Category Archives: OliX Pharmaceuticals

OliX Pharmaceuticals RNAi Hair Growth Success

Recently, I wrote a post on microRNA (miRNA) and hair growth. In there, I also discusses messenger RNA (mRNA). Now we have RNA interference (RNAi) as a hair loss treatment. Thanks to OliX Pharmaceuticals (South Korea).

OliX Pharmaceuticals RNAi Hair Loss Product OLX104C

OliX Pharmaceuticals (South Korea) just made a major announcement. Their RNAi based hair loss product OLX104C successfully grew back hair in mice following just one single injection. The mice were suffering from androgenetic alopecia due to them being given excess dihydrotestosterone (DHT).

“We are advancing a novel and potentially durable approach to treating hair loss” — CEO Dong Ki Lee

OliX Pharmaceuticals RNAi Hair
OliX Pharmaceuticals and its RNAi product OLX104C. Before and after hair growth in mice.

In this preclinical study, OLX104C was administered topically to a mouse model via an injection. The before and after photos are amazing. Interestingly, they compare the results to the anti-androgen Flutamide.

More importantly, OliX is the real deal. Their news page is very impressive with regular significant developments. This includes raising $37.2 million in December 2020 (h/t reader “James”). They also received US FDA Phase 2a approval in November, 2020 to treat hypertrophic scars.

On OliX’s pipeline page, they state that small interfering RNA (siRNA) has limitations in terms of stability, delivery and toxicity. This is not a problem with RNAi therapeutics. Edit: Per the patent, they are using asymmetric siRNA to inhibit male pattern hair loss gene expression. Update: OliX signs agreement with LGC Biosearch Technologies to accelerate production of asymmetric siRNA for the treatment of androgenic alopecia.

Dr. Lee will present at today’s SMi’s 12th Annual RNA Therapeutics virtual conference. He will discuss OLX104C at this event. OliX plans to initiate clinical trials of OLX104C “by 2022”.

This has been the best week in hair loss news in several years. It also seems like 100s of millions of people around the world will take mRNA vaccines during the next several years. In effect, this will speed up scientific progress and cause many to not worry about long-term side effects. Perhaps a mistake, but I will selfishly not complain too much if it speeds up the realization of a hair loss cure.