Kintor Pharmaceutical from China

A new Chinese company named Kintor Pharmaceutical is working on an interesting hair loss drug. It is extremly rare to hear about any Chinese company involved in hair loss cure research.

Very strange, considering the country’s rapid pace of scientific advancement and massive population. Moreover, Chinese men and women are nowadays balding at much faster rates than in the past.

Kintor Pharmaceutical and Hair Loss

Four days ago, China-based Kintor Pharmaceutical (also known as Suzhou Kintor Pharmaceuticals) got significant Chinese media coverage. This interest was related to the company’s prostate cancer, breast cancer and hair loss drugs. h/t reader “Bekoo”.

Earlier this month, Kintor Pharmaceutical also had a very successful IPO in Hong Kong.

While the company’s main focus seems to be its prostate cancer and breast cancer drugs, its androgenetic alopecia drug trials are also advancing rapidly. Their main androgen receptor blocking drug candidate is called pyrilutamide (KX-826) and it is applied to the scalp topically. The company’s proxalutamide drug slows or stops cancer cell growth by entirely inhibiting androgens.

Make sure to also read my past post on androgen receptor destruction.

Also to be noted, Cassiopea’s Breezula is an AR antagonist that is ahead of Kintor when it comes to product release date.

Pyrilutamide

The one disappointing news is that Kintor aims to take on Johnson & Johnson’s Minoxidil. This could mean that topical pyrilutamide is unlikely to be much better than Minoxidil. I hope I am wrong. Recently completed phase one trials in China proved that pyrilutamide is safe and causes no major side effects in humans.

Kintor is currently conducting phase 2 clinical trials for pyrilutamide on 160 men in China, and phase 1 trials on 30 men in the US. Phase 3 trials on 600 people in China, US and Japan are planned for as soon as 2021. I would guess that the US FDA and Japanese PMDA will never accept Phase 2 results from China as any kind of proof to proceed to Phase 3 trials in the US and Japan.

So how can the company proceed so fast in the US and Japan?

Below is the pipeline from the company’s website:

Kintor Pharma Pipeline
Kintor Pharma Androgenetic Alopecia and Prostate Cancer Pipeline.

30 thoughts on “Kintor Pharmaceutical from China”

  1. Maybe they are targeting minox to be seen as the new topical hair loss treatment and not necessarily targeting minox in terms of results effectiveness. Just a thought?

    Any word on that shampoo that is suppose to make minox more effective?

        1. Thanks. No pipeline page on there, and website footer says copyright 2018. Otherwise, seems quite interesting.

  2. Jake+Palmer I have a question for you, So if Tsuji transplants the cloned follicles on a human scalp it will take 1 month to see for sure if tumors will form and then if no tumors In the first month it’s a safe treatment? Thanks

    1. That’s a bit of a naive question, 1 month is incredibly short.

      Tumorigenesis is very difficult to foresee and needs comprehensive and time consuming testing. First you start with animal testing and then you proceed with highly controlled human testing.

      Most cell-based treatments (autologous) seem to be very safe in that respect. But it’s a young technology, hard to tell what happens after 3, 5, 20 years of initial treatment. If humanity wants to advance in medicine, it needs to take certain risks. Japan for example is very liberal in that respect, some would say too liberal…

    2. Yeah for the most part. There have been instances of stem cell injections causing tumors 8 years later. But what’s really happening is, at the moment of injection, the “cancer” cells are simply dividing so slow, that they don’t clump together into a bulge until it gets to a certain point. There’s people who have cancer that don’t even know it. But whenever you inject a cell into the body that is cancerous because theres faults in the dna from replication, they start growing like wildfire immediately. General scans can detect such abnormalities. Tsuji did say he was gonna test the procedure on monkeys before he tested it on humans. In my opinion and I advise everybody on this. I’m not going to get the procedure, no matter how much it costs, until I see a year of results, cancerous screening tests, and results from these tests.

      1. Jake+palmer, thanks for your great recent comments. We definitely need more commentators here who have a good grasp of the science.

      2. For example take a look at this.

        https://www.the-scientist.com/news-opinion/japan-approves-ips-cell-therapy-trial-for-spinal-cord-injury-65484

        Ips cells “cloned cell” trials have been taking place in Japan since 2015. Mainly for spinal cord injuries, blind people, etc. 80-90% of the time it cures the patients from these problems. And most of these ips trials happen from Riken. Japan is the one of a handful of countries that mandates stem cell screening upon injection. Here in the U.S, it’s kind of a free for all. So though I’m hopeful, I’m still keeping an open eye on long term effects from ips cells.

  3. Forgot the company name admin. It was posted on FT. It was shampoo that was supposed to be released this year. It was suppose to trigger a mechanism on the scalp so that minox would for non responders. They have other treatments in the pipeline as well.

  4. So maybe we could take KX in combination with Minox to wield better results assuming it actually works?

  5. What are the other hairloss drug options to test against then Admin? There are no real topical alternatives AFAIK

  6. “So how can the company proceed so fast in the US and Japan?”

    It won’t need to. China’s middle class out-numbers the entire US population. It’s the largest market in the world. And if it cures baldness, expect medical tourism and the application for Chinese tourist visas to sky-rocket. It won’t need USA or Japanese or European approval.

    1. If second generation oral NSAA’s aren’t curing AGA in the many mCRPC trials that have been conducted, some weak topical AR antagonist hasn’t got a hope in hell.

  7. It seems everyone is forgetting this and other prospective anti-AGA topicals will not cure AGA; they will not regrow lost hairs. Rather, they will maintain whatever hair an AGA sufferer has left. Frankly, I wouldn’t be too elated at this Kintor product and others like it. I just hope Tissuse and Tsuji come through before 2025.

    1. I doubt it maybe 2040 and I hope I’m wrong but I used to look at all those doom and gloom guy’s posts saying they’ve been waiting since 1990s and how it’s always 5 years away and thinking “ha we’re like a level 3 civilization now no way will science take that long those guys are just ignorant” but as time has gone on I realized I was ignorant they knew what they were talking about.

      1. Well said H. Unfortunately it’s how it is with our industry. People say tsuji. Tissue etc will be out by 2023 to 2025 lol. I think 2030 to 2040 is a very good time frame. Some rich people might get it earlier but mass use of hair cloning will be around that time frame when its perfected, safe and easily done at a hair clinic.

        1. I’ll be 37 by that time so hopefully I just confront this and get over it i hope we all do or find peace with it somehow even though it sucks.

  8. I think what admin says about an eventual “cure” being a conglomerate of treatments could have legs. Lets say microneedling, and if product X, does up to 15% and product Y does 10%, product Z etc… who knows maybe they could synergize well. Every new treatment/cure will fail…until it doesn’t.

    1. Micro-needling just makes me think of those Edwardian chemists that tried to turn copper into gold. Not inspiration but desperation.

  9. Any word on whether the PDUFA late August date for Cassiopea’s 1% cream has been delayed? Yesterday, the former FDA commissioner said on CNBC that the virus has caused a case backlog that will delay some PDUFA dates. Hopefully not this one.

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