Hope Medicine Trials and Fundraising

Hope Medicine LogoRead this entire (regularly updated) post for a history of Hope Medicine and Bayer’s HMI-115. This treatment targets the prolactin receptor to cure hair loss. Hope Medicine raised $56 million in funding last year.

Update: June 22, 2022 — Hope Medicine’s website is now working. Thanks to reader “Pinotq” for letting us know. See their research section and pipeline pages.

Update: April 12, 2022 — For some reason, Australian Phase 1 trials for Hope Medicine’s HMI-115 are starting today. They will involve 20 participants and are expected to be completed in July 2023. The trials will be led by the renowned hair loss expert Dr. Rodney Sinclair. Also see his current clinical trials recruiting page hair section.

Update: April 14, 2022 — Lots of excitement on Reddit.

Meanwhile, US Phase 2 trials should start at any moment now (read further below). This difference in trial progression by country is very strange. Perhaps is has to do with some stricter Australian government requirements.

Update: January 26, 2022

Hope Medicine HMI-115 Phase 2 Trials

Hope Medicine just received FDA approval to commence Phase 2 clinical trials in the US for its HMI-115 product to treat androgenetic alopecia! HMI-115 is a human monoclonal antibody drug that targets the PRL receptor for the treatment of male and female pattern hair loss. Last year, the US FDA also approved Phase 2 trials of the same drug to treat endometriosis.

The Phase II clinical trial of HMI-115 for the treatment of androgenetic alopecia:

“Will be an international multi-center, randomized, double-blind, placebo-controlled study. It will be carried out in the United States, Australia and other countries.”

Update: November 28, 2021

New CEO Henri Doods Interview

A reader sent me the below screenshot of Hope Medicine CEO Henri Doods’ Chinese magazine (page 17) interview that I mentioned earlier. If anyone can translate into English, please post in the comments. Click on the image to expand.

Hope Medicine Doods Interview
Hope Medicine CEO interview.

Update: September 20, 2021

Hope Medicine CEO Henri Doods
Hope Medicine CEO Henri Doods.

Reader “Karl” just notified us that there is a brand new cover page interview of Hope Medicine’s CEO Dr. Henri Doods in a Chinese magazine “tradetree.cn”. If anyone can gain access to it (see here) and translate into English, please try. Not worth purchasing as yet in my opinion.

Per Karl, Phase 2 clinical trials for hair loss product HMI-115 are planned for Q4 2021 (but no proof anywhere else). This matches what we expected per the prior updates that I discussed in May (see further below). Note that HMI-115 is the same as Bayer’s prolactin receptor antibody. Hope Medicine has the rights to the development of this product.

May 9, 2021

Hope Medicine (China) Raises $56 Million

Until now, Kintor Pharmaceutical (China) was the main reason for the excitement. However, this weekend, the participants on this site’s hair loss chat are discussing Hope Medicine. Out of the blue, this startup company received $56 million in a Series B round of financing. Investment firms Qiming Venture Partners and Grand Flight Investment led the way.

Other investors include: HighLight Capital; Sinovation Ventures (a venture capital firm led by former Google China head Kai-Fu Lee); and Trustbridge. More here.

HMI-115 PRL Receptor Targeting: Bayer License

“Previously, HopeMed signed an exclusive license agreement with Bayer AG on the development and commercialization of a human antibody (HMI-115) targeting the prolactin (PRL) receptor for the treatment of male and female pattern hair loss. At present, HMI-115 has completed phase I clinical trials in the European Union, with positive safety results. The global multi-center phase II clinical trials for androgenic alopecia and will soon be launched.

Ruiping Xiao
Dr. Rui-Ping Xiao

Note that I first covered Hope Medicine in my 2019 post on its partnership with Bayer in regards to the prolactin receptor. The company was founded by Dr. Rui-Ping Xiao, the dean of the College of Future Technology of Peking University. Apparently, she is also an associate editor of the New England Journal of Medicine. Update: See this page for much more on Dr. Xiao Ruiping.

The most unusual part of this story is that Hope Medicine’s official website (hopemedinc.com) has not worked for weeks. I have e-mailed several of their employees, and will update this post if I get any response.

Increasing Hair Loss Company Funding

  • This latest news comes just one month after we heard that Aneira Pharma received $25 million from Valkyrie Group.
  • South Korea’s Han Bio also seems to have received enough funding to open its new dermal papilla storage plant in May 2021.
  • In September 2020, Stemson Therapeutics received $7.5 in additional funding.

74 thoughts on “Hope Medicine Trials and Fundraising”

  1. The number of different approaches is amazing: cell-culturing, dht/hormones, antibodies, cell-signaling pathways, wounding, gene/Crispr, prostaglandines, lactate,…

    I hope something comes to fruition.

    Btw Stemore of Korea also works on antibodies. They renamed their company: “Epibiotech” – I always wonder why that is necessary as they don’t market a product (yet).

    1. There are a lot of moves happening in South Korea that we don’t know about yet, I speculate

  2. I notice that topical finasteride named “Caretopic” is out in Italy, not galenic version, it’s an industrial versione.

  3. Great article and progress in hair loss treatment angles. Nice too see so many different approaches to fight mpb. Sad thing is we have a 99.9% chance these all fail and we are just stuck with big 3 again. Makes you think what is going on behind the scenes.

  4. I’m really excited to see some of the long term results of this treatment. I always guessed DHT was a reason for hair miniaturization but was not the sole culprit. Fingers crossed on this one. It will certainly be expensive. Is it an injection that will be required periodically life long? Or for a certain period of time?

  5. Tired of painting my scalp with dermach every morning.. can we please cure this? I need a life :(

    1. Pfff replicel didnt say anything new ! Whats going on with stemson therapeutic human trials that are set to begin this year ? Please thank you!

  6. Researchers have found a way to heal skin tissue without scar formation… at least in mice :D

    The crazy part is that those mice also generated new hair follicles in this process, might be interesting if this works for human heads as well after hair transplants! And the best thing is the drug has already been approved almost 20yrs ago by the FDA for a certain eye disease.

    1. That s sound crazy good no ? I mean if this could work, it would be the end of hairloss or almost for women in my case no ?
      With 50 mg of spironolactone i don’t have hairloss…if this could regenerate hair follicles
      then i would maintain my new hair follicle while on spiro…
      But does that mean we would have to really damage our scalp to do so ?

  7. Stemson is our cure.. Unlimited supply of hair, for all forms of hair loss.. Forget all other bs, like Tsuji, or Histogen.

    Stemson is it.

      1. That’s IF they make it and bring the cure to market. And believe me some people out there are ready to sell their kidneys for the cure.

  8. You are already going down a path again where people will undoubtedly be disappointed in the end. If you read their statement in depth it clearly states, that they have fda clearance to enter a clinical trial for the condition “endometriosis”. This will not be a trial for male pattern baldness. In fact the term “hair” is only mentioned three times in that text and two times its part of the word “chairman” lol. I think they are going ahead with endometriosis for now because it would be a condition covered by insurance companies and the anti body will be very costly. I am afraid, that trials and development for AA will take much longer than that if they will happen at all. Thats the reality, hair loss is a non priority for companies like this.

  9. Has anyone here used topical dutasteride from Strut? At $69 for a 30 day supply, I’m considering it, if it works well. I’d appreciate any feedback if there are any Strut users here.

    1. @Rick – Have you looked into Happy Head’s topical formulation? They use fin instead of dut, but also higher concentration of minox. I might try that next year, but in the meantime, I’m experimenting with something else and want to give it 4-6 months. I think we’re all just biding time until something like Kintor comes out. Let’s face it – the Big 3 are less than ideal.

  10. So how will the potent monoclonal prolactin (PRL) receptor antibody be administered? Like regerons antibody cocktail through an IV?

  11. Hey, has anyone ever tried microneedling by itself (w/o minox, fina, etc.)? Only my temples are shedding from now, I’d like to try but not sure about the efficacy. Thx.

  12. Dr. Chen answered everyone’s questions in the FAK inhibitor post FYI. Doubt he will have time to come back again, and the research is still not in human trials. So no use getting too excited this early in the game!

    1. Admin –

      Have a thought for you – and I have a fairly strong conviction that you’ll want to explore this path, If you feel secure it it’s outcome. Have you researched DAO’s, and how they democratize fundraising, etc? Most notably, a DAO backed my millions of individuals nearly purchased a copy of the constitution? Would love to chat with you about it if you’d like. I think this community could be converted… and be a contributor to the growth of a, or multiple, solutions. Those who would participate would be given first access to information and potentially trials – all within the boundaries and rules written within the DAO. Engagement would be super high…. And the publicity ……..(good for the industry)…. Worth a discussion piece, or maybe not. I’m glad to help but I think you should be the one running it – can explain why also. Well, let me know!

      1. Hey Jon,,

        Thanks for the idea! Unfortunately, I am starting a new contract job soon and also have to run this site and the Discord. Not yet sure I have time, but maybe you can e-mail me (see the contact us page for e-mail address) and I can star the e-mail for now?

    1. Unfortunately, the image size was too large and this was the best I could do after optimizing. Make sure you clicked on the image to open in a separate tab (where it looks a bit clearer and larger).

  13. I don’t know much about Hope but I find the initiation of their Phase 2 trial very exciting. As I understand it, this is not just a maintenance treatment but potentially a hair growth treatment, given that the study in stump-tailed macaques, resulted in nearly a doubling of terminal hairs……………of course we all know how success in animals doesn’t translate well to humans. Still, I am hopeful that they are geared up for enrollment giving us the possibility of pictorial proof of success sometime in the next 12 months.

    1. Thanks for checking Ollie. I will post in our Discord too in case some people feel like checking for updates regularly.

  14. Admin would you categorize their approach as a potential cure for baldness or rather a more efficient treatment? I read somewhere their treatment includes minoxidil which does not make me optimistic tbh.

    1. @ red its a treatment you have to rub a product or take meds or both at the same time ,it doesn’t sound as good as hair cloning.

    1. These results suck and show no improvement. Why even post this. Its 2022 I thought we all should be more alert after all the scams the past 20 yrs. Sorry for coming on so strong but I’m tired of these companies showing junk and thinking they have a good treatment. Show me legit regrowth of at least a full Norwood then it will catch my attention.

    1. Lorence,

      Well stated mate. I reckon that the focus should be on the big 3: HOPEMED, STEMSOM, MOOGENE

  15. 2022…crickets.
    3022…Rogaine changes branding on its tin.
    4022…hair loss finally cured.
    4023…asteroid hits planet.

    1. Summy its sad to see how your optimism and vision have decayed over the years. I remember you when you used to be so open to all these new treatments in research back in 2013. God bless and Godspeed.

      1. Yes Aaron, in regards to hair loss, I cannot deny…my hope has been tested of late-that is true. Call me a disappointed optimist if you will. What scares me more is that I’ve been on here almost ten years! Cheers mate.

      1. Let’s not exaggerate and keep our feet on the ground…
        I’m mean, the pipeline is pretty promising but I will get excited when some of these products come to the drugstore counter tbh!

  16. We are happy to announce that the manuscript entitled “Dual-Mode Vasodilator M119 Delivery to Hair Follicle via Dissolving Microneedle for Advanced Alopecia Treatment” was accepted for publication in Advanced Therapeutics.

    Here, it is suggested that TOP-M119 (M119), a novel drug acting as a vasodilator in the scalp, and M119-loaded DMN with a specially designed shape can be used for the alopecia treatment.


      1. Unfortunate News- cosmerna shut down their cosmetics it was rejected by the Eu just like Korea now they are gonna attempt clinical trials so 5-10 years we will know . Next in the group buy I’m in we have tried kx826 99% purity for over 3 months and we so heart side effects but no improvement or maintenance .

        1. Dude Pegasus stfu bro we don’t need that negativity that they failed just use fin or dut and in 5 years we will have something.

          1. what will we have in 5 years ? I am desperate. I am a female and 41. I be had maintenance through 20 years thank to the pill and 25 mg Spiro. Now i have to give up the pill because apparently at 40 you should not take estrogens anymore…i am desperate progestative only pill won’t work, and that no men will look at me, while now they all think i am this thing from heaven (clearly they re blind but i take it).. i feel my life is over, that i’ve been living as a fraud till now and that i am about to be discovered…i feel like shit.

            You have no idea what this hairloss hell means for a woman, it is a death sentence.

            1. Very sorry to hear you feel this way. I do understand you more than you could ever believe. But don’t do that mistake of thinking that hair define you, thinking that is a death sentence more than losing hair itself.

              1. As a woman it does define you. In the media you see short women, tall women, skinny women, fat women, dwarves, women bald because they have cancer, sometimes women with hairloss because they have alopecia aerata or universalist (the clean kinds and acceptable kind)…never will you see a woman with androgenic alopecia.

                If i meet a guy now, what should I do “a by the way, in a year from now i am might be as bald as you best buddy Robert, will you still be willing to see me naked and touch me ?” Seriously… I am a monster of nature, it is a sign to tell dudes to stay away from me… I am not able to deal with this.

            2. Everyone’s body is biochemically unique. Different processes progress at unique (to you) rates. Why is the cutoff age for estrogens 40 instead of 39 or 41? Is it just a rule of thumb and not unique to you? Most women at 40 shouldn’t take estrogens? Or has a doctor told you something about you based on symptoms that you’re getting from taking estrogen?

  17. Fukuda has been pretty active in terms of research – just this June:



    Seems that he is totally ready for his human trials. Unfortunately there is no information or website from his new company available. Maybe Admin you could ask him directly?

    1. Thanks Ben. I updated and republished the Fukuda post and also added a new interesting video that you will like. I also e-mailed Dr. Fukuda. He did not respond the last time I tried, but fingers crossed.

  18. HopefullyNot…have you tried rogaine? There are compound minoxidil that have finasteride in it that can work well topically for you to grow back hair. Also look into using essential oils like peppermint rosemary and aloe vera as well. This can help slow down loss. Try taking a hair vitamin and collagen. I heard the spirolactone works well for women. Even transplants work very well for women. Check out Dr Konior in Chicago. He deals with female pattern hair loss. If you have a more norwood pattern like a man instead of a woman lugwid…then you will hsve even more donor to use for more hair follicle. I’ve seen women almost bald like a dude get a fue transplant and got good coverage. Plus women can style their hair more than guys and cover any loss. Check out the stuff I listed. Hopefully this helps….just know many women lose their hair. I am noticing more lately. Eat healthy diet as well. Check your ferritin levels too. You could have low ferritin even if your iron levels show normal range. Demand your doctor check it along with your thyroid. Iron ferritin should be around 70 for optimal hair growth.

    1. I am Spiro already my hairloss has been stable for almost 20 years. But i be to get off the combined pill and Spiro might not be enough, plus I cannot up my dosage because it upset my stomach…. I tried Rogaine, it never did anything for me. I take hair vitamins everyday, besides making my hair grow faster it does not do much. But thanks. As for hair transplant, i have a diffusé thinning and considered not a good candidate so far…. But thank you

    2. I still have donor hair though, since I haven lost any hair at the back of my head, it is diffuse on the top and a bit on the side..people don’t notice so far cause my hair is short but i am afraid of getting off the pill

    3. What are the type of minoxidil that contains finasteride ? Can I find them online ? I live in Europe… Thanks a lot.

      1. You could try the minoxidilmax website.

        Oral minoxidil could be an option too, just be aware of potential hypertrichosis. Dr Donovan has a good series of articles on it.

        Best wishes.

        1. Well, i am already on Spiro..i fear oral minox will give me side effects .i have mild side effects from Spiro..classic minox never did anything for me…maybe if it has finasteride in it…

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