November 12, 2023
Some new hair loss related content from Dr. Andrew Huberman in his recent interview with Dr. Michael Eisenberg. They have a detailed discussion on dihydrotestosterone (DHT) reduction from finasteride or dutasteride and post-finasteride syndrome (PFS). Summary here.
I really don’t think that there is a “wave of PFS” as Dr. Huberman states in his Tweet below. But there are no doubt some very unlucky people who got this side effect on a permanent basis.
Young men taking Rx drugs to prevent/reverse hair loss is causing a wave of PFS: Post Finasteride Syndrome (serious libido, erectile & mood issues, some of which persist even after they cease finas.). The RCTs focused on older men which is why PFS is controversial. PFS &…
— Andrew D. Huberman, Ph.D. (@hubermanlab) November 12, 2023
April 10, 2023
Huberman Lab Podcast on Hair Loss
What a great Monday surprise. A few hours ago, the prolific and very intelligent neuroscientist Dr. Andrew Huberman released a two-hour Huberman Lab Podcast related to hair loss and hair regrowth. Video is embedded further below after the timestamps screenshot. His podcast is among the most popular ones on Apple iTunes and Spotify.
I just had time to listen to an hour of the episode so far, but wanted to post a summary now as this will be trending today. From the YouTube video timestamps, it is clear that there are a few important things omitted. And some hair growth treatments are exaggerated or discussed in too much detail (e.g., caffeine) relative to their potential benefit.
It seems like there is no major discussion on hair transplants. Nor on five potentially upcoming new androgen receptor (AR) antagonist/degrader/inhibitor/blocker/reducer products. Dr. Huberman does cover oral Minoxidil for hair loss, but it is not labeled as a key category. No sections on exosomes, yet PRP is covered. And nothing on hair multiplication or hair cloning.
But despite the significant omissions, still quite interesting. Especially when you consider that Dr. Huberman says that he is not concerned about his own hair at all. So he had to research the subject without the passion that all of us have when it comes to our own hair loss. I always thought that Dr. Huberman had some hair thinning, but in this podcast video his hair seems ok.
Just started going through the podcast, but do not see any timestamp for androgen receptor (AR) degraders/inhibitors/blockers/reducers. The new game in town, at least in terms of the number of companies targeting the AR to reverse hair loss.https://t.co/i4JrSMZsaz
— HairLossCure2020 (Hair Loss News) (@HLcure2020) April 10, 2023
Dr. Kyle Gillett (see his YouTube channel) helped Dr. Huberman with this latest podcast. Last year, the former was interviewed by the latter and replied to a question I had on Twitter.
Admin, its unfortunate that we are in a bear market with venture capital funding dwindling daily.
This is why i have so much hope in HMI-115. Backed by bayer’s money/interest. Biggest prelim results we are ever seen. Its currently in clinical trials so there is no turning back now. We won the fight administrator and you were at the centre of it.
One day when hairloss is cured. People are going to come back to the forum and read the comments and remember what balding is like. Who knows….maybe being bald will be a trend in the future and everyone will wanna be bald XD
love ya admin
Pfft, people wanting to be bald? It would be an extreme minority. I want mega long thick Rapunzel hair. The longer and thicker the better. I’ve wanted butt length hair and longer all my life, stupid hair cycling genes won’t allow it plus am dealing with male pattern baldness and hopefully not something worse in addition. Hair loss can be cured as soon as scientists stop playing with mice and start testing humans instead.
That and the FDA getting out of the way in slowing down or hindering options. Plus with clinical trials being expensive, it’s no wonder progress is so slow. Too many gatekeepers, bureaucrats and greedy pigs getting in the way towards a cure coming to market.
Then certain drug makers want to keep selling their garbage that makes people sick and barely works. Think Pfizer wants a cure that will phase out Propecia? Think again! The drug is putting millions in their pockets and I doubt they want that changed. We need to find a way to get rid of these barriers to get hair loss of every kind cured, with real cures, not CRAP cures! If we treated hair loss in the way of Covid there’d be a cure coming pretty quickly, not this laggard bs of 5 more years and then nothing comes! We’re all sick of that!
The medical industry is corrupt and sucks and same goes for these college campus labs that experiment in animals, have success and don’t translate that success to people! F them!!! Also they need to find a way to increase the anagen hair phase so maybe I can have my locks reach my bum as I’d like.
I understand how you feel and I started balding at 16. So I know how it feels when you are the only person in your class going bald and everyone else has such thick hair.
But I really think the FDA approval process is necessary. It’s robust and sets the gold standard for drug testing in the world . If you want you can Google something called the thalidomide tragedy. It shaped drug testing in the usa.
Tadalafil as an alternative to oral minoxidil! Anyone has any experience with this? Also oral minox causing high prolactin and possible ED and Gyno… That’s new to me! Also if anyone can confirm that claim plz
M—I did have some ED issues on oral minox, but perhaps this was also nocebo. My erections did come back straight away after I stopped it.
Oral minox and ED….
Whow, trolls and vested interests did a good job.
It still amazes me the garbage that can be found on the internet.
To be specific..no ED issues with OM in my case!
Mrka—I’m not trolling, I’m simply telling you my experience; like I said, it could even be placebo.
Nocebo sorry.
Me neither, but everyone’s different.
I wonder if Huberman confused oral Minoxidil with oral Finasteride or oral Dutasteride for a brief instance?
Same Admin , I thought he was confused too but he repeated his concern with minoxidil twice at least in the video and I saw another episode about male hormone optimization with Dr Kyle Gillett where he mentioned it there too. As for tadalfafil I was going to give that a try but a google search will tell you that it increases Testosterone and even worse it can increase Androgen receptors density which both might be leading to worsening of my hair so I changed my mind.
What about this new product that Bayer is expected to launch in 2023? Any news?
Lorence,
Your timeline is very inaccurate. Phase 2 in China will most likely conclude in April 2023 and phase 1 in Australia (lead by Rodney Sinclair – arguably one of the best in the field) . When phase 1 is completed in australia we will get initiation of phase 2 in the multi global phase 2 trial .
I know this drug is extremely exciting but we just gotta wait a bit longer. The reason I get excited is because my friends family member was in the endometriosis trial and the safety profile is extremely favourable based on her experience
If all things go as plan (which never happens) the best case scenario will be 2027 . That is because we will have only a 6 month phase 2 due to the efficacy being shown already . Until then save up 30k USD :D
Huberman discusses Post Finasteride Syndrome:
https://twitter.com/hubermanlab/status/1721872841354645805
https://twitter.com/hubermanlab/status/1723823069377200427