Category Archives: Rei Ogawa

Brief Items of Interest, February 2016

Hair loss news first:

— Thanks to commentator “nosyu” from Japan for posting a link with news from today regarding hair and skin focused Japanese company Adjuvant Cosmetics, the renowned Dr. Takashi Tsuji (RIKEN Center for Developmental Biology) and Organ Technologies getting into some kind of partnership agreement.  The Japanese to English translation did not work well enough for me to gather all the details. Make sure to do a  search on this blog for Dr. Tsuji to read past posts that I have written about him.

— Since I started writing this blog, of all the researchers and companies involved in the hair loss world, Replicel has by far and away provided us with the most regular updates.  This past month has been no exception.  Here is a new video with Replicel’s CEO Lee Buckler starting his presentation at 16:11.  The presentation was part of the Japan External Trade Organization (JETRO)’s “Investing in Japan” conference in Toronto, Canada that took place on January 29th 2016.  The focus of the conference was on Japan’s booming regenerative medicine market.  Lee also discusses Replicel’s partner Shiseido.  From the same conference, here is a pdf of Lee’s presentation.  And finally, here is a new letter from the CEO.

— The latest issue of Nature Biology has an interesting article titled “Biotechs target stagnant baldness market.”  Only half the article is visible for free online, but you can find some hair loss forum threads where people are posting links to the full article.  Some of those links came up with security warnings on my browser, so I am not posting them here.  My favorite and at the same time least favorite sentence from the article:  “It’s been 25 years since Propecia (finasteride), from Merck of Kenilworth, New Jersey, was approved by the US Food and Drug Administration (FDA) in 1992.

— Study from Japan suggests that COL17A1 (collagen gene) could be a new target for therapy in preventing hair loss.

Kerastem clinical trial page was updated at the end of January 2016.  Go under the locations section of that page to see if there is a clinic near you where you can volunteer.  US only for now it seems.

— I discussed Dr. Rei Ogawa and his surprising mechanotherapy theory on this blog before in 2014.  Now Mr. Ogawa is back again as a co-author of this surprising article on how scalp massage positively impacts dermal papilla cells.  Really hard to believe, but these authors are all respected scientists from a developed country (Japan) with a generally solid reputation insofar as accuracy of research goes.

Excellent new article summarizing latest hair loss treatment options.  One of the co-authors is the famous Dr. Antonella Tosti.

Polichem (which is working on a topical Finasteride product called P-3074) was purchased by Spain’s Almirall.   Also see this new positive study from Italy on P-3074.

— Did Dr. Bernard Arocha just perform the first ever documented ARTAS beard transplant?

Irish men are increasingly opting for hair transplants.  Is a reduction in alcohol consumption next?

And now on to medical items of interest:

Partisanship in the US hurting 21st Century Cures Act.  Thank goodness for Japan, Canada and probably some other countries by now.

— I have discussed Dr. Anthony Atala and the Wake Forest Institute for Regenerative Medicine several times on this blog before.  This week, both were widely covered by the media due to the completion of their 3D bioprinter that can make bone, cartilage and muscle (a culmination of 10 years of work it seems)!  Full journal article here.  No mention about hair in there, but a Canadian team’s 3D bioprinter related article from 2014 mentions the eventual feasibility of adding hair follicles to the new skin.  Some quotes from Dr. Atala here.

UK scientists get gene editing go ahead.  Now western scientists may become less prone to criticize the Chinese too much as they did last year.

Oldest heart transplant recipient dies 33 years after getting a new heart.  Amazing story.  In another article I read, his son said that he died from kidney problems and still had no heart problems.

— If you have older family members that you want to live longer, you might want to try to find a sketchy doctor who can help remove their senescent worn out cells without government approval.  Or ask Liz Parrish for advice on South American clinics.

A major boost for cryonics.

A major boost for cancer treatment.

— This week “New Scientist” had an interesting article titled “First fully approved off-the-shelf stem cells launch in Japan.”  You have to register to read it, so here is the pasted version.

Dr. Rei Ogawa’s Mechanotherapy and Tom Hagerty’s Scalp Exercises

At the recent WCHR2014, Japan based Dr. Rei Ogawa of Nippon Medical School (Tokyo) made a very unique and original presentation on mechanotherapy and its use for hair loss. Luckily, his whole excellent presentation was recorded and posted on youtube.

Mechanotherapy for Hair Loss

I am embedding the video here, but would recommend clicking on it (on the lower right side of the video, click on the YouTube icon) and once inside youtube, subscribing to user “Scientific Event Horizon”  and checking out every video that has already been uploaded by that user. At least half of the below video does not deal with hair loss directly, but it is still well worth watching in its entirety. Also for more on mechanotherapy, see this Nippon Medical School page in its entirety.

Tom Haggerty and Scalp Exercises for Hair Loss

While watching the video, I suddenly remembered am old hair loss guru “friend” by the name of Tom Hagerty. Ever since I first started reading about hair loss on the internet well over ten years ago, Mr. Hagerty has had a steady and unique presence via his interesting website on scalp exercises that he himself developed and which that can supposedly reverse hair loss or at least stop further hair loss (Mr. Hagerty does have a good head of hair for his age).

I used to frequent his website and old limited-activity forums regularly ten or more years ago and even ordered his DVD despite my major reservations about his whole concept. The only reason I ordered the DVD was that the price was low (I think around $30 at the time), and Mr. Hagerty communicated with me a few times via e-mail and via his forums and sounded extremely sincere and helpful.  We both lived in the same state at the time too.

In any event, I saw his DVD, but out of laziness as well as due to Propecia and Rogaine giving me decent results (or my hair just naturally fluctuating between good and bad for a few years), I never stuck with the scalp exercises and even stopped visiting hair loss forums frequently for a few years. Perhaps I tried Mr. Hagerty’s  scalp exercises for a week at most? Funnily enough, a few years ago, Jotronic from Hasson & Wong also posted a video about scalp exercises in order to improve real scalp laxity prior to getting a strip hair transplant.

After making the connection from mechanotherapy to scalp exercises, my mind wondered on to the more recent widely publicized phenomena of wound healing and dermarolling. See my post on dermarolling and visit the forum threads I posted in there to learn more.  It seems like mechanotherapy, dermarolling and wounding, scalp exercises and perhaps even Rogaine and low level laser therapy (LLLT) could all impact cells, tissues and  molecular signalling pathways in the scalp region. And not just impact blood flow as typically always first postulated.

Perhaps I am reading too much into this, but it would really be quite something if Tom Hagerty’s unique scalp exercises were scientifically proven to be highly effective and a basic form of mechanotherapy (without the use of any mechanical device). Was Tom years ahead of the world’s foremost scientists? Should I try to find his DVD in my storage and take it more seriously?

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