Category Archives: Hasson & Wong

Dr. Hasson Ditches Oral Finasteride and Switches to Topical

In 2014, I wrote a post on topical finasteride that has since became one of the most read posts on this blog ever. In hindsight, this is not surprising when considering the fact that I get emails about topical finasteride at least several times a month. People really want to ditch oral finasteride and switch to the topical version in order to reduce their chances of side effects.

Local compounding pharmacies in most cities will be able to make topical finasteride for you if you ask them. However, most of us are eagerly awaiting two thoroughly tested products that could be available for sale worldwide in the near future.

  1. The first of these two is Spanish (previously Swiss) company Polichem’s P-3074 product, which I have covered on this blog several times in the past. European Phase 3 clinical trials for P-3074 are almost completed, while US Phase 3 clinical trials are expected to be completed in May 2018. Moreover, in 2016, an Italian study found the product (when applied to the scalp twice per day) to have superior results to oral finasteride. Several other favorable studies from prior years have also been covered on this blog in the past. P-3074 is vehicled in Hydroxypropyl-Chitosan.
  2. The second of these two products is Canadian hair transplant clinic Hasson & Wong’s topical Finasteride, which is being manufactured in partnership with Italy’s Farmacia Parati. Without this partnership with a well known reputable pharmacy, I would have not put this product in the same category as Polichem’s product. The Hasson & Wong product is a liposomal formulation that has been modified via the attachment of silicone particles to the liposomes.

Perhaps a third company can develop nanoparticle based finasteride delivery in the future?

Dr. Hasson Provides an Update

Since 2014, Dr. Victor Hasson has provided this blog with regular updates about the status of his clinic’s topical finasteride (e.g., see here and here). While Canadian hair loss sufferers have been able to obtain the product from his clinic (and Europeans have been able to access the product via Farmacia Parati), people in other regions of the world including the US have had no such luck. There are a number of regulatory hurdles that Dr. Hasson has been trying to overcome in order to sell in the US.

Last week, Dr. Hasson called me out of the blue and mentioned some new developments, the gist of which are highlighted in the latest blog post on his website. I did not record his call, but below are some highlights that I recollect:

  • Dr. Hasson will answer any intelligent reader questions if you post them in the comments to this post.
  • Hasson & Wong will no longer prescribe oral finasteride and has entirely moved to topical finasteride as their latest blog post mentions.
  • Since February 2017, they have been using their third generation of topical finasteride.
  • Results from topical finasteride (based on analysis of around 800 patients in the Vancouver, BC area over the past several years) have been at least as good as those from oral finasteride.
  • Side effects from topical finasteride have so far been nonexistent.
  • The Hasson & Wong clinic will post a number of updates with patient photos related to this latest development on their website in the coming weeks.
  • US sales should finally become a reality in the near future as Dr. Hasson has selected some pharmacies in the US that will compound his proprietary product.
  • I asked about topical dutasteride (which interests me more than topical finasteride), and Dr. Hasson mentioned that this product is next in line. He talked about some scientific reason that makes the topical dutasteride molecule even more amenable to the scalp and scalp absorption than the topical finasteride molecule. I will ask him to elaborate in the comments to this post.
  • Dr. Hasson mentioned that it has been difficult for him to get his hands on sufficient quantities of dutasteride and therefore their research in that area has lagged. Results from topical dutasteride are superior to those from topical finasteride, as would be expected from what we know about the oral versions of both drugs.

Hasson & Wong and the Case of the Missing Blog Post

My post from 2014 on topical finasteride became one of the most popular ones ever written on this blog.  This was not surprising, as literally hundreds of thousands (no exaggeration) of people around the world are nervous about taking oral finasteride and are hoping to switch to or start a topical version as soon as possible.  It seems like the topical version will results in fewer side effects and less systemic absorption, although this idea has been debated in the past.  Different topical formulations will probably have significantly different levels of systemic absorption depending on technology used.

One can get topical finasteride compounded at any local compounding pharmacy (my own local one said that they fulfill one such request each year).   However, hair loss sufferers have for years been hoping for reputable multinational pharmacies or companies to manufacture the product in bulk and sell it globally.  In recent years, two entities have taken the lead in making this finally happen:

  1. Switzerland-based Polichem via its P-3074 product.
  2. The Canada-based Hasson & Wong clinic via its topical liposomal gel product developed in conjunction with Farmacia Parati of Italy.

Hasson & Wong’s Topical Finasteride is Finally Here — Or is It?

A few days ago, the Hasson & Wong clinic announced on its blog that topical finasteride was finally a done deal and available with a prescription GLOBALLY!  However, their blog post was later removed from their website!

Dr. Hasson Explains

Since Dr. Hasson posted on this blog before and I had talked to him about this via phone in the past too, I decided to call him last Thursday and find out more about why that blog post was removed. Luckily, he was kind enough to talk to me right away.

According to Dr. Hasson, the reason that the blog post was removed is due to some legal issues and clarifications that are still pending. Throughout the course of developing this topical product, their clinic has had to deal with numerous regulations.  I assume that they have to adhere to Canadian regulations, European regulations, and perhaps even US regulations.  Dr. Hasson mentioned numerous hurdles and headaches involved in following all these protocols.

In any case, Dr. Hasson is extremely confident about this product. While oral finasteride does not cause major side effects in the vast majority of patients that take the drug according to virtually all studies and according to virtually all doctors that I have talked to, there are still some patients who seem to get long-term problems (usually less than 5 percent, although some recent studies suggest a higher number).  Topical finasteride will likely resolve this issue. According to Dr. Hasson, in the past around 50-60 percent of their patients were on oral finasteride, but lately this number has declined to around 20 percent.  Not surprising considering all the “I am scared of finasteride side effects” threads that we have been reading on hair loss forums in the past year…not to mention news items about lawsuits.

The most exciting things that Dr. Hasson told me about this silicone based liposomal gel topical finasteride product were that:

  1.  It will not be systemically absorbed to any significant extent (see this report for more).  In the deleted blog post, it said the topical finasteride systemic absorption rate will be 1/18th the systemic absorption rate of oral finasteride.
  2.  Every morning (or night) when you shower, the silicone in the product will be washed away entirely from your scalp.  So that silicone is not dangerous as some have suggested on the forums.

Note that this product is not FDA approved, as the cost and time-frame involved in getting that done is not worth it for any hair transplant clinic, including one as successful as Hasson & Wong.  So if you do end up using this gel and getting any kind of side effects, I am not responsible whatsoever.  It begs to repeat what I have said a few times before — when it comes to hair loss, any products you buy or any decisions you make should never ever be based on my opinions.  I am not a scientist, nor a doctor, nor well versed in biology or chemistry.

Also, while European prescriptions will be handled by Farmacia Parati, Canada prescriptions (and I think US ones too) will be handled by a local pharmacy in the vicinity of the Hasson & Wong clinic in Vancouver, Canada that will be compounding the product themselves.  Hasson & Wong have been using this pharmacy for many years and there is no issue of legitimacy and reliability here.

So in summary, we are very very close, and hopefully Polichem will release their P-3074 product too in the next year or two so that we can have two choices.  Dr. Hasson said that topical dutasteride is next in line. Great idea, considering that my dutasteride testimonials post is also one of the most popular posts ever made on this blog.

FYI — for those in Europe, make sure to read this 14 pages and counting Italian hair loss forum thread on Hasson & Wong’s topical finasteride product.  Right click and select translate to English via your browser if necessary.