Dexpanthenol could be of use in treating hair loss. Or at least in treating the inflammation, itching and scalp discomfort often associated with androgenetic alopecia.
Reader “James” posted an interesting link today. South Korea based Hyundai Pharm just released Dexpanthenol based over-the-counter (OTC) tablets to treat hair loss. The brand name is Dexnoxyl.
Hyundai Pharm claims that this is the first ever OTC hair loss treatment in South Korea. Each of the 120 tablets contains 100 milligrams of the key active ingredient Dexpanthenol (also called Panthenol).
Does Dexpanthenol work for Hair Loss?
Today is the first time that I ever heard of Dexpanthenol. However, it is “the alcohol analog” of pantothenic acid (vitamin B5). And Vitamin B5 is used in some hair loss shampoos. Another South Korean company sells a Dexpanthenol containing shampoo called TS Shampoo. Reviews are not bad at 4.2/5 starts.
And yet another Korean company sells a salicylic acid and Dexpanthenol containing product. The key ingredient in these shampoos supposedly helps dissolve excess secretion from the sebaceous glands (aka sebum). The latter is a key reason for problems such as dandruff and seborrheic dermatitis.
Interestingly, in 2020, a Turkish author wrote two papers in favor of Dexpanthenol being able to treat pattern hair loss:
- Dexpanthenol may be a novel treatment for male androgenetic alopecia (May 2020).
- Systemic Dexpanthenol as a novel treatment for female pattern hair loss (September 2020).
A related clinical trial started in Iran in 2019. Edit: Results can be found here and they are positive. However, as one of the readers pointed out, we need before and after photos.
I would be very surprised if this new tablet product from Hyundai Pharm can regrow hair in totally bald areas of the scalp. However, I would not be surprised it it really does improve scalp health and reduces inflammation. Thereby possibly preventing more rapid progression in hair loss.
Note that Panthenol is widely used in various cosmetics and personal-care products. It helps with moisturization and can stimulate collagen regeneration. Panthenol promotes the acetylation of choline to acetylcholine
Eye drops and nasal sprays also often contain Panthenol to combat dryness. Reported side effects are minimal and generally limited to skin irritation and inflammation.
20 thoughts on “Dexpanthenol for Hair Loss from Hyundai Pharm”
Already available OTC … https://www.docmorris.de/panthenol-100-mg-jenapharm-tabletten/06150835?pp=GOOGLESHOP&mt=c&dc=c&dm=&erid=EAIaIQobChMI_um0n7757wIVAp_VCh3NEQITEAQYASABEgKJ1fD_BwE&gclsrc=aw.ds&&gclid=EAIaIQobChMI_um0n7757wIVAp_VCh3NEQITEAQYASABEgKJ1fD_BwE
Same drug Dexpanthenol in 100mg.
Is this the right brand that was just realeased?
Nice find admin…..question, so if one were to purchase vitamin b5, is that essentially the same?
Almost certain its not the same.
Interesting new cover story on anti-aging:
That has been around for along time, billionaires use young blood to live longer.
My personal fulfillment goes hand in hand with the slow pace of research to cure baldness …
I know we’re closer, but I’d really like to know how much closer …
I wonder if Dexpanthenol works well with microneedling…
“Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing.”
Note how similar this sounds to Follica…
“The Follica platform can be used to induce skin reepithelialization, which creates a “window of opportunity” during which the fibroblast growth factor 9 pathway could be modulated to potentiate hair neogenesis.”
**Reminder on the importance of increased fibroblast expression: overexpressing Fgf9 led to two to three-fold increase in the number of new hair follicles (Cots Study)**
I found the results from the Iran trial comparing Biotin + Dexpanthenol against the control (5% Minoxidil + 1mg Finasteride).
“Comparison between the three groups mean hair loss and mean hair diameter and percentage of hair growth during the four times in the biotin and biotin + dexpanthenol group were significantly better than the control group (p <0.05)."
"Based on the results of this study, it can be concluded that biotin and dexpanthenol can be helpful along with the routine treatment of androgenic alopecia."
No pictures though. All I care about really is pictures.
Another version here:
“Hair regrowth is highly feasible among next-generation regenerative medicine, and it is expected to be the world’s first and originated in Japan as a pioneer. Under the current Japanese policy, hair regrowth is an aesthetic treatment, so it is a self-financed medical treatment except for rare diseases, so there is not much national support for research and development. Since ventures are small and unstable, it is expected that all of us will aim to realize them by the people and companies. RIKEN is soliciting donations from the general public and companies, and is also seeking a wide range of partner companies.”
UK supplier here:
Sorry this is a bit off topic, but for those of you who do derma rolling, do you combine it with red light therapy? I’ve read that derma rolling and red light therapy for hairloss can cancel eachother out if done in too tight of a time window since the healing properties of red light can undo the wounding from the derma roller. What do you think of this? Should one be done at night and the other in the morning? Thanks.
You can also check this information about anti-age technologies / Maybe it will work for hair too
Any updates from Dr tsuji?
Kintor Pharmaceutical Announces AR-PROTAC (GT20029) Approved for Acne and Androgenic Alopecia Clinical Trials in China
I’m confused by the methods cited in the study: Were just [Biotin + Dexpanthenol] compared against control [5% Minox + 1mg Fin], or were [Biotin + Dexpanthenol + 5% Minox + 1mg Fin] aka Biotin + Dexpanthenol + “baseline treatment” compared against control [5% Minox + 1mg fin]?