestorone (DHT), assuming that gene is not responsible for anything else important; or cut out the gene responsible for hair being sensitive to the ravages of DHT; or any other such iterations.

Interestingly, in 2016, a well respected Chinese scientist named Dr. Chunyu Han claimed to have discovered a gene editing technique to cure hair loss. For some reason, he was really into the hair loss aspect despite not being bald himself. However, Mr. Han has since been discredited.

Josiah Zaynor

Perhaps the most famous of these DIY genetic biohackers is Josiah Zaynor. In 2017, he supposedly used CRISPR to knock out the myostatin gene in himself. A successful outcome would lead to him becoming significantly more muscular, since myostatin inhibits muscle growth. However, this attempt did not succeed. Mr. Zaynor later had some regrets about his self-experiment. Note the also own a company that sells do-it-yourself Crispr bacterial gene modification kits.

Myostatin gene mutation muscular dogs
A muscular dog without the myostatin gene.

If a renegade biohacker ever does succeed in knocking out myostatin via any kind of gene modification technique and then also becomes overly muscular, watch out. At present, genes, epigenetics and genetic interplay are all way too complex by the standards of our current understanding. Perhaps self-experimenters, artificial intelligence, big data analytics/bioinformatics, and renegade Chinese scientists will all combine to speed up our ultimate mastery of human biology.

Liz Parrish

Liz Parrish needs no introduction. I have covered her on this blog a few times. She supposedly underwent two gene therapies in 2015 to try to reverse her aging. One of the therapies was to increase her telomere length and the other was to increase her muscle mass.

In her latest blog update from 2018, she claims that her telomere length has increased from 6.71 kb in 2015 to 8.12 kb in 2018. Make sure to read my post on telomerase activation and hair growth. She also points out that this telomere length improvement was shown in her white blood cells, but I she does not yet know if it is happening in all her body’s cells.

Belgian Blue Cattle Myostatin Mutation
Belgian Blue muscular cattle with myostatin mutation.

Moreover, Ms. Parrish claims that her body’s muscle composition also improved after her 2015 procedure, and her muscle mas remains greater to this day. I would be curious to know if she has changed her diet and exercise regimen in any way since 2015.

Tristan Roberts

In 2017, Tristan Roberts self-injected himself with a gene therapy to treat his HIV. Story here. He provided an update in 2018, and aims to make a second version of the gene therapy without using any bacterial DNA.

Dr. George Church — The Augmented Human Being

On very rare occasions, I write posts covering biological or medical subjects and breakthroughs that are either:

a) Entirely unrelated to a hair loss cure, or

b) Potentially related to a hair loss cure in the long run, but this is just happenstance and not the original intention behind my covering the said subject.

This post falls under the second category.

Dr. George Church

I have discussed Dr. George Church a few times on this blog before. In my opinion, there is a good possibility that he will be known as one of the 10-20 greatest scientists the world has ever witnessed when all is said and done.  Interestingly enough, Dr. Church got an F on one of his graduate program college courses at Duke University in 1976, and he has proudly posted that letter of rejection from Duke on his current Harvard University website.  Talking about his site, it is well worth  going through this part of it in great detail.  Dr. Church was adopted as a child.  In his own words, he has had “early-onset health problems (insurance companies take note): heart attack, carcinoma, narcolepsy, dyslexia, pneumonia, motion sickness.

Several days ago, a new interview (more like a speech) of Dr. Church was posted on youtube, and I was very impressed by the range of subjects that Dr. Church covers in this video.  The title of this video is “The Augmented Human Being.”  Hopefully, this augmentation will imply a full head of hair for all, even though that is  probably the last thing that Dr. Church is thinking of when he discusses things such as CRISPR and genetic therapy in the video.

It is quite revealing that the above video only had a little under 500 views when I embedded it in this post, despite being online for two days.  In sharp contrast, the one week old gorilla video now has close to 11 million views.  Dr. Church could bring back that now dead gorilla back to life just like he will the extinct woolly mammoth.

Dr. Church is currently 61 years old, but from the looks of it, I doubt that he will retire any time soon despite his health problems.  He is a workaholic.

During the past few months Dr. Church has been all over the news almost every single day.  Some highlights:

Aldous Huxley increasingly looks prescient.