Natural Remedies for Thinning Hair

Herbs and Natural Products for Hair Growth.
Modulation of Hair Growth by Natural Products. Source: Pharmaceutics, Dec 2021.

The hair loss industry is rife with countless stories and testimonials on home remedies and natural cures for hair loss. People prefer to try natural treatments to treat their thinning hair before considering alternatives. They are often misled into believing that such treatments will lead to complete hair regrowth (or reversal of grey hair).

For the most part, such testimonials are bogus scams to promote various natural hair loss products. I have been following the hair loss world fairly regularly for over 15 years. During that time, I have reached the conclusion that natural hair loss treatments virtually never regrow hair that has been lost for a long time. In the best case scenario, you might grow some peach fuzz in totally bald areas of the scalp.

However, natural remedies can definitely reduce the rate of hair fall and made existing thinning hair become thicker and stronger. There are hundreds of studies proving as such, some of which I discuss in this post. Moreover, if you have a severe vitamin or mineral nutritional deficiency, supplementation can sometimes work miracles and stop your hair loss in its tracks. However, these latter situations are extremely rare.

Update: May 2023 — According to a new literature review, herbal extracts and formulations derived from plants may be effective at reducing hair loss. These include Urtica dioica, Humulus lupulus, Serenoa repens, Vitis vinifera, Pygeum africanum, Cucurbita pepo and more. Also beneficial to hear health include certain individual herbal compounds, micronutrients, bee products and keratin. Also see my posts on CBD oil and hair growth.

Update: November 2022 — A new systemic review in JAMA concluded that natural products and supplements can be effective against treating hair loss. None of these are likely to regrow hair in totally bald areas of the scalp. but they can make existing hair thicker per the research. Among the supplements praised in these findings include Nutrafol and Viviscal. Also recommended are zinc, apple nutraceuticals, capsaicin, isoflavones, pumpkin seed oil, tocotrienols, and omega 3 and 6 with antioxidants. Another November 2022 study analyzes the molecular mechanism of natural products that activate the Wnt/β-Catenin signaling pathway for reducing hair loss.

Update: April 2022 — According to a literature review, natural products to consider for treating androgenetic alopecia include: saw palmetto, caffeine, melatonin, marine extracts, rosemary oil, procyanidin, pumpkin seed oil, and cannabidiol oil.

Update: December 2021 — Modulation of hair growth promoting effect via natural products. A really through article analyzing numerous herbal products and phytochemicals that benefit hair.

Home Remedies for Hair Loss

There is solid evidence that certain natural products can improve the quality of existing hair. Besides increasing hair thickness, some natural treatments can significantly reduce shedding and the rate of hair fall. On a related note, make sure to read my post on amino acids for hair growth.

Some natural home remedies keep hair in anagen (growth) phase longer, others directly impact growth factors and signaling pathways. In 2019, UC Irvine scientists published a good overview on botanical, herbal and other alternative treatments for hair thinning.

Vitamin and Mineral Supplements for Stronger Hair

Natural Home Remedies for Hair Loss
Home Remedies and Natural Products for Hair Loss.

A large number of natural products for faster hair growth entail vitamin and minerals supplements. Among the most important include vitamin B12 and vitamin B7. If you have a severe deficiency in these vitamins, it could cause hair loss.

A 2018 study concluded that micronutrients such as vitamins and minerals play an important (but not entirely clear) role in normal hair follicle development and immune cell function. This includes vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, iron, selenium, and zinc.

Having said all of the above, note that most Americans are not severely deficient in vitamins and minerals. In many cases, excessive foot and drink intake is leading to overnutrition. Moreover, a 2022 Council for Responsible Nutrition (CRN) survey found that 75 percent of US adults taking some type of nutritional supplement. The vast majority of supplement users tend to be regular users.

Vitamin B12 and Hair Loss

Natural Treatments such as Vitamin B12 for Hair Loss
Natural Treatments like Vitamin B12 for Hair Loss.

There are a number of studies that have found vitamin B12 deficiency to lead to hair loss. The good news is that supplementation with this important vitamin can lead to a reversal in hair loss.

According to a report from Harvard Health, serious deficiency in vitamin B12 can be corrected via either: weekly shots of vitamin B12; or daily high-dose B12 pills.

Natural Treatments for Hair Growth

In this post, I will discuss natural hair loss treatment products that have some solid scientific backing. You should assume that none of these natural products will bring back hair in totally bald areas.

Surprisingly, most of the below mentioned studies have come out in 2014 through 2019. Some people try to combine many of the natural ingredients mentioned below into homemade shampoos.

Propolis

Bee propolis was big news last year due to new research findings. Propolis is a product made by bees, and it has anti-inflammatory properties that result in healthier hair in mice. For more, see the published study from Japan on propolis and hair growth in mice. Several hair products with bee propolis in them have good reviews on Amazon, including Iden Bee Propolis Treatment and Iden Bee Nourished shampoo & conditioner duo pack.

Saw Palmetto

Saw Palmetto berry extract comes from a plant native to the United States. For years it has been claimed that Saw Palmetto reduces DHT levels resulting in less enlarged prostates and more scalp hair (just like the drug Finasteride, but a lot weaker). Although the proof of effectiveness on hair growth is far from certain, there is enough anecdotal evidence and research work to warrant including this plant in this post about natural cures. Some of the best dermatologist recommended hair loss shampoos include Saw Palmetto as a key ingredient.

Oleuropein (Olive Drupe)

We keep reading about the miracle of olive oil and a Greek/ Mediterranean diet’s positive impact on human lifespan. Now there is yet one more reason to buy olives: a study from earlier this year from South Korea found that topical application of oleuropein induces anagen hair growth in mice. The study is quite technical and it seems like oleuropein stimulates the critical Wnt10b/β-catenin signaling pathway (which is also crucial when it comes to human hair). Oleuropein also upregulates IGF-1, KGF, HGF, and VEGF gene expression in mice. Amazon has a highly rated oleuropein supplement for sale.

Procyanidin B-2 (Extracted from Apples)

There are a number of studies that tout the benefits of Procyanidin B-2 (derived from Apples) for hair growth. DS Labs Revita Hair Growth Shampoo is probably the most famous product that contains Procyanidin B-2.

Sandalwood (Sandalore)

In 2018, sandalwood (via the synthetic sandalore) was a bid deal in the hair loss world. Scientists found that just a whiff of sandalwood scent used in perfumes can lead to increased hair growth. Apparently, the olfactory receptor OR2AT4 regulates human hair growth. Dr. Ralf Paus (UK) and Giuliana Pharma (Italy) led the above research. Sandalore and related odorants have been shows to even benefit wound healing. Aromotherapy and scalp massage using rosemary and sandalwood oil is also considered beneficial.

Caffeine

Many hair loss shampoos include caffeine as a key ingredient. See my detailed post on how caffeine can lead to hair growth stimulation. One study from 2014 suggests that caffeine really does have a beneficial effect on human scalp hair. And this 2017 study from India also comes to a similar conclusion.

Peppermint Oil

Yet again in mice. Apparently peppermint oil 3% results in better hair growth than Minoxidil 3% according to a 2014 study. According to Dr. Jennifer Ashton, peppermint oil vasolidates. However, it needs to be diluted with another oil before it can be applied and massaged into the scalp.

Pumpkin Seed Oil

A rare human study from 2014 finds that pumpkin seed oil is beneficial to hair growth on men with androgenic alopecia. Many natural DHT blockers contain pumpkin seed oils and extracts as a key ingredient.

Rosemary Oil

An increasing numbeer of dermatologists are recommending rosemary oil for the scalp to improve hair health. One study found that rosemary oil was as effective as Minoxidili 2% in growing hair in people with androgenetic alopecia.

Argan Oil

A lot of people use argan oil for its hair benefits. According to this guide, Argan oil is used as a moisturiser, conditioner and softener for skin and hair. Originally from Morocco, argan oil contains large amounts of Vitamin E and other beneficial fatty acids.

Epigallocatechin-3-gallate (EGCG) from Green Tea

EGCG (usually derived from the dried leaves of green tea) has attained a stellar reputation worldwide for its purported health benefits and weight reduction properties. There is not enough proof of many of these benefits, but green tea in general has become synonymous with good health. So it is no surprise that there are several studies that have concluded EGCG to have a favorable impact on mouse hair as well as on human hair. Note that black tea also has hair benefits due to the presence of theaflavin antioxidant polyphenols.

Epilobium

There are some reports that epilobium inhibits DHT just like Saw Palmetto, but I am not entirely convinced by the evidence. Nevertheless, numerous people on hair loss forums have tried this natural product so I am including it here.

Turmeric (Curcumin)

In recent years, turmeric has garnered significant interest as a miracle cure for all kinds of ailments ranging from cancer to Alzheimer’s disease. While curcumin clearly has anti-inflammatory properties, proof regarding major health benefits is still limited. However, the following article and anecdotal reports made me want to include turmeric in this post for now.

Seaweed

A number of studies from Asia suggest seaweed extracts are beneficial to hair. One detailed study from South Korea touts the benefits of Grateloupia elliptica (a seaweed native to Jeju Island) on scalp hair growth. This same strain of seaweed as well as several others seem to also reduce inflammation in mice.

Mangrove Tree Extract

In 2021, scientists from Thailand found that an extract from mangrove trees stopped hair loss and even promoted hair growth. The extract (Avicennia Marin) contains the key chemical Avicequinon-C. This chemical inhibits the enzyme that produces hair loss hormones (i.e., dihydrotstosterone).

Methyl Vanillate

Topical methyl vanillate (a plant derived natural ingredient) increases hair count and hair mass index by inducing Wnt10b mRNA expression in the scalp. According to the study, methyl vanillate has recently been shown to activate the Wnt/β-catenin signaling pathway, which has become a key target in the treatment of androgenic alopecia by numerous researchers in recent years.

Other less known natural and herbal remedies for hair loss include:

Cuscuta Reflexa (Dodder Plant)

A few studies have shown that Cuscuta Reflexa inhibits 5 alpha-reductase activity and hence benefits hair growth. e.g., see here and here.

Increasing PGE2 and PGF2α for Hair Growth

I originally wrote this post in 2020 and covered the hair growth effects of increasing prostaglandin E2 (PGE2) and prostaglandin F2α (PGF2α). Not to be confused with decreasing prostaglandin D2 (PGD2) for more hair.

Update: December 14, 2022

Dermaliq Therapeutics: Prostaglandin F2α Analogue Clinical Trials

Earlier today, Dermaliq Therapeutics (US) announced that it has begun Phase 1b/2a clinical trials for its DLQ01 solution (h/t “Nick”). This product is a topical Prostaglandin F2α analogue (thought to contain latanoprost) that will be used to grow hair in men with androgenetic alopecia (aka male pattern baldness). You can check out Dermaliq’s home page for its pipeline.

The DLQ01 topical formulation is based on hyliQ®, Dermaliq’s novel and proprietary platform technology. The trials will be conduced at Dr. Rodney Sinclair’s cliinic in Australia and will last for six months. Dr. Sinclair is currently also conducting trials for Hope Medicine’s HMI-115 prolactin blocker. Make sure to read that post for one trial volunteer’s biweekly updates.

According to Dr. Betsy Hughes-Formella (Chief Scientific Officer at Dermaliq):

“Dermaliq’s hyliQ® technology has the potential to transform follicular and dermal delivery of a broad range of active ingredients. DLQ01 is just the start of a promising pipeline targeting follicular delivery.”

June 27, 2020

In a number of past posts, I have discussed how hair loss is impacted by prostaglandins (lipids). Most of my focus has been on how a reduction in prostaglandin D2 (PGD2) levels benefits hair growth. In this post, I will discuss how an increase in levels of prostaglandin E2 (PGE2) and PGF2a (PGF2α) leads to hair growth.

PGE2, PGF2α and Hair Growth.
Increase PGE2 and PGF2α for hair growth. Reduce PGD2.

It has also been hypothesized that the balance between PGE2 and PGD2 levels controls hair growth. Increased levels of PGD2 and reduced levels of PGE2 have been observed in the scalps of men suffering from androgenetic alopecia (AGA). Also of note, PGE2 is known to act synergistically with PGF2 alpha

PGE2 and Hair Growth

PGE2 (also known as dinoprostone) is a naturally occurring prostaglandin that is also known to interact with Wnt signaling. A number of studies have shown that increasing PGE2 levels on the scalp can benefit hair growth.

An interesting 2019 study found that one of the ways in which skin and tissue injury can sometimes lead to hair growth is via an increase in PGE2.

A 2018 case report from Spain found that the drug Omeprazole induced hypertrichosis (excessive body hair) in two children. This side effect resulted from a significant increase in prostaglandin E2 levels. Once Omeprazole therapy was stopped, the excess body hair entirely disappeared after six months.

One of the ways in which Minoxidil works to grow hair is via increasing PGE2 levels.

Dexamethasone and Sulfasalazine can both increase prostaglandin E2 levels significantly.

Natural products such as castor oil are thought to raise PGE2 levels, and potentially benefit hair growth. Even if true, such gains will be modest at best in my opinion.

PGF2α (aka PGF2a) and Hair Growth

PGF2α acts by binding to the prostaglandin F2α receptor. When injected into the body or amniotic sac, PGF2α can either induce labor or cause an abortion in a pregnant woman. PGF2a levels are higher in people with non-balding scalps.

In the past, I have written in detail about the glaucoma drug Bimatoprost. This drug is an analog of prostamide F2a, which is almost the same as prostaglandin F2a. Bimatoprost raises both PGF2a and PGE2 levels, and is therefore the key ingredient in eyelash hair growth drug Latisse.

Another analogue of prostaglandin F2a is the well known drug Latanaprost. It prolongs the anagen phase of the hair cycle via the prostaglandin effect.

Another glaucoma and high eye pressure relief drug named Travoprost has a patent related to its scalp hair growth properties. Travaprost raises both PGF2α and PGE2 levels on the scalp when applied topically.

The only other major PGF2a analogue pharmaceutical on the market is called Carboprost.