DS Labs: Revita and Spectral DNC for Hair Loss

DS Laboratories (the flagship brand of DS Healthcare) makes the well known Revita and Spectal DNC line of hair loss products. Men and women can both use these products.

Update 2019: Ownership change in the Miami-based DS Labs. The CEO remains Dr. Fernando Tamez. Also note that DS Laboratories introduced a broad-spectrum CBD hair growth shampoo in 2019. The product is known as Revita CBD. It contains cannabidiol, a compound that is extracted from cannabis. Make sure to read my post on CBD oil, hemp and hair growth.

Revita from DS Laboratories

Revita Shampoo from DS Labs.
Revita Shampoo from DS Laboratories.

The most famous product from DS Labs is the Revita shampoo for hair growth stimulation. It contains several dihydrotestosterone blockers as well as ketoconazole, caffeine, and biotin. Make sure to also read my posts on natural DHT blockers and Nizoral shampoo.

According to DS Healthcare, Revita combines antioxidant and anti-androgenic properties. It also contains powerful hydrating molecules, hair-growth stimulants, and amino acids. Around 1,900 Amazon reviews currently give the product an average rating of 4.1 out of 5 stars. The company also sells Revita conditioner.

Spectral DNC Hair Loss Products

Spectral DNC-N with 5% Nanoxidil.
Spectral.DNC-N with 5% Nanoxidil from DS Healthcare.

DS Laboratories also makes the well known Spectral.DNC-N topical hair loss treatment. It contains the company’s proprietary Nanoxidil® alternative to Minoxidil (Rogaine). The product makes use of nanosome delivery technology. I have not read of any users claiming major side effects. However, please do your own research from reading many customer reviews.

According to the official product description:

The compounds used in Spectral.DNC-N have in clinical studies shown to open ion channels within cells; suppress dihydrotestosterone; prevent perifollicular fibrosis; provide antioxidant effects; prolong the anagen phase of hair follicles;  increase expression of VEGF; suppress protein-kinase-C isozymes; and block chronic inflammation.

Other well known products sold by DS Laboratories include: the Spectral.CSF hair revitalizing treatment for women; and the Dandrene brand anti-dandruff shampoo.

Nanoxidil

Nanoxidil is a molecule that resembles Minoxidil, but supposedly causes fewer adverse reactions. It comes in a liposome formulation that contains a potassium channel opener, pyrrolidinyl diaminopyrimidine oxide, azelaic acid, lysophosphatidic acid and copper tripeptide-1. A 2008 study from South Korea found 5% Nanoxidil to benefit hair growth in mice via increased IGF-1 expression and decreased TGF-beta1 expression.

A 2018 study found that topical Spectral DNC-N (which contains Nanoxidil 5%) reduced hair shedding in women with female pattern hair loss. It also increased hair mass and density. One of the authors of this study is the well known hair loss research scientist Dr. Antonella Tosti.

DS Healthcare Patent

Last week, DS Healthcare Group filed its second patent (first one was filed in October 2013) related to a new proprietary topical hair loss treatment.  From the news release regarding this development:

This new patent addresses the composition and methods of a new compound described as a calcium-activated potassium channel opening agent for topical treatment of hair loss.”

According to the company’s (now former) CEO Daniel Khesin, this patent-pending molecule will produce better hair regrowth than topical minoxidil.

PDO Scalp Threading Treatment for Hair Growth

Polydioxanone (PDO) threads have become a popular treatment option for facial rejuvenation, facelifts and wrinkle reduction in recent years. This is especially true in Asian countries such as South Korea, where PDO threading is a common cosmetic procedure.

Polydioxanone filament is a synthetic absorbable suture that is prepared from polyester. PDO sutures have been used safely in surgical practices for decades. While PDO is the most commonly used material, some scientists have also successfully tested gold threads for hair growth. These gold threads were embedded with absorbable polyglycolic acid (PGA).

More recently, doctors have been using thread-embedding therapy (TET) for hair growth purposes. Some sources use other words to describe this technology, including “thread lifting”, “threading” and “polydioxanone monofilament threads”. Well known brand names include PDOgro (discussed further below) and EuroThreads. You can find numerous online reviews for these procedures when it comes to facial applications.

Polydioxanone Monofilament Threads and Hair

A detailed 2015 study from South Korea showed positive hair growth results in mice treated with TET. The logic behind this type of procedure is similar to the logic behind wounding and hair growth. As well as to the related microneedling and dermarolling phenomena.

The hair threads and associated wounding work by: stimulating collagen regeneration; increasing blood flow; and improving circulation. Moreover, various growth factors are increased after the scalp skin has been disrupted. The threading treatment also enhances hair growth related gene expression, and activates fibroblasts and elastin.

Polydioxanone threads seem to be the most popular option for this type of procedure. In June 2017, a new study from India (with Dr. Rachita Dhurat as a co-author) caused significant excitement about this procedure. The study authors inserted 30 millimeter PDO microfilament threads in five male patients suffering from androgenetic alopecia (AGA). Between 20 to 40 threads were inserted into each scalp.

At 12 weeks, all five patients had appreciable increases in hair count. Of significance, none of these patients had previously seen any hair growth from using either Finasteride or Minoxidil. According to the above paper, poly-dioxanone has high flexibility and retention strength. It is also non-allergenic and has a slow absorption rate of around 6–8 months.

And most recently, in December 2019, a new study from Egypt concluded that:

“Poly‐l‐lactic acid microthread therapy combined with minoxidil may improve hair density, hair thickness, and hair appearance better than minoxidil alone.”

PDOgro™ Hair Growth and Dr. Alan Bauman

PDO (polydioxanone) Threads via PDOgro Threading
Dr. Bauman performing a scalp PDO thread insertion procedure.

Over the course of 2019, Dr. Alan Bauman from Florida has become heavily involved in the PDOgro™ procedure for hair regrowth. I first read about this in a February 2019 press release.

The PDOgro™ process is performed under local anesthesia via the insertion of PDO MasterThreads (MasterThreadsUSA, NY).

Over the past few months, Dr. Bauman has sent me a bunch of information and videos about this procedure. He thinks that it has significant hair growth benefits. Below is a video in which he is demoing the PDOgro procedure on a live patient at a conference in early 2019. Dr. Bauman was already performing this hair loss treatment in 2018 per this slightly older video.

Scalp Threading Plus Minoxidil and PRP

Doctors who offer PDO thread treatments on the scalp often add concurrent topical hair loss medications into the mix. Some might also offer to add PRP as a combination treatment. Medication absorption rates are probably increased after the wounding process.

It would be quite ironic if “PDO threads plus added compounds” turns out to be as effective as Follica’s “wounding plus added compounds” hair loss treatment.