My favorite hair loss researcher Dr. Takashi Tsuji of RIKEN (and OrganTech) is back again. His 2017 book on organ regeneration is now even available on Amazon and includes hair regeneration.
This time, Dr. Tsuji has written an article for the May 2024 edition of the Japanese science journal Newton Press. The below image summarizing his latest work is after Google translation. Also see Tsuji Lab for Organ Regeneration.
The co-author is Dr. Masayuki Yanagisawa. Interestingly, his team has been reliably following up on very long-term results of Finasteride use for hair loss in Japanese men. They have published 2.5-year, 5-year and 10-year results so far. And they will likely release 15-year results in 2025. A painstaking, large-scale, long-term hair loss patient tracking effort that is unmatched.
Dr. Takashi Tsuji: Complete Hair Regeneration
The full Japanese language Newton magazine article by Dr. Takashi Tsuji can be found on OrganTech’s website. According to “Theo”, below are the main sentences of interest after translation (and corrections by me where I thought necessary):
- Dr. Tsuji is currently developing a regenerative follicle organ with further improvements. This is because it became clear to his RIKEN team that besides hair follicles, the surrounding scalp tissue is also damaged in severe cases of androgenetic alopecia )(AGA).
- In some severe cases, the subcutaneous tissue becomes thinner and harder (Admin: See my articles on thinner and tighter scalps in bald regions and the damaged arrector pili muscles in balding scalps). In this case, even if the follicle organ is transplanted, it will not be reborn.
- Per Dr. Tsuji, they found that stem cells that support the development of hair follicles are missing in some subcutaneous tissues (Admin: Perhaps this is the “missing progenitor cells” in bald areas that we have heard about in the past? Or the phenomenon of escaping hair follicle stem cells?).
- Taking this as an opportunity, Dr. Tsuji’s team has developed the second generation of his hair multiplication process. In this version, they combine the conventional regenerated hair follicle organ primordium (first generation), plus also regenerate hair follicle development related supporting cells.
- In addition, they succeeded in developing the third generation of the seated hair follicle organ, which was cultured in vivo and differentiated to complete hair follicle (Admin: This is above my understanding and I am not sure why they need a third generation).
- Dr. Takashi Tsuji quote:
“If our third generation of regenerative hair follicles can be transplanted, it will be equivalent to self-hair transplantation, and hair-regenerative medicine will be completed.”
However, he warns that it is also important to confirm whether there is no inflammation, infection and cancer. This is not proven in humans as yet. Dr. Tsuji confirmed that inflammation and infection can be controlled, and that malignancy does not occur in mice using the first-generation regenerative hair follicle organ.
Tsuji and OrganTech Partnership
Dr. Tsuji also mentions that his venture (via OrganTech) has restarted and they are on track to begin clinical research (trials?) in 2024. The company plans to start clinical trials on humans for the second generation after 2026; and for the third generation after 2027.
Just as with Stemson Therapeutics, the time-frame is very disappointing. I am also confused as to whether they are conducting clinical trials in 2024 or clinical research.
Updates from Theo:
Everything is going according to plans. It will be human clinical trials in 2024 for first generation hair follicles with improved growth. They will test two technologies (the old one and the new one).
For third generation hair follicles, I think Dr. Tsuji means technology for totally bald guys without donor hairs. Same thing that Stemson is doing. Stemson will start pre-clinical or clinical trials somewhere in 2026. It will take at least 10-12 years to get to the market and another couple of years to get cheaper.
OrganTech third generation hair follicles will get into human trials by 2027 and it will be on the market by 2030. So, at least 6-7 years earlier than any competition.
Also, OrganTech and OrganEcoTech will start their business partnership for artificial skin on the 1st of April 2024. And that means very good chances at becoming a profitable company with no begging for funding.
Another translation of Dr. Tsuji’s new article:
Theo asked a Japanese guy that he knew from the net to translate the text for me.
Human clinical trials are starting in 2024 for hair follicle organ/primordium first generation.
I asked the Japanese guys if human clinical studies = human clinical trials in Japanese. He told me YES, so do not be confused by the phrase “clinical studies”. It means clinical trials by Western meaning.
OrganTech CEO, Takashi Kondo, in his interview from one month ago also clarified that human trials are starting in 2024.
Also, he sent me the below text with 100% correct translation. Admin: Seems close enough to the previous translation.
There’s a problem in serious cases of AGA where the hypodermis becomes thin, leading to it stiffening. In cases where this has happened, transplanting hair follicles will not result in hair regrowth.
They looked into the problem, and found that the stem cells responsible for supporting the development of hair follicles is located in part of the hypodermis, and that function had become lost.
Because of this, they decided to work on a second generation of regenerative hair follicles. This combines their initial first generation (hair follicle restoration organ copies) with hair follicle development organ copies (copies of the stem cells the hypodermis is missing).
They managed to cultivate this second generation of regenerative hair follicles outside of a living organism, and separate out a complete hair follicle. They say they also succeeded in creating a third generation restorative hair follicle organ.
They are planning on human clinical studies for the 2nd generation hair follicle in 2026, and 3rd generation in 2027.
Dr. Tsuji claims that if they succeed in transplanting their 3rd generation restorative hair follicle organ, it will be just like transplanting real hair. A perfect hair restoration procedure. However, even if it works on mice, it doesn’t mean that it will be easy to get it to work on humans. They need to be sure that it won’t have problems with inflammation, infection or cancer.
Inflammation and infection are manageable problems (if they even happen in the first place). Moreover, they have confirmed that the mice that the first generation hair follicle regeneration technology was used upon did not develop cancer.
Ugh…and if everything goes well, it will hit the marketplace in 2035.
I think Japan trials are much faster. But still a lot later than originally anticipated :-(
Wonder if Dr. Tsuji can use his first or second generation technology in those who still have half their hair (and relevant stem cells) left?
Edit: New update from “Theo” at the bottom of the post.
This is what I said recently! According to Takashi Kondo’s interviews, everything seemed to indicate that his clinical trials were going to be the multiplication and injection of multiplied cells, although he frequently used the words regenerative medicine, hair regeneration, hair follicle primordia… This is not bad news, I I think on the contrary, because in the end the companies that we believed were going to have the cure for baldness (hair cloning) are working on this technique, which is not the cure for baldness, but it IS the cure for people who still They keep their hair, or part of it. I recently contacted HairClone who are also working on this technique and are already conducting clinical trials, they hope to offer the technique to the public sometime in 2025. The cost for storing the follicles will be $5000 initially and $150 thereafter. per year by saving them progressively. The treatment will be approximately the price of a hair transplant $3000-4000. Once again I say to all the readers of the page that I feel deeply sad for those of you who no longer have your hair because this “cure” is not going to help you and I would like a definitive cure to be close but I think there are still many many many years…. And to you, administrator, I can tell you that I feel very identified with your line of thought and that your research is well-founded and I really like reading your points of view because I see that you know perfectly the mechanism of androgenetic alopecia and It is a pleasure to learn things from you as I consider you to be an expert on this topic!!
Thanks Alvaro. I would say that I am not even 7/10 when it comes to understanding the biology of some of these findings… But I appreciate the vote of confidence!
Also, what do you mean by helping people that have kept their hair? So say you are a nw 3… how would these injections keep the rest of your hair from falling out and how could you generate growth back to a NW 1 if you already lost those hairs? Doesn’t make much sense… the only way hair loss is cured is if you can turn on each hair follicle to reverse hair miniturization and bring back each follicle to produce healthy hair … and it sounds we are a long ways from that. Hair clone if it ever happens will have its limitations and probably just be like finasteride. Seems like every drug in studies besides Stemson talks about certain hair count per cm which Is already comparable to finasteride a drug we already have.
I understand what you’re saying, friend Tyler. The reason for my optimism is that Tsuji, like Stemson, Fukuda and other companies such as Epibiotech or Hairclone, are working on this technique, which I repeat will only be a cure if the person with androgenetic alopecia keeps their hair. The reason why hair cloning (the creation of a new follicle from scratch) will take much longer to be available (more than 10-15 years) is that we have seen that it is a much more complex process than it seems, while This technique is based on the extraction of cells from the base of the hair from the donor area and the multiplication and injection into the follicles of the area affected by alopecia, so it is apparently a much simpler process. As we all know, the follicles of the donor area are immune to alopecia, so by injecting their cells into follicles susceptible to DHT and replacing their cells lost due to alopecia, with cells from follicles immune to DHT, probably, after successive tailored injections. that the affected cells disappear, replacing them with immune cells, the result will be that all of your hair is not affected by alopecia. I understand your question that if a NW3 wants to return to the state of NW0, they would first have to undergo a hair transplant in the hairless areas and then maintain the result throughout their lives without needing to take other medication. This is the reason why I understand that a NW7 person who cannot opt for a hair transplant feels tremendously disappointed with the time it takes to wait for the real cure that is hair cloning…
I agree to some point. I wouldn’t agree with guys donors being immune though to DHT. There are lots of guys with androgenic alopecia who still have miniturization in their donor. Look at a lot of NW5-7 they don’t all have thick donors… lots of them have thinned out some in their donor which makes it tricky for hair transplants because it’s hard to determine stability of the donor. Also, there are many men that have Dupa. So I don’t think donors are dht resistant. We need something that will trigger and regrow terminal hair throughout the whole head.
This is true Tyler. And it’s a question I asked HairClone 4 years ago when they were starting to develop their technique. It was a concern that I had because my hair transplant was performed from the nape of the neck to the center of the crown and seeing my father’s history (NW 7) I knew that many hairs used in the transplant were still susceptible to DHT. HairClone’s answer is that they have a method to determine exactly which 100-120 follicles to choose for cell multiplication to ensure 100% that these follicles are immune to DHT, for example the terminal hairs on the back of the neck, which They form a tagline… Do you understand me? My father’s case is also what you tell me, that the hairs in the donor area have also weakened, but if you choose those 100-120 follicles well to multiply the cells, you could thicken and improve the appearance of all the other weakened ones, even of the donor area, as well as in a case of DUPA…
In addition, Tyler thinks that in a head full of hair there are between 100,000 and 150,000 follicles, in the most extreme cases of NW7 alopecia that I have seen in my life, the person always keeps some hair in the donor area that has not yet fallen out. will resist forever, that is why I believe that in all people it would be possible to extract at least 50 follicles that preserve the ideal characteristics… But it is true that in a person with a history of extreme NW7 or DUPA who has not yet reached the final level of your alopecia, we would have to see which hairs are suitable for multiplication, that is why I understand you and I believe that the suitable hairs would be those on the back of the neck.
My dad still has crazy thick super fast growing lower beard area hair. Also a possible follicle donor source.
I think I read in the past that beard hair is often even thicker than scalp hair when transplanted in a BHT procedure.
It would also be a good administrator possibility since beard hairs would be ideal since they are 100% resistant to DHT! But in this case I do not know if injecting multiplied beard cells into the follicles of the scalp would have the effect of manifesting themselves in such a way that by replacing the cells damaged or lost due to alopecia with beard cells in the scalp, these follicles They end up becoming beard hairs that are different (thicker) since they are genetically coded differently. In the case that you say about your father that these beard hairs grow quickly and are long, perhaps it could be another solution!
And on the subject of BHT, it can also be another solution for people with DUPA or with larger alopecia like NW5, as my friend Tyler commented with this technique of multiplication and injection of multiplied cells from the donor area to fill in the areas with little density or even to perform a hair transplant to cover the frontal area and fill with BHT both the middle area of the head and the gaps in the donor area and thicken the miniaturized hair. I know that in the end it is an operation and as I have gone through this it is not something quick or pleasant but if this technique becomes available I tell you that you will only have to go through this once and keep the result forever without fear of having to undergo more operations, or take medication for life… I hope I am right
and what about women…we can’t get a bht…
well unless we might since we have follicles there too they just aren’t stimulated by hormones to have beard…so we have blond almost invisible hair there…
Hi Alvaro,
What are your views on Pelage?
Hello KV, I understand that medications for alopecia are important above all for the maintenance and stabilization of hair loss, but I do not believe that they can ever represent a cure for baldness, and I am not in favor of dependence on a medication per se. life, but this is just my opinion. Sorry
Finally, we must say that we are very close to a revolution in the world of hair. After many years with few medicinal solutions (finasteride, minoxidil and more recently dutasteride) and the only solution to cover completely unpopulated areas, hair transplantation. If the injection of multiplied dermal papilla cells from the donor area works, for those of us who take dutasteride and minoxidil to preserve our hair, with successive injections of cells from the donor area we will be able to replace the affected cells from the donor area from time to time. baldness that will die, due to resistant cells from the donor area, reaching a point where all the cells in our area affected by alopecia are resistant and we can have cured our alopecia and all this without continuing to take dutasteride, finasteride or minoxidil in this process . Times are very close to changing guys!!!
Alvaro, while I appreciate you being optimistic I think those claims are very bold. How do you figure we are close? We don’t even know if Stemson will work and they are at least 12 years away if it does even work. Tsuji sounds like it’s a ways from happening as well… at least 5 years and to be completely honest I think it’s a joke. Remember the claims he made saying hair loss would be cured by 2020? Well it’s 2024 and he’s not close.
And finally, it is true that if this technique works, it will basically be a maintenance technique as well as a 100% effective medication against hair loss. But in my opinion, I would prefer a thousand times to make my hair resistant to alopecia through a mechanical process, than to depend on a medication for the rest of my life, which in addition to having side effects, no medication has currently been proven to be 100% effective.
When I read that Stemson’s cure “might” come out in 10-12 years, the breath was lost from my lungs.
I am sure this company will also fail. If baldness is ever cured, it will definitely be done by an American or European company. I also spoke with a stem cell researcher about the iPSC solution. Stating that the biggest problem of iPSC is tumor formation, he said: If we are going to manipulate it to prevent tumor formation, it will cause a sharp drop in the efficiency and strength of these cells. He also believed that the reason Stamson was slow to start clinical trials was precisely this problem: tumor formation. I don’t know, but baldness may not be cured for another 100 years.
Sorry but Stemson release in 2036 is stupid and cannot be true at this point. They recently mentioned they plan multiple products and maybe could even go directly to Phase 3 with the Aderans product. So I dont know what super new crazy tech they are talking about but before that there will be other products coming.
I mean even Acorn, Kangstem and Epibiotech will release earlier. And there are many others too.
But at the end if 2036 would be true then there would be at least 30 topical and oral drugs and some devices way before that and you dont need OrganTech anyway. I think Tsuji is overrated. Lets focus on the many companys with Phase 2 and Phase 3 treatments in the pipeline.
I can only agree with John Doe. There are other options besides TSUJI.
How can one still mention Acorn, they have nothing. They preserve your cells, that’s it. They don’t offer any treatment – not now and not in the future. It almost sounds like a scam.
Kangstem sounds more serious, but let’s be realistic: they just started their venture, it’s probably many years away.
Epibiotech so far only shone with literally hundreds of press releases and collaborations. And that 10 years after its inception. Their cell therapy trial (DP-cell not organoid or primordia) )was initially announced for 2022. They still haven’t started.
Even Fukuda stepped on the brakes with the recent announcements.
Everything cell-related is further away than we hoped. I think Stemson looks like the best contender, the clearest product path and the most transparency. With Aderans there’s even a chance of an early release of a new cell therapy.
Hi Ben, I agree with you. All the Stem Cell research is delayed and more complicated than expected. And nobody wants to risk cancer just to get few hair back. Till we get to a final cure I like the idea to use known and approved drugs like Dermaliq, Aneira, Triplehair, Veradermics, Moogene and Bioresearchpharma do it. I guess we will have all these drugs in 2-3 years.
BTW I mentioned Acorn because they say they do come to a “pivotal Phase” next year and start marketing products.
https://www.pharmavoice.com/press-release/20240306-acorn-biolabs-appoints-crystal-muilenburg-as-chief-commercial-officer/
Amplifica has to be in that list surely?
Did not cover this last year:
https://sj.jst.go.jp/news/202309/n0929-01k.html
“I believe that we have shed light on a possible initial idea for biological methods that could be used to improve hair quality and in anti-aging.”
Hi Admin, what do you think of BioResearchPharma?
https://bioresearchpharma.com/
Interesting. Don’t think I ever heard about them before. If they start trials, I will probably write a post.
“BRP-011 (latanoprost acid) is an active metabolite of latanoprost (200 times stronger agonist of the PGFα receptor than latanoprost), and therefore a potent activator of prostaglandin-dependent hair growth.”
What happened to the hair loss drug that “Omega Therapeutics” was developing? Do you have any news about it? I was actually excited, because according to the company, the medicines it developed act genetically through modifications in DNA – I don’t know if that’s how it works, but that’s what I understood, I’m a layman in the area.
Their pipeline does not explicitly break out hair loss.
https://omegatherapeutics.com/pipeline/#pipeline
However, in their March 2024 Corporate Presentation, they do mention “SFRP1 Alopecia” once:
https://ir.omegatherapeutics.com/static-files/3983e78e-24f9-4864-b9f0-8f7a2c2eca2c
Still too early to tell if it will ever go to trials.
It was then withdrawn, as there was previously a drug in its pipeline in development that targeted this gene. But anyway, thank you for answering me.
https://seekingalpha.com/article/4622344-omega-therapeutics-working-in-epigenetic-anti-cancer-programs
If OrganTech aims to release the third generation follicles by 2030, does that mean that we can expect the first and second generation follicles to be out before that? Also was wondering which generation of follicles would be applicable for hair regeneration in hair transplant scars
What is meant by 1st, 2nd, and 3rd generation follicles? – Is Tsuji going through with clinical trials on lab grown follicles in 2024?
I believe that, like Fukuda, he refers to the fact that the 1st generation will be the multiplication of cells, the 2nd the implantation of primordia and the 3rd the transplantation of cloned follicles.
We need an explanation of 1st to 3rd generation follicles.
Guys,
u r all looking this „issue“ from competely different angle. one day we wake up and see that cure has been found.
i believe there is a lot of research currently being done under the wraps.
What is the potential revenue of this „cure“? i would say 100x covid at least.
This is at least 100B usd we are talking. Even Brad Pitt is a potential candidate..
Dont worry. this wil come fron big pharma.. we just dont know when..
New translation sent from Theo at the bottom of the post. Seems similar to the previous one. In any case, we just have to remember 2024, 2026 and 2027. And hope that the 2024 version helps people who still have significant amounts of hair left.
Is the 2024 version essentially just what HairClone was trying to achieve?
Hair Loss Cure 2030
Oh, c’mon Slick, I think you’re being far too generous mate. It’s 2040 plus a century. Then they can dig up my scull and pop a follicle on it…can’t wait.
Lol.. We’re both wrong. The cure is always “5 years away” (just long enough for people to forget or get over the original promise).
Update: The Tsuji Lab at RIKEN has now closed and relocated for the purposes of clinical trials. Note that the phrase “clinical research” is equivalent to “clinical trials” in these Japanese to English translations.
https://www.bdr.riken.jp/en/research/labs/tsuji-t/index.html
[Closed Mar. 2024]
https://www.riken.jp/support/organ_regen/index.html
“Therefore, in order to complete the basic research stage at RIKEN at the end of March 2024 and shift the research phase to clinical research aimed at social implementation, Dr. Takashi Tsuji will relocate his research base. “
Yo creo que los ensayos clínicos SI se realizarán dentro de este año y estarán destinados a la inyección de células multiplicadas en los cabellos miniaturizados, por lo que si es asi veo muy factible que puedan ofrecer la técnica al público en 2026. Por esta razón creo que Stemson, pretende pasar directamente a la fase 3 porque sabe que pronto alguna de estas empresas ofrecerán este tratamiento.
Translation:
I believe that the clinical trials WILL be carried out within this year and will be aimed at injecting multiplied cells into miniaturized hair, so if this is the case I see it as very feasible that they can offer the technique to the public in 2026. For this reason I believe Stemson intends to go directly to phase 3 because he knows that soon one of these companies will offer this treatment.
https://www.kenja.tv/president/detke26zb.html
I stand corrected HAIR CLONING isn’t going to happen until 2035 I’ve been saying that for years now I’ll see you guys in 2035 but now that we know the truth admin why continue with this blog that just gets people hopes up for nothing.
Marc, with the recent first ever successful pig kidney to human transplant…maybe we will be able to transplant lion mane hair or gorilla fur to our heads way before Tsuji, Fukuda or Terskikh technologies come to market! Without even taking strong immune suppressants. Do not give up.
FYI — I thought you said 2040 a while back? You are 5 years more optimistic now?
Admin thanks for not being mean to me I’m just very disappointed : ( admin and I always been saying between 2030 and 2035 because that’s what wikipedia has it coming out . But honestly admin or yoyo so I can get this straight hair cloning/multiplication is definitely not going to happen before 2030 from Dr takashi tsuji or junji Fukuda trichoseeds Co or stemsons therapeutics please give me a honest educated guess because so I can just get a fue done for my Norwood 2-3 but man I don’t want all those pot scars on the back of my head I like to get fade haircuts but anyway should I just forget about hair cloning completely? Thanks for all your work and time
Marc, unfortunately, too many companies have overpromised on their time estimates. I can just report on those promises each time they are made. Probably at least 10 companies since I started this blog made excessively bold claims. Made more believable by new regulations in various countries that could lead to much faster clinical trials.
You would not even need hair cloning or hair multiplciation if Follica/Cotsarelis are correct about the below phenomenon:
Ok admin it’s just very frustrating ok I think I see what you are saying basically just hope I’m alive long enough for the year 2035 so Dr takashi tsuji is really going to take 10 more years ? And I thought junji Fukuda trichoseeds was close to commercialization he even said it himself in a interview last year man can’t AGI help speed up the process? Thanks again for your time and effort.
Don’t lose hope man friend! Perhaps all readers of the page feel the same frustration as you, knowing that we have been waiting for years for a definitive solution to our problem that never arrives and floods us with frustration, but now, on the near horizon, there is the possibility of a treatment with multiplied cells. of the donor area in our miniaturized follicles can replace medications such as finasteride, dutasteride and minoxidil. The important thing about this is that for the first time a treatment based on the multiplication of autologous cells would be used. Who tells us that if this treatment is put into practice soon, someone will dare to multiply epithelial and mesenchymal cells and when injecting them new follicles will emerge in totally bald areas? We have to go step by step, and in your case friend who still has part of your hair, a transplant and this treatment would be a cure for you. You are a good administrator person, because you understand our frustration and you are always polite with us and thank you for your work on the page, which is spectacular!!
Are you being facetious ?
Alvaro is legit. But translates from Spanish at times.
I am not a joker friend and I can understand that you are pessimistic but not that you are rude, especially if I have tried to give you hope so that you feel better, but I see that you don’t care about anything but your ego. Well, good luck in your life!! With that attitude you won’t get very far.
I’ve found this evaluation of the Regenera/Reginera method from 2018 in which they state that: “There is no actual treatment capable of creating hair follicles de novo, since a hair follicle is not a single tissue but a tiny, full anatomical structure. Hair restoration treatments claim to increase the number of follicles and to be able to improve hair general conditions, its health or appearance. Hair transplant aside, the truth is there is no actual treatment capable of creating hair follicles de novo, since a hair follicle is not a single tissue but a tiny, full anatomical structure. ”
https://www.sciencepublishinggroup.com/article/10.11648/j.ijcda.20180401.12
This is not something that we don’t know. Just one more time confirmed that there is a long way for science to create new follicles.
The interesting thing in the article is the description of the Regenera method. I haven’t heard of it before and initially thought that it is like PRP. It appears that it gives better results than PRP in preserving the miniaturized hair follicles. So it could be a way to keep what you have until better treatments come to the scene: “The Regenera® method is no exception to
this rule, and its action is based on the regeneration and recovery of severely non-functional but still-alive hair follicles.
The Regenera® protocol uses a special microdermatome
(Regeneracons®) that breaks up the structure of skin by
means of 2.5-mm biopsies and filters elements smaller than
50 micras [5], such as cells. The processed material is
reinjected into the patient’s skin at the scalp. Fiber proteins
and the stratum corneum are naturally excluded, since the
cell fraction obtained is the biological product desired with
therapeutic action. No added chemicals or any other physical
processing medium is used. The Regenera® protocol involves
the following sequential main steps: i) Local anesthetic—
Lidocaine 2% without adrenaline—, ii) Skin micrograft from
the napearea—2.5 mm punch x 3—, iii) Micrograft placed in
the Regeneracons® and in the machine —mechanical
deaggregation at 80 rpm for 1 minute—, v) Recovery of the
filtered cells, and vi) Deep intradermal injection.”
In various sources it is stated that the effects of the treatment last for 1-3 years which is great although I didn’t find any study on the method that shows promising results. The price starts from $2500.
If anyone has tried or heard of it it will be good to share more info.
Hi, I’m sharing another interesting research on a new molecule similar to metformin that shows positive results comparable and even slightly better from minoxidil without toxicity. It is very rare for research to show promising results for women and this molecule actually performs better for female mice in the lab. It targets the stem cells proliferation and metabolism by switching from mitochondrial to glycolytic metabolism which seems to be better for stem cells by providing the building blocks for cell proliferation and protection from oxidative stress. The research states that the novel molecule generates better results in female mice and similar to minoxidil in male mice at 1% without toxicity. The molecule is IM176OUT05 or IM (N-1-(2-methyl) phenethyl biguanide hydrochloride).
https://www.nature.com/articles/s12276-018-0185-z
Hace 15 años la empresas ponían 5 años para los avances, ahora 15/20 años. Se dieron cuenta que 5 años pasan demasiado rápido y la gente pedía explicaciones, lo mismo pasará en 20..