Histogen HST-001 Phase 1b/2a Trial Results

Histogen HST 001
Histogen Hair Stimulating Complex (HST 001) trial schedule.

In 2012, Histogen announced 24-week results from their Phase I/II clinical trial of their hair stimulating complex (HSC). This product is also known as HST-001 and used to treat male pattern hair loss.

In 2021, Histogen just announced 26-week results from their Phase 1b/2a clinical trial of HST-001.

HSTO for the win!

Mockery aside, CEO Richard Pascoe said that a larger clinical trial will commence in the second half of 2021.

It seems like the hair stimulating complex works well in growing some hair in men with androgenetic alopecia. However, just as with the week 18 results, the placebo group also witnessed similar increases in hair count. There were no significant issues with safety or side effects.

I cannot be bothered to find out if some in the placebo group were using any kind of hair loss treatments such as Minoxidil. Most likely, that would not be allowed.

Per Histogen’s website, the HSC contains growth factors including KGF, VEGF, and follistatin.

52 thoughts on “Histogen HST-001 Phase 1b/2a Trial Results”

  1. It doesn‘t sound promising, to be honest.

    I mean, „no statistical significance compared to placebo“ is a killer line.

    But why there is „significant efficacy“ overall is a mystery to me.

    Must be one hell of a placebo!

    1. Abysmal and just purely shameful at this point. The researchers at histogen are now entering career researcher status.

      The truly groundbreaking treatments that I’m focused on are (and I mean that relative to what we have now):

      1. Follica
      2. RCH DP injections
      3. Kintors pipeline

      Follica with RCH and ky or kintors SARDS can be a good bet for early stage balding. The truth is, I don’t see any current hope for advance stages of alopecia besides cloning. I do think most of the good pharmaceuticals will be coming out of China. I hope india gets into the game because they have had success in treating many diseases before

    2. I agree and we know now that “humans” can make a flu vaccine in 9 months (make it 3 or 4 vaccines actually) … Serious researchers just don’t care about hair or skin. Our only hope is serendipity, a happy accident, like Minox or Fin. ;-)

  2. I imagine in the second half of 2031or will it be 2041 that they’ll release some more p*ss-poor results? I understand things take time, but this is getting ridiculous. What on earth do these Histo lab-coats do all day? Should be called Fund Stimulating Complex.

      1. the real concern is who are the investors of this treatment…the poor lads.

        These are the reasons why there is the decay of trust in alopecia biotech initiatives, as admin mentioned in a previous post. Histogen needs to wrap things up and let others use that capital

  3. What a joke. I think that the first time that I read about Histogen was more than ten years ago, and still they are on phase 1b and 2a , lol .

    1. they actually had good results before. wtf is going on with this company. they should just donate whatever money they have to tsuji and exit stage right

  4. http://en.huapont.cn/product/74.html

    HISTOGEN PARTNERED WITH HUAPONT CHINA WHICH MAKES DUTASTRIDE

    DUTASTERIDE

    Dutasteride 164656-23-9
    Therapeutic class:
    treatment of symptomatic BPH
    Chemical Formula:
    C27H30F6N2O2
    Molecular Weight:
    528.53
    CAS No.:
    164656-23-9
    Synonyms:
    AVODART®
    Regulatory:
    Written Confirmation is available upon request/DMF open part: available upon request
    Specification:
    In-house
    MSDS:
    available upon request

    1. Thanks admin for the positive news on RCH-01 after histogen was a complete failure. But the thing is that RCH-01 only produces a 10% increase in hair density which is nothing and the affects only last for 9 months and one has to fly to Japan. There truly isn’t a hair loss cure truly .microneedling will still be the best option for another 10 years. There’s a reason why elon musk is not investing in generative medicines with his smart mind he probably saw that it’s far and away from reality. I hope he does cloning experiments on Mars cus it seems like no other country wants to touch cloning. In my humble opinion

    1. Thanks. Went to spam first, but I happened to check that folder today. Rassman told me in January that he would give me an update on this later this year. May bug him in March.

    1. Samumed had clinical evidence, even for terminal follicle count. They are not a “miracle cure”, but… It’s realistic and better than Minoxidil.

      Follica + SM04554 will be interesting, I think…

  5. I can’t wait for the SAMUMED update soon. I’m hoping to get some of that or some Wenlevi/Breezula (or both) on the grey market and be a guinea pig. It seems like things are happening.

  6. Admin riken made another update on there Facebook page today regarding Dr tsuji hair cloning, just thought you might, find it interesting.

      1. You do good work admin, may I ask you for your educated opinion on a potential release date for Dr tsuji hair cloning ? Thanks for your work

  7. Hairlosscure2020, here’s the cure for baldness- let’s decode it!

    BAY-1158061 is the hair loss drug which makes Finasteride and Minoxidil look like onion juice. Seriously.

    After six months of treatment, the number of hairs in the hair loss area nearly DOUBLED, even in areas that had previously been nearly COMPLETELY BALD, and the effect continued for more than four (4 !) years AFTER the drug was discontinued. And these numbers were thick terminal hair increase, not vellus. The drug also literally worked better the balder the area was.

    This study was not done in mice, but in macaque monkeys. This is the gold standard as these monkeys actually have male pattern baldness characteristics. In laymans words, this is a huge deal. And as this wasn’t amazing enough, you also only need 1 injection every 14 days and you are done.

    Chances are you haven’t even heard about this drug at all. However it is currently being worked on behind the scenes at one of the biggest pharma companies in the world Bayer AG. As of now it has passed phase 1 clinical trials (focus on safety).

    BAY-1158061 is a prolactin receptor silencer. It consists of many amino acids set together to form a polypeptide antibody for the prolactin receptor.

    Bayer does not want us to find out the whole sequence to this antibody, and thus getting the treatment already through grey market channels.

    so….WHAT DO WE NEED TO DO?

    Hairlosscure2020 work your magic. Let’s decode the patent, or send it to your scientifically gifted friend (it will help tremendously). We think we have the sequence but we need the N and C terminus/terminals.

    All info you need to crack the code is here:

    https://patentimages.storage.googleapis.com/a2/fb/31/23bcc752e93829/WO2019011719A1.pdf

    https://patentscope.wipo.int/search/docs2/pct/WO2014036076/pdf/75c_IIgrSeDbTWrJkER6AspOntyvGYWMGtwaHxpaO55gKab6gel3Dl722vE3ha8lSW4L0M33CEr9RskMuU7_YZHoznDBR7gXV1KBxfEFnt7Kg3Fni9RQ07F0rIxR_6Ri?docId=id00000024176613

          1. Hi there are a few comment replies in the thread that will also disappear due to the order in which they were made. Your comment has nothing controversial in it, so I will leave as is. And your real name is not there anyway.

  8. One slight but important correction to your post is that in the 18 week update they stated that placebo lost hair while (although not statistically significant from baseline) the group treated with HST showed growth of new terminal and vellus hairs

    This inconsistency is very confusing and is very poor reporting on histogen part either deliberate or incompetent either are a bad sign – best thing they can do is actually publish the detail study results and let people see the data

      1. I agree very confusing- this is the worst worded press release I have read in a long time – to make matters worse the whole reference to “statistical significance vs placebo” is excluded from their investor presentation which was updated 17th Feb – if it is such a key point should be in there for sure!

        I have written to the company pointing out these inconsistencies and asking for some clarification – If they bother to reply then will let you all know what they say.

  9. This sounds extremely interesting…………thanks Tom and Admin. Despite the fact that I try to read all posts and comments, I don’t recall the original prolactin receptor post of April 2019. Can’t wait to hear more. I did a quick search and found the study below using BAY-1158061 in postmenopausal women which indicates a very strong safety profile. I don’t see anything new but if safety was confirmed 2 years ago, I can’t believe there hasn’t been some good progress since.
    https://www.researchgate.net/publication/325401324_Monoclonal_Antibody_Against_Prolactin_Receptor_A_Randomized_Placebo-Controlled_Study_Evaluating_Safety_Tolerability_and_Pharmacokinetics_of_Repeated_Subcutaneous_Administrations_in_Postmenopausal_Wome

  10. Admin a YouTuber goes by the channel name hairliciously posted a video earlier today he has a email interview with Dr tsuji in the coming days.

    1. Woofy you beat me to it but I was going to mention it. But yeah admin the youtuber hairliciously was granted a opportunity for a email interview. And hes asking the public to send him questions to ask Dr tsuji, and I think you admin with all your knowledge can work well with hairliciously to formulate a good questionnaire for Dr tsuji we basically just want to know when are human trials going to start and commercialization of the procedure. In your name Lord Jesus Christ please let hair cloning be able to happen.

  11. Admin totally agree about our endocrine systems. The last 20 years are food supply has been gmo, altered, new chemicals, pesticides, 3d printed meats, plastic causing alterations with our hormones etc. That’s just the food part. Then you got pollution, chemicals we breathe in from various places. It’s crazy. This causing havoc on our bodies daily. Imagine what its doing to our hair. I don’t see this ever getting better for our society and just worse. Only thing we can do is try to eat organic, grass fed meats and stay away from chemicals.

  12. So Dr Rassman hairy nevus treatment would fall under FDA biologics? So does anyone know what the biologic approvel process is like? And why does exosomes not go though that but his treatment does?

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