Category Archives: Progenitor Cells

Ear Hair Cells Regenerated by Increasing Progenitor Cells

Update: For more on ear hair cell regeneration and reversing hearing loss, make sure to check out Frequency Therapeutics. The company has mentioned that they might also work on scalp hair loss.


I had a somewhat unusual post already half written for today, but commentator “baldings” posted a very important link that changed my plans.

This new link pertains to an article titled “Drug treatment could combat hearing loss” and on the surface seems to have little bearing with scalp hair loss. However, hearing loss is usually caused by permanent damage to many of the 15,000 hair cells in each inner ear.

In the article, the author discusses a new paper that is published in the February 21 issue of Cell Reports. In fact the findings of this paper are so important that the cover page of the journal has a photo taken directly from the paper:

Ear Hair Follicle Regeneration

In this paper, a team of scientists (from MIT, Brigham and Women’s Hospital, and Massachusetts Eye and Ear) have found a way to regenerate tiny inner ear hair follicles via a drug combination treatment.

This combination is a two step process where in the first step, a combination of drugs expands the progenitor cell population. In the second step, another combination of drugs induces the new cells to differentiate into hair cells.

In one variation of the experiment, the second step was not even necessary because “once the progenitor cells were formed, they were naturally exposed to signals that stimulated them to become mature hair cells“.

I am pretty certain that I have read articles in the past about ear hair cell regeneration and might even have mentioned one or two of them in passing on this blog before. However, this particular article and associated study warranted its own separate post and stuck out for two key reasons:

  1. The researchers succeeded in regenerating mouse ear hair cells via creating new progenitor cells. This is quite astounding to me because in regular scalp hair loss, scientists have found that hair is not lost due to the death of hair cells, but rather, due to the death of progenitor cells. So if these scientists can create new progenitor cells in the ear that lead to ear hair regeneration, I do not see how they can not try to use the same method to create new progenitor cells in the scalp.
  2. The researchers accomplished their potentially ground breaking achievement via stimulating the Wnt signaling pathway. I have discussed that pathway numerous times on this blog in the past, since it seems to be crucial for scalp hair growth. Moreover, well known company Samumed’s hair loss drug is targeting that same pathway.

Will ear hair cell research and findings become applicable towards scalp hair cell research? I really hope so and this new article makes me think that the answer is: “highly likely”.