Over the years, I have mentioned a number of times that people with androgenetic alopecia (AGA) tend to have higher rates of scalp itching, dandruff, seborrheic dermatitis, sebum production and inflammation. I feel that treating these conditions can improve the chances of your hair follicles surviving the onslaught of dihydrotestosterone (DHT) for a little longer.
I have also discussed my own positive experiences in treating dandruff with bestselling shampoos, in particular Nizoral and Head & Shoulders. Also see my summary on natural treatments for dandruff.
DHT and Skin Disorders
I was not planning to write this post, but earlier today I saw an interesting new video on DHT and skin disorders. It is an hour long and I only watched one-half of it (via the timestamp subjects that I found of most interest).
The narrator analyzes a number of studies and also discusses Clascoterone (Winlevi) and androgen receptor antagonist KX-826 (Pyrilutamide). I find the video a bit disjointed, but it is a great overall effort. He covers acne, dermatitis, overactive sebaceous glands (and their suppression), scalp inflammation and other DHT-mediated skin disorders.
Of particular note, the video specifically breaks out Clobetasol (a corticosteroid) and Tacrolimus (an immunosuppressive agent) to combat scalp inflammation. Clobetasol propionate shampoos can be purchased online, but require a prescription. The same is the case with Tacrolimus ointments and creams. Do make sure to talk to your dermatologist if you ever try such products. And watch out for any potential side effects, especially with long term use.
Interesting and not surprising. My scalp itching started when I began losing hair.
Yes, the scalp also redness.
Maybe someone can tell me why I get significant chest discomfort and lower BP when I apply a small amount of Clobetasol to my scalp? Haven’t used it in 1.5 then tried it recently to calm my scalp and a few hours later my chest really was uncomfortable and it just continued to get worse and bp drops, and fatigue.
https://clinicaltrials.gov/study/NCT05324293?tab=results
Trial is completed
Is this the trial that Reddit guy was on?
Yes
Thanks. I was particular interested in this one. Can’t wait to get more details. Fingers crossed.
FYI — when a post has few comments, you guys can discuss off-topic subjects or random new developments as much as you want.
I just do not want the popular posts to get sidetracked too much.
What happened to Pyralutimide? wasnt it supposed to finish its final stage study in September?? anyone know?
Then why girls can have acne or similar skin disorders if they don’t have much DHT ?
Very good point!
I am a female, I have AGA, and even with very very very low DHT my AGA is progressing (I on an antiandrogeniv bcp + 100 mg Spiro + RU 3 times a week), yet since I am on the progestin pill only and gave up oetsro progestative pill, my AGA treatment does not work as well.
Oestrogens are very protective od DHT and androgens.
It’s not how much DHT or androgens you have it’s how sensitive you are to it.
Anybody has read this about metformin :
Metformin Promotes the Hair-Inductive Activity of Three-Dimensional Aggregates of Epidermal and Dermal Cells Self-Assembled in vitro
https://pubmed.ncbi.nlm.nih.gov/34883492/
https://www.cfspharmacy.pharmacy/blog/post/topical-metformin-for-alopecia
I am surprised I am not reading more about it