Category Archives: Stress and Hair Loss

Stress Does not Cause Permanent Hair Loss

In my opinion, excessive stress can almost never cause permanent hair loss in humans. At worse, it causes temporary telogen effluvium hair shedding. I explain my reasons in the numbered bullet points in the second half of this post. Grey hair is also rarely caused by stress, even though that myth will never go away. See my two posts on the cure for grey hair cure for more details. And of course the main reason for all of this is hair loss genes.

Update: June 21, 2024

Stress Hair Growth UK-5099
An interesting image from the study comparing hair treated with UK-5099 versus hair treated with UK-5099 plus Integrated Stress Response (ISR) inhibitor ISRIB.

Integrated Stress Response and Hair Growth

Yet another new study suggests a connection between stress and hair loss. Covered by sites such as Daily Mail and NY Post as well as The University of Manchester scientists found that when a mechanism called Integrated Stress Response (ISR) was over-activated, it had a negative impact on hair growth.

However, what really stood out to me is that the researchers made use of the Pelage Pharmaceuticals affiliated UK-5099 compound to inhibit the Mitochondrial Pyruvate Carrier (MPC). MPC inhibition promotes lactate generation, which activates epithelial hair follicle stem cells (eHFSCs). Earlier this year Yuva Biosciences (in partnership with Bosley) came out with a new hair loss foam product that partially restores mitochondrial function.

The senior author of this study, Dr. Talveen Purba, said the following:

“We were testing a drug that targets metabolism in human hair follicles to influence how cells generate energy, which (based on the work of others) we expected to stimulate stem cells. However, we found the opposite was true: Hair growth was instead blocked, as cells, including stem cells, quickly stopped dividing.”

May 8, 2021

On rare occasions, new studies come out that suggest that hair loss and grey hair are often caused by stress. I never buy such findings. Nevertheless, I will discuss such new studies when they get widely reported in the global media.

Stress effects the hair growth cycle.
Stress pushes hair into a resting Telogen phase.

Chronic Stress and Hair Loss

On March 31, 2021, researchers from Harvard University released findings (in mice) that chronic stress causes permanent hair loss. These findings were published in numerous newspapers around the world. The lead researcher was the respected Dr. Ya-Chieh Hsu, and the paper was published in Nature on March 4, 2021.

It was titled: “Corticosterone inhibits Gas6 to govern hair follicle stem-cell quiescence.” Chronic stress seems to increase levels of the corticosterone stress hormone in mice. This in turn prolongs hair follicle stem cell (HFSC) quiescence, resulting in hair follicles remaining in an extended resting phase.

The scientists believe that restoring Gas6 gene expression overcomes the stress-induced inhibition of HFSC activation and hair growth. Another summary from Harvard Stem Cell Institute (HSCI).

“Stress essentially just elevates this preexisting ‘adrenal gland–hair follicle axis,’ making it even more difficult for hair follicle stem cells to enter the growth phase to regenerate new hair follicles.” — Dr. Hsu.

Ronald Reagan Hair
Ronald Reagan never had any hair loss despite insane levels of stress. But he was not a mouse of course.

Since that day, readers have regularly posted or e-mailed me links to newly published versions of the story. This has annoyed me, since I do not believe these findings hold much merit in humans. However, to avoid further e-mails, I am now writing my counterarguments.

Besides the fact that the research was done in mice, there are some obvious issues that the researchers have surprisingly failed to address.

The Hair Loss and Stress Myth

  1. Why do young people virtually never go bald? In my whole life, I have never seen a person below age 14 suffering from androgenetic alopecia (male pattern hair loss). The few young children that I have seen with major baldness had: alopecia areata (or alopecia totalis and alopecia universalis); or were undergoing chemotherapy treatments for cancer; or were suffering from progeria (Hutchinson-Gilford). I am of course not counting any pre-teens who shave their head as a fashion statement.
  2. Major baldness is rare even in those who are younger than 20 years in age. And also not too common in those who are below 25. It is surely not believable that young people do not suffer from major stressful events!? If anything, stress is perhaps worst in those who are in high school and college. Permanent hair loss is almost always caused by male hormones (hence the term androgenetic alopecia) and NOT stress. More specifically, male pattern hair loss is usually due to a person’s genetic sensitivity to the effects of dihydrotestosterone (DHT). The latter in turn is converted from testosterone via the 5-alpha-reductase enzyme. Also make sure to read my post on destroying the androgen receptor.
  3. Why do Native Americans who are not mixed with Europeans never go bald? Are the Harvard Researchers implying that Native Americans never have chronic stress? Why do eunuchs never go bald?
  4. The findings do not address why women are less likely to have significant hair loss in comparison to men. Especially in their younger years. Most news sources seem to suggest than women in fact have more stress than men. So if anything, they should have higher rates of baldness than men.
  5. Why does stress not seem to impact body hair growth? Or even nail growth. Most men get an increasing amount of body hair as they get older. I have never heard someone say that they permanently lost their body hair after prolonged stress. Nails are made from keratin, just like scalp hair. Yet stress does not seem to cause nail stem cells to go into a permanent “resting phase”. Even people over the age of 100 have to keep cutting their fingernails and toenails unfortunately. My elderly father still has to shave his beard daily, while his hands shake a lot.
  6. Mahathir Mohamad Hair
    95-year old Mahathir Mohamad has not lost any hair even with a lifetime of stress.

    Why do many people who go through tremendous stress in their lives still never go bald? Among the most famous examples of this are: 93-year old now deceased ex-US president Ronald Reagan. And 95-year old still living ex-Malaysian prime minister Dr. Mahathir Mohamad. These two men went through numerous periods of chronic stress during their long lives.

  7. A lot of such research findings are in mice, rats, rabbits, hamsters and other such animals. Or sometimes just in extracted human skin rather than on actual human scalps. It is also virtually impossible for researchers to accurately measure and compare years of stress levels in humans.

Stress and Hair Greying

Interestingly, the same Harvard researcher (Dr. Ya-Chieh Hsu) and her team published a paper in January 2020 titled: “How stress causes gray hair.” At the time, I also ignored the work due to skepticism. Especially in regards to how findings in mice do not necessarily translate to humans.

Some of the same arguments I made earlier apply to these conclusions. Why do you almost never see children with grey hair? Young people often suffer from chronic stress. Yet I would guess that less than one percent of those below age 15 have prematurely graying hair.

I do think that the chances of getting more rapid development of grey hair after prolonged stress is at least somewhat possible in many humans. i.e., it could slightly speed up your genetic proclivity of hair graying.

However, I do not believe that stress can cause permanent hair loss in almost any humans.