Category Archives: Adipose-Derived Stem Cells (ADSC)

Adipose-Derived Stem Cell Constituent Extract

It has been a while since I wrote a post related to adipose-derived stem cells (ADSCs) and hair growth. Adipose cells are also called fat cells.

Adipose‐Derived Stem Cell Constituent Extract

A potentially groundbreaking new study from South Korea was published yesterday. Thanks to Chris and Joe who both e-mailed me with links. This study concluded that adipose‐derived stem cell constituent extract (ADSC‐CE) helps hair regrowth in patients with androgenetic alopecia.

Adipose-derived stem cell constituent extract (ADSC-CE) and hair growth.
Adipose-derived stem cell constituent extract (ADSC‐CE) treatment increased hair count and hair thickness in the study. © 2020 Tak/Lee/Cho/Kim — Stem Cells Translational Medicine, published by Wiley Periodicals, Inc. on behalf of AlphaMed Press.

According to the authors, this is the first time that ADSC‐CE and its benefits on hair growth have been demonstrated via a a randomized, double‐blind, vehicle‐controlled clinical trial. Many other past studies have shown the benefits of ADSC (often via intradermal injections) on male and female pattern hair loss sufferers.

This latest study was widely covered in the media, including by the Daily Mail and New Atlas. The trial was conducted at Busan (Pusan) National University Yangsan Hospital and led by Dr. Sang Yeoup Lee. The actual trial was completed in 2016, so I am not sure why results were delayed till 2020.

The study was published in the journal Stem Cells Translational Medicine. The famous Dr. Anthony Atala is editor-in-chief of  this journal. He is quoted as saying that this treatment offers hope to hair loss sufferers.

ADSC-CE Before and After Hair Growth.
ADSC-CE hair growth photo at 8 weeks and 16 weeks. One of the four results presented in the study.

Hair counts (+28.1%) and hair diameter (+14.2%) both increased substantially in 34 patients who completed the study. Original patient enrollment was 29 men and nine women. Encouragingly, these results persisted 16 weeks post treatment, with no major side effects. The treatment entailed twice‐daily self‐application of an ADSC‐CE topical solution all over the scalp.

The authors assumed that ADSC‐CE is likely to penetrate scalp tissue more than existing products that are manufactured using conditioned media (ADSC‐CM).

Adipose (Fat) Cells and Hair Growth

A lot evidence on the benefits of fat cell injections upon hair has been accumulating over the past decade. Even as far back as 1954, there was a study published suggesting a connection between scalp thickness, fat loss and balding.

I have written around 10 posts in the past that cover ADSC and closely related subjects, although none in the past couple of years.

For example:

  • See my past post on Stromal Vascular Fraction (SVF) enhanced adipose transplantation and the STRAAND clinical trials.
  • And on Advanced adipose-derived stem cell protein extract (AAPE).
  • Also see my past posts on Kerastem and the company’s STYLE clinical trials.
  • I have also analyzed important work from Dr. Valerie Horsley’s lab regarding adipocytes and their essential role in  hair follicle regeneration. Last year, I also discussed fat layer loss and tightness in balding scalps.

21st Century Cures Act to Accelerate Medical Progress

21st Century Cures Act

— As expected, on November 30th the US House of Representatives passed the groundbreaking 21st Century Cures Act with a high level of bipartisan support. This Act has been discussed on hair loss forums fairly regularly over the past year since it would allow for faster times for hair loss drugs and stem cell therapies to come to market without the need for completion of extensive phase 3 clinical trials.

I think this development will prevent more western pharmaceutical, medical device and stem cell therapy related companies from moving research and development activities to countries such as Japan. A somewhat similar Act has already been passed in that country. There are still a lot of uncertainties on the final regulations, and the rules could always end up being stricter for products related to cosmetic conditions such as hair loss. Wired magazine calls this development “inject and see” and warns of the obvious dangers of such an approach for patients.

— I covered firefighter Pat Hardison and his groundbreaking full face transplant on this blog before. I did not realize that he also got a full new head of hair and not just a new face..

— On Twitter, Dr. Alan Bauman recently posted an unbelievable before and after photo of a hair loss patient who was treated with adipose-derived stem cells (ADSC). The photo was from a Boston Biolife led presentation at the recent World Stem Cell summit held in Florida in early December.

I contacted Boston Biolife and they said the doctor who made this presentation might send me the actual full presentation if I e-mailed him, but so far no response. I would normally consider such a great result from ADSC to be a scam or a one-time exceptional case that does not warrant too much discussion. However, I ended up including it here because the presentation was made at a seemingly reputable stem cell summit.

Adipose Derived Stem Cells Hair Growth
Adipose-Derived Stem Cells Hair Treatment

— On December 7th Aclaris Therapeutics announced that it had initiated phase 1 clinical trials for its ATI-50001 JAK inhibitor product to treat alopecia totalis and alopecia universalis. Also, in late November they had an earnings call, with the most relevant part pasted below:

“In addition to progressing our JAK treatment program for the treatment of alopecia areata and as we reported on our last call, we have initiated preclinical development of additional JAK inhibitors which we are developing for topical use both in vitiligo and androgenetic alopecia, which is also known as male or female pattern baldness. The program includes the development of ATI-5003, which is a covalently binding JAK3-specific inhibitor, and the preclinical and formulation work continue to progress as expected.”

— New study from Germany: “Hair follicle stem cell cultures reveal self‐organizing plasticity of stem cells and their progeny”.

Rafael Nadal gets a hair transplant.

And now on to medical items of interest:

World’s oldest woman turns 117 and credits an eggs and cookies diet combined with no husband.

— I covered the crazy skin gun video from 2011 on this blog before. After five years of waiting, it seemed like the concept was a fantasy and would never take off. Now the US based company that is behind this product, RenovaCare, has been awarded a patent for its skin gun technology. And they also got covered by CNN this month.

3D printed organs look, feel and bleed like the real thing.

Dementia (including Alzheimer’s) could soon be treatable. Or at least stabilized and manageable.

Mice lifespans extended by 30 percent and organs rejuvenated via reprogramming the genome. Actual study.

Some new information on Google’s Calico.

More good news on diabetes drug Metformin, which also helps with cancer treatment. This drug has been in use for over 60 years.