Increasing PGE2 and PGF2a for Hair Growth

In a number of past posts, I have discussed how hair loss is impacted by prostaglandins (lipids). Most of my focus has been on how a reduction in prostaglandin D2 (PGD2) levels benefits hair growth. In this post, I will discuss how an increase in levels of prostaglandin E2 (PGE2) and PGF2a (PGF2α) leads to hair growth.

PGE2, PGF2a and Hair Growth.
Increase PGE2 and PGF2a for hair growth. Reduce PGD2.

It has also been hypothesized that the balance between PGE2 and PGD2 levels controls hair growth. Increased levels of PGD2 and reduced levels of PGE2 have been observed in the scalps of men suffering from androgenetic alopecia (AGA). Also of note, PGE2 is known to act synergistically with PGF2 alpha

PGE2 and Hair Growth

PGE2 (also known as dinoprostone) is a naturally occurring prostaglandin that is also known to interact with Wnt signaling. A number of studies have shown that increasing PGE2 levels on the scalp can benefit hair growth.

An interesting 2019 study found that one of the ways in which skin and tissue injury can sometimes lead to hair growth is via an increase in PGE2.

A 2018 case report from Spain found that the drug Omeprazole induced hypertrichosis (excessive body hair) in two children. This side effect resulted from a significant increase in prostaglandin E2 levels. Once Omeprazole therapy was stopped, the excess body hair entirely disappeared after six months.

One of the ways in which Minoxidil works to grow hair is via increasing PGE2 levels.

Dexamethasone and Sulfasalazine can both increase prostaglandin E2 levels significantly.

Natural products such as castor oil are thought to raise PGE2 levels, and potentially benefit hair growth. Even if true, such gains will be modest at best in my opinion.

PGF2α (aka PGF2a) and Hair

PGF2α acts by binding to the prostaglandin F2α receptor. When injected into the body or amniotic sac, PGF2α can either induce labor or cause an abortion in a pregnant woman. PGF2a levels are higher in people with non-balding scalps.

In the past, I have written in detail about the glaucoma drug Bimatoprost. This drug is an analog of prostamide F2a, which is almost the same as prostaglandin F2a. Bimatoprost raises both PGF2a and PGE2 levels, and is therefore the key ingredient in eyelash hair growth drug Latisse.

Another analogue of prostaglandin F2a is the well known drug Latanaprost. It prolongs the anagen phase of the hair cycle via the prostaglandin effect.

Another glaucoma and high eye pressure relief drug named Travoprost has a patent related to its scalp hair growth properties. Travaprost raises both PGF2α and PGE2 levels on the scalp when applied topically.

The only other major PGF2a analogue pharmaceutical on the market is called Carboprost.

Birth of a Nation and Hair Transplant Boom

I live in the greater Seattle region. We just gave birth to the world’s newest country (no. 196) called CHAZ. Now renamed to CHOP. This area is home to Amazon, Boeing, Microsoft, Starbucks, Zillow, Costco, Nordstrom, T-Mobile, Expedia, Nirvana, Jimi Hendrix, the world’s two richest men, Bruce Lee’s grave and much more. Yet CHAZ is surely Seattle’s proudest moment ever?

Earlier this month, the National Guard arrived in Seattle due to looting and ransacking of the most popular nearby high-end mall. Not to mention total chaos in the downtown core itself. The high-end mall looting occurred at exactly the same time as the local police inspector was prostrating to a crowd just several hundred meters away. A successful decoy tactic by some of the protesters + looters acting in cahoots?

The controversial mall owner is not causing anyone to shed tears. However, I do feel sympathy for numerous smaller retail shop owners in my region and throughout the US. Instead of a hair loss cure, 2020 has brought us armageddon.

Mac Jack's Beer to Keep Calm
Mac & Jack’s Beer to get through 2020.

Our Seattle Mayor calls this whole tragic situation the summer of love. Our Governor pretends to be totally oblivious about the new breakaway country of CHAZ. Our third most powerful politician aims to make this new country permanently independent from the police. She is also leading the way in massively raising taxes on Amazon. The most popular video about my city on Youtube is called “Seattle is Dying“.

I nevertheless always remain calm, cool and collected by drinking locally made Mac and Jack’s African Amber Ale. Until recently, it was only available in draft at bars. It seems like they now sell this beer in cans at stores too.

As Long as you have Hair, Death is Okay

The wise Elton John once stated that even when he thought he was being burglarized and potentially murdered, his only concern was his hair. He wanted to make sure that his dead body was shown in newspapers the next day with a full head of hair. You never want looters to kill you when your baldness is visible and not hidden. This advice is better than buying guns, which I still refuse to do.

By his own admission, Elton John’s most valuable possession is his great hairpiece. His past bad hair transplants did not work out well at all, but the hairpiece is fabulous.

Hair Transplants Booming

It should be noted that hair transplants have improved drastically in the decades since Mr. John had his mishaps. Hair transplant news related articles have been especially frequent these past few weeks.

As always, British newspapers cover hair restoration related topics far more thoroughly than US media. Many of the US readers will not recognize some of the celebrities mentioned below. In chronological order:

Cheyenne Jackson Strip Hair Transplant Scar
Cheyenne Jackson’s Strip Hair Transplant Scar.
  • Australian cricket legend Shane Warne believes that he is the leading force in ending the stigma around hair transplants. I did not realize that Mr. Warne suffered so much in front of the cameras as a professional athlete and celebrity. He is an ambassador for Advanced Hair Studio.
  • Also from the UK, 25-year old Stuart Scott got a hair transplant after suffering from hair loss since his teens. The final straw was when a women on Plenty of Fish rejected him due to his baldness. Now he gets far more interest from women due to his increased scalp coverage. His hair transplant cost was “more than £2000”.
  • Hollyoaks star Stephanie Davis is pleased with her British Hair Clinic hair transplant results. She used to be bullied due to her her high hairline.
  • 31-year old boxer Tyson Fury does not care about his hair loss. He has refused numerous free hair transplant offers from leading clinics. Well down Mr. Fury.