Reshaping the Perifollicular Microenvironment

It is not often that I get to cover hair loss research from China. This week, several people mentioned an interesting new study from Zhejiang University.

Cerium Microneedle Patch Hair Follicle.png
Dissolvable microneedle patch with Cerium may reverse hair loss. Via and improved perifollicular microenvironment. Source: ACS Nano.

Cerium Nanoparticle Microneedle Patch

The research team was led by Dr. Fangyuan Li and Dr. Jianqing Gao. The team delivered cerium nanoparticles (coated in a lipid compound) via a microneedle patch into the skin of balding mice.

Video can be viewed here.

Lo and behold, the bald mice grew back their hair faster than with Minoxidil. The most interesting findings of this experiment all pertained to an improved perifollicular microenvironment:

  1. Reduced oxidative stress around the hair follicles from the effect of the cerium chemical. The cerium nanoparticles help reduce oxidative stress by removing reactive oxygen compounds. In a similar manner to antioxidants.
  2. The formation of new blood vessels around the mice’s hair follicles, with subsequent improved blood circulation.
  3. Higher levels of p-S6, a compound only active in hair follicle stem cells (at the onset of new hair development).

The microneedle patch was made by combining the ceria nanoparticles with hyaluronic acid and pouring the mixture into a mold.

48 thoughts on “Reshaping the Perifollicular Microenvironment”

  1. Unique search. We want to communicate with the researcher to find out the treatment is ready for human treatment or in the clinical trial stage
    Is treatment expensive?

  2. Hi admin,

    I have finished the information regarding our conversations.

    It should be in your inbox.

    For everyone else I had to change emails as yandex was showing everything as spam.

    The new email is quentintaramino@gmail.com

    Disclosure, this is not affiliated with hlc2020.

    I have had more than 100 emails regarding my posts and I will get back to everyone as soon as I possibly can.

      1. More than Minoxidil and if it’s genuine it sounds like a win to me… Obviously not cure better treatment for sure!

    1. Yes, but you have repeated yourself at least 100 times by now. And always in unrelated-to-the-subject posts.

      May I suggest improving your perifollicular microenviromment while you await 2035?

      1. Sure I apologize. Its just that why run this blog knowing that a real cure as in hair cloning is still a decade away from reality? And really truly nothing else will help.

        1. Because it is interesting for so many people to follow after the unbiased news from the hairloss world. If it is not interesting for you, why not just stop visiting this website?

          1. It’s a free country. Bro if you think there will be a viable cure within this decade your sadly mistaken. And you can take that to the bank.

            1. It’s not really just the cure that is interesting for me (and probably for many other ppl too). Any treatment that is more effective than fin/minox or works on a different mechanism is a big plus for me.

                1. Marc I feel sorry for you. You’re a complete loser. You believe nothing will happen for 10yrs yet you have nothing better to do than spam a hairloss blog regularly. Lol. You deserve to be bald forever.

                  1. I’m sorry you feel like that. You sound like a scientologists,how’s that going for you? What level clarity are you at ?

                2. Dude you’re really helping nobody with these comments. In 10 years, the world can turn upside down and back several times and nobody, not you nor me, can know what and when will come next, including in the hairloss industry. What I do with my money is my business as is what I consider a waste. To talk to you here is the real waste for sure so this is my final reply to you. Good luck, get a hair system or enter a monastery or smth coz you really do sound depressed.

  3. This is interesting for sure. I hope it doesnt vanish which seems to be the norm. I hope they take their findings and sell them to an interested company that has the funds needed to take it to the next level.

  4. This is very interesting and all progress is welcomed. That said, in mice, they’ve already found many ways to cure baldness and even stop aging. Why can’t humans be the same? Are there secretive establishment interests putting a stop to progress, or is the leap from mice to people really so complicated?

    1. Do you have fur? I guess not :) so yeah it’s more complicated. For example I remember reading that in a mouse a follicle sends signals to its neighboring follicles so positive effects are magnified.

  5. Something that works better than minox is already a huge step forward for some of us, I often look in the mirror and tell myself: it would take so little to have normal looking hair, you see I only have diffused thinning, my biggest problem is the advancement of my hairline that I’ve been keeping under control with sessions of painful dermaroller once a week.

  6. It’s interesting but when I hear “mice” now I’m like, dang. Because that almost always means it’s many years away. Still, the good news is companies are still working on this issue and open to new ways to fixing it.

  7. I find this sentence from the abstract interesting: “The dysregulation of the hair follicle niche induced by excessive reactive oxygen species (ROS) and insufficient vascularization in the perifollicular microenvironment is the leading cause of AGA”. I think it’s reasonable that androgens are mediators and not the source culprit.

  8. Recently published overview of hair follicle regeneration best sums up where the science is currently—Tissue engineering strategies for human hair follicle regeneration: How far from a hairy goal?

    HOW FAR?
    “significant limitations may further hamper an operational clinical solution for hair loss:

    1) bioengineered hair reconstruction will imply large-scale production of cell-based structures and the development of xeno-free and well-defined culture expansion media for clinical usage. Robust culture systems that allow stem cell expansion while maintaining their intrinsic properties are still missing.

    2) even if generation of functional and cycling HF units is achieved, a huge gap still exists until the conception of a clinically relevant bioengineered product that responds to physiological stimuli (eg, neuronal stimuli) and aesthetic context (hair type, density, pigmentation, and orientation)

    3) the low efficiency of organ induction, together with glitches in HF eruption and/or growth direction, may hinder the establishment of the effective therapy.

    4) a cost-effective cellular expansion and in vitro cell-based bioengineering for hair loss will be challenging. The establishment of a patient-customized therapy will necessarily make it highly expensive.

    CONCLUSION
    “future efforts are still needed to bridge such knowledge into an effective translational tissue engineering solution.”

    https://stemcellsjournals.onlinelibrary.wiley.com/doi/10.1002/sctm.19-0301

    1. Interesting article, seems like solid research. You gotta be careful though – sponsor is a hair-transplant-clinic, in fact Cristiano Ronaldo’s one. I don’t know about their intentions.

      Firstly, the paper is from 2019, so it’s not the newest one. But here are my takes on your points:

      1) Both Stemson and Yokohama stated officially that they already have a robust and safe mass-production process, ready for scalability.
      2) All contenders (Stemson, Yokohama, Tsuji, Epibiotech) know about these issues and I think it can only be looked at during a human clinical trial.
      3) Afaik induction is mainly solved, the rest is also going to be established during a human clinical trial.
      4) Especially Fukuda from Yokohama University said that their technique of the cultivation and expansion is easy to establish and not expensive.

      CONCLUSION
      “future efforts are still needed to bridge such knowledge into an effective translational tissue engineering solution.”

      That is very obvious, and it’s still a long way to go. But the companies involved are well-funded and offer fantastic knowledge and expertise in the field.

      @admin: Follicum finally officially dropped out of the development of their topical peptide treatment.

  9. Hi Admin,

    Fantastic coverage as always!! No pun intended with coverage lolol… I may have overlooked but didn’t see the safety profile with this method?

  10. About 15 years ago, I realized that we have a cure that will keep surgeons job security intact while allowing humankind to enjoy a full head of hair.

    We can grow human hair on mice. The protocol would basically take cells from the human, multiply and grow in immunocompromised mice with DNA of the human, then harvest the hairs and transplant into human. No worries about growth factors, cancer, hair direction, 3D scaffolding, ect. Unfortunately, we’d have to do it in a country that does not have ethics laws against the practice. But this is a totally viable and possible solution with the technology and knowledge we currently have. Really wish I had a genius doctor friend with a lab in a 3rd world country.

    1. If it was that simple, it would exist somewhere already no ? Plus we can already grow skin from human cells no ? So why not just do it on artificial skin from your own cells ?

    1. Exosomes and PRP – doesn’t sound new to me. Both proven to be non- or minimally-effective.

      By the way, Dr. Wasserbauer is also a supporter of “Hairclone”.

    1. Thanks. Various people also keep emailing me about this company that is hyperactive with its blog posts and marketing! Sketchy for sure, but still worth following. Might update my Han Bio post soon.

      1. Trust when I say han bio and Dr Fukuda and Dr Tsuji will not have Nathan. And shisiedos rch-01 is not that much better then minoxidil. We all have to wait for stemsons therapeutic to come out in 2030.

  11. well..i guess we are doomed. I dreams of locks, i envy all other women and even men..this will have led my life in the most negative way possible. If only…

    1. @hopefullnot just hang on until 2030 when stemsons therapeutic comes out . because trust me when I say no one else will be able to do it especially Dr tsuji and Dr Fukuda and Hanbio they have fraud written all over there faces. Sorry it’s the complete truth and any lotion or topical or injectable Will not give you a full Head of hair it just won’t do the job , only hair cloning Will help but trust me it’s a decade away I’ve spoken to several prominent surgeons and dermatologist in north America practically all of them from Toronto to new York to Los Angeles and Miami even in Tijuana they all told me the same exact thing.

      1. Hopefully I’ll be able to clone myself in ten years, then let the other prick worry about hair loss for a change.

  12. The ups and downs are crazy. We get a hint of some progress and we’re cheering then…it falls apart. One day there is hope, the next very little. Horrible cycle. I try to be realistic but it’s tough. I know we’re all in the same boat. With all of the scientists out there and so many counties working it, seems crazy we can’t get anything better than what we have now. Obviously, the big brains are working the more urgent issues. Still.

    Sigh.

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