Low-Level Laser Therapy (LLLT) for Hair Loss

HairMax LaserComb LLLT
Low-Level Laser Therapy with HairMax LaserComb.

Until several years ago, I used to be a skeptic when it comes to low-level laser therapy (LLLT) for hair loss. This is not to say that I felt there was zero logic in using lasers to treat scalp hair loss.

In fact, for years, I have heard of laser body hair removal causing the unwanted and opposite side effect of laser hair growth stimulation in some people. A phenomenon termed as paradoxical hypertrichosis. Affecting 3 percent of hair removal patients per a recent study.

However, I felt that the benefits of LLLT aka photobiomodulation (PBM) on scalp hair are modest at best. Lasers used for body hair removal at clinics are far more powerful and different from those used to treat scalp hair loss. Even less powerful at-home laser hair removal devices are often stronger than those used to treat scalp hair loss.

Updated: April 13, 2022

New Studies on LLLT for Hair Loss

Since I first wrote this post, a number of new studies in support of low-level laser light therapy for hair growth have been published.

  • An April 2022 study from China finds that low-level laser treatment promotes skin wound healing in mice by activating hair follicle stem cells. I always think of LLLT and wounding as somewhat overlapping in concept.
  • A December 2021 study from China found hair growth promoting effects from 650 nm red light stimulation.
  • September 2021 findings from Dr. Gentile of Italy: “All the articles selected and analyzed reported a positive effect of LLLT for MPHL and/or FPHL treatment without side effects”.
  • A May 2021 study concluded that low-level light therapy downregulates scalp inflammatory biomarkers in men with androgenetic alopecia. Moreover, LLLT also boosts the effectiveness of Minoxidil on hair growth. Note that this research was conducted in France by the reputable L’Oréal.
  • Also from May 2021, yet more findings that photobiomodulation therapy activates β-Catenin in hair follicle stem cells.
  • A 2020 literature review of ten controlled clinical trials concludes that LLLT appears to be safe and effective for treating pattern hair loss in both men and women. However, the authors caution that some studies “have a relationship with the industry”.
  • According to this summary, as of September 2020 there were 66 LLLT devices registered with the US FDA.
  • A 2019 study from Thailand conducted proteomic analysis of dermal papilla cells before and after treatment with low-level laser therapy. The analysis revealed 11 up-regulated and 2 down-regulated proteins in LLLT treated DP cells compared with baseline.

Also of note, at the recent 2022 AAD conference, there was a session on Photobiomodulation (PBM) therapy and hair growth. One of the items of discussion pertained to the use of LLLT in combination with PRP.

Low-Level Laser Therapy Wavelengths

The lasers that are used in LLLT typically have a wavelength of anywhere between 600 to 900 nanometers (nm). Anything below 600 nm tends to work less effectively. However, one study found lower wavelength blue light (453 nm) to be more effective.

The bestselling laser hair growth devices all use wavelengths of red or near-infrared light (i.e., around 650 nm). Of note, a study from South Korea found that a higher wavelength of 830 nm gave the best results (albeit in mice). For more on this subject, see my posts on low level laser therapy for hair loss wavelengths. Also check out my post on the use of higher wavelength fractional lasers for stimulating hair growth.

LLLT Debate

This old debate from 2008 between Dr. Feller and Dr. Bauman is quite interesting. Dr. Bauman was also part of a now famous 2004/2005 Dateline NBC show that followed 5 patients on different treatment protocols. The HairMax Lasercomb resulted in the most favorable (but not stellar) hair regrowth results. See patient “George” and his before and after photos at 8:10 onwards in this video:

Laser Devices for Hair Growth

Nowadays, numerous physicians support the use of FDA cleared at-home low-level laser devices for hair growth. The Amazon.com customer reviews for LLLT products typically average around 4.0 out of 5.0 stars.

However, I would advise always looking at reviews with a critical eye. Only give credence to reviewers who have their names verified. Make sure to focus on those who have posted reviews of many different types of products over several years.

6 thoughts on “Low-Level Laser Therapy (LLLT) for Hair Loss”

  1. I think laser therapy treatments that are designed for home-use such as laser comb or cap are more cost effective. But when it comes to the efficacy, it’s still debatable. Also, how well it works really depends on individuals.

    Regardless, thanks for the video clip. It was interesting to see their perception to hair laser therapy in general.

  2. I am Leonard Stillman, Director of Professional Services at Lexington International, LLC, manufacturers of the HairMax LaserComb. This post is NOT for commercial purposes, but is to notify your readers of a landmark clinical paper that was published in January 2014, in a peer-review medical journal. The article provides complete information on 4 studies with 225 subjects, which conclusively proved the efficacy and safety of the HairMax LaserComb in treating male and female pattern hair loss.

    The article is entitled: Efficacy and Safety of a Low-level Laser Device in the Treatment of Male and Female Pattern Hair Loss: A Multicenter, Randomized, Sham Device-controlled, Double-blind Study

    Below is a link to the complete article:

    http://link.springer.com/article/10.1007/s40257-013-0060-6

    Here are 2 quotes which contain the conclusions of the authors, taken directly from the article:

    “LLLT may provide a promising treatment option for patients who do not respond to either finasteride or minoxidil, and who do not want to undergo hair transplantation.”

    “Additionally, while topical minoxidil solution or foam is widely used to treat pattern hair loss and is generally well tolerated, the treatment needs to be applied once or twice daily, and be in contact with the scalp for at least 4 hours. Such application can be impractical for many users, leading to noncompliance and reduced efficacy. As an alternative, the [HairMax] lasercomb treatment is safe and easy to apply, with 8–15 min of treatment three times per week, and leaves no residue on the scalp. Such user friendliness of the [HairMax] lasercomb may lead to better patient compliance and improved efficacy.”

    We invite your readers to visit our web site to see if the HairMax LaserComb is right for them.

  3. Hey admin, you seemed to be in tune with a lots that’s going on in the world of hairloss so I was just hoping you may be able to steer me in the right direction. Im looking to purchase an at home laser device for hair growth.

    Hair clinics are trying to sell me the 3000 dollar laser cap. But then I see products like Theradome which are under a thousand. Do you have any thought/opinions if the theradome is equivalent to the pricier laser cap. I want the best available, just don’t know if there pricier tag means its the best. Thanks for any help you can give on this Admin. Love the work you do over here!

  4. Interesting. I’m skeptical as well (I know, big surprise). I guess I’d like to hear from actual users that say it helped them. I haven’t heard any but I’m sure if I looked hard enough I’d find them. Seems there are quite a few that pay big bucks for some of these devices and aren’t satisfied. Could be the level of whatever – power, rays etc just wasn’t right? Not all devices are the same, I’m sure, but we aren’t i lump them all together.

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