Kintor Pharmaceutical from China

Kintor Pharmaceutical (China) just completed the enrollment of 120 patients in its Phase II clinical trials for Pyrilutamide for hair loss. See the bottom half of this post for my original discussion on Kintor. Their stock is traded on the Hong Kong Hang Seng Index.

Key quote from CEO Dr. Youzhi Tong:

“We will accelerate the progress of its phase II/III clinical study so as to bring benefits to the people suffering from alopecia as soon as possible.”

Update: Feb 2, 2021 — Kintor’s investigational new drug (IND) application of GT20029 for androgenetic alopecia and acne vulgaris was accepted by the National Medical Products Administration (NMPA) of China.

Kintor has moved forward with its trials faster than any other hair loss company. I am glad to see a Chinese company finally entering the hair loss cure market. Scientific and technological progress seem to happen faster in China than in the west. Hopefully, clinical trials for hair loss products will follow the same pattern. It seems like COVID-19 has not hurt Chinese scientific research progress. Or even their New Year’s Eve celebrations.

Side note: In July 2020, Kintor and Applied Biology (US) collaborated on using Proxalutamide for the Treatment of COVID-19. There is a school of thought that suggests anti-androgens could help reduce Coronavirus fatalities. To date, more men have died from the disease then have women.

Below is the pipeline from Kintor’s website:

Kintor Pharmaceutical Pyrilutamide Pipeline
Kintor Pharmaceutical Pyrilutamide Androgenetic Alopecia Pipeline.

May 26, 2020

A new Chinese company named Kintor Pharmaceutical is working on an interesting hair loss drug called Pyrilutamide . It is extremely rare to hear about any Chinese company involved in hair loss cure research. Very strange, considering the country’s rapid pace of scientific advancement and massive population. Moreover, Chinese men and women are nowadays balding at much faster rates than in the past.

Update: August 4, 2020 — Phase Ib trials are now complete.

Kintor Pharmaceutical and Hair Loss

Four days ago, China-based Kintor Pharmaceutical (also known as Suzhou Kintor Pharmaceuticals) got significant Chinese media coverage. This interest was related to the company’s prostate cancer, breast cancer and hair loss drugs.

Earlier this month, Kintor Pharmaceutical also had a very successful IPO in Hong Kong.

While the company’s main focus seems to be its prostate cancer and breast cancer drugs, its androgenetic alopecia drug trials are also advancing rapidly. Their main androgen receptor blocking drug candidate is called pyrilutamide (KX-826) and it is applied to the scalp topically. The company’s proxalutamide drug slows or stops cancer cell growth by entirely inhibiting androgens.

Make sure to also read my past post on androgen receptor destruction.

Also to be noted, Cassiopea’s Breezula is an AR antagonist that is ahead of Kintor when it comes to product release date.

Pyrilutamide

The one disappointing news is that Kintor aims to take on Johnson & Johnson’s Minoxidil. This could mean that topical pyrilutamide is unlikely to be much better than Minoxidil. I hope I am wrong. Recently completed phase one trials in China proved that pyrilutamide is safe and causes no major side effects in humans.

Kintor is currently conducting phase 2 clinical trials for pyrilutamide on 160 men in China, and phase 1 trials on 30 men in the US. Phase 3 trials on 600 people in China, the US and Japan are planned for as soon as 2021. I would guess that the US FDA and Japanese PMDA will never accept Phase 2 results from China as any kind of proof to proceed to Phase 3 trials in the US and Japan.

So how can the company proceed so fast in the US and Japan?

50 thoughts on “Kintor Pharmaceutical from China”

  1. Not great that it will compete with Minox, but at least they are targeting the androgen receptor finally.

  2. Maybe they are targeting minox to be seen as the new topical hair loss treatment and not necessarily targeting minox in terms of results effectiveness. Just a thought?

    Any word on that shampoo that is suppose to make minox more effective?

        1. Thanks. No pipeline page on there, and website footer says copyright 2018. Otherwise, seems quite interesting.

  3. Jake+Palmer I have a question for you, So if Tsuji transplants the cloned follicles on a human scalp it will take 1 month to see for sure if tumors will form and then if no tumors In the first month it’s a safe treatment? Thanks

    1. That’s a bit of a naive question, 1 month is incredibly short.

      Tumorigenesis is very difficult to foresee and needs comprehensive and time consuming testing. First you start with animal testing and then you proceed with highly controlled human testing.

      Most cell-based treatments (autologous) seem to be very safe in that respect. But it’s a young technology, hard to tell what happens after 3, 5, 20 years of initial treatment. If humanity wants to advance in medicine, it needs to take certain risks. Japan for example is very liberal in that respect, some would say too liberal…

    2. Yeah for the most part. There have been instances of stem cell injections causing tumors 8 years later. But what’s really happening is, at the moment of injection, the “cancer” cells are simply dividing so slow, that they don’t clump together into a bulge until it gets to a certain point. There’s people who have cancer that don’t even know it. But whenever you inject a cell into the body that is cancerous because theres faults in the dna from replication, they start growing like wildfire immediately. General scans can detect such abnormalities. Tsuji did say he was gonna test the procedure on monkeys before he tested it on humans. In my opinion and I advise everybody on this. I’m not going to get the procedure, no matter how much it costs, until I see a year of results, cancerous screening tests, and results from these tests.

      1. Jake+palmer, thanks for your great recent comments. We definitely need more commentators here who have a good grasp of the science.

      2. For example take a look at this.

        https://www.the-scientist.com/news-opinion/japan-approves-ips-cell-therapy-trial-for-spinal-cord-injury-65484

        Ips cells “cloned cell” trials have been taking place in Japan since 2015. Mainly for spinal cord injuries, blind people, etc. 80-90% of the time it cures the patients from these problems. And most of these ips trials happen from Riken. Japan is the one of a handful of countries that mandates stem cell screening upon injection. Here in the U.S, it’s kind of a free for all. So though I’m hopeful, I’m still keeping an open eye on long term effects from ips cells.

  4. Forgot the company name admin. It was posted on FT. It was shampoo that was supposed to be released this year. It was suppose to trigger a mechanism on the scalp so that minox would for non responders. They have other treatments in the pipeline as well.

  5. So maybe we could take KX in combination with Minox to wield better results assuming it actually works?

  6. What are the other hairloss drug options to test against then Admin? There are no real topical alternatives AFAIK

  7. “So how can the company proceed so fast in the US and Japan?”

    It won’t need to. China’s middle class out-numbers the entire US population. It’s the largest market in the world. And if it cures baldness, expect medical tourism and the application for Chinese tourist visas to sky-rocket. It won’t need USA or Japanese or European approval.

    1. If second generation oral NSAA’s aren’t curing AGA in the many mCRPC trials that have been conducted, some weak topical AR antagonist hasn’t got a hope in hell.

  8. It seems everyone is forgetting this and other prospective anti-AGA topicals will not cure AGA; they will not regrow lost hairs. Rather, they will maintain whatever hair an AGA sufferer has left. Frankly, I wouldn’t be too elated at this Kintor product and others like it. I just hope Tissuse and Tsuji come through before 2025.

    1. I doubt it maybe 2040 and I hope I’m wrong but I used to look at all those doom and gloom guy’s posts saying they’ve been waiting since 1990s and how it’s always 5 years away and thinking “ha we’re like a level 3 civilization now no way will science take that long those guys are just ignorant” but as time has gone on I realized I was ignorant they knew what they were talking about.

      1. Well said H. Unfortunately it’s how it is with our industry. People say tsuji. Tissue etc will be out by 2023 to 2025 lol. I think 2030 to 2040 is a very good time frame. Some rich people might get it earlier but mass use of hair cloning will be around that time frame when its perfected, safe and easily done at a hair clinic.

        1. I’ll be 37 by that time so hopefully I just confront this and get over it i hope we all do or find peace with it somehow even though it sucks.

  9. I think what admin says about an eventual “cure” being a conglomerate of treatments could have legs. Lets say microneedling, and if product X, does up to 15% and product Y does 10%, product Z etc… who knows maybe they could synergize well. Every new treatment/cure will fail…until it doesn’t.

    1. Micro-needling just makes me think of those Edwardian chemists that tried to turn copper into gold. Not inspiration but desperation.

  10. Any word on whether the PDUFA late August date for Cassiopea’s 1% cream has been delayed? Yesterday, the former FDA commissioner said on CNBC that the virus has caused a case backlog that will delay some PDUFA dates. Hopefully not this one.

  11. Has anyone heard about RU58841? Apparently it works better than Finasteride without the sexual side effects but they claimed it didn’t affect the hormones. Came out in the 90’s. It’s a Topical anti-androgen as well which also claimed to only stop DHT from binding to the receptor in the scalp and also claimed not to be systemic. Although many people on various forums apparently had side effects. Coincidentally it has never completed its full trials presumably because it did go systemic and resulted in side effects. Having an Anti Androgen that powerful that could potentially go systemic would be dangerous.

    This leads me to these new Anti-androgens like Breezula or Kintors Drug (Pyrilutamide) which claim not to affect hormones and not be systemic. I wonder if they’d also turn out to go systemic and result in sexual and/mental side effects as well.

    Currently RU58841 is available as a “research compound”. I always felt like since it’s available, these new companies could possibly be using it/something similar because RU58841 can be used with various vehicles such as Minoxidil. Also because the name of RU58841 has changed a few times over the years.

    For example, Follica has a Micro-needling system that using Minoxidil as well + a compound which in applied in Clinic.

    Ofcourse it’s possible that there’s no RU58841 used in any of the new treatments in the pipeline. But definitely something to be wary of regarding the potential of these new topicals going systematic and resulting in similar mental/sexual side effects as Finasteride/Dutasteride/RU58841.

  12. Kintor…Here’s hoping?!
    Rebranding idea…Hair Loss Cure 2020+
    (C,mon Admin, you know it works).
    Happy New Year.

  13. Another Chinese Company is Hope Medicine with this Bayer Drug. Any news from them?
    Also Applied Biology will finish a big Phase 3 Trial with the Kintor drug shortly beginning of this year for Covid. Could this be marketed this year already fast track?

    1. I mentioned the Covid one in the post, but not yet sure about approval. My guess is they have to approve this year or else will become pointless. Not sure about the Bayer status, but will check.

  14. I said it before and I will say it again: we will have this drug from Kintor before Breezula. Finally a company that doesn’t sit on products and waste time

  15. Off Topic: Is it true that after a certain number of years finasteride stops working? This question has been asked a thousand times, but since there isn’t much on the horizon still, let’s go back and talk about what we already have.

  16. If you ask me, hair cloning was solved back in 2010. I think the quality of hairs produced still remains a challenge. Most researchers are trying hard to mimic the scalp environment to ensure direction and hair thickness correspond to the patients original hair type. That issue wasn’t solved till 2018 when Stemson created micro wells and a lollipop, ” a 3d printed organ mold” for transplantation. the idea is you’d transplant these scaffold in with the cells to make sure they dont separate and you get shitty hairs that either die off or become in grown hairs. If you ask me I still think creating a hair follicle is easy. creating 10,000 is easy. creating 10,000 that have the thickness and curl patten is extremely hard. If you ask me, I could see a cure by 2030, but I think something else will come sooner. I Think a solution could be allogeneic transplant. I think millionaire and billionaire will pay a 100$ a follicle to get donated hair follicles form people that match their hair type, remove the receptors through radiation and implant fresh hair follicles from another person. If we dont have cloning we’ll probably have this by 2030. But I should say this, both of these treatments will most likely be for the wealthy for at least 10 years. Its the same thing as insulin, cost pennies to make but you sell it for thousands of dollars. sad to say but I think people should either start saving in anticipation or wait till 2045 when it becomes economically available.

    1. @jake this has made the most sense more than any other commentator. Histogen is really our only hope and microneedling with minoxidil.

      1. @tom first, timelines change based on liquidity in the market. that’s like saying apple will make the iPhone 10 and it runs out of money 2 years before consumer expectations. Timelines are based on how well a company is funded. Its odd though. Healthcare is the one industry investors aren’t willing to wait 10 years to receive an x multiple on their money. infrastructure, tech, finance, are industries investors are willing to invest for decades to get a return. Your timelines are as good as the companies in the market. All I was trying to say is I firmly believe ips cells as a whole will be used in medicine within the decade given advancing technologies, but I think there will be a premium for a long time. those that think that cloning will be out within the decade are right, but those that think it will be offered to the common man are dead wrong. I dont see it being widespread for decades because nano scale manufacturing of cells and bio degradable scaffolds is really really really expensive. Doing anything on the cell level is expensive. So I say that if your dead set on improving yourself, start saving money

    2. Sei qui che ancora parli ? Non ti sono bastate le tue teorie su tsuji? Parlavi di 2025 e invece? Adesso cosa dici ? La,verità e che non sai nulla ! Sei una persona normale che dice tante cose!

  17. Oh stop with the “CHINA OMG SO FAST” thing. It’s BS. I’m an unbiased and independent consultant for s investor (one of out babies just jumped to over 1 billion in evaluation and it’s not an EV company) and I specialize in the innovation sector. In the last 10 years, I didn’t see anything mindblowing or truly interesting coming out of China. And please don’t start with Alibaba or Tencent or Huawei. They didn’t “invent” anything. Their international patents are non-existent, their science papers are mostly absolute garbage (they need to send their students to US universities) and don’t get me even started on the quality issues.

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