Kintor Pharmaceutical to Start Phase 3 Trials


Kintor Pharmaceutical (China) is definitely the real deal. They are moving faster than any other company in the history of the hair loss industry. I think all my readers will agree.

Kintor will Start Phase III Trials in China in January 2022

In the latest update from today (November 24th, 2021), Kintor Pharmaceutical announced that it will begin Phase 3 trials in China in January 2022!

The company’s IND application for the pivotal study (phase III) of pyrilutamide (KX-826) was cleared by China’s National Medical Products Administration. KX-826 is the first androgen receptor (AR) antagonist to enter phase III clinical trials anywhere in the world.

This is perhaps the best news in the hair loss world so far in 2021.

Update: November 12, 2021 — Kintor Pharma just started Phase II clinical trials in women in China with a first dose of pyrilutamide (KX-826). This trial pertains to androgenetic alopecia in women (i.e., female pattern hair loss).

Update: September 8, 2021 — Kintor Pharma just announced that its Phase II clinical study for KX-826 to treat androgenetic alopecia was a success. Primary endpoint was met. More detailed results will be released later per CEO Dr. Youzhi Tong. Phase III clinical trials in China will commence in the fourth quarter of 2021. Even better, Phase II trials are also currently taking place in the US. And Phase II trials for women will take place in China

Update: July 11, 2021 — The US FDA just approved Kintor’s Phase II clinical trial for pyrilutamide (KX-826) to treat androgenetic alopecia. Note that the company’s trials in China are already mid-way through Phase II per their pipeline page.

They area also working on another hair loss product named GT200029 that is an “AR-PROTAC” compound. Its Phase 1 trials will start in China this month.

April 15, 2021

Kintor Pharma: AR Antagonist and AR Degrader

Earlier today, it was announced that Kintor received approval in China to begin clinical trials for GT20029. This product will be in tincture or gel format, and will be tested for the treatment of androgenetic alopecia and acne.

  • The GT20029 product is an androgen receptor degrader (AR Degrader). It is developed using Kintor’s proprietary Proteolysis Targeting Chimera (PROTAC) platform. According to the press release, this is the world’s first topical androgen receptor (AR) compound (AR-PROTAC) to enter clinical trials. GT20029 degrades the AR protein via the E3 ubiquitin ligase pathway. During preclinical studies, GT20029 did not cause any notable side effects or systemic drug accumulation.
  • Note that Kintor’s main product for treating male pattern hair loss is KX-826 (Pyrilutamide) and is an androgen receptor antagonist (AR Antagonist). I covered the latter in prior updates to this post if you read till the end. KX-826 is currently in Phase 2 clinical trials in China and in Phase 1 trials in the US.

Note that Cassiopea’s Breezula (Clascoterone) is an AR antagonist that is well ahead of KX-826 when it comes to clinical trial stage. Kintor’s website has a very interesting article discussing both AR antagonist products and hair loss in China in general.

Make sure to also read my related past post on destroying the androgen receptor to reverse hair loss.

Feb 2, 2021

Clinical Trial Status

Kintor’s investigational new drug (IND) application of GT20029 for androgenetic alopecia and acne vulgaris was accepted by the National Medical Products Administration (NMPA) of China.

Kintor has moved forward with its trials faster than any other hair loss company. I am glad to see a Chinese company finally entering the hair loss cure market. Scientific and technological progress seem to happen faster in China than in the west. Hopefully, clinical trials for hair loss products will follow the same pattern.

Side note: In July 2020, Kintor and Applied Biology (US) collaborated on using Proxalutamide for the Treatment of COVID-19. There is a school of thought that suggests anti-androgens could help reduce Coronavirus fatalities. To date, more men have died from the disease then have women.

Below is the pipeline from Kintor’s website:

Kintor Pharmaceutical Pyrilutamide Pipeline
Kintor Pharmaceutical Pyrilutamide Androgenetic Alopecia Pipeline.

 

Kintor Pharmaceutical (China) also recently completed the enrollment of 120 patients in its Phase II clinical trials for pyrilutamide for hair loss. See the bottom half of this post for my original discussion on Kintor. Their stock is traded on the Hong Kong Hang Seng Index.

Key quote from CEO Dr. Youzhi Tong:

“We will accelerate the progress of its phase II/III clinical study so as to bring benefits to the people suffering from alopecia as soon as possible.”

May 26, 2020

A new Chinese company named Kintor Pharmaceutical is working on an interesting hair loss drug called pyrilutamide . It is extremely rare to hear about any Chinese company involved in hair loss cure research. Very strange, considering the country’s rapid pace of scientific advancement and massive population. Moreover, Chinese men and women are nowadays balding at much faster rates than in the past.

Update: August 4, 2020 — Phase Ib trials are now complete.

Kintor Pharmaceutical and Hair Loss

Four days ago, China-based Kintor Pharmaceutical (also known as Suzhou Kintor Pharmaceuticals) got significant Chinese media coverage. This interest was related to the company’s prostate cancer, breast cancer and hair loss drugs.

Earlier this month, Kintor Pharmaceutical also had a very successful IPO in Hong Kong.

While the company’s main focus seems to be its prostate cancer and breast cancer drugs, its androgenetic alopecia drug trials are also advancing rapidly. Their main androgen receptor blocking drug candidate is called Pyrilutamide (KX-826) and it is applied to the scalp topically. The company’s Proxalutamide drug slows or stops cancer cell growth by entirely inhibiting androgens.

Pyrilutamide

The one disappointing news is that Kintor aims to take on Johnson & Johnson’s Minoxidil. This could mean that topical Pyrilutamide is unlikely to be much better than Minoxidil. I hope I am wrong. Recently completed phase one trials in China proved that pyrilutamide is safe and causes no major side effects in humans.

Kintor is currently conducting phase 2 clinical trials for pyrilutamide on 160 men in China, and phase 1 trials on 30 men in the US. Phase 3 trials on 600 people in China, the US and Japan are planned for as soon as 2021. I would guess that the US FDA and Japanese PMDA will never accept Phase 2 results from China as any kind of proof to proceed to Phase 3 trials in the US and Japan.

So how can the company proceed so fast in the US and Japan?

137 thoughts on “Kintor Pharmaceutical to Start Phase 3 Trials”

  1. Not great that it will compete with Minox, but at least they are targeting the androgen receptor finally.

  2. Maybe they are targeting minox to be seen as the new topical hair loss treatment and not necessarily targeting minox in terms of results effectiveness. Just a thought?

    Any word on that shampoo that is suppose to make minox more effective?

        1. Thanks. No pipeline page on there, and website footer says copyright 2018. Otherwise, seems quite interesting.

  3. Jake+Palmer I have a question for you, So if Tsuji transplants the cloned follicles on a human scalp it will take 1 month to see for sure if tumors will form and then if no tumors In the first month it’s a safe treatment? Thanks

    1. That’s a bit of a naive question, 1 month is incredibly short.

      Tumorigenesis is very difficult to foresee and needs comprehensive and time consuming testing. First you start with animal testing and then you proceed with highly controlled human testing.

      Most cell-based treatments (autologous) seem to be very safe in that respect. But it’s a young technology, hard to tell what happens after 3, 5, 20 years of initial treatment. If humanity wants to advance in medicine, it needs to take certain risks. Japan for example is very liberal in that respect, some would say too liberal…

    2. Yeah for the most part. There have been instances of stem cell injections causing tumors 8 years later. But what’s really happening is, at the moment of injection, the “cancer” cells are simply dividing so slow, that they don’t clump together into a bulge until it gets to a certain point. There’s people who have cancer that don’t even know it. But whenever you inject a cell into the body that is cancerous because theres faults in the dna from replication, they start growing like wildfire immediately. General scans can detect such abnormalities. Tsuji did say he was gonna test the procedure on monkeys before he tested it on humans. In my opinion and I advise everybody on this. I’m not going to get the procedure, no matter how much it costs, until I see a year of results, cancerous screening tests, and results from these tests.

      1. Jake+palmer, thanks for your great recent comments. We definitely need more commentators here who have a good grasp of the science.

      2. For example take a look at this.

        https://www.the-scientist.com/news-opinion/japan-approves-ips-cell-therapy-trial-for-spinal-cord-injury-65484

        Ips cells “cloned cell” trials have been taking place in Japan since 2015. Mainly for spinal cord injuries, blind people, etc. 80-90% of the time it cures the patients from these problems. And most of these ips trials happen from Riken. Japan is the one of a handful of countries that mandates stem cell screening upon injection. Here in the U.S, it’s kind of a free for all. So though I’m hopeful, I’m still keeping an open eye on long term effects from ips cells.

        1. Thanks Jake+Palmer

          Overtime, I would like to see how these teams developing “pre-injection/transplant” screening methods to detect cancerous cell lines. I could see them running PCR to identify key markers (mutated proteins in the cell growth cycle). In general, I only see this technology helping every area of medicine.

  4. Forgot the company name admin. It was posted on FT. It was shampoo that was supposed to be released this year. It was suppose to trigger a mechanism on the scalp so that minox would for non responders. They have other treatments in the pipeline as well.

  5. So maybe we could take KX in combination with Minox to wield better results assuming it actually works?

  6. What are the other hairloss drug options to test against then Admin? There are no real topical alternatives AFAIK

  7. “So how can the company proceed so fast in the US and Japan?”

    It won’t need to. China’s middle class out-numbers the entire US population. It’s the largest market in the world. And if it cures baldness, expect medical tourism and the application for Chinese tourist visas to sky-rocket. It won’t need USA or Japanese or European approval.

    1. If second generation oral NSAA’s aren’t curing AGA in the many mCRPC trials that have been conducted, some weak topical AR antagonist hasn’t got a hope in hell.

  8. It seems everyone is forgetting this and other prospective anti-AGA topicals will not cure AGA; they will not regrow lost hairs. Rather, they will maintain whatever hair an AGA sufferer has left. Frankly, I wouldn’t be too elated at this Kintor product and others like it. I just hope Tissuse and Tsuji come through before 2025.

    1. I doubt it maybe 2040 and I hope I’m wrong but I used to look at all those doom and gloom guy’s posts saying they’ve been waiting since 1990s and how it’s always 5 years away and thinking “ha we’re like a level 3 civilization now no way will science take that long those guys are just ignorant” but as time has gone on I realized I was ignorant they knew what they were talking about.

      1. Well said H. Unfortunately it’s how it is with our industry. People say tsuji. Tissue etc will be out by 2023 to 2025 lol. I think 2030 to 2040 is a very good time frame. Some rich people might get it earlier but mass use of hair cloning will be around that time frame when its perfected, safe and easily done at a hair clinic.

        1. I’ll be 37 by that time so hopefully I just confront this and get over it i hope we all do or find peace with it somehow even though it sucks.

  9. I think what admin says about an eventual “cure” being a conglomerate of treatments could have legs. Lets say microneedling, and if product X, does up to 15% and product Y does 10%, product Z etc… who knows maybe they could synergize well. Every new treatment/cure will fail…until it doesn’t.

    1. Micro-needling just makes me think of those Edwardian chemists that tried to turn copper into gold. Not inspiration but desperation.

  10. Any word on whether the PDUFA late August date for Cassiopea’s 1% cream has been delayed? Yesterday, the former FDA commissioner said on CNBC that the virus has caused a case backlog that will delay some PDUFA dates. Hopefully not this one.

  11. Has anyone heard about RU58841? Apparently it works better than Finasteride without the sexual side effects but they claimed it didn’t affect the hormones. Came out in the 90’s. It’s a Topical anti-androgen as well which also claimed to only stop DHT from binding to the receptor in the scalp and also claimed not to be systemic. Although many people on various forums apparently had side effects. Coincidentally it has never completed its full trials presumably because it did go systemic and resulted in side effects. Having an Anti Androgen that powerful that could potentially go systemic would be dangerous.

    This leads me to these new Anti-androgens like Breezula or Kintors Drug (Pyrilutamide) which claim not to affect hormones and not be systemic. I wonder if they’d also turn out to go systemic and result in sexual and/mental side effects as well.

    Currently RU58841 is available as a “research compound”. I always felt like since it’s available, these new companies could possibly be using it/something similar because RU58841 can be used with various vehicles such as Minoxidil. Also because the name of RU58841 has changed a few times over the years.

    For example, Follica has a Micro-needling system that using Minoxidil as well + a compound which in applied in Clinic.

    Ofcourse it’s possible that there’s no RU58841 used in any of the new treatments in the pipeline. But definitely something to be wary of regarding the potential of these new topicals going systematic and resulting in similar mental/sexual side effects as Finasteride/Dutasteride/RU58841.

  12. Kintor…Here’s hoping?!
    Rebranding idea…Hair Loss Cure 2020+
    (C,mon Admin, you know it works).
    Happy New Year.

  13. Another Chinese Company is Hope Medicine with this Bayer Drug. Any news from them?
    Also Applied Biology will finish a big Phase 3 Trial with the Kintor drug shortly beginning of this year for Covid. Could this be marketed this year already fast track?

    1. I mentioned the Covid one in the post, but not yet sure about approval. My guess is they have to approve this year or else will become pointless. Not sure about the Bayer status, but will check.

  14. I said it before and I will say it again: we will have this drug from Kintor before Breezula. Finally a company that doesn’t sit on products and waste time

  15. Off Topic: Is it true that after a certain number of years finasteride stops working? This question has been asked a thousand times, but since there isn’t much on the horizon still, let’s go back and talk about what we already have.

  16. If you ask me, hair cloning was solved back in 2010. I think the quality of hairs produced still remains a challenge. Most researchers are trying hard to mimic the scalp environment to ensure direction and hair thickness correspond to the patients original hair type. That issue wasn’t solved till 2018 when Stemson created micro wells and a lollipop, ” a 3d printed organ mold” for transplantation. the idea is you’d transplant these scaffold in with the cells to make sure they dont separate and you get shitty hairs that either die off or become in grown hairs. If you ask me I still think creating a hair follicle is easy. creating 10,000 is easy. creating 10,000 that have the thickness and curl patten is extremely hard. If you ask me, I could see a cure by 2030, but I think something else will come sooner. I Think a solution could be allogeneic transplant. I think millionaire and billionaire will pay a 100$ a follicle to get donated hair follicles form people that match their hair type, remove the receptors through radiation and implant fresh hair follicles from another person. If we dont have cloning we’ll probably have this by 2030. But I should say this, both of these treatments will most likely be for the wealthy for at least 10 years. Its the same thing as insulin, cost pennies to make but you sell it for thousands of dollars. sad to say but I think people should either start saving in anticipation or wait till 2045 when it becomes economically available.

    1. @jake this has made the most sense more than any other commentator. Histogen is really our only hope and microneedling with minoxidil.

      1. @tom first, timelines change based on liquidity in the market. that’s like saying apple will make the iPhone 10 and it runs out of money 2 years before consumer expectations. Timelines are based on how well a company is funded. Its odd though. Healthcare is the one industry investors aren’t willing to wait 10 years to receive an x multiple on their money. infrastructure, tech, finance, are industries investors are willing to invest for decades to get a return. Your timelines are as good as the companies in the market. All I was trying to say is I firmly believe ips cells as a whole will be used in medicine within the decade given advancing technologies, but I think there will be a premium for a long time. those that think that cloning will be out within the decade are right, but those that think it will be offered to the common man are dead wrong. I dont see it being widespread for decades because nano scale manufacturing of cells and bio degradable scaffolds is really really really expensive. Doing anything on the cell level is expensive. So I say that if your dead set on improving yourself, start saving money

    2. Sei qui che ancora parli ? Non ti sono bastate le tue teorie su tsuji? Parlavi di 2025 e invece? Adesso cosa dici ? La,verità e che non sai nulla ! Sei una persona normale che dice tante cose!

  17. Oh stop with the “CHINA OMG SO FAST” thing. It’s BS. I’m an unbiased and independent consultant for s investor (one of out babies just jumped to over 1 billion in evaluation and it’s not an EV company) and I specialize in the innovation sector. In the last 10 years, I didn’t see anything mindblowing or truly interesting coming out of China. And please don’t start with Alibaba or Tencent or Huawei. They didn’t “invent” anything. Their international patents are non-existent, their science papers are mostly absolute garbage (they need to send their students to US universities) and don’t get me even started on the quality issues.

  18. I’m not impressed! If it’s not hair cloning , then I don’t want to hear about another shampoo or topical treatment! Bye my friend I’ll see you in the 2030s when hair cloning is slated to be a reality !

  19. If it can revive completely smooth bald spots, I’d be thoroughly impressed. I’d like to see a NW 7 become a NW 0.

  20. Haven’t been on this site for quite a while.
    Unfortunately the latest developments don’t seem promising at all.
    I don’t want to sound sceptic but it looks like there won’t be any new treatment in the near future that works better than avodart or finasteride.
    I was optimistic few years ago but now it looks like the situation back in 2013.
    To all the new guys here I suggest you start using finasteride or avodart to at least maintain what you already got, get a hair transplant if you want your hairline to look better and don’t rely on dull hopes. Don’t make the same mistake many of the users here did.

    I wish all of you a head full of hair.
    Godspeed to all of you.

  21. I have to questions about this:

    1. Where did the commentators get the 5 years for GT20029

    2. How will KX fare in relation to Breezula? is there any information or results?

  22. This is actually great news. Now let’s see if they post any pics from phase 1 or if the trialist got regrowth. If this can grow tons of hair then we got something great. If it can maintain your hair that will be great for younger mpb folks.

    What happened to Breezula?

  23. Kintor is my fav company. They are moving way faster then EVERYONE else. As stated, they are developing two different treatments for pattern loss. They recognize the potential revenue. Breezula does not excite me anymore after learning that 10% of users develop HPA axis challenges. I personally think that most of those that cannot tolerate finasteride will probably not be able to use breezula as well. Again this is my unprofessional opinion. If your endocrine system cant make necessary adjustments to fin then there is a good chance it will fail to adjust to breezula’s steroid.

  24. Promising. I wish more info was available though. A product soon (ish) but what can or does the product do? Photos? I’m sure it’s all coming but for them to be this close with so little info out….just seems odd. But still, good news. So long as the side effects aren’t too bad and it actually does something. I’m so hesitant to get my hopes up these days.

  25. Excellent news Admin! It is also very exciting, according to the press release, that we will get the Phase II read out from Kintor’s China study sometime within the next 2 and a half months.

  26. Hey all I guess everyone is finished commenting on Kintor. On another note, anyone else notice that those with nice hair often have thick eyebrows? I know there are always exceptions but on average most of the guys I know with solid hair, like I mentioned, have nice thick eyebrows. I would say there is a definite link there. Looking at old pics of my younger self, my eyebrows are not as thick as say when I was 21 years old, so I lost some ground there as well. Thyroid tests have always come back in range so I dont think there is an issue there. Anyone?

    1. I have Brezhnev eyebrows and without fin and minox I would have been fully bald. Same goes for my dad who is fully bald.

  27. If Kintor are legit and the majority of skin-hats can get some hair back without any issues-I imagine they will make billions. Not really that enthused about Breezula tbh, it might be good or just ok? Who knows? Wait a few years, then add in the inevitable set-backs, etc. If you get bored, you can always count how many hair loss companies have flamed out in the meantime. At least Kintor don’t seem to be farting around like some of the dusty old lab-coats at other companies appear to be.

    1. @marc

      I’m kind of with you on this. I’m just not convinced a topical can really do what I need done. If I want a full head of relatively thick hair, I feel like it’s gotta be cloning. I mean, I’ll take even a little growth but come on…a topical isn’t going to grow hair from a shiny spot on my head. It’s just not. Might make the small and weak hairs stronger but it’s not growing something from nothing. Only cloning is going to do that.

      1. @james1 exactly, no topical or injectable serum will give the full thick hairline. It’s nonsense to even talk about anything that’s not hair cloning related! Dude I spoke to a British hair loss consultant and he told me hair cloning will probably come out between 2025 and 2028. That’s a long time from now and that’s if he’s right which I pray he is but I doubt it.

        1. Eh, that’s not too far away actually. But the problem is when it first comes out it’ll be insanely expensive. It’s not about when it comes out (when they can finally do it), but when it will be available (and realistic key affordable) for the masses – or at least a good chunk of thr population. Not helpful for most of its 10 mil lol

  28. The thing that really sucks is lets say a treatment that fully works finally comes out. I aint going to jump aboard immediately. That waiting period to see if there are any serious side effects is whats gonna make me go completely bald.

  29. I think cloning is gonna take a decade. we can grow hair its just the hair doesn’t look natural, it kinks, curls in the wrong places. if you guys want grass on your head go ahead. tbh I think allogeneic hair transplants will happen if someone puts 10-20 million into finalizing trials. you take someone else’s hair that mates your curl pattern and color, blast it with uv rays to remove dendritic cells so their able to bypass immune cells. now allogeneic hair transplants will be super expensive. picture paying people 1000 for 100 follicles, multiple that by 1000 for 100,000 hairs. yeah a million-2 million for hair. tbh id pay that. hair loss really gets to you, its crazy. but yeah if have every hair transplant doctor have a sample of my hair cross check it to patients and pay patients to get a fraction of their hair, thats where I see this going really. and 100 follicles isn’t alot per person, its 1/10 of an eyebrow, 1 square cm so id imagine people would take 1000 for a 100 hairs for a procedure their already doing

  30. aa25 lets just pray to god that verteporfin will work great and for many more transplants if needed. it would get around hair cloning, and the fda because it already approved.

    1. @woofy 97 verteporfin would have already been tested already. We just want to know about hair cloning! Which won’t happen until after 2025 to 2028 Pfffff that’s a long time from now

      1. Marc we don’t know if veterporfin has been tested yet. Let’s just hope it works because I’m not waiting till 2028 for hair cloning you have to wait years and then when it’s finally out and FDA approved or approved in some other country they will punch you with the outrageous price tag. (even though I don’t care about the price it’s more of piece of mind) but anyways no thanks

  31. I don’t understand the hype around Verteporfin. Where is any evidence whatsoever that applying it after removing from a hair follicle from the back of the head will result in the skin regenerating a new one?

    1. @Anthony
      Exactly there’s no proof and verteporfin has been around for a long time. I’m pretty sure someone would have tried it already. Sorry woofy97 but verteporfin isn’t going to help anyone! My apologies if I’m coming off rude but it’s the truth!

  32. I’m no expert, but ‘2025-2028’ and then some! It’s like when someone goes to renovate their home and naively forecasts a reasonable budget, only to see the damn thing blow out to a third, or in some cases, half over the original estimate. Hair cloning sounds great and all, but I imagine it’s light years away? Very happy to be proven wrong tho. Btw: has anybody put any coins in Tsuji’s cup lately?

    1. Dr tsuji isn’t embarrassed he came off completely as a fraud quack scientist/dr. He’s done well never hear from him again except for a new line of conditioner to go with his shampoo, other than that we’re not going to get hair cloning from Dr tsuji. And let’s be honest here who has any faith in Dr junji fukuda, the same Dr who said French fries oils can regrow hair and he even put out a date of 2023 to start human trials doesn’t that sound familiar to what Dr tsuji said in 2018 c’mom give me a break and ukhairclone where are they at I thought they were supposed to be offering stem cell treatments in 3rd quarter of 2021? Just another fraud like histogen and Dr tsuji and Dr junji fukuda we all have to wait for stemson therapeutics I thought they were finished with pig trials there major investor fortunis capital said IN a vimeo video earlier this year that there pig trials were a success and that they were hoping to start human trials later this year but Jan the long time commentator and my balding brother just said they never started it I’m like WTF someone is lying here. But anyways there’s really no hope other than stemson in my humble opinion but I’m right

    2. @Kim yeah between 2025 to 2028 which is almost a decade and then some More easily. Hair cloning is not going to happen until the next decade.

      1. @Jan they do not mention pig trials at all, and that vimeo video from fortunis capital said they’ve just finished pig trials in the beginning of this year in there latest news release. Jan you personally told me that they finished pig trials now your saying they never started it

      2. Jan bro why are you saying that they didn’t start pig trials yet. If you’re the one that sent us the link of fortunis capital saying they’ve completed pig trials and they were planning for human trials for later this year, Jan bro if you can please answer me back it would be greatly appreciated Sir Jan.

  33. Sounds promising! Looking forward to seeing how “statistically significant and clinically meaningful” this turns out to be.

  34. Hey Admin, any updates on the Almirall Topical Finasteride? I was really looking forward to that but it seems it just disappeared… Shouldn’t it be available in Europe by now?

    Thanks :)

  35. Just for fun, and even though it seems like the possibility of a real breakthrough is always just a mirage, I’m going to be unobjectively optimistic here: You could make the assumption that if they can make an early call that their Phase II trial was a success, maybe the results are readily apparent from simply visible observation……………in other words, maybe they don’t need to “count hairs” and tally numbers to see that, statistically, they made it over the hump. If that were true, I would think the benefit might be at least a consistent 20% improvement.

  36. Good news indeed. But this is coming from the country that reported 0 covid cases. I’m taking it with a grain of salt. Pics, or it didn’t happen.

    1. China has reported almost 5,000 Covid deaths thus far. South Korea less than 3,000. Japan close to 17,000. Vietnam 14,000. Maybe US totals are miscounted to a much larger extent?

      1. Maybe, but unlikely, unless you were to raise the same quizzical eyebrow in the direction of India, Brazil, the UK, Russia, France, Argentina, Columbia, Italy, Mexico, Peru, Argentina etc?

        1. On a per capita basis, India and Russia have a much lower death rate than the US.

          And Africa (with around 50 countries) has a total Covid death count of less than 200,000. In a population of 1.4 billion.

          Seems strange that at least 80 percent of the countries in the world have very low per capita Covid deaths. Are they all lying?

          In one of the local bars I go to, a long-time sick 85-year-old man had a stroke after a few drinks and died last year. They told his wife that it was due to Covid. She was too tired to try to get a second opinion.

          1. Admin, This just got political very fast. I know of two adults who both had all Covid symptoms and then died of Covid. I don’t think the doctors and nurses are lying on a nationwide scale, and we see some truth given that America has that “free press” thing. I do, however, think foreign governments don’t bother reporting deaths, because they have the same mentality that the former President of the US originally had (image, prestige, and economy are everything.. downplay and deny all threats to that). China, in particular, controls all info and creates their own reality. I’ve been there a few times. There’s a reason their news is government-controlled and their internet is locked down. We shouldn’t be naive about the competitiveness and lack of transparency of foreign governments. The U.S. had a massive vaccine rollout and was mostly masked up (office work from home), yet these other nations report 1-10% of the deaths the U.S. has seen? I highly doubt it.

            1. All I am implying is that by accepting the US numbers, we are indirectly accusing 80 plus percent of the world of lying. Maybe even close to 90 percent if we analyze per capita deaths. Nowhere did I mention politics, so it seems like you made some assumptions? I voted neither Trump nor Biden, but maybe you stereotyped?

              https://apnews.com/article/03408313b495c486be3a2e781338259b

              “The Department of Health said it had been counting as coronavirus deaths all people who died and tested positive for the disease.”

              https://www.factcheck.org/2020/04/hospital-payments-and-the-covid-19-death-count/

              “Recent legislation pays hospitals higher Medicare rates for COVID-19 patients and treatment, but there is no evidence of fraudulent reporting.”

              — I hope so, especially in diagnosing deaths in those over 80.

              1. Admin, There are enough countries reporting similar numbers to the U.S. such that it helps me trust the U.S. The numbers are scrutinized in so many ways at the county and city level, and it’s my belief that at least some doctors and reporters would find some BS if it existed (this may be my naive outlook). A conspiracy of that size is unhideable in my opinion. The other countries reporting similar numbers to the U.S. are somewhat civilized, like the U.K., France, and even Brazil. So, the countries that I’d expect to be more forthright are the one’s reporting high numbers (despite the bad image). I trust the western countries more than all the rest (many quasi-dictatorships). I say that this is political because choosing which governments to trust or claiming lies and conspiracy tends to be a political belief thing. Anyway, I suppose that none of us know for sure, but I believe reports from doctors and nurses around the country. It’s possible that there’s an agenda to claim Covid deaths and make more money somehow, but I do have a little bit of faith in the medical professionals as a whole (many thousands of doctors and nurses saying what they’re seeing jibes with the numbers). And anecdotally, I know people that sadly didn’t survive it. In summary, good ole France and U.K. have validated everything. That’s half a Eurotrip :-)

                1. Personal experiences definitely make a difference.

                  The only 1 person that I or my family know relatively well who died from Covid got the Sputnik vaccine a month prior to death. And between me and my family, we likely know at least 2,000 people worldwide. Including in countries with almost no strictly enforced months long lockdowns.

                  1. I know 2 that died from covid and some that survived it and can barely breathe from scarred lungs (and dizziness still, six months later).

                    My mother went to the hospital last week (non covid related) and had to wait 10 hours to be seen – hospital was full of covid patients. No joke, 10 hours. The waiting room was packed and everyone had been waiting for a very long time. Some with serious issues. It was a mess. The staff was stressed out. I don’t think it’s sustainable, long term. It’s not just about deaths. Many that survive it survive it because of hospital treatment but we can’t keep hospitals at 200% capacity forever. Where does that leave those with other injuries and illnesses?

                    Anyway, let’s hope what’s getting reported on this hair “cure” is legit. Time will tell.

    2. bw. Agreed. As with any company where the goal is to hype things and raise capital (that no one keeps track of), we should always have a healthy skepticism. And China absolutely restricts and controls information. That said, there’s a chance this is legitimate, so it’s good news. Maybe we’ll get some real-world accounts of U.S. participants. Clear before and after photos in identical lighting are the gold standard that seem so incredibly difficult to produce Lol.

  37. Agree. Consistant global pics with head locked into place and using the same camera/lighting to show results is what we want to see. Take it all with a grain of salt otherwise. (Pray the company is not reversing the time-sequence of the hair loss pics too.)

  38. Hi everyone, has anyone heard how it’s going for Dr tsuji fund raising to start human trials. He should have that 4.7 million he was asking for by now don’t you think?

  39. Admin
    I will buy PTD-DBM with valproic acid.
    This is the treatment of male pattern baldness based on studies .
    Anyone in favor of the idea?
    Is it a definitive cure for baldness?
    Will the hair fall out again after finishing treatment for 3 months or 6 months?
    Knowing that PTD-DBM is very expensive.
    Please help from forum members.

  40. Admin please get an appointment / itw with Queen Xiao Rui-Ping to talk about BAY and HMI, she’s the only one in the near future who has the key of our pain in her hands.
    Thanks from France.

    1. I have e-mailed her and if she responds I will post on the blog. Please do not ask again as you already did 3 times this week :-)

      1. Definitely suspicious PintoQ. Compounding that is the fact that the FDA is taking a while to approve them for phase 3. There is certainly more to the story than we are seeing at face value.

  41. Will it be possible to import the treatment from China in 2024 or will we have to wait FDA/EMA allow it in 2025-2026 ?

  42. Encouraging! Not telling anyone anything new here, but there’s two ways this can go. 1. Phase III ends in Mediocre, ambiguous claims and results, backed up with mediocre, ambiguous ‘maybe it does something but nah I can’t really tell’ imagery. or 2. Oh my goodness, there really IS a definite reversal of fortunes outcome here, what WAS definitely thin or bald now IS populated with hair and thicker. As always, we hope for scenario two, while staying guarded enough about the likelihood of scenario one for it not to be too disappointing.

    1. Currently I am skeptical of the latter simply because of the lack of transparency. I am getting samumed vibes from this medication. Regardless, we know that simple inhibiting androgens will not lead to hair follicle neogenesis. It will increase hair weight and length though, Androgens are involved in hair miniaturization but are not the cause of male patterned baldness. DHT is actually a very important molecule in formation of scalp hair follicles. It helps make them thick and robust. I am more interested in recent works of inhibiting the PRL receptors found in the hair follicle and this is exciting.

  43. If there aren’t any photos, I’m not getting excited. Not sure how they can expect anyone to get excited without them. We’ve been through too much. When I see (good/solid) photos, I’ll do a dance.

    1. The main redeeming factors for Kintor are that they are moving super fast and working in both China and the US.

      Scam companies tend to take almost 10 years from initial press releases to Phase 2 trial completion. Leading us along the whole way while focusing on their stock price movement.

      1. Good points. I’m not saying they’re a scam. But I need photos to get excited. I mean, rogain isn’t a scam but it’s not growing my hair back, you know what I mean? It may help some but not all. It may help all but only increase density by .02%. Who knows? It’s interesting and I’m definitely curious, just not excited yet. They clearly have the funding. Could be great and I hope to heck it is.

        1. Yes, but if its a disappointment or scam, at least we will know just 2-3 years after first hearing of the company:-)

          They could have moved much slower and pronged the “hair loss cure (or great treatment) coming” stock speculation for many more years.

  44. Been losing hair for 6 years.
    In that time I went from 80% density to 20%. Tried everything and went as far as to use finasterude and avodart together while using minox.
    Not only has it been difficult to see any effect but in the last year the bottom has fallen out… I recently stopped filling my scripts but
    after a couple months I got motivated again and started using a ketoconazole shampoo while awaiting new meds. In that time my hair loss COMPLETELY stopped. I can barely pull hairs out. Wtf is this?
    Had used it before but not consistently.
    I know I can chalk it up as just a positive response and I know scalp health is more beneficial than most of us give it credit but how could heavy reductase inhibitors and minox do nothing while this shampoo is completely effective alone?
    I’m a diffuse thinner as well and what I have resembles female pattern balding so I was already confused by my case.
    Is this bizarre as I think?
    It’s been a month I’m starting to hope to see regrowth now that I’ll be back on the meds too but I’m not gonna expect anything

    1. John if you are experiencing true diffuse thinning (FBB) allele than your hairloss will eventually halt prior to complete bald.

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