Shiseido DSC Cell Hair Multiplication Procedure Is Finally Here

Update: June 27, 2025

Warning for Foreigners Wanting the S-DSC Hair Growth Treatment in Japan

Recently, a US-based reader e-mailed me a few times as he is desperate to get the Shiseido S-DSC treatment in Japan. It became available in that country to Japanese citizens in June 2024 (read this entire post). Per my May 14, 2025 update, it seems like foreign nationals can finally get this treatment, but they need “a reference through an intermediary”. This reader asked me to contact any Japanese person I know who could help.

Of course I thought of my old friend Japanese hair loss blogger Fuji Mark Kagurazaka right away and contacted him. He became inactive in 2024, but is now back in full form. Mr. Kagurazaka called one of the four clinics in Japan that are now offering this treatment, and the response was not great. I have extracted it from Fuji’s colossal write-up.

“So, they were looking for a Japanese person to consult with, including arranging an interpreter. It would be nice if I could interpret myself, but I am completely unable to speak any foreign language, including English. So, I decided to contact Akihabara Skin Clinic, a treatment facility for S-DSC® hair regeneration medicine, located in Chiyoda Ward, Tokyo, which is not a large hospital.

Unfortunately, the result was that an interpreter cannot be used. The patient himself must be able to speak Japanese, understand the explanation in Japanese, and give consent in Japanese. The answer was very harsh for a foreigner who does not speak Japanese, but I got the impression that it was inevitable because it would be an expensive and complicated treatment.”

Fuji Maru will call the other clinics soon to see if he has any better luck. But my belief is that one should not try to go to Japan for this treatment at the moment. Remember that the entire process takes around two months. Your hair follicle tissue cells are harvested and then multiplied in a cell processing and culture facility (which can take up to six weeks). Then you get the cultured DSC cells injected into your scalp. It is not worth the stress if there is no English communication possible throughout the process. The high cost and no guaranteed results are also not ideal.

I am still excited that Shiseido’s treatment finally came out after over a decade of covering it. But I think it is best to wait and watch for now.

Update: June 24, 2025

Effects Last More than a Year

Dr. Ryoji Tsuboi has been writing an interesting blog on his clinic’s site. In the latest post, he ends with the following statement (slightly reworded by me):

“The method implemented by Shiseido (in which I am also involved) entails injecting cells called hair bulb root sheath cells (S-DSC) into the scalp. The cells are harvested from the patient’s own hair follicle tissue, multiplied in a cell processing and culture facility, and then injected into areas of thinning hair to promote hair growth. Because the cells are injected, the effects can be expected to last for more than a year. This regenerative medical treatment is quite expensive. So I think this is a treatment that people who can afford it should try as an added bonus.”

Update: May 14, 2025

Shiseido’s S-DSC Hair Loss Treatment now Available to Foreign Citizens?

For almost one year, we have been waiting to see if Shiseido’s new dermal sheath cup cell hair multiplication treatment (S-DSC) will become available for non-Japanese citizens. It seems like this is close to a reality now based on the below e-mail that reader “Eko” received from Tokyo Medical University (one of four centers in Japan that is currently offering this treatment):

“Thank you very much for your trust in our hospital. Do they have Japanese health insurance? If you have Japanese insurance, please take a letter of introduction and come directly to the hospital to make an appointment. In addition, the hospital does not accept overseas patients directly. All international patients must be referred through an intermediary. We can provide you with information on several agencies to assist you in making further medical arrangements. Please let us know if you have any questions.”

I have kept the hospital’s contact information in Eko’s comment in this post, but will refrain from posting it here. It might end up being very difficult in getting this appointment via an intermediary. Also note that they are not claiming any major hair regrowth from this treatment. And you will be required to visit the clinic at least four times, and perhaps more if you want the injections very year.

Shiseido DSC Treatment Cost

Shiseido’s DSC cell injection treatment costs $16,000 to $25,000. Much higher than I expected. And you will need this at least once a year or two in all likelihood. Per Tokyo Medical’s site, the cost will run from:

“2,300,000 yen (excluding tax) to 3,500,000 yen (excluding tax).”

Shiseido Dermal Sheath Cell Hair Multiplication.
Shiseido (Japan)’s Dermal Sheath Cup Cell Hair Multiplication Process. Image from Toho University.

June 28, 2024

Shiseido’s Dermal Sheath Cup Cell Hair Multiplication Treatment Has Arrived

Today might be among the five most important days in the hair loss world since I first started writing this blog in 2013. Shiseido’s decade-plus-long much awaited dermal sheath cup (DSC) cell hair multiplication (cell culturing and implantation) procedure is finally here for patients starting July 1, 2024. Albeit only in Japan, where they have favorable regulations for faster in-clinic use when it comes to regenerative medicine and stem cell based technologies.

Shiseido (Japan) completed small-scale Phase 3 equivalent trials for this hair multiplication technology in 2023. The results were positive but modest, with no major side effects. I hope the results will improve as they use this autologous DSC cell transplantation process in more patients and gain experience.

For now, you should only expect existing scalp hair thickening and perhaps minimal hair regrowth if you are lucky. Thicker hair in and of itself could lead to a slowdown in further damage from the ravages of dihydrotestosterone (DHT).

You can read today’s full announcement here (h/t “Theo”). The technology is described as having been developed by Tokyo Medical University Hospital, Kyorin University Hospital, and Shiseido. Interestingly, they leave out any mention of Replicel (Canada), with which Shiseido has had past legal issues after a technology sharing agreement went wrong.

S-DSC® Hair Regenerative Medicine

Shiseido has also created a new website related to S-DSC hair regenerative medicine, where the “S” stands for Shiseido. The about S-DSC page is very interesting. S-DSC® treatment promotes hair growth by supplementing the thinning areas of your scalp with your own cultured DSC cells.

They only make claims that existing hair will get thicker and more voluminous, while scalp inflammation will be reduced. Perhaps they also want to temper expectations, even if some people may get good regrowth? Interestingly, women might get better results then men.

S-DSC Hair Regenerative Medicine
S-DSC Hair Regenerative Medicine Treatment.

The key person who led the development of this technology is Professor Emeritus (Department of Dermatology, Tokyo Medical University) Dr. Ryoji Tsuboi. I feel like a genius for using his image as my main one on my global hair loss research page from the get go. I originally picked Dr. Tsuboi over Dr. Takashi Tsuji just due to a more interesting image of the former at a white board.

Hair Regenerative Outpatient Treatment Begins in Japan on July 1, 2024

Associate Professor Shiro Niyama of the Department of Dermatology at Toho University Ohashi Hospital will start offering this “hair regenerative treatment for thinning hair” using cultured autologous hair bulb root sheath cell products (S-DSC®) from July 1st 2024. Patients will be required to get a referral, and also be responsible for their own costs due to the elective nature of the procedure. Note that this treatment is available for both men and women.

In the procedure itself:

  1. First, healthy scalp tissue of about 5 mm diameter is taken from a non-balding area such as the back of the head.
  2. From this, DSC cells are isolated.
  3. S-DSC is produced after about 6 weeks of culture and quality inspection (a total of 7 vials of S-DSC can be produced).
  4. Once production is completed, patients will return to the hospital and the cultured DSC cells will be injected with a special syringe.

Also check out the November 2023 study from the same team that is titled: “High migratory activity of dermal sheath cup cells associated with the clinical efficacy of autologous cell-based therapy for pattern hair loss.” The conclusion was that ITGA6-positive DSC cells, with superior migratory activity, may promote cell migration into nearby hair follicles.

Update: October 12, 2024

Shiseido’s Treatment has a 30-60% Success Rate?

When Shiseido’s hair loss treatment came out in June 2024 and I wrote this post, I was certain that this is the best news of the year. I was also optimistic that this dermal sheath cup (DSC) cell hair multiplication procedure would ultimately be superior to Minoxidil, and perhaps even match Finasteride results.

However, since Shiseido is only offering this S-DSC procedure to Japanese citizens at the moment, it will be a while before we get more details about success rates. So I am updating this post due to a possible new report on Shiseido’s efficacy, though it is a bit speculative and anecdotal.

In a new hair multiplication related article in Japanese newspaper Nikkei, they mention the “Big 3” of OrganTech (Japan — led by Dr. Takashi Tsuji), Stemson Therapeutics (US) and TrichoSeeds (Japan — led by Dr. Junji Fukuda). According to Nikkei, Stemson (Edit: Since folded) and OrganTech will start clinical trials in 2026 for their “Gen 2“ hair regeneration treatment. Junji Fukuda states that they have created a similar technology as OrganTech, but plan to start clinical trials in 5 years from now (i.e., in 2029).

The title of the article is:

“Planting hair seeds to treat alopecia. Clinical trials underway in Japan and overseas”.

However, the most significant news is via implication. In the article, it says that “Gen 1“ treatment is already in practical use in Japan with a success rate of 30-60% (which is ambiguous). This is quite likely to be Shiseido’s treatment, now available at four locations in Tokyo.

  1. Toho University announcement.
  2. Akihabara Skin Clinic S-DSC page.
  3. Tokyo Medical University S-DSC page.
  4. Kyorin University Hospital.

In the article, it says that for “Gen 3“ they are planning to use animal stem cells. “Theo” was not sure what this meant, and neither am I. If anyone subscribes to Nikkei, please read the entire article and give us your thoughts.

In general, I do not think that cosmetics behemoth Shiseido would ever take over a decade to bring something to market with only modest benefits. Lets keep our fingers crossed.

186 thoughts on “Shiseido DSC Cell Hair Multiplication Procedure Is Finally Here”

  1. Hello,

    Thanks for the update @Alvaro but as @Admin said I don’t understand if the treatment works in women or not (there’s a little contraction in your post).

  2. What’s more, another thing that caught my attention is that they say the treatment will cost between €10,000 and €15,000, but in 10 years of taking dutasteride, you could spend €5,000. Let’s not be confused, this technique isn’t a cure for baldness; it’s an alternative to daily medication, and the results won’t be very different from those obtained. But the question is whether this treatment will make hair resistant to DHT for life until another cure is found.

    1. Wow dude, you pay a lot for Dutasteride! I pay $22 for 90 days of generic pills from Costco, that works out to less than $1000 over ten years ($880).

      1. I don’t pay that much for Dutasteride Yoda either, but the fact that doctors compare the price of paying for the DSC technique with what you would pay for Dutasteride in 10 years makes me think that it won’t be necessary to continue taking Dutasteride.

  3. On Shisheido’s DSC treatment homepage, they’ve implemented a section (since July) where they interview doctors from three of the four hospitals that offer the technique and their experiences with patients! One of the most striking things I’ve seen is that they believe hair loss in women would be resolved with DSC injections every three months without the need for medication (dutasteride or finasteride). This is because this treatment isn’t effective in women. I wonder, what about men? Would this replace daily medication? I’ve also seen that they are very happy with the results after one year in 100% of patients. They say they only see an improvement in hair volume in 20-40% of patients, but that all experience an increase in thickness. I’ve said many times that this won’t cause new hair to grow, but it will thicken the miniaturized hair. The only question that remains is whether the treated hair will not fall out again even if it continues to miniaturize, and whether the medication can be stopped.

      1. I realized, admin, there was a problem with the translation. I meant that dutasteride or finasteride aren’t effective in women, but DSC treatment is because it thickens the miniaturized hairs.

  4. Another institution (Kyorin University) started to offer this treatment, making it the 4th institution to offer this treatment.

    1. Thanks, Eko, my friend. I see you’re also interested in this therapy and the HairClone one. I hope we can treat each other soon, since the Shiseido one is already available.

      1. Thanks man! I hope ij the near future this treatment proves to be effective and it opens up to the general public!

  5. I need to see impressive results before opening up the coffers. They definitely need to have an arm that caters to the English speaking world.

    1. This seems like it could be a great breakthrough, but I have not seen evidence. Are before-and-after photos available?

  6. Yes, I saw it, admin that Eko contacted the Tokyo Medical University. I also think this would be the ideal place to do the treatment, but due to language issues, it’s difficult to contact them. The issue with the agency and intermediaries is because in Japan, if you don’t have medical insurance, you have to cover 100% of the treatment costs, while with insurance you would only have to pay 30% (or something like that). You also have to make an appointment… Contacting a Japanese person who could explain things to us better would help me personally a lot.

    1. There is way too much uncertainty to spend a large amount of money on this. It could very well only work for one year.

    1. You’re welcome, admin, I’d like to meet a Japanese patient who has received the treatment, and especially how to do it if you’re not from there, since language is a barrier. I’d be happy to share the results on this page if I could get treatment now.

      1. Did you see my earlier blog update Alvaro? They say that they can provide you with information on several agencies to assist you in making arrangements to get treated in Japan.

  7. $15k being high is relative. If the results can take me to a NW1 or NW0, I’d gladly pay $250k. If all it produces is comparable to what I’m doing now, Fin & oral Min…than no, not worth it.

    1. Would you really have $250k to spend on a cosmetic procedure? We’ve got some ballers on this board….

      1. @LJ I sold my mining company for a big chunk of change. I never have to work again. I’m 48 and really want my hair back.

  8. I don’t think €15,000 is an unreasonable price to start with… Currently, a hair transplant with an experienced surgeon who offers a certain level of security and results after the operation usually ranges between €4,000 and €6,000. It’s a very high price, yes, but we’re talking about the fact that if the treated hair acquires DHT-immune cells from the donor hair, those hairs will never fall out again. I’d like to confirm this with the treated patients because it’s not a matter of growing new hairs but rather preserving existing ones. That is, if the cells extracted from the donor area are incorporated into the DHT-sensitive follicles and replace them, those hairs will not fall out. They will weaken and become miniaturized until the affected DP cells are completely lost, but with successive injections to replace these cells with resistant ones, the hair will eventually have the same genetic characteristics in the recipient area as in the donor area.

  9. 15k is insane. Good luck to them lol. At this price, especially with US clinics needing their profit (and you know how the US clinics are), it’ll be way too expensive for most people.

    1. On some conditions it may financially viable for a decent amount of ppl:
      – they offer financing
      – it is a one and done or they offer a reasonable membership monthly fee if you have to keep getting it
      – the success rate is VERY high so its with the money or they need a partial refund if it doesn’t take

      I mean it would still be like having to do PRP indefinitely but that makes it more affortable vs like 15k every 2 years or whatever.

    2. 15k for an effective, sustainable procedure at this market stage would be more than fair. 15k for a slightly advanced minoxidil (if even) is a scam.

      1. Exactly. There’s also no need to speculate about ‘immunisation of the hair against DHT,’ as there’s no evidence supporting such a concept.

    1. Can’t be him, he always started out with the same greeting, something like “Hello, I’m Fuji Maru Kagurazaka….” on every freakin post!

  10. What are we looking at in terms of results and pricing? What’s considered a win for a NW3, and extra 15 hair/cm?

    1. On one of their site’s various FAQ sections, they say pricing needs to be discussed with each clinic directly. I seem to recollect an estimate from the past, but now can’t find it. I doubt it will be more than $5,000, but perhaps you need to go every year? If you are seriously contemplating going there, read all my past posts on Shiseido, including this one (plus check out all the links in the post).

      Below is one of my recent comments in another post in response to “Ben”:

      “I am hoping they can improve on past results after testing the injection procedure on many people. The trial results language was often a bit unclear in the past, and they had a limited number of participants. I can’t imagine that so many years of work from Replicel and Shiseido would result in less than Minoxidil type hair growth. Perhaps Finasteride level great long-term results (in the Japanese men study) is pushing it.”

      36 participants:

      https://pubmed.ncbi.nlm.nih.gov/37752738/

      65 participants:

      https://www.jaad.org/article/S0190-9622(20)30272-3/abstract

  11. Hey everyone,
    The latest institution that started to offer DSC treatment is “Tokyo Medical University Hospital” is possibly allowing this treatment to foreign patients through certain agencies.
    Below is their response e-mail to my inquiry;

    Thank you very much for your trust in our hospital.

    Do they have Japanese health insurance? If you have Japanese insurance, please take a letter of introduction and come directly to the hospital to make an appointment.

    In addition, the hospital does not accept overseas patients directly. All international patients must be referred through an intermediary. We can provide you with information on several agencies to assist you in making further medical arrangements. Please let us know if you have any questions.

    —————————————————————————————————
    Tokyo International Co., Ltd.
    Tel: 03-4400-5589
    E-mail: tokyoguoji@vip.163.com
    https://www.tokyo-med.net
    —————————————————————————————————

    1. Thank you very much, Eko. We hope we can resolve this issue soon and that we can all benefit. A hug, my friend.

  12. Never mind, just saw it its in the facilities section you are right they added a new facility. I will e-mail them to ask if they accept non-Japanese patients. Thank you for the update.

      1. I sent them a mail 3 days ago but no reply. When I call the institution they answer right away but they don’t speak English not even 1 word. If there are any Japanese (Or Japanese speaking) followers who read these comments, it would be great if you can help us. It would be great if a Japanese speaking person calls them and gets some brief information.

  13. There’s an update on their website stating that they offer the technique at the Tokyo hospital. Does anyone know if they already offer it to non-Japanese citizens here?

    1. Hey Alvaro,
      Can you please share the link of the update? I checked the website and couldn’t see any update. Thanks.

  14. But what about this? Don’t they offer it to those of us from outside Japan? Why so much secrecy? This is disgusting.

    1. I exchanged e-mail with both Oashi hospital and Akihabara clinic (only 2 places this treatment is available).

      Oashi said until now they treated around 9 people with this procedure. I asked if I can come to Japan to take it. They said since the effectiveness was only tested in Japanese people, they are currently only offering it to Japanese citizens.

      Akihabara clinic said they are only treating women with this treatment. Men are not able to get this treatment in Akihabara.

  15. Hey admin, I subscribed to Nikkei just to be able to read this article. There nothing super interesting, but I can send it to you as screenshots if you wish.

  16. Many years ago, a clinic in Spain carried out a clinical trial transplanting only the cells of the hair follicles from the donor area with a much finer extractor than the one used in traditional hair transplants to the bald recipient area, promising regeneration of the donor area. of 100%. In the end, this technique was abandoned because the results were much less effective than those of a conventional hair transplant (the donor area was not regenerated 100% because the cells were basically extracted from the entire donor area, without multiplying them, and by injecting them into areas where hair had been completely lost they were not able to create new follicles). More than 10 years have passed since this and no one has ever conducted a clinical trial again… This trial had all the logic in the world and that is why I have followed Hairclone closely for years and recently they are developing it Tsuji, Fukuda and now Shisheido is offering it. If you multiply the dermal papilla cells with resistance to DHT and inject them into affected hair, those hairs could be regenerated and survive infinitely because androgenetic alopecia is determined in more than 80% by genetics. It’s a simple technique, I don’t understand why they haven’t offered it in so many years, I hope we can use it once and for all…

  17. Dear,

    Nice to meet you, this is Andrea.

    I congratulate you very much for your website which is always constantly updated and with remarkable news.

    I suffer from androgenetic alopecia and therefore I have very thin hair. A question, do you have any news on the results of the hair multiplication technology just launched by Shiseido?

    If you can answer me I would be grateful.

    A warm greeting.

    1. Hi Andrea, unfortunately it is only available for Japanese citizens at present. We also don’t yet know how good the results have been so far.

  18. I only really hope that they offer the treatment outside of Japan as soon as possible… We have been researching for many years and I know that there are many people like me… and it is always one disappointment after another… please, my God, please tell you. I ask, but that we can use this and pay whatever but that we can do it….

    1. I hope you are right my friend. They have been offering this treatment in Japan for 6 months now. Probably hundreds of Japanese patients received this treatment by now. Don’t you think if it was very effective, we would know by now? I mean i hope it’s effective….

  19. You are wrong friend! Stemson will offer this solution if it offers it….! I would only trust Stemson for the definitive cure for baldness, which is hair cloning but very very very long term (: . Shisheido has experience and you can read it on his website. Those of us who have been informing ourselves for a long time know that for some years ago there was a therapy with Replicel Rch-001 I think??? It was the same procedure as Hairclone… Now the results say that it is 60% effective in women and 40% in men, I think, isn’t it a lie? They know what they are doing and I assure you that when they offer this technique outside of Japan it will be a 100% safe alternative to dutasteride and Minoxidil!!! I just hope they offer it as soon as possible because I will be the first patient. Regarding other comments from Organtech, I totally agree, they are companies that seek marketing and credibility 0!!! Don’t worry about the results of the Japanese in Shisheido, when they offer it to the rest of us they will change the results. rules of the game…. for everyone (:

  20. Admin,

    Great work, any idea when we as US folks can go to Japan assuming we have the means? Also what is our biggest hope now? Sanford Burnham, Riken, Tsuji?

  21. Excuse me, but my critical ability on medical issues is not good, and I tend to be guided by the comments of people who know more than me. I’m just a person who suffers a lot from alopecia and turns to these media in search of “hope.” Can anyone tell me why the optimism about the treatment of this article has faded? I have read all the comments and at first you took it as great news and suddenly as almost another failure. Am I wrong?

  22. Hello everyone! Lately I haven’t visited the forum much for work reasons, but now I have a little more freedom. I have read the last comments on this post and you are right Ben! The administrator is not Google to answer each of the users but you also have to think that each person who comes to read the page has the same problem that affects the rest of us and has the right to be informed (always with respect). That said, I understand that we have all been tired for so many years and I have no problem with any reader. Yoyo, for example, has the interest and ability to investigate new developments and news, doing a great favor to this website, just like you, Ben. . Regarding my point of view, although this DSC solution from Shiseido has not yet demonstrated its levels of effectiveness in real patients, I can assure you 100% of the readers that it is an effective solution to preserve the hair that you still have until it exists. hair cloning without the need to use medication, which is also not proven to be 100% effective. The only step left is for them to offer this technique outside of Japan and we can use it. If it’s any consolation, I have recently suffered a very strong telogen effluvium and I have lost a very large amount of hair, but it is best not to get nervous and know that it is due to seasonal change and stress and that it will recover because the body is wise. Greetings to all

      1. Hi admin

        I’m new here and I don’t know what the procedure is like regarding the functions of the website.

        I asked my question above and on Instagram too, but I’m asking my questions again to see if you can help me.

        Hi I’m Angel from Spain Nice to meet you all!

        I have a doubts The question is the following: Will there be some type of hair cloning in which the procedure is injectable and not grafted and in which a hair follicle is generated from scratch as if it were grafted?

        As I understand it, hair companies are working on three techniques or three procedures but the doubt I have is if in the cell multiplication procedure a cell could be injected and new hair would grow from scratch even for scars.

        I expect your response

        Thanks again

        Kind regards

        Angel

        1. Okay, let me jump in…

          The technology you ask for is a DP-cell-type one (Dermal Papillae). It’s supposed to be effective for reviving follicles that are miniaturizing and should strengthen healthy follicles too (the amount of DP-cells in a follicle determines the thickness of the hair). It’s likely not effective for hair that is long gone.

          There’s 2 companies which are officially working on that: Epibiotech and Hairclone. Both have failed to deliver so far and I doubt any of them will be successful – solely based on their disappointing history. Trichoseeds/Fukuda have something similar in the works, but there’s only little information available so that’s more speculative.

          Then there is a DSC-cell-therapy („Dermal Sheath Cup Cells“) from Shiseido which is already available in Japan, but I suspect it to be not satisfyingly effective.

          The most promising injectable type of therapy is the Stemson/Aderans-method which is afaik dermal fibroblasts and epithelial cells. It has shown good effects in trials and is imho the only cell therapy which is worthwile to follow and highly likely the first one available of all of the ones above. Yet all of them are not a cure.

          The only real cure is the implantation of a early stage follicle where the growth of hair is imminent. But this is not a single cell injection, it’s basically an organ transplant. There’s 3 serious contenders for that technology: OrganTech, TrichoSeeds and Stemson. My personal opinion is that Stemson is the only real hope in that endeavor, for different reasons.

          Regarding scars, I don’t know. Scar tissue is a different area and cell injections might not work there as the membrane of the skin is not able to let a follicle grow in and out of the skin.

          You‘ll find every useful information to these ventures on this very blog, thanks to admin.

          I am no expert so take my infos with a grain of salt and make your own picture of the field.

          I‘d like to add again that admin has no obligation to answer any questions – this is not a customer service center and he probably earns not even remotely enough money which would justify his endless hours writing articles.

          1. Thanks for the detailed response Ben!

            Angel, please check out all the links in the below page, especially for companies in the US, Japan and South Korea. In case Ben missed anything. e.g., Han Bio and Kangstem.

            https://www.hairlosscure2020.com/hair-loss-research-around-the-world/

            Some of the South Korean companies are trying so many different things at the same time, that is is hard to take them seriously for now.

            For example, in one article, Epibiotech is described as having expertise in four key areas:

            — Hair papilla cell isolation and cultivation technology.

            — Induced pluripotent stem cell manufacturing technology.

            — Organoid-based hair follicle cell differentiation technology.

            — Gene editing technology.

            Their pipeline is also very wide ranging, but their website does not seem to load for me when I tried today.

            https://epibiotech.com/en/

          2. Also Ben, don’t forget the hair growth vaccine from Amplifica Scube3, this together with Stemson and Organ Tech, I think they will be the anti-baldness triad.

            1. I don’t forgot anything – you specifically asked for cell/cloning-type treatments.

              Every other treatment is somehow influencing signalling-pathways, except Keratin and Minox maybe.

              Scube3 is not being trialed atm. OrganTech disappointed over and over again. Stemson is serious though. South Korean ventures are traditionally bad except Olix.

              Be careful with your expectations regarding full cures, it’s a long way. Our best shot seems to be Pelage at the moment, but don’t be too optimistic.

      1. Thanks Ben, though in this case he did say please. I just prefer people asking here rather than via Instagram or Twitter messaging.

      2. Ben, don’t be so stubborn about that.

        I already said that this is the first time I’ve entered the forum and I don’t know the functions of the site.

        I also asked him politely.

        If that’s not education for you, then I think you really have a big problem with understanding or logic that escapes my logic.

        No hard feelings.

        Greetings

    1. Thanks! It is also mentioned on their main site that I linked to in the October 12 update (bottom part).

      Edit: Now I have broken out both clinics separately too.

  23. New press release:

    https://www.nikkei.com/nkd/disclosure/tdnr/20240808566465/

    Translation:

    August 8, 2024

    Started contract manufacturing of new specific cell processed product (“S-DSC®”) for hair regeneration.

    In recent years, research into hair regeneration as a treatment for alopecia has progressed, and results have shown that hair growth may be promoted by culturing DSC cells located beneath the dermal papilla cells, which are thought to be essential for hair growth, and administering them to the scalp as “S-DSC®.” This treatment involves extracting hair bulb sheath (DSC) cells from the scalp at the back of the head where hair loss has not occurred, and then multiplying the cells in vitro.

    We have concluded contracts with medical institutions for the outsourcing of the manufacture of the specific cell processed product “S-DSC®” and have been working on
    establishing a contracting system. Now that the medical institutions have established a system for providing this treatment and we are ready to accept contract manufacturing from medical institutions, we will begin accepting contract manufacturing of “S-DSC®”.

    “S-DSC®” is manufactured at our company’s manufacturing facilities under the technical support of Shiseido Co., Ltd., and process supervision by the company. We are pleased to announce that we have begun accepting contract manufacturing of specific cell processed products used in the following:

    A specific cell process (called “S-DSC®” in this treatment) is administered to the area of hair loss.

    We have recently announced the launch of a new treatment for male and female pattern hair loss using cultured autologous hair bulb sheath cells (hereinafter referred to as the “Treatment”).

    Everyone We will manufacture appropriately. We will disclose it promptly. The impact of this matter on the financial results for the fiscal year ending September 2024 will be minor. However, if a timely disclosure becomes necessary in the future, that’s all.

    For more information on this treatment, please visit the following website:

    S-DSC Hair Regenerative Medicine: https://www.s-dsc.com/

    1. What are your thoughts on this admin, is Shiseido gonna solve everything or what? I only got on this wild ride in 2018, so still feel new to the game.

  24. Admin,

    I’ve been following this site for a decade now, and funny enough this was one of the first treatments I had hope for. I have both the work flexibility and the means to go to japan to try this out, but do you have an email to get in contact with the right person at Toho Univ Derm Clinic? I checked out their website and not one email offered…

      1. I called that number but they only speak Japanese on the other end. They must have an email. Do you have any contacts at shiseido you can ask?

            1. I emailed one person that might be able to help. No response as yet, but now I found another person today and have also e-mailed him. Would be great if they accept you as a patient.

              1. Hi Able42,

                I got a response from someone who contacted the doctor in charge at this particular clinic at Toho University. They did not give me his e-mail address and I think they prefer the privacy.

                In any case, the doctor said that for now, they are only accepting Japanese patients :-(

                I hope they change this requirement in the future.

    1. Sorry for the pessimism… but no newspaper has given relevance to this new therapy, once again we are faced with nothing.

      1. Plus people keep saying it’s a cure. Are all these same people going to spend 10-20k every few years? Doubtful (esp in this economy). If people can’t afford a HT they can’t afford this. It strengthens existing hair…to some extent. But will it 100% stop all hair from falling out? I’m not convinced. And nobody should be convinced this early.

        Imo, this shows great progress (and promise) but I’m not going to call it a cure. It’s a (potentially) huge step.

          1. Some comments above mention the word cure. I guess I should have said “some people” vs just people.

    1. I’m still here! Just been extremely busy. Still squirting Fin on my head and popping Min. (I’m not going down without a fight.) A mate of mine is completely bald though. Reckons his brain is so big, it pushed all his hair out! Don’t tell me it’s been boring without me admin?!

      1. Glad you are still kicking SK. Only the spam comments that I have to weed out are ever as creative as yours!

  25. Eirion therapeutics have started phase 1 for et-02 topical for androgenetic alopecia.. They go on to say that they believe et-02 can also prevent and treat hair greying and they plan to persue that in the future but if it’s the same then will the trials for androgenetic alopecia not also show that it is reactivatiing melanocyte stem cells and be a double celebration? I’m confused as to why they are doing them separately can someone explain as to why that may be, thanks

    https://www.prnewswire.com/news-releases/eirion-therapeutics-announces-initiation-of-first-in-human-clinical-trial-evaluating-topical-et-02-for-the-treatment-of-androgenic-alopecia-302186429.html

    1. Wow Andy that’s fantastic news. I was always intrigued by them, but lost my interest as there was no new information from them. They are well financed and have product candidates for other indications already in human trials.

      Better late than never, they originally planned trials for 2022. Happy to have another contender officially in trials – it’s a small circle if we are honest. This is the only true measurement of seriousness, is a company in a trial or not. Everything else is a pipe dreams, a scam or a decade away.

    2. Hi Andy, they still need to demonstrate efficacy separately for hair greying indications.
      My guess is that once Phase 1 finishes they will have two separate phase 2 studies.
      Good find Andy. Eirion AGA ET-02 topical is a really promising thing that if it works could potentially reactivate dormant hair follicles.
      The study is 24 subjects over 28 days. I hope they are fast enough to finish it by years end.
      To me ET-02 is up there next to SCUBE3. I do hope it will at least have better efficacy than GT20029.

      1. It’s exciting but….10-23k every few years for thickening only? That’s not all that great, esp when you consider whatever the price ends up being in Japan (let’s say 15k) the US market will jack it up (double at least). Just wait. I see clinics/docs here already coming up with plans for their new mansion.

        Out of range for most people. It’s the price of a HT but a HT lasts way longer (with better results).

        1. I do not think this will be approved in the US anytime soon. Japan and South Korea seem to be where the action will take place in the near future.

        2. “I see clinics/docs here already coming up with plans for their new mansion.” Where and can you proof that? I am really interested in this treatment and I will prove that as soon as possible.

    3. This should probably be it’s own topic…

      …and I don’t see that this company has been covered here before. I found a link from 2021 when they got some funding.

      https://www.gorerangecapital.com/post/eirion-therapeutics-inc-closes-40-million-series-a-investment-and-licensing-deal-with-shanghai-ha

      This company has been going for some time with this. And for all I know claims are made to substantiate raising finances -that this topical (oral variant also in the works) should work superior to minoxidil (considering 60% do not get serious results from topical minox). The mechanism does not deal with androgen receptors but keeping the follicle chugging along.

      Their pipeline: https://moonink6.wixsite.com/eirion/pipeline

      1. Search for their name via top right magnifying glass icon. I covered Eirion in a grey hair cure post. Will do a separate post this year.

  26. In the immortal words of the poet Alexander Pope, hope springs eternal!

    Now if we can just switch “hope” with “hair”…

    Thanks for the hope in the meantime, admin.

  27. We still don’t know much about the details of the procedure, and I haven’t read anything on mainstream channels yet, something doesn’t add up…

  28. It‘s the very first cell-therapy to be commercially released, which is an absolute watershed in the history of hairloss-treatments.

    I hope this is a good signal to all the other developers around the world.

    I think we have to wait for more results, I remain skeptical that it‘s a) effective enough and b) lasting. I hope to be wrong though.

    The Aderans-method seems much better to me. According to the trials it is a one-off treatment which is long-lasting and gives you thickening of existing hair plus minor regrowth. Fingers crossed that they start phase 3 soon!

    1. I feel compelled to have to rectify my previous comments. When I read the news and the article, something didn’t add up to me with the acronym DSC. I had always read the dermal papilla cells as DP and searching for information about this, I understood that the hair bulb contains the dermal papilla inside (which determines the thickness, length and color of the hair), although I always I had considered that both terms were equal. The difference in this is that the other companies (Stemson-Aderans, Tsuji, Fukuda, Epibiotech, HairClone…) that were working on this method of multiplication and injection of autologous cells work with DP unlike this company Shiseido that works with DSC, that is, the cells of the hair bulb, which is the envelope of the dermal papilla, and from what I have briefly read these cells have the potential to induce the growth of new dermal papilla (DP) cells or even induce the growth of new hairs!!! If this is so, this technique is better than what other companies are developing, but we need more information.

      1. When I talk about how these cells (DSC) may even have the potential to create new hairs, it is because they are mesenchymal cells, those with which Fukuda worked, for the creation of hair follicle germs, and which have the potential to transform into cells. of the dermal papilla (DP) but perhaps also in other hair bulbs and consequently in new hair. This may be a bit bold to say, but reading between the lines, I imagine this is what they mean. I understand you, administrator, when you say that the comments that this technique will only improve thickness and reduce inflammation are very cautious, but in any case we need time to see how this technique evolves and an analysis of the results, but in my opinion this treatment has a lot of benefits. potential, almost as much as a real cure!!

        1. And furthermore, these DSC cells are those at the base of the hair bulb, which are the ones that have the potential to induce the creation of the other cells, since the cells of the hair bulb themselves are called DS. I am happy to learn more every day and above all to know that the first technique in the world of this type in terms of hair loss has preferred to multiply these mesenchymal stem cells rather than DP cells, which other companies are developing, and that it will be just as effective because the lost DP cells can be replaced, but much better to multiply these DSC cells and induce the creation of new DP cells. Very excited again!!(:

        2. Alvaro, your expectations are way too high for this. It was tested by replicel and basically failed, then again by shiseido and barely showed any efficacy. Theorising about the science behind this is pointless; the results speak for themselves.

  29. What does this mean for Replicel moving forward ? With Replicel still holding patents and marketing rights to this procedure outside of Asia it will be interesting to see if Shiseido or some other large Pharma will swoop in and try to buy Replicel. This is very good news for the long suffering Replicel shareholders !

  30. Is the cost 10k – 23k USD accurate admin? How does someone international go about getting a referral for this treatment in Japan.

    I can’t seem to find any before and after photos in the references you linked, are you aware of any you could point me to please?

    1. They say prices will vary by clinic once more in Japan start offering. $10k seems about as high as I would expect if you need this procedure every few years. Hopefully the person who posted these numbers converted from Yen to $ correctly.

  31. The photo posted are not that bad in terms of thickness. But they need spread this treatment in the world, do you think it is going to happen soon?

  32. Reading shiseido text in japanese.
    Seems like no serious sides but treatment seems like not last forever and 60% of male patient felt hair loss progresses after treatment which will cost 10k to 23k.

    I dont see anything positive ….

  33. While this is great news it does seem disappointing to read that results are merely modest. I’m not sure how to quantify that exactly, but it sounds a bit underwhelming and certainly far from a cure. I do wonder however if repeated treatments lead to greater results. I think it’s best to hold off for now and let them gain experience and see what works best and to which extent. Nonetheless I am modestly excited to see this come to fruition.

  34. Wow never thought Shiseido would come through. Thought they were just another Follica or Histogen lol. Now I am almost 50, but maybe a first Japan trip is needed.

    1. From what I read, one would need to go to Japan for ~2 months to have this treatment as they need to culture the cells before treatment, or is there some suggestion that they will expand the harvesting globally and allow shipping of cells so international patients can then fly out once the treatment is ready?

      1. Yes, but 6 weeks not 2 months. This is truly fantastic news as we head into a new era away from the classic route of finasteride and minoxidil. We know that DHT is what caused hair loss as it kills off DP cells at the base of follicles. If we replace those DP cells with fresh DP cells then we see new hair growth. Shiseido is the world’s 4th largest cosmetic company and have been around for more than 100 years so they are not just any company. This is going to expand to other cities around Japan such as Tokyo and Hiroshima.

        1. But the point is, who has 6-8 weeks to visit and stay in Japan to go through this procedure if that’s the requirement? Don’t get me wrong, it’s encouraging news in this lacklustre area of medicine, but it may be a while before it’s useful to anyone on this board.

          1. It depends on how long each treatment lasts for, though at this point I need regrowth as well as thickness. 6 weeks is nothing if something lasts for 10 years, but I doubt that is the case with DSC cell injections.

            1. Fair point, but also not everyone has such long holidays from work nor can take them all at once like that, I’d be surprised if even a significant minority of posters here could take 6 weeks off work to stay in Japan for this procedure, even if it realistically lasts a few years.

              1. I forgot to add that the 6 weeks time frame makes it more legitimate to me. They could easily have said 2 weeks and drastically increased their client base.

                1. Presumably at the cost of massively disappointing their customer base at some point in the future, this is a high tech expensive treatment for discerning gentleman managed by one of the biggest cosmetics companies in the world. I don’t think they’re worried about pitching this to the hoi polloi.

  35. Albeit good news, isn’t this just hair transplant, now with more hairs to plug? Please correct me if I’m missing something.

    1. No friend, this technique consists of extracting a small amount of hair from the donor area (which is not affected by alopecia), and from those hairs extracting the cells of the dermal papilla, or hair bulb, that is, where a hair is born and multiply them. These cells are what determine the length, thickness and color of the hair and in people with baldness, these cells are destroyed in the area of ​​alopecia by the action of dihydrosterone (DHT), which is why we talk about hair miniaturization. hair, because as these cells are lost, the hair becomes increasingly finer until the hair bulb has completely disappeared and there is no longer any possibility of saving that hair because it has been left without a root. But with this technique you can replace the affected cells with immune cells, which is why the miniaturized hair will become progressively thicker, because the greater the number of DP cells, the greater the thickness. And in this case, by replacing DP cells genetically programmed to be sensitive to DHT with DP cells immune to alopecia, this is a potential cure for many people who experience alopecia in early stages. I hope you have understood me!!

        1. Thank you very much administrator! For those of us who have been worried about hair loss for so long, and visiting this page, we can only thank you from the bottom of our hearts for all the information work that you do selflessly. I started visiting this page when I was 18 when I started losing my hair and now I’m 28 and from the beginning I was clear that the cure was hair cloning, because in the end a hair graft is moving the hair from one place to another and the Medications only serve to maintain what you have and depend on them… That is why I am so happy about this news, which in the end is science, and I am sure that everything will change from now on!!

          1. Cells or hair follicles from donor area that are resistant to DHT, would turn into DHT sensitive when they grafted into the recipient (DHT sensitive) area. That’s similar to what happens after hair transplant . We will still have to use DHT blocker and/or minoxidil to protect them from the DHT effect.

            1. Sensitivity to DHT is not determined by the area of ​​the head where baldness mainly occurs, but by the androgen receptors located in the follicles of this area. That is why generally hair grafts, in which the hair is moved from the donor area to the bald area, this transplanted hair is permanent and will no longer fall, because the hair from the donor area does not have as many androgen receptors and is resistant to DHT. The same thing happens with this treatment, but instead of moving entire follicles, only the cells of the dermal papilla or root are moved, to replace the cells that are lost due to alopecia in the bald area. Of course, it is not a cure for people who have already lost a large part of their hair and it is true that it will be necessary to repeat this treatment from time to time because the alopecia will continue its course.

              1. That’s not true, Alvaro. Look at anyone who had hair transplant, you will find out that if they don’t use propecia, the transplanted hair will mostly fall out over time (not only the native hair as they claim
                ). Plus there are signaling mechanisms in the recipient area that transforms the grafted hair into sensitive ones to DHT over time. The baldness area has many signaling mechanisms (not only DHT or receptors) that reprogram the newly implanted follicles, at least partially. I’m an old scientist with PHD in gene therapy, btw, and have extensively researched, read and watched experts opinions on that issue. Plus I had one transplant surgery, myself, and it was negatively impacted by not using DHT blocker after surgery. I hope that this new cell therapy works though. Fingers crossed.

                1. I have seen guys whose transplant still looks amazing 20 years later. I think the permanent donor hair remains permanent in at least half of people.

                  In many people, the problem is that the permanent donor zone hair is not permanent. My grandfather lost all his hair in the permanent zone by age 60.

                  On a kind of related note, check out the Jeff Bezos’s grandfather story on this blog. His grandfather’s ass hair lasted on his hand (once grafted) for a lifetime lol

                2. I don’t need to look at someone who has undergone hair transplant surgery because I underwent one myself. If you have not taken medication after your operation, the alopecia will continue its course and the native hairs that you retained will have disappeared. What the administrator says is also totally true, that many doctors, as happened in my case, took hair for the transplant that are still sensitive to DHT because in my case they took hair from the crown area, and many people with their Fully developed alopecia experiences a fall in its donor area. That is why I have always said that to perform this technique, there must previously be a test or diagnosis to determine that the multiplied cells come exclusively from hairs that are 100% resistant to the effect of DHT.

              2. Definitely not true… for many men donor hair will thin as well over time if dht blockers aren’t taken. Even with medication donor still can thin…. I have also watched numerous world renown hair transplant surgeons talk about this… and all of them agree transplants thin over time because donor hair miniaturizes.

      1. But it won’t work in DP cells that do no produce hair anymore ?
        So it is still not satisfying, only interesting for people who started to bald recently no ?

    2. Would that not be a cure though? Unlimited donor supply? If I had 10k-50k grafts or whatever I would be getting mega sessions every time I lost density lol

  36. Today is a great day for the hair loss world!!! I was sure that sooner rather than later this treatment was going to be effective because it was not a complex process and this day has arrived and I am glad that it came like this, by surprise, instead of following schedules that are always delayed or never arrive. until the end!!! I am very happy for everyone and especially for you, administrator, for all the informative work that you have done for many years, and that, like the other readers, you have felt the desperation of following the work of so many companies that have never materialized and that at the same time The final solution for us for so many years has been hair grafts, finasteride and minoxidil as truly effective methods. Well, the time to continue taking these medications daily has changed and we will be able to preserve our hair with a transfer of resistant DP cells from the donor area to replace the weakened and lost ones affected by DHT. Great news, congratulations on your work and your perseverance administrator.

    1. Thanks Alvaro!!

      And everyone, please let me know if your comments do not get approved in 2 days. I had to remove the old spam comment detection plugin and try something else unfortunately. It is time consuming.

          1. Admin, I told you that you just need to add an “s” at the end of the website title to buy yourself 9 more years with this domain. So, “Hair Loss Cure 2020s” … Done :-)

              1. Admin, Continuing an old discussion… Does it really redirect webpages to change the aesthetic title to 2020s? The URL would stay the same. The point was to keep the old URL related and making sense.

                  1. Yes. Knowing that you’re stuck with the 2020 URL, you can just tweak the visual title to 2020s (so that it still sort of matches the URL but covers an extra decade). Anyway, “Hairloss Cure 2020s” is an option for a title. That said, it’s already 2025 and no one seems too bothered by 2020, so doing nothing is also a good option :-) Just giving an idea.

    2. While I am a very positive person I think this is getting a little too optimistic… it may serve as a very short term therapy but I don’t think it’s going to be anything better than the current medical treatments we have today. Will be expensive and very little effectiveness… it sounds like another Cosmerna or PRP like treatment. It may catch buzz for a couple weeks or months and then will fizzle. We need gene editing or full blown hair cloning for a cure.

      1. I am just excited that a country is allowing cell culturing and implantation to anyone who gets referred.

        A first. Japan and South Korea will lead the way it seems. Shiseido’s Phase 3 trials were small and inadequate my US standards. Yet they are allowed to proceed.

        And we have had no FDA approved hair loss treatments since Finasteride and Minoxidil.

  37. Incredible news, even if it ends up being just hair thickening (as long as guaranteed, unlike PRP). Congratulations on your 10+ years of patience covering Shiseido and Replicel Admin!

  38. Hair thickening? As in increasing hair shaft diameter? Any word on pricing? This is great news and hopefully leads to a way to increase new hair growth, the panacea we are all looking for.

    1. Rick C. check out my past post on Shiseido where I discuss their Phase 3 results (link is in the post).

      As far as cost, it says the following on their new site:

      “This treatment is offered as an elective medical service, so please contact each medical institution for details on costs.”

      They plan to offer this at more centers in Japan, but initially, only Toho University Ohashi Hospital.

      1. I don’t understand the excitement with this product. It only thickens existing hairs? Does it even prolong the anagen phase of hair cycles?

  39. I remember reading about this treatment on your page years ago, when it was considered a proper cure. Such a disappointment unfortunately, though I’m surprised they released a product at all not hearing about them for a long time.

    1. Sorry Admin, this does not seem any better than Fin. There is no info on how low it will last. Whether continual treatments will be needed. No info on the cost and sounds just like CosmeRNA.
      Surely this might be better than nothing. How much better?

      1. Agreed… it will be like cosmerna and will go quiet after initial buzz. It’s surprising that no “hair loss experts” are even talking about it…

        1. They only claim hair thickening. All forums and blogs have been talking about Shiseido and Replicel for over 10 years. The new links in this post are due to “Theo” e-mailing me. They are Japanese sites…I would have never found the Toho University site by myself.

      2. Even they do not claim it to be better than Fin Abbot. Did you read the entire post?

        It is a miracle that we can now get our own hair cells cultured and multiplied and then implanted back into our scalps.

        1. Is there any possibility that this can be repeatedly performed to eventually culture the entire scalp?

          I’ve been a reader of your blog for years. And years back I couldn’t afford any of these. I pray that this is the final nail in the coffin.

          1. The part that worries me is that a 5 mm diameter hole will be taken from healthy scalp. Won’t that leave a visible circular scar every time that can only be covered with longer surrounding hair? That would add up with repeated procedures

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