Category Archives: Cryonics

Brief Items of Interest, February 2016

Hair loss news first:

— Thanks to commentator “nosyu” from Japan for posting a link with news from today regarding hair and skin focused Japanese company Adjuvant Cosmetics, the renowned Dr. Takashi Tsuji (RIKEN Center for Developmental Biology) and Organ Technologies getting into some kind of partnership agreement.  The Japanese to English translation did not work well enough for me to gather all the details. Make sure to do a  search on this blog for Dr. Tsuji to read past posts that I have written about him.

— Since I started writing this blog, of all the researchers and companies involved in the hair loss world, Replicel has by far and away provided us with the most regular updates.  This past month has been no exception.  Here is a new video with Replicel’s CEO Lee Buckler starting his presentation at 16:11.  The presentation was part of the Japan External Trade Organization (JETRO)’s “Investing in Japan” conference in Toronto, Canada that took place on January 29th 2016.  The focus of the conference was on Japan’s booming regenerative medicine market.  Lee also discusses Replicel’s partner Shiseido.  From the same conference, here is a pdf of Lee’s presentation.  And finally, here is a new letter from the CEO.

— The latest issue of Nature Biology has an interesting article titled “Biotechs target stagnant baldness market.”  Only half the article is visible for free online, but you can find some hair loss forum threads where people are posting links to the full article.  Some of those links came up with security warnings on my browser, so I am not posting them here.  My favorite and at the same time least favorite sentence from the article:  “It’s been 25 years since Propecia (finasteride), from Merck of Kenilworth, New Jersey, was approved by the US Food and Drug Administration (FDA) in 1992.

— Study from Japan suggests that COL17A1 (collagen gene) could be a new target for therapy in preventing hair loss.

Kerastem clinical trial page was updated at the end of January 2016.  Go under the locations section of that page to see if there is a clinic near you where you can volunteer.  US only for now it seems.

Excellent new article summarizing latest hair loss treatment options.  One of the co-authors is the famous Dr. Antonella Tosti.

Polichem (which is working on a topical Finasteride product called P-3074) was purchased by Spain’s Almirall.   Also see this new positive study from Italy on P-3074.

— Did Dr. Bernard Arocha just perform the first ever documented ARTAS beard transplant?

Irish men are increasingly opting for hair transplants.  Is a reduction in alcohol consumption next?

And now on to medical items of interest:

Partisanship in the US hurting 21st Century Cures Act.  Thank goodness for Japan, Canada and probably some other countries by now.

— I have discussed Dr. Anthony Atala and the Wake Forest Institute for Regenerative Medicine several times on this blog before.  This week, both were widely covered by the media due to the completion of their 3D bioprinter that can make bone, cartilage and muscle (a culmination of 10 years of work it seems)!  Full journal article here.  No mention about hair in there, but a Canadian team’s 3D bioprinter related article from 2014 mentions the eventual feasibility of adding hair follicles to the new skin.  Some quotes from Dr. Atala here.

UK scientists get gene editing go ahead.  Now western scientists may become less prone to criticize the Chinese too much as they did last year.

Oldest heart transplant recipient dies 33 years after getting a new heart.  Amazing story.  In another article I read, his son said that he died from kidney problems and still had no heart problems.

— If you have older family members that you want to live longer, you might want to try to find a sketchy doctor who can help remove their senescent worn out cells without government approval.  Or ask Liz Parrish for advice on South American clinics.

A major boost for cryonics.

A major boost for cancer treatment.

— This week “New Scientist” had an interesting article titled “First fully approved off-the-shelf stem cells launch in Japan.”  You have to register to read it, so here is the pasted version.

Brief Items of Interest, October 2015

Hair loss news first:

— Prolific hair loss forum participant “Hellouser” is planning to attend the 9th World Congress for Hair Research in Miami from November 18-21, 2015. I suspect that this Congress will be the best one yet. Last year I asked blog readers to raise funds for “Desmond” from Australia to go to the 8th World Congress for Hair Research in South Korea, and this year I am asking people to help raise funds for “Hellouser” from Canada to attend this Congress in the US. Desmond’s videos from last year’s conference were excellent and an absolute must watch. I hope “Hellouser” also manages to film many of the most anticipated presentations this year. Please see his gofundme page for more.

— I covered Samumed in a detailed post last year.  It seems like the company updated its clinical trials page last month and might still be recruiting volunteers (although one forum member said they stopped after getting too many calls). I called their Ohio testing location and left a voicemail on 10/16/15 and will update this section if they call me back. Update: Ohio location staff called me back on 10/19/15 and are still accepting volunteers this week.  Perhaps of more significance, Samumed is a Silver level sponsor of the earlier mentioned upcoming 9th World Congress for Hair Research. They are clearly not going away, and their Wnt pathway activation strategy is entirely different from what other companies such as Allergan, Histogen and Replicel are doing.

— An interesting new study tiled “The In-Vitro Development of Polarized Hair Bearing Skin” using LGR6+ epithelial stem cells. A bit too technical for me to analyze in detail in this brief updates post.

— Dr. John Cole made an interesting update to his “looking for PRP volunteers” thread (NO LONGER THERE AS OF 2016) on the Bald Truth Forums. In his own words, he is trying out the following formulations:

“1. PRP plus calcium gluconate (CG) Vs. PRP plus CG plus recothrombin
2. PRP plus calcium gluconate (CG) Vs. PRP plus CG plus autologous thrombin
3. PRP plus calcium gluconate (CG) Vs. PRP plus CG plus ACell
4. PRP plus calcium gluconate (CG) Vs. PRP plus CG plus AmnioFX
5. PRP plus calcium gluconate (CG) AmnioFX plus ACell Vs. PRP plus CG plus AmnioFX
6. PRP plus calcium gluconate (CG) Vs. Ultrasound cell lysis to release growth factors of PRP plus CG
7. PRP plus calcium gluconate (CG) Vs. PRP plus CG plus dalteparin plus protamine microparticles.”

— While we are talking about the details of PRP, on October 10 Dr. Jerry Cooley posted the following on the Hair Restoration Network forums:

“About PRP, that’s a great question. Actually, there a lot of different ways to ‘do’ PRP. Adding ACell is just one variable. Some of these other variables are: the device used to centrifuge the blood, the concentration of platelets achieved, the total volume injected, the size of the syringe and needle used to do the injecting, the level in the scalp it is injected, whether the PRP is ‘activated’, the use of microneedling, etc. All of these can affect the result in my opinion.”

— And yet more on PRP:  Dr. Jeffrey Rapaport keeps getting great publicity on his PRP treatment for hair.

FYI:  Although I discussed PRP a lot in this post, I still think its a gamble when it comes to growing back lost hair. If you do go for this procedure, it is probably worth contacting Dr. Joseph Greco first (search this blog’s “Categories” menu for more on him) and then contacting other doctors for a second and third opinion. [Update: Dr. Greco sent me some feedback that I have pasted in the comments to this blog post].

And now on to medical items of interest:

Deleting genes could bolster lifespan by 60 years. Only done in yeast cells as of now, but perhaps Liz Parrish can help speed this up in humans too?

George Church and colleagues do it yet again. They modify 62 genes in pigs used the CRISPR/Cas9 gene-editing technology. Humanity is a giant step closer to the day when organs can be harvested from pigs and implanted into humans without fear of rejection.

— If organ donations from pigs take too long to become a reality, there is always the possibility of ever improving artificial organs. The third ever patient to be fitted with an artificial Carmat heart is doing well six months post transplant. He is 73 years old. The first such patient died 2.5 months after getting an artificial heart and the second such patient died 9 months after getting an artificial heart  due to a motor control malfunction.

— I was unaware that earlier this year US based Alcor cryogenically preserved its youngest ever patient: a two-year old Thai child (just her brain). Now the BBC has published a very good article with video covering the family. Both parents are highly educated medical scientists and really believe that we are not too far from when science can bring back the dead, so long as they or their brains have been frozen immediately upon death. I am very creeped out by this, but at the same time fascinated. The parents seem like very reasonable and compassionate human beings. Also see this interesting new article on the science behind cryonics as well as last month’s NY Times front page article on Kim Suozzi’s brain preservation via cryonics.

An interesting side note: I once met this lady at a conference and she told me that she was involved in the freezing of baseball legend Ted Williams at Alcor in 2002. She told me that even at the age of 83, his legs were extremely muscular!

— A good article on Japan’s push to lead the world in stem cell research, including fast tracking clinical trials. We in the hair loss world know all about this and are hoping that many western companies take advantage of these favorable laws and conduct their trials in Japan.

— DARPA seeks to treat bodies with light, electricity, sound and magnets.

— Instead of obsessing over Lamar Odom, the US media should be covering stories such as the ones above, or this one that will make you all fuzzy inside. Pipe dreams of course.